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1. Full Text A pragmatic view on pragmatic trials
by Patsopoulos, Nikolaos A
Dialogues in Clinical Neuroscience, ISSN 1294-8322, 2011, Volume 13, Issue 2, pp. 217 - 224
Clinical trials have been the main tool used by the health sciences community to test and evaluate interventions, Trials can fall into two broad categories:... 
Trial | Pragmatic | Evidencebased medicine | Randomized controlled trial | Comparative | Treatment Outcome | Clinical Trials as Topic - methods | Evidence-Based Medicine | Research Design | Humans | Clinical Research | evidencebased medicine | pragmatic | trial | comparative | randomized controlled trial
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2. Genetics of multiple sclerosis: An overview and new directions
by Patsopoulos, Nikolaos A
Cold Spring Harbor Perspectives in Medicine, ISSN 1943-0264, 07/2018, Volume 8, Issue 7
The contribution of genetic inheritance in multiple sclerosis was established early on. Although multiple sclerosis is not a Mendelian disease, its incidence... 
RHEUMATOID-ARTHRITIS | OLIGOCLONAL BANDS | RISK LOCI | SUSCEPTIBILITY LOCI | NO EVIDENCE | HEAVY-CHAIN LOCUS | AFRICAN-AMERICANS | MENDELIAN RANDOMIZATION | CLINICAL-COURSE | GENOME-WIDE ASSOCIATION | CELL BIOLOGY
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3. Full Text Immediate-release methylphenidate for attention deficit hyperactivity disorder (ADHD) in adults
by Epstein, Tamir and Epstein, Tamir and Patsopoulos, Nikolaos A and Patsopoulos, Nikolaos A and Weiser, Mark and Weiser, Mark
The Cochrane database of systematic reviews, ISSN 1469-493X, 2014, Volume 9, Issue 9, p. CD005041
Background Symptoms of attention deficit hyperactivity disorder (ADHD), diagnosed mainly in children, often persist into adulthood. Adults in this group have a... 
METAANALYSIS COMBINING PARALLEL | MEDICINE, GENERAL & INTERNAL | EFFICACY | UTAH RATING-SCALE | DOUBLE-BLIND | OROS METHYLPHENIDATE | PLACEBO-CONTROLLED TRIAL | PREVALENCE | PHARMACOTHERAPY | OVER CLINICAL-TRIALS | DEFICIT/HYPERACTIVITY DISORDER | Central Nervous System Stimulants - therapeutic use | Central Nervous System Stimulants - adverse effects | Humans | Middle Aged | Adolescent | Methylphenidate - therapeutic use | Adult | Methylphenidate - adverse effects | Attention Deficit Disorder with Hyperactivity - drug therapy | Randomized Controlled Trials as Topic
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4. Full Text Sensitivity of between-study heterogeneity in meta-analysis: proposed metrics and empirical evaluation
by Patsopoulos, Nikolaos A and Evangelou, Evangelos and Ioannidis, John PA
International Journal of Epidemiology, ISSN 0300-5771, 10/2008, Volume 37, Issue 5, pp. 1148 - 1157
Background Several approaches are available for evaluating heterogeneity in meta-analysis. Sensitivity analyses are often used, but these are often implemented... 
Heterogeneity | Sensitivity analysis | Sequential algorithm | Meta-analysis | sequential algorithm | SYSTEMATIC REVIEWS | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | GENETIC ASSOCIATION | sensitivity analysis | CLINICAL-TRIALS | meta-analysis | LEVEL | INDIVIDUAL PATIENT DATA | META-REGRESSION | heterogeneity | EXPLORING HETEROGENEITY | Databases, Genetic | Treatment Outcome | Meta-Analysis as Topic | Algorithms | Models, Statistical | Humans | Theory and Methods
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5. Full Text Genetic and epigenetic fine mapping of causal autoimmune disease variants
by Farh, Kyle Kai-How and Marson, Alexander and Zhu, Jiang and Kleinewietfeld, Markus and Housley, William J and Beik, Samantha and Shoresh, Noam and Whitton, Holly and Ryan, Russell J. H and Shishkin, Alexander A and Hatan, Meital and Carrasco-Alfonso, Marlene J and Mayer, Dita and Luckey, C. John and Patsopoulos, Nikolaos A and De Jager, Philip L and Kuchroo, Vijay K and Epstein, Charles B and Daly, Mark J and Hafler, David A and Bernstein, Bradley E
Nature, ISSN 0028-0836, 02/2015, Volume 518, Issue 7539, pp. 337 - 343
Genome-wide association studies have identified loci underlying human diseases, but the causal nucleotide changes and mechanisms remain largely unknown. Here... 
TRANSCRIPTION FACTORS | B-CELLS | ENHANCER LANDSCAPE | READ ALIGNMENT | RISK LOCI | FOXP3 OCCUPANCY | CROHNS-DISEASE | MULTIDISCIPLINARY SCIENCES | REGULATORY T-CELLS | SUSCEPTIBILITY LOCI | GENOME-WIDE ASSOCIATION | Genome-Wide Association Study | Epigenomics | Humans | Autoimmune Diseases - immunology | Organ Specificity | Autoimmune Diseases - genetics | Transcription Factors - metabolism | Nucleotide Motifs | T-Lymphocytes - metabolism | Epigenesis, Genetic - genetics | Base Sequence | Polymorphism, Single Nucleotide - genetics | T-Lymphocytes - immunology | Enhancer Elements, Genetic - genetics | Consensus Sequence - genetics | Autoimmune Diseases - pathology | Chromatin - genetics | Epigenetic inheritance | Chromosome mapping | Genome-wide association studies | Causes of | Genetic aspects | Research | Autoimmune diseases | Methods | Studies | Haplotypes | Transcription factors | Disease | Cytokines | Epigenetics | Gene loci | Mutation | Gene expression | Immune system
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6. Full Text Reasons or excuses for avoiding meta-analysis in forest plots
by Ioannidis, John P A and Patsopoulos, Nikolaos A and Rothstein, Hannah R
BMJ, ISSN 0959-8138, 06/2008, Volume 336, Issue 7658, pp. 1413 - 1415
Heterogeneous data are a common problem in meta-analysis. John Ioannidis, Nikolaos Patsopoulos, and Hannah Rothstein show that final synthesis is possible and... 
Data Interpretation, Statistical | Meta-Analysis as Topic | Sample Size | Statistics as Topic | Data Display | Analysis
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7. Full Text Immediate-release methylphenidate for attention deficit hyperactivity disorder (ADHD) in adults
by Epstein, Tamir and Patsopoulos, Nikolaos A and Weiser, Mark
Cochrane Database of Systematic Reviews, ISSN 1469-493X, 05/2016, Volume 2016, Issue 5
MEDICINE, GENERAL & INTERNAL
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8. Full Text Polarization of the effects of autoimmune and neurodegenerative risk alleles in leukocytes
by Raj, Towfique and Rothamel, Katie and Mostafavi, Sara and Ye, Chun and Lee, Mark N and Replogle, Joseph M and Feng, Ting and Lee, Michelle and Asinovski, Natasha and Frohlich, Irene and Imboywa, Selina and Von Korff, Alina and Okada, Yukinori and Patsopoulos, Nikolaos A and Davis, Scott and McCabe, Cristin and Paik, Hyun-Il and Srivastava, Gyan P and Raychaudhuri, Soumya and Hafler, David A and Koller, Daphne and Regev, Aviv and Hacohen, Nir and Mathis, Diane and Benoist, Christophe and Stranger, Barbara E and De Jager, Philip L
Science, ISSN 0036-8075, 2014, Volume 344, Issue 6183, pp. 519 - 523
To extend our understanding of the genetic basis of human immune function and dysfunction, we performed an expression quantitative trait locus (eQTL) study of... 
TRANSCRIPTOME | MULTIDISCIPLINARY SCIENCES | GENOME-WIDE ASSOCIATION | Autoimmune Diseases - ethnology | Humans | Immunity, Innate - genetics | Transcriptome | Autoimmunity - genetics | Monocytes - immunology | Rheumatic Fever - genetics | Adaptive Immunity - genetics | Autoimmune Diseases - genetics | CD4-Positive T-Lymphocytes - immunology | Ethnic Groups - genetics | Parkinson Disease - ethnology | Multiple Sclerosis - ethnology | Genetic Predisposition to Disease - genetics | Genome-Wide Association Study | Multiple Sclerosis - genetics | Neurodegenerative Diseases - genetics | Parkinson Disease - genetics | Rheumatic Fever - ethnology | Alleles | Alzheimer Disease - ethnology | Genetic Predisposition to Disease - ethnology | Polymorphism, Single Nucleotide | Neurodegenerative Diseases - ethnology | Alzheimer Disease - genetics | Quantitative Trait Loci | Allelomorphism | Nervous system | Genetic aspects | Degeneration | Leukocytes | Autoimmune diseases | Health aspects | Risk factors | Leucocytes | Immunology | Genetics | Gene loci | Ribonucleic acid--RNA | Neurological disorders
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9. Full Text Limited statistical evidence for shared genetic effects of eQTLs and autoimmune-disease-associated loci in three major immune-cell types
by Chun, Sung and Casparino, Alexandra and Patsopoulos, Nikolaos A and Croteau-Chonka, Damien C and Raby, Benjamin A and De Jager, Philip L and Sunyaev, Shamil R and Cotsapas, Chris
Nature Genetics, ISSN 1061-4036, 03/2017, Volume 49, Issue 4, pp. 600 - 605
Most autoimmune-disease-risk effects identified by genome-wide association studies (GWAS) localize to open chromatin with gene-regulatory activity. GWAS loci... 
PARTITIONING HERITABILITY | GWAS | VARIANTS | INTEGRATION | COLOCALIZATION | GENETICS & HEREDITY | SIGNALS | TRAITS | EXPRESSION | GENOME-WIDE ASSOCIATION | Autoimmune Diseases - genetics | Genetic Predisposition to Disease - genetics | Gene Regulatory Networks - genetics | Gene Expression - genetics | Humans | Polymorphism, Single Nucleotide - genetics | Genome-Wide Association Study - methods | Immunity - genetics | Quantitative Trait Loci - genetics | Quantitative trait loci | Genetic research | Research | Genetic susceptibility | Gene expression | Health aspects | Hypotheses | Genomes | Disease | Methods
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10. Full Text Relative Citation Impact of Various Study Designs in the Health Sciences
by Patsopoulos, Nikolaos A and Analatos, Apostolos A and Ioannidis, John P. A
JAMA, ISSN 0098-7484, 05/2005, Volume 293, Issue 19, pp. 2362 - 2366
CONTEXT The relative merits of various study designs and their placement in hierarchies of evidence are often discussed. However, there is limited knowledge... 
CONTROLLED-TRIALS | MEDICINE, GENERAL & INTERNAL | ARTICLE | METAANALYSIS | JOURNALS | RECOMMENDATIONS | Biomedical Research | Bibliometrics | Publishing - statistics & numerical data | Research Design - statistics & numerical data | Analysis | Medical sciences | Meta-analysis | Studies | Scientific method | Health | Methods | Impact analysis
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11. Full Text Analysis of shared heritability in common disorders of the brain
by Anttila, Verneri and Bulik-Sullivan, Brendan and Finucane, Hilary K and Walters, Raymond K and Bras, Jose and Duncan, Laramie and Escott-Price, Valentina and Falcone, Guido J and Gormley, Padhraig and Malik, Rainer and Patsopoulos, Nikolaos A and Ripke, Stephan and Wei, Zhi and Yu, Dongmei and Lee, Phil H and Turley, Patrick and Grenier-Boley, Benjamin and Chouraki, Vincent and Kamatani, Yoichiro and Berr, Claudine and Letenneur, Luc and Hannequin, Didier and Amouyel, Philippe and Boland, Anne and Deleuze, Jean-François and Duron, Emmanuelle and Vardarajan, Bai N and Reitz, Christiane and Goate, Alison M and Huentelman, Matthew J and Ilyas Kamboh, M and Larson, Eric B and Rogaeva, Ekaterina and George-Hyslop, Peter St and Hakonarson, Hakon and Kukull, Walter A and Farrer, Lindsay A and Barnes, Lisa L and Beach, Thomas G and Yesim Demirci, F and Head, Elizabeth and Hulette, Christine M and Jicha, Gregory A and Kauwe, John S. K and Kaye, Jeffrey A and Leverenz, James B and Levey, Allan I and Denys, Damiaan and Derks, Eske M and Figee, Martijn and de Haan, Lieuwe and Huyser, Chaim and Brainstorm Consortium and The Brainstorm Consortium
Science, ISSN 0036-8075, 2018, Volume 360, Issue 6395, pp. 1313 - 1313
Disorders of the brain can exhibit considerable epidemiological comorbidity and often share symptoms, provoking debate about their etiologic overlap. We... 
ANOREXIA-NERVOSA | POPULATION-BASED TWIN | DEFICIT HYPERACTIVITY DISORDER | LONG-TERM SURVIVAL | ALZHEIMERS-DISEASE | MULTIDISCIPLINARY SCIENCES | GENETIC CORRELATIONS | BODY-MASS INDEX | MAJOR DEPRESSIVE DISORDER | BIPOLAR DISORDER | GENOME-WIDE ASSOCIATION | Genetic Variation | Mental Disorders - genetics | Genome-Wide Association Study | Phenotype | Brain Diseases - classification | Quantitative Trait, Heritable | Brain Diseases - diagnosis | Humans | Mental Disorders - classification | Risk Factors | Brain Diseases - genetics | Mental Disorders - diagnosis | Anorexia | Disorders | Cognitive ability | Bipolar disorder | Posttraumatic stress disorder | Mental depression | Epidemiology | Risk factors | Consortia | Proteins | Ischemia | Etiology | Classification | Gilles de la Tourette syndrome | Alzheimer's disease | Neurological disorders | Neurodegenerative diseases | Comorbidity | Behavior disorders | Anorexia nervosa | Risk analysis | Patients | Neurological diseases | Correlation analysis | Heritability | Attention deficit disorder | Headache | Mental disorders | Medical services | Schizophrenia | Risk sharing | Genomes | Heterogeneity | Biological effects | Risk assessment | Stroke | Phenotypes | Migraine | Attention deficit hyperactivity disorder | Eating disorders | Personality | Genetic diversity | Statistics | Activity patterns | Crohn's Disease | Population (statistical) | Scaffolding | Diagnostic systems | Alzheimers disease | Life Sciences | Human health and pathology | Mental Disorders | Neurons and Cognition | Brain Diseases | Genetics
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12. Full Text Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis
by Beecham, Ashley H and Patsopoulos, Nikolaos A and Xifara, Dionysia K and Davis, Mary F and Kemppinen, Anu and Cotsapas, Chris and Shah, Tejas S and Spencer, Chris and Booth, David and Goris, An and Oturai, Annette and Saarela, Janna and Fontaine, Bertrand and Hemmer, Bernhard and Martin, Claes and Zipp, Frauke and D'Alfonso, Sandra and Martinelli-Boneschi, Filippo and Taylor, Bruce and Harbo, Hanne F and Kockum, Ingrid and Hillert, Jan and Olsson, Tomas and Ban, Maria and Oksenberg, Jorge R and Hintzen, Rogier and Barcellos, Lisa F and Agliardi, Cristina and Alfredsson, Lars and Alizadeh, Mehdi and Anderson, Carl and Andrews, Robert and Søndergaard, Helle Bach and Baker, Amie and Band, Gavin and Baranzini, Sergio E and Barizzone, Nadia and Barrett, Jeffrey and Bellenguez, Céline and Bergamaschi, Laura and Bernardinelli, Luisa and Berthele, Achim and Biberacher, Viola and Binder, Thomas M.C and Blackburn, Hannah and Bomfim, Izaura L and Brambilla, Paola and Broadley, Simon and Brochet, Bruno and Brundin, Lou and Buck, Dorothea and Butzkueven, Helmut and Caillier, Stacy J and Camu, William and Carpentier, Wassila and Cavalla, Paola and Celius, Elisabeth G and Coman, Irène and Comi, Giancarlo and Corrado, Lucia and Cosemans, Leentje and Cournu-Rebeix, Isabelle and Cree, Bruce A.C and Cusi, Daniele and Damotte, Vincent and Defer, Gilles and Delgado, Silvia R and Deloukas, Panos and Di Sapio, Alessia and Dilthey, Alexander T and Donnelly, Peter and Dubois, Bénédicte and Duddy, Martin and Edkins, Sarah and Elovaara, Irina and Esposito, Federica and Evangelou, Nikos and Fiddes, Barnaby and Field, Judith and Franke, Andre and Freeman, Colin and Frohlich, Irene Y and Galimberti, Daniela and Gieger, Christian and Gourraud, Pierre-Antoine and Graetz, Christiane and Graham, Andrew and Grummel, Verena and Guaschino, Clara and Hadjixenofontos, Athena and Hakonarson, Hakon and Halfpenny, Christopher and Hall, Gillian and Hall, Per and Hamsten, Anders and Harley, James and Harrower, Timothy and Hawkins, Clive and Hellenthal, Garrett and Hillier, Charles and ... and Wellcome Trust Case Control Consor and Int IBD Genetics Consortium IIBDGC and International Multiple Sclerosis Genetics Consortium (IMSGC) and Wellcome Trust Case Control Consortium 2 (WTCCC2) and International IBD Genetics Consortium (IIBDGC) and Institutionen för fysik, kemi och biologi and Linköpings universitet and Bioinformatik and Tekniska högskolan
Nature Genetics, ISSN 1061-4036, 2013, Volume 45, Issue 11, pp. 1353 - 1362
Using the ImmunoChip custom genotyping array, we analyzed 14,498 subjects with multiple sclerosis and 24,091 healthy controls for 161,311 autosomal variants... 
AUTOIMMUNE | ALLELES | METAANALYSIS | GENOTYPE IMPUTATION | GENETIC RISK | INFORMATION | ANNOTATION | PRIMARY BILIARY-CIRRHOSIS | DISEASE | GENETICS & HEREDITY | GENOME-WIDE ASSOCIATION | Genetic Variation | European Continental Ancestry Group - genetics | Genetic Predisposition to Disease | Genome-Wide Association Study | Gene Frequency | Humans | Multiple Sclerosis - immunology | Genotype | Multiple Sclerosis - genetics | Chromosome Mapping | Polymorphism, Single Nucleotide | Genetic Loci | Multiple sclerosis | Chromosome mapping | Genetic susceptibility | Genetic variation | Genetic aspects | Identification and classification | Methods | Testing | Confidence intervals | Disease | Quality control | Genomes | Stratigraphy | Autoimmune diseases | Gene expression | Meta-analysis | Teknik och teknologier | TEKNIKVETENSKAP | Engineering and Technology | TECHNOLOGY
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13. Full Text Heterogeneity in meta-analyses of genome-wide association investigations
by Ioannidis, John P.A and Patsopoulos, Nikolaos A and Evangelou, Evangelos
PLoS ONE, ISSN 1932-6203, 09/2007, Volume 2, Issue 9, p. e841
Background. Meta-analysis is the systematic and quantitative synthesis of effect sizes and the exploration of their diversity across different studies.... 
BIOLOGY | Genome-Wide Association Study | Meta-Analysis as Topic | Diabetes Mellitus, Type 2 - genetics | Humans | Genetic Heterogeneity | Polymorphism, Genetic | Type 2 diabetes | Genetic markers | Analysis | Genomics | Disease susceptibility | Genetic aspects | Genomes | Investigations | Genetic polymorphisms | Publications | Linkage disequilibrium | Bias | Diabetes mellitus | Markers | Parkinsons disease | Data processing | Exploration | Principal components analysis | Epidemiology | Meta-analysis | Datasets | Confidence intervals | Medicine | Studies | Genetic variance | Heterogeneity | Synthesis | Mathematical analysis | Replication | Diabetes | Hygiene
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