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The New England Journal of Medicine, ISSN 0028-4793, 09/2014, Volume 371, Issue 11, pp. 1005 - 1015
About 25% of young adults with ALL have Ph-like genotypes, which are associated with poor outcomes with conventional treatment. In this gene-expression study,... 
MEDICINE, GENERAL & INTERNAL | MODELS | B-CELL PRECURSOR | INHIBITOR THERAPY | IMATINIB | PEDIATRIC ACUTE LEUKEMIAS | GENE FUSION | EXPRESSION | ETV6-NTRK3 FUSION TRANSCRIPTS | CRLF2 | DELETION | Oligonucleotide Array Sequence Analysis | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - metabolism | Humans | Child, Preschool | Infant | Male | Young Adult | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Heterografts | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - mortality | Adult | Female | DNA, Neoplasm - analysis | Receptors, Cytokine - metabolism | Child | Philadelphia Chromosome | Receptors, Cytokine - genetics | Signal Transduction - genetics | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - genetics | Animals | Protein Kinase Inhibitors - therapeutic use | Adolescent | Survival Analysis | Mice | Polymorphism, Single Nucleotide | Genome, Human | Protein-Tyrosine Kinases - antagonists & inhibitors | Development and progression | Care and treatment | Genetic aspects | Research | Lymphocytic leukemia | Tyrosine metabolism | Cell proliferation | Adolescence | Tyk2 protein | Leukemia | Genes | Clinical trials | Oncology | Genomes | Kinases | Cell activation | Janus kinase 2 | Xenografts | Teenagers | Children | Protein-tyrosine kinase | Age | Tyrosine | Young adults | Genomic analysis | Acute lymphatic leukemia | Stat5 protein | Lymphatic leukemia | Gene expression | Philadelphia chromosome | Interleukin 7 receptors | Thymic stromal lymphopoietin | Lymphocytes B | Cell lines
Journal Article
Cancer Cell, ISSN 1535-6108, 08/2012, Volume 22, Issue 2, pp. 153 - 166
Genomic profiling has identified a subtype of high-risk B-progenitor acute lymphoblastic leukemia (B-ALL) with alteration of , a gene expression profile... 
GROWTH-FACTOR RECEPTOR | BCR-JAK2 FUSION GENE | ONCOLOGY | NUCLEAR-PORE | MYELOPROLIFERATIVE NEOPLASMS | ACUTE MYELOID-LEUKEMIA | OF-FUNCTION MUTATIONS | FLT3 MUTATIONS | CHILDHOOD | B-PROGENITOR | CHRONIC MYELOMONOCYTIC LEUKEMIA | CELL BIOLOGY | Recurrence | Humans | Molecular Sequence Data | RNA, Messenger - metabolism | Receptor, Platelet-Derived Growth Factor beta - genetics | Protein-Tyrosine Kinases - genetics | DNA Mutational Analysis | Base Sequence | Trans-Activators - genetics | Phosphorylation - drug effects | Philadelphia Chromosome | Receptors, Cytokine - genetics | Genetic Predisposition to Disease | RNA, Messenger - genetics | Risk Factors | Gene Expression Regulation, Leukemic - drug effects | Signal Transduction - genetics | Enzyme Activation - drug effects | Mutation - genetics | Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics | Animals | Signal Transduction - drug effects | Cell Transformation, Neoplastic | Oncogene Proteins, Fusion - genetics | Precursor Cell Lymphoblastic Leukemia-Lymphoma - enzymology | Mice | Protein Kinase Inhibitors - pharmacology | Gene Rearrangement - genetics | Sequence Deletion - genetics | Tyrosine | Platelet-derived growth factor | Cytokines | Genes | Oncology, Experimental | Genomes | Research | Gene expression | Population genetics | Hunger | Medical genetics | Genetic research | Nucleotide sequencing | Acute lymphocytic leukemia | Cancer | DNA sequencing
Journal Article
Pharmacological Reviews, ISSN 0031-6997, 06/2008, Volume 60, Issue 2, pp. 181 - 195
Sphingosine 1-phosphate (S1P) is a bioactive sphingolipid metabolite involved in many critical cellular processes including proliferation, survival, and... 
Journal Article
Nature Genetics, ISSN 1061-4036, 05/2015, Volume 47, Issue 6, pp. 607 - 614
Journal Article
PHARMACOLOGICAL REVIEWS, ISSN 0031-6997, 06/2008, Volume 60, Issue 2, pp. 181 - 195
Sphingosine 1-phosphate (S1P) is a bioactive sphingolipid metabolite involved in many critical cellular processes including proliferation, survival, and... 
BREAST-CANCER CELLS | SPHINGOSINE 1-PHOSPHATE RECEPTOR | KINASE INHIBITOR SUPPRESSES | PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY | PROTEIN-COUPLED RECEPTOR | GENE-DEFICIENT MICE | PHARMACOLOGY & PHARMACY | RANDOMIZED CONTROLLED-TRIAL | MAST-CELL DEGRANULATION | NOVO RENAL-TRANSPLANTATION | ENDOTHELIAL BARRIER FUNCTION | Hypersensitivity - enzymology | Sulfhydryl Compounds - pharmacology | Apoptosis - drug effects | Humans | Immunosuppressive Agents - therapeutic use | Antibodies, Monoclonal - therapeutic use | Antineoplastic Agents - therapeutic use | Hypersensitivity - drug therapy | Lysophospholipids - immunology | Propylene Glycols - therapeutic use | Antineoplastic Agents - pharmacology | Immunosuppressive Agents - pharmacology | Propylene Glycols - pharmacology | Multiple Sclerosis - enzymology | Signal Transduction | Sphingosine - physiology | Antibodies, Monoclonal - pharmacology | Fingolimod Hydrochloride | Neoplasms - enzymology | Receptors, Lysosphingolipid - physiology | Sphingosine - immunology | Neoplasms - drug therapy | Phosphotransferases (Alcohol Group Acceptor) - metabolism | Sphingosine - pharmacology | Phosphotransferases (Alcohol Group Acceptor) - antagonists & inhibitors | Sphingosine - analogs & derivatives | Animals | Receptors, Lysosphingolipid - agonists | Sphingosine - therapeutic use | Sulfhydryl Compounds - therapeutic use | Enzyme Activation | Lysophospholipids - physiology | Multiple Sclerosis - drug therapy
Journal Article
JAMA, ISSN 0098-7484, 02/2015, Volume 313, Issue 8, pp. 815 - 823
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2015, Volume 10, Issue 8, pp. e0135134 - e0135134
Osteonecrosis is one of the most common, serious, toxicities resulting from the treatment of acute lymphoblastic leukemia. In recent years, pediatric acute... 
MULTIPLE-MYELOMA | INITIATING CELLS | INDUCED OSTEONECROSIS | MULTIDISCIPLINARY SCIENCES | MOUSE MODEL | PEDIATRIC-PATIENTS | GENE-EXPRESSION | IMPROVES SURVIVAL | GLUCOCORTICOID RESISTANCE | CHILDHOOD | CHILDREN | Corticosterone - administration & dosage | Neoplasm Transplantation | Dexamethasone - administration & dosage | Drug Administration Schedule | Humans | Mice, Inbred C57BL | Child, Preschool | Male | Antineoplastic Agents - administration & dosage | Disease-Free Survival | Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Animals | Time Factors | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Adolescent | Female | Mice | Osteonecrosis - prevention & control | Child | Fusion Proteins, bcr-abl - metabolism | Disease Models, Animal | Drug Screening Assays, Antitumor | Care and treatment | Dexamethasone | Patient outcomes | Central nervous system depressants | Development and progression | Research | Acute lymphocytic leukemia | BCR protein | Pediatrics | Animal models | Glucocorticoids | Transplants & implants | Toxicity | Leukemia | Xenotransplantation | Multiple myeloma | Clinical trials | Oncology | Osteonecrosis | Arthritis | Anticancer properties | Biomedical materials | Xenografts | Bone marrow | Biocompatibility | Children | Fusion protein | Drug dosages | Pharmaceutical sciences | Medical research | Dosing | Effectiveness | Acute lymphatic leukemia | Abl protein | Lymphatic leukemia | Survival | Patients | Chemotherapy | Index Medicus
Journal Article
Journal Article