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Journal of Medicinal Chemistry, ISSN 0022-2623, 01/2015, Volume 58, Issue 1, pp. 480 - 511
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 09/2012, Volume 3, Issue 9, pp. 726 - 730
GPR40 (FFA1) is a G-protein-coupled receptor, primarily expressed in pancreatic islets, the activation of which elicits increased insulin secretion only in the... 
AM-1638 | FFA1 | full agonist | insulin secretagogue | GPR40 | AMG 837 | CHEMISTRY, MEDICINAL | ACIDS | MODULATORS | RECEPTOR AGONIST | TYPE-2 DIABETES-MELLITUS
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 07/2018, Volume 9, Issue 7, pp. 757 - 760
GPR40 (FFA1) is a G-protein-coupled receptor, primarily expressed in pancreatic islets and enteroendocrine L-cells, and, when activated, elicits increased... 
AM-1638 | FFA1 | AMG 837 | full agonist | insulin secretagogue | GPR40 | AM-6226 | CHEMISTRY, MEDICINAL | SMALL-MOLECULE MODULATORS | ACIDS | RECEPTOR | TAK-875
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 06/2013, Volume 4, Issue 6, pp. 551 - 555
GPR40 (FFAR1 or FFA1) is a target of high interest being pursued to treat type II diabetes due to its unique mechanism leading to little risk of hypoglycemia.... 
AM-1638 | FFA1 | Tricyclic | AMG 837 | AM-5262 | FFAR1 | GPR40 | Full agonist | Spirocycles | TARGET | CHEMISTRY, MEDICINAL | ACID | spirocycles | MODULATORS | full agonist | RECEPTOR | IDENTIFICATION | ADME PROPERTIES | tricyclic
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 07/2016, Volume 7, Issue 7, pp. 666 - 670
Two 1-(4-aryl-5-alkyl-pyridin-2-yl)-3-methylurea glucokinase activators were identified with robust in vivo efficacy. These two compounds possessed higher... 
Type 2 diabetes | glucokinase activator | methylurea-substituted pyridines | GKA | CHEMISTRY, MEDICINAL | DIABETES THERAPY
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 2006, Volume 16, Issue 5, pp. 1191 - 1196
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 07/2016, Volume 7, Issue 7, pp. 714 - 718
Glucokinase (GK) catalyzes the phosphorylation of glucose to glucose-6-phosphate. We present the structure–activity relationships leading to the discovery of... 
Glucokinase activator | GKA | AM-2394 | CHEMISTRY, MEDICINAL | THERAPY | GLUCOSE | TYPE-2 DIABETES-MELLITUS
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 12/2014, Volume 5, Issue 12, pp. 1284 - 1289
Glucokinase (GK) activators represent a class of type 2 diabetes therapeutics actively pursued due to the central role that GK plays in regulating glucose... 
Type 2 diabetes | glucokinase activator | GKA | methyl urea-substituted pyridines | CHEMISTRY, MEDICINAL | PLASMA-GLUCOSE | RISK | TYPE-2 | DISCOVERY | PATHOPHYSIOLOGY
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 2005, Volume 15, Issue 23, pp. 5154 - 5159
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 12/2010, Volume 1, Issue 9, pp. 488 - 492
In an effort to develop potent, orally bioavailable compounds for the treatment of neoplastic diseases, we developed a class of dual VEGFR-2 kinase and tubulin... 
VEGFR | Tubulin | antimitotic | tumor vasculature | vascular disrupting agent | angiogenesis | CHEMISTRY, MEDICINAL | POTENT INHIBITORS
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 2003, Volume 44, Issue 2, pp. 229 - 232
Unsymmetrical imidazolidines were obtained in 75–91% yield by treating monoalkoxycarbonyl vicinal diamines at room temperature with aqueous 37% formaldehyde in... 
CHEMISTRY, ORGANIC | N,N'-BISACYLIMIDAZOLIDINES | ALDEHYDES | MODELS | ANALOGS
Journal Article
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