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ISSN 2040-2503, 2/2017, Volume 8, Issue 2, pp. 259 - 267
Due to the relatively high rate of DNA damage that can occur during cell cycle progression, the DNA damage response (DDR) pathway is critical for the survival... 
Journal Article
JOURNAL OF NATURAL PRODUCTS, ISSN 0163-3864, 04/2019, Volume 82, Issue 4, pp. 1045 - 1048
The novel N-acyldehydrotyrosine analogues known as thalassotalic acids A-C were isolated from a marine bacterium by Deering et al. in 2016. These molecules... 
PHARMACOLOGY & PHARMACY | CHEMISTRY, MEDICINAL | AGENTS | TYROSINASE INHIBITORS | MELANIN | PLANT SCIENCES
Journal Article
Biochemistry, ISSN 0006-2960, 9/2013, Volume 52, Issue 37, pp. 6515 - 6524
Replication Protein A (RPA) is the primary single stranded DNA (ssDNA) binding protein in eukaryotes. The N-terminal domain of the RPA70 subunit (RPA70N)... 
Journal Article
Biochemistry, ISSN 0006-2960, 03/2009, Volume 48, Issue 12, pp. 2799 - 2806
Journal Article
Journal Article
CHEMMEDCHEM, ISSN 1860-7179, 04/2016, Volume 11, Issue 8, pp. 893 - 899
Replication proteinA (RPA) is an essential single-stranded DNA (ssDNA)-binding protein that initiates the DNA damage response pathway through protein-protein... 
CHEMISTRY, MEDICINAL | hit optimization | ASSAY | high-throughput screening | 70N DOMAIN | MODEL | DISCOVERY | protein-protein interactions | P53 TRANSACTIVATION DOMAIN | replication proteinA | PHARMACOLOGY & PHARMACY | BINDING | medicinal chemistry | ATR | Proteins | Optimization
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 02/2015, Volume 6, Issue 2, pp. 140 - 145
Replication Protein A is the primary eukaryotic ssDNA binding protein that has a central role in initiating the cellular response to DNA damage. RPA recruits... 
fragment-based discovery | Replication protein A | medicinal chemistry | BINDS | CHEMISTRY, MEDICINAL | FRAGMENT-LINKING | DNA | 70N DOMAIN | DISCOVERY | ATR | INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY | 60 APPLIED LIFE SCIENCES
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 07/2013, Volume 4, Issue 7, pp. 601 - 605
Replication protein A (RPA) is a ssDNA binding protein that is essential for DNA replication and repair. The initiation of the DNA damage response by RPA is... 
DNA damage | fragment-based discovery | Replication protein A | P53 TRANSACTIVATION DOMAIN | REPAIR | RPA | CHEMISTRY, MEDICINAL | DNA | BINDING
Journal Article
01/2010, ISBN 1124443355
Phosphopantothenoylcysteine synthetase (PPCS) is the second enzyme in the universal Coenzyme A (CoA) biosynthetic pathway. PPCS is responsible for catalyzing... 
Organic chemistry | Pharmacy sciences
Dissertation
01/2010, ISBN 1124443355, Volume 72, Issue 3
Phosphopantothenoylcysteine synthetase (PPCS) is the second enzyme in the universal Coenzyme A (CoA) biosynthetic pathway. PPCS is responsible for catalyzing... 
Enzymes | Thiols | phosphopantothenoylcysteine decarboxylase | amines | Coenzyme A | Exploration | Nucleotides | Fusion protein | ATP | Condensation | CTP
Book Chapter
MedChemComm, ISSN 2040-2503, 2017, Volume 8, Issue 2, pp. 259 - 267
Due to the relatively high rate of DNA damage that can occur during cell cycle progression, the DNA damage response (DDR) pathway is critical for the survival... 
P53 TRANSACTIVATION DOMAIN | CHEMISTRY, MEDICINAL | STRANDED-DNA-BINDING | SMALL-MOLECULE INHIBITORS | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE | BASIC CLEFT | 70 KDA SUBUNIT | RPA PHOSPHORYLATION | DISTINCT ROLES | ATR | REVEALS
Journal Article
Analytical Chemistry, ISSN 0003-2700, 08/2019, Volume 91, Issue 16, p. 10713
The ultimate performance of flow-based measurements in microfluidic systems is currently limited by their accuracy at the nanoliter-per-minute scale. Improving... 
Accuracy | Uncertainty | Interrogation | Fluorescence | Flow control | Measurement methods | Flow velocity | Scaling | Flowmeters | Flow rates | Microfluidics | Photobleaching | Index Medicus
Journal Article
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