Cell, ISSN 0092-8674, 09/2013, Volume 155, Issue 1, p. 135
Summary Self-renewal and differentiation of stem cells are fundamentally associated with cell-cycle progression to enable tissue specification, organ...
Journal Article
Methods in Molecular Biology, ISSN 1064-3745, 01/2016, Volume 1366, pp. 561 - 572
Regulation of Activation Induced Deaminase (AID) by the hormone estrogen has important implications for understanding adaptive immune responses as well as the...
Ig switch circle transcripts | Activation induced deaminase | Adaptive immune responses | Estrogen | Splenic B-cells | Somatic hypermutations | AID | Autoimmune diseases | Transcription, Genetic - drug effects | B-Lymphocytes - enzymology | Estrogens - pharmacology | Cytidine Deaminase - genetics | Gene Expression Regulation | Estrogen Antagonists - pharmacology | Workflow | Spleen - cytology | Spleen - drug effects | Cell Separation - methods | RNA, Messenger - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Dose-Response Relationship, Drug | B-Lymphocytes - drug effects | Animals | Spleen - enzymology | Time Factors | Cytidine Deaminase - metabolism | Female | Mice, Inbred BALB C | Mutation | Real-Time Polymerase Chain Reaction | Estradiol - pharmacology
Ig switch circle transcripts | Activation induced deaminase | Adaptive immune responses | Estrogen | Splenic B-cells | Somatic hypermutations | AID | Autoimmune diseases | Transcription, Genetic - drug effects | B-Lymphocytes - enzymology | Estrogens - pharmacology | Cytidine Deaminase - genetics | Gene Expression Regulation | Estrogen Antagonists - pharmacology | Workflow | Spleen - cytology | Spleen - drug effects | Cell Separation - methods | RNA, Messenger - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Dose-Response Relationship, Drug | B-Lymphocytes - drug effects | Animals | Spleen - enzymology | Time Factors | Cytidine Deaminase - metabolism | Female | Mice, Inbred BALB C | Mutation | Real-Time Polymerase Chain Reaction | Estradiol - pharmacology
Journal Article
Cell, ISSN 0092-8674, 09/2013, Volume 155, Issue 1, pp. 135 - 147
Self-renewal and differentiation of stem cells are fundamentally associated with cell-cycle progression to enable tissue specification, organ homeostasis, and...
EPIBLAST | DEPENDENT KINASE | INHIBITION | RETINOBLASTOMA PROTEIN | FGF | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | PLURIPOTENCY | DIFFERENTIATION | G1 PHASE | EXPRESSION | CELL BIOLOGY | Embryonic Stem Cells - metabolism | Embryonic Stem Cells - cytology | Pluripotent Stem Cells - cytology | Signal Transduction | Humans | Gene Knockdown Techniques | Pluripotent Stem Cells - metabolism | Smad3 Protein - genetics | G1 Phase | Cell Cycle | Smad2 Protein - genetics | Cell Differentiation | Cyclin D - genetics | Cyclin D - metabolism | Stem cell research | Bone morphogenetic proteins | Transforming growth factors | Stem cells
EPIBLAST | DEPENDENT KINASE | INHIBITION | RETINOBLASTOMA PROTEIN | FGF | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | PLURIPOTENCY | DIFFERENTIATION | G1 PHASE | EXPRESSION | CELL BIOLOGY | Embryonic Stem Cells - metabolism | Embryonic Stem Cells - cytology | Pluripotent Stem Cells - cytology | Signal Transduction | Humans | Gene Knockdown Techniques | Pluripotent Stem Cells - metabolism | Smad3 Protein - genetics | G1 Phase | Cell Cycle | Smad2 Protein - genetics | Cell Differentiation | Cyclin D - genetics | Cyclin D - metabolism | Stem cell research | Bone morphogenetic proteins | Transforming growth factors | Stem cells
Journal Article
Cell, ISSN 0092-8674, 03/2014, Volume 156, Issue 6, p. 1338
Journal Article
Cell, ISSN 0092-8674, 03/2014, Volume 156, Issue 6, p. 1338
Journal Article
Development (Cambridge), ISSN 0950-1991, 02/2015, Volume 142, Issue 4, pp. 607 - 619
Activin/Nodal growth factors control a broad range of biological processes, including early cell fate decisions, organogenesis and adult tissue homeostasis....
Nodal | Activin | Differentiation | Pluripotency | Cell cycle | Stem cells | TGF-BETA | ZEBRAFISH | NODAL EXPRESSION | MOUSE EMBRYOS | SELF-RENEWAL | REGULATORY NETWORK | DEVELOPMENTAL BIOLOGY | INDUCED DIFFERENTIATION | GENE | MAINTAINS PLURIPOTENCY | FUNCTIONAL-ANALYSIS | Pluripotent Stem Cells - cytology | Humans | Activins - metabolism | Nodal Protein - metabolism | Signal Transduction - genetics | Stem Cells - cytology | Stem Cells - metabolism | Pluripotent Stem Cells - metabolism | Cell Differentiation - genetics | Animals | Nodal Protein - genetics | Signal Transduction - physiology | Activins - genetics | Cell Differentiation - physiology
Nodal | Activin | Differentiation | Pluripotency | Cell cycle | Stem cells | TGF-BETA | ZEBRAFISH | NODAL EXPRESSION | MOUSE EMBRYOS | SELF-RENEWAL | REGULATORY NETWORK | DEVELOPMENTAL BIOLOGY | INDUCED DIFFERENTIATION | GENE | MAINTAINS PLURIPOTENCY | FUNCTIONAL-ANALYSIS | Pluripotent Stem Cells - cytology | Humans | Activins - metabolism | Nodal Protein - metabolism | Signal Transduction - genetics | Stem Cells - cytology | Stem Cells - metabolism | Pluripotent Stem Cells - metabolism | Cell Differentiation - genetics | Animals | Nodal Protein - genetics | Signal Transduction - physiology | Activins - genetics | Cell Differentiation - physiology
Journal Article
Methods in molecular biology (Clifton, N.J.), 2016, Volume 1366, p. E1
Journal Article
Genes and Development, ISSN 0890-9369, 02/2016, Volume 30, Issue 4, pp. 421 - 433
Coordination of differentiation and cell cycle progression represents an essential process for embryonic development and adult tissue homeostasis. These...
HESCs | Cyclin D | Differentiation | Neuroectoderm | Endoderm | Cell cycle | KINASE-ACTIVITY | differentiation | endoderm | TGF-BETA | cell cycle | SELF-RENEWAL | PROLIFERATION | PLURIPOTENCY | DEVELOPMENTAL BIOLOGY | G1 PHASE | CHROMOSOMAL INSTABILITY | CELL BIOLOGY | MOUSE DEVELOPMENT | neuroectoderm | GENETICS & HEREDITY | TRANSCRIPTIONAL ROLE | hESCs | TUMORIGENESIS | Cell Cycle - genetics | Chromatin - metabolism | Genome-Wide Association Study | Phosphorylation | Embryonic Stem Cells - cytology | Epigenesis, Genetic | Neural Plate - cytology | Cell Differentiation - genetics | Endoderm - cytology | Gene Expression Regulation, Developmental | Protein Binding | Cyclin D - genetics | Cyclin D - metabolism | Cyclin D proteins | Research | Genetic transcription | Cell differentiation | Stem cells | Research Paper
HESCs | Cyclin D | Differentiation | Neuroectoderm | Endoderm | Cell cycle | KINASE-ACTIVITY | differentiation | endoderm | TGF-BETA | cell cycle | SELF-RENEWAL | PROLIFERATION | PLURIPOTENCY | DEVELOPMENTAL BIOLOGY | G1 PHASE | CHROMOSOMAL INSTABILITY | CELL BIOLOGY | MOUSE DEVELOPMENT | neuroectoderm | GENETICS & HEREDITY | TRANSCRIPTIONAL ROLE | hESCs | TUMORIGENESIS | Cell Cycle - genetics | Chromatin - metabolism | Genome-Wide Association Study | Phosphorylation | Embryonic Stem Cells - cytology | Epigenesis, Genetic | Neural Plate - cytology | Cell Differentiation - genetics | Endoderm - cytology | Gene Expression Regulation, Developmental | Protein Binding | Cyclin D - genetics | Cyclin D - metabolism | Cyclin D proteins | Research | Genetic transcription | Cell differentiation | Stem cells | Research Paper
Journal Article
Cell, ISSN 0092-8674, 03/2014, Volume 156, Issue 6, pp. 1338 - 1338
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 01/2009, Volume 206, Issue 1, pp. 99 - 111
The Journal of Experimental Medicine The immunological targets of estrogen at the molecular, humoral, and cellular level have been well documented, as has...
BREAST-CANCER | MEDICINE, RESEARCH & EXPERIMENTAL | CHROMOSOMAL TRANSLOCATIONS | SOMATIC HYPERMUTATION | INDUCED CYTIDINE DEAMINASE | CLASS-SWITCH RECOMBINATION | IMMUNOLOGY | DNA DEAMINATION | NF-KAPPA-B | AUTOIMMUNE-DISEASE | B-CELL LINE | MOLECULAR-MECHANISMS | Gene Expression Regulation, Enzymologic - drug effects | Transcription, Genetic - drug effects | Oncogene Proteins, Fusion - metabolism | Estrogens - pharmacology | Humans | Cytosine Deaminase - metabolism | fas Receptor - genetics | Estrogen Receptor alpha - metabolism | Female | Electrophoretic Mobility Shift Assay | Response Elements - genetics | Immunoglobulin Class Switching - drug effects | B-Lymphocytes - metabolism | Cytosine Deaminase - genetics | Cell Line | B-Lymphocytes - cytology | Cytidine Deaminase - genetics | Cells, Cultured | Reverse Transcriptase Polymerase Chain Reaction | B-Lymphocytes - drug effects | Animals | Oncogene Proteins, Fusion - genetics | Cytidine Deaminase - metabolism | Cell Line, Tumor | Protein Binding | Mice | Mice, Inbred BALB C | Mutation | Somatic Hypermutation, Immunoglobulin - genetics | Immunoglobulin Class Switching - genetics
BREAST-CANCER | MEDICINE, RESEARCH & EXPERIMENTAL | CHROMOSOMAL TRANSLOCATIONS | SOMATIC HYPERMUTATION | INDUCED CYTIDINE DEAMINASE | CLASS-SWITCH RECOMBINATION | IMMUNOLOGY | DNA DEAMINATION | NF-KAPPA-B | AUTOIMMUNE-DISEASE | B-CELL LINE | MOLECULAR-MECHANISMS | Gene Expression Regulation, Enzymologic - drug effects | Transcription, Genetic - drug effects | Oncogene Proteins, Fusion - metabolism | Estrogens - pharmacology | Humans | Cytosine Deaminase - metabolism | fas Receptor - genetics | Estrogen Receptor alpha - metabolism | Female | Electrophoretic Mobility Shift Assay | Response Elements - genetics | Immunoglobulin Class Switching - drug effects | B-Lymphocytes - metabolism | Cytosine Deaminase - genetics | Cell Line | B-Lymphocytes - cytology | Cytidine Deaminase - genetics | Cells, Cultured | Reverse Transcriptase Polymerase Chain Reaction | B-Lymphocytes - drug effects | Animals | Oncogene Proteins, Fusion - genetics | Cytidine Deaminase - metabolism | Cell Line, Tumor | Protein Binding | Mice | Mice, Inbred BALB C | Mutation | Somatic Hypermutation, Immunoglobulin - genetics | Immunoglobulin Class Switching - genetics
Journal Article
Genes & Development, ISSN 0890-9369, 2015, Volume 29, Issue 7, pp. 702 - 717
Stem cells can self-renew and differentiate into multiple cell types. These characteristics are maintained by the combination of specific signaling pathways...
DPY30 | NANOG | hESCs | Activin/Nodal | H3K4me3 | SMAD2/3 | METHYLATION | COMPLEXES | PLURIPOTENCY | DEVELOPMENTAL BIOLOGY | BIVALENT PROMOTERS | SPECIFICATION | MOUSE EMBRYO | GENOME | CELL BIOLOGY | GENETICS & HEREDITY | HISTONE MODIFICATIONS | EMBRYOGENESIS | NEURAL DIFFERENTIATION | Chromatin - metabolism | Nanog Homeobox Protein | Signal Transduction | Embryo, Mammalian | Homeodomain Proteins - metabolism | Humans | Cells, Cultured | Smad2 Protein - metabolism | Activins - metabolism | Nodal Protein - metabolism | Smad3 Protein - metabolism | Cell Differentiation - genetics | Animals | Histones - genetics | Histone-Lysine N-Methyltransferase - metabolism | Epigenesis, Genetic - genetics | Mice | Embryonic Stem Cells | Chromatin - genetics | Chromatin | Genetic aspects | Cellular signal transduction | Research | Embryonic stem cells | Analysis | SMAD2 | Nodal | Research Papers | Activin
DPY30 | NANOG | hESCs | Activin/Nodal | H3K4me3 | SMAD2/3 | METHYLATION | COMPLEXES | PLURIPOTENCY | DEVELOPMENTAL BIOLOGY | BIVALENT PROMOTERS | SPECIFICATION | MOUSE EMBRYO | GENOME | CELL BIOLOGY | GENETICS & HEREDITY | HISTONE MODIFICATIONS | EMBRYOGENESIS | NEURAL DIFFERENTIATION | Chromatin - metabolism | Nanog Homeobox Protein | Signal Transduction | Embryo, Mammalian | Homeodomain Proteins - metabolism | Humans | Cells, Cultured | Smad2 Protein - metabolism | Activins - metabolism | Nodal Protein - metabolism | Smad3 Protein - metabolism | Cell Differentiation - genetics | Animals | Histones - genetics | Histone-Lysine N-Methyltransferase - metabolism | Epigenesis, Genetic - genetics | Mice | Embryonic Stem Cells | Chromatin - genetics | Chromatin | Genetic aspects | Cellular signal transduction | Research | Embryonic stem cells | Analysis | SMAD2 | Nodal | Research Papers | Activin
Journal Article
The Journal of Immunology, ISSN 0022-1767, 07/2009, Volume 183, Issue 2, pp. 1238 - 1244
Regulation of activation-induced deaminase (AID), an essential factor in Ig diversification, can alter not only somatic hypermutation and class switch...
CLASS SWITCH RECOMBINATION | SOMATIC HYPERMUTATION | INDUCED CYTIDINE DEAMINASE | REPLACEMENT THERAPY | AID GENE | ESTROGEN | GENE CONVERSION | IMMUNOLOGY | NF-KAPPA-B | EXPRESSION | B-CELL LINE | Transcription, Genetic - drug effects | Cytidine Deaminase - antagonists & inhibitors | Somatic Hypermutation, Immunoglobulin | Lymphocyte Activation | Cytidine Deaminase - genetics | Mice, Inbred C57BL | Spleen - cytology | Down-Regulation - drug effects | Promoter Regions, Genetic - drug effects | RNA, Messenger - biosynthesis | Animals | B-Lymphocytes - immunology | Female | Mice | Immunoglobulin Class Switching | Progesterone - pharmacology
CLASS SWITCH RECOMBINATION | SOMATIC HYPERMUTATION | INDUCED CYTIDINE DEAMINASE | REPLACEMENT THERAPY | AID GENE | ESTROGEN | GENE CONVERSION | IMMUNOLOGY | NF-KAPPA-B | EXPRESSION | B-CELL LINE | Transcription, Genetic - drug effects | Cytidine Deaminase - antagonists & inhibitors | Somatic Hypermutation, Immunoglobulin | Lymphocyte Activation | Cytidine Deaminase - genetics | Mice, Inbred C57BL | Spleen - cytology | Down-Regulation - drug effects | Promoter Regions, Genetic - drug effects | RNA, Messenger - biosynthesis | Animals | B-Lymphocytes - immunology | Female | Mice | Immunoglobulin Class Switching | Progesterone - pharmacology
Journal Article
STEM CELLS, ISSN 1066-5099, 08/2011, Volume 29, Issue 8, pp. 1176 - 1185
Activin/Nodal signaling is necessary to maintain pluripotency of human embryonic stem cells (hESCs) and to induce their differentiation toward endoderm....
Human | Smad2/3 | Mouse | Induced pluripotent stem cells | Epiblast stem cells | Activin | Embryonic stem cells | Pluripotency | Endoderm | PATHWAYS | DNA-BINDING | CHROMATIN IMMUNOPRECIPITATION | CROSS-LINKING | FATE DECISIONS | CELL & TISSUE ENGINEERING | CELL BIOLOGY | ONCOLOGY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | IN-VIVO | GENOME-WIDE ANALYSIS | NANOG | HEMATOLOGY | Cell Line | Embryonic Stem Cells - metabolism | Promoter Regions, Genetic | Nanog Homeobox Protein | Homeodomain Proteins - metabolism | Humans | Smad2 Protein - metabolism | Activins - metabolism | Nodal Protein - metabolism | Smad3 Protein - metabolism | Stem Cells - cytology | Gene Regulatory Networks | Stem Cells - metabolism | Sequence Analysis, DNA | Endoderm - metabolism | Luciferases, Firefly - biosynthesis | Chromatin Immunoprecipitation | Endoderm - cytology | Base Sequence | Luciferases, Firefly - genetics | Cell Differentiation | Genes, Reporter
Human | Smad2/3 | Mouse | Induced pluripotent stem cells | Epiblast stem cells | Activin | Embryonic stem cells | Pluripotency | Endoderm | PATHWAYS | DNA-BINDING | CHROMATIN IMMUNOPRECIPITATION | CROSS-LINKING | FATE DECISIONS | CELL & TISSUE ENGINEERING | CELL BIOLOGY | ONCOLOGY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | IN-VIVO | GENOME-WIDE ANALYSIS | NANOG | HEMATOLOGY | Cell Line | Embryonic Stem Cells - metabolism | Promoter Regions, Genetic | Nanog Homeobox Protein | Homeodomain Proteins - metabolism | Humans | Smad2 Protein - metabolism | Activins - metabolism | Nodal Protein - metabolism | Smad3 Protein - metabolism | Stem Cells - cytology | Gene Regulatory Networks | Stem Cells - metabolism | Sequence Analysis, DNA | Endoderm - metabolism | Luciferases, Firefly - biosynthesis | Chromatin Immunoprecipitation | Endoderm - cytology | Base Sequence | Luciferases, Firefly - genetics | Cell Differentiation | Genes, Reporter
Journal Article
Journal of Cell Science, ISSN 0021-9533, 11/2011, Volume 124, Issue 22, pp. 3727 - 3732
MAINTAINS PLURIPOTENCY | GERM-CELLS | SELF-RENEWAL | NANOG | DIFFERENTIATION | EMBRYOGENESIS | CONTRIBUTES | EXPRESSION | LINES | FATE DECISIONS | CELL BIOLOGY | Pluripotent Stem Cells - metabolism | Transcription Factors - metabolism | Embryonic Stem Cells - metabolism | Mice - genetics | Animals | Embryonic Stem Cells - cytology | Pluripotent Stem Cells - cytology | Mice - metabolism | Cell Differentiation | Embryonic Development | Transcription Factors - genetics | Mice - embryology
Journal Article
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A role for the RNA pol II-associated PAF complex in AID-induced immune diversification
Journal of Experimental Medicine, ISSN 0022-1007, 10/2012, Volume 209, Issue 11, pp. 2099 - 2111
Antibody diversification requires the DNA deaminase AID to induce DNA instability at immunoglobulin (Ig) loci upon B cell stimulation. For efficient cytosine...
ACTIVATION-INDUCED DEAMINASE | MEDICINE, RESEARCH & EXPERIMENTAL | CLASS SWITCH RECOMBINATION | SOMATIC HYPERMUTATION | CHROMATIN | INDUCED CYTIDINE DEAMINASE | TRANSCRIPTION ELONGATION | GENE CONVERSION | POLYMERASE-II | IMMUNOLOGY | DNA DEAMINATION | ANTIBODY DIVERSIFICATION | Chromatin - metabolism | Antibody Diversity | Immunoprecipitation | Humans | Immunoglobulins - genetics | DNA-Binding Proteins - metabolism | RNA Interference | HEK293 Cells | Transcriptional Elongation Factors - genetics | Nuclear Proteins - genetics | Immunoglobulin Class Switching | B-Lymphocytes - metabolism | High Mobility Group Proteins - metabolism | Cytidine Deaminase - genetics | Nuclear Proteins - metabolism | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Blotting, Western | Transcription Factors - metabolism | Transcriptional Elongation Factors - metabolism | Animals | Cytidine Deaminase - metabolism | Cell Line, Tumor | Protein Binding | HeLa Cells | Chromatin - genetics | High Mobility Group Proteins - genetics
ACTIVATION-INDUCED DEAMINASE | MEDICINE, RESEARCH & EXPERIMENTAL | CLASS SWITCH RECOMBINATION | SOMATIC HYPERMUTATION | CHROMATIN | INDUCED CYTIDINE DEAMINASE | TRANSCRIPTION ELONGATION | GENE CONVERSION | POLYMERASE-II | IMMUNOLOGY | DNA DEAMINATION | ANTIBODY DIVERSIFICATION | Chromatin - metabolism | Antibody Diversity | Immunoprecipitation | Humans | Immunoglobulins - genetics | DNA-Binding Proteins - metabolism | RNA Interference | HEK293 Cells | Transcriptional Elongation Factors - genetics | Nuclear Proteins - genetics | Immunoglobulin Class Switching | B-Lymphocytes - metabolism | High Mobility Group Proteins - metabolism | Cytidine Deaminase - genetics | Nuclear Proteins - metabolism | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Blotting, Western | Transcription Factors - metabolism | Transcriptional Elongation Factors - metabolism | Animals | Cytidine Deaminase - metabolism | Cell Line, Tumor | Protein Binding | HeLa Cells | Chromatin - genetics | High Mobility Group Proteins - genetics
Journal Article
Stem Cells and Development, ISSN 1547-3287, 07/2014, Volume 23, Issue 13, pp. 1437 - 1451
Human stem cell research represents an exceptional opportunity for regenerative medicine and the surgical reconstruction of the craniomaxillofacial complex....
Comprehensive Review | MEDICINE, RESEARCH & EXPERIMENTAL | SOMATIC-CELLS | DIRECTED DIFFERENTIATION | INDUCED PLURIPOTENT | OSTEOGENIC DIFFERENTIATION | IPS CELLS | MOUSE EPIBLAST | CELL & TISSUE ENGINEERING | TRANSPLANTATION | INTERACTION NETWORK | IN-VITRO | BONE-GRAFTS | SMOOTH-MUSCLE-CELLS | HEMATOLOGY | Animals | Craniocerebral Trauma - therapy | Epigenesis, Genetic | Humans | Pluripotent Stem Cells - physiology | Bone Regeneration | Cell Differentiation | Maxillofacial Abnormalities - therapy | Regenerative Medicine | Mesenchymal Stem Cell Transplantation | Mesenchymal Stromal Cells - physiology | Reconstructive Surgical Procedures | Stem cell research | Usage | Surgery, Plastic | Care and treatment | Head injuries | Regenerative medicine | Analysis
Comprehensive Review | MEDICINE, RESEARCH & EXPERIMENTAL | SOMATIC-CELLS | DIRECTED DIFFERENTIATION | INDUCED PLURIPOTENT | OSTEOGENIC DIFFERENTIATION | IPS CELLS | MOUSE EPIBLAST | CELL & TISSUE ENGINEERING | TRANSPLANTATION | INTERACTION NETWORK | IN-VITRO | BONE-GRAFTS | SMOOTH-MUSCLE-CELLS | HEMATOLOGY | Animals | Craniocerebral Trauma - therapy | Epigenesis, Genetic | Humans | Pluripotent Stem Cells - physiology | Bone Regeneration | Cell Differentiation | Maxillofacial Abnormalities - therapy | Regenerative Medicine | Mesenchymal Stem Cell Transplantation | Mesenchymal Stromal Cells - physiology | Reconstructive Surgical Procedures | Stem cell research | Usage | Surgery, Plastic | Care and treatment | Head injuries | Regenerative medicine | Analysis
Journal Article
Journal of Molecular Medicine, ISSN 0946-2716, 09/2009, Volume 87, Issue 9, pp. 893 - 897
It is well established that hormones can cause cancer, much less known is how they induce this change in our somatic cells. This review highlights the recent...
Autoimmunity | APOBEC3 | Hormones | AID | DNA mutations | Cancer | MEDICINE, RESEARCH & EXPERIMENTAL | CELLS | SOMATIC HYPERMUTATION | SEX-HORMONES | TRANSLOCATIONS | INDUCED CYTIDINE DEAMINASE | C-MYC | BREAST-CANCER | GENETICS & HEREDITY | ESTROGEN | NF-KAPPA-B | EXPRESSION | Nucleotide Deaminases - physiology | Gene Expression Regulation, Enzymologic - drug effects | Estrogens - pharmacology | Neoplasms - etiology | Humans | Immune System - drug effects | Neoplasms - enzymology | Mutation | Immune response | Gene mutations | Estrogen | Genetic aspects | Research | Health aspects
Autoimmunity | APOBEC3 | Hormones | AID | DNA mutations | Cancer | MEDICINE, RESEARCH & EXPERIMENTAL | CELLS | SOMATIC HYPERMUTATION | SEX-HORMONES | TRANSLOCATIONS | INDUCED CYTIDINE DEAMINASE | C-MYC | BREAST-CANCER | GENETICS & HEREDITY | ESTROGEN | NF-KAPPA-B | EXPRESSION | Nucleotide Deaminases - physiology | Gene Expression Regulation, Enzymologic - drug effects | Estrogens - pharmacology | Neoplasms - etiology | Humans | Immune System - drug effects | Neoplasms - enzymology | Mutation | Immune response | Gene mutations | Estrogen | Genetic aspects | Research | Health aspects
Journal Article
18.
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Alternative Induction of Meiotic Recombination From Single-Base Lesions of DNA Deaminases
Genetics, ISSN 0016-6731, 05/2009, Volume 182, Issue 1, pp. 41 - 54
Meiotic recombination enhances genetic diversity as well as ensures proper segregation of homologons chromosomes, requiring Spo11-initiated double-strand...
FISSION YEAST | CAENORHABDITIS-ELEGANS | SOMATIC HYPERMUTATION | GENETICS & HEREDITY | DOUBLE-STRAND BREAKS | CLASS-SWITCH RECOMBINATION | C-ELEGANS | HOMOLOGOUS RECOMBINATION | SCHIZOSACCHAROMYCES-POMBE | ANTIBODY DIVERSIFICATION | FUNCTIONAL-PROPERTIES | Meiosis - physiology | Saccharomyces cerevisiae - genetics | Humans | Caenorhabditis elegans Proteins - metabolism | DNA Breaks, Double-Stranded | Saccharomyces cerevisiae - metabolism | Schizosaccharomyces - genetics | Recombination, Genetic | Schizosaccharomyces pombe Proteins - metabolism | In Situ Nick-End Labeling | Rad51 Recombinase - metabolism | Chromosome Segregation | Caenorhabditis elegans - metabolism | Schizosaccharomyces pombe Proteins - genetics | Rad51 Recombinase - genetics | Animals, Genetically Modified | Caenorhabditis elegans - genetics | Cytidine Deaminase - genetics | Esterases - metabolism | Saccharomyces cerevisiae Proteins - genetics | Esterases - genetics | Endodeoxyribonucleases | Schizosaccharomyces - metabolism | Animals | DNA Repair | Saccharomyces cerevisiae Proteins - metabolism | Caenorhabditis elegans Proteins - genetics | Apoptosis | Physiological aspects | Research | Gene mutations | Genetic recombination | Biological diversity | Proteins | Cell division | Yeast | Mutation | E coli | DNA repair | Investigations
FISSION YEAST | CAENORHABDITIS-ELEGANS | SOMATIC HYPERMUTATION | GENETICS & HEREDITY | DOUBLE-STRAND BREAKS | CLASS-SWITCH RECOMBINATION | C-ELEGANS | HOMOLOGOUS RECOMBINATION | SCHIZOSACCHAROMYCES-POMBE | ANTIBODY DIVERSIFICATION | FUNCTIONAL-PROPERTIES | Meiosis - physiology | Saccharomyces cerevisiae - genetics | Humans | Caenorhabditis elegans Proteins - metabolism | DNA Breaks, Double-Stranded | Saccharomyces cerevisiae - metabolism | Schizosaccharomyces - genetics | Recombination, Genetic | Schizosaccharomyces pombe Proteins - metabolism | In Situ Nick-End Labeling | Rad51 Recombinase - metabolism | Chromosome Segregation | Caenorhabditis elegans - metabolism | Schizosaccharomyces pombe Proteins - genetics | Rad51 Recombinase - genetics | Animals, Genetically Modified | Caenorhabditis elegans - genetics | Cytidine Deaminase - genetics | Esterases - metabolism | Saccharomyces cerevisiae Proteins - genetics | Esterases - genetics | Endodeoxyribonucleases | Schizosaccharomyces - metabolism | Animals | DNA Repair | Saccharomyces cerevisiae Proteins - metabolism | Caenorhabditis elegans Proteins - genetics | Apoptosis | Physiological aspects | Research | Gene mutations | Genetic recombination | Biological diversity | Proteins | Cell division | Yeast | Mutation | E coli | DNA repair | Investigations
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 2005, Volume 334, Issue 2, pp. 386 - 394
Induction of apoptosis is pivotal for eliminating cells with damaged DNA or deregulated proliferation. We show that tumor suppressor ARF and ATM/ATR kinase...
Rad51 | ARF | ATM | DNA double-strand breaks | DNA repair | Oncogenes | Apoptosis | ATR | p53 | P53 PROTEIN | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | DNA-DAMAGE | oncogenes | apoptosis | DOUBLE-STRAND BREAKS | SERINE 139 | HISTONE H2AX | BIOPHYSICS | IN-VIVO | TUMOR-SUPPRESSOR | BAX | CYTOCHROME-C RELEASE | Cell Line | Tumor Suppressor Proteins - metabolism | Humans | Oxidative Stress - physiology | Cell Cycle Proteins - metabolism | Oncogene Proteins - metabolism | Tumor Suppressor Protein p53 - metabolism | Ataxia Telangiectasia Mutated Proteins | Cyclin-Dependent Kinase Inhibitor p16 | DNA-Binding Proteins - metabolism | Animals | Mice | Apoptosis - physiology | Tumor Suppressor Protein p14ARF - metabolism | Protein-Serine-Threonine Kinases - metabolism | Fibroblasts - metabolism | Aircraft industry | Tumor proteins | Phosphotransferases | DNA | ONCOGENES | APOPTOSIS | NEOPLASMS | CELL PROLIFERATION | ARGON FLUORIDES | 60 APPLIED LIFE SCIENCES | STRAND BREAKS | DNA REPAIR | PHOSPHOTRANSFERASES | GENE REGULATION | VIRUSES
Rad51 | ARF | ATM | DNA double-strand breaks | DNA repair | Oncogenes | Apoptosis | ATR | p53 | P53 PROTEIN | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | DNA-DAMAGE | oncogenes | apoptosis | DOUBLE-STRAND BREAKS | SERINE 139 | HISTONE H2AX | BIOPHYSICS | IN-VIVO | TUMOR-SUPPRESSOR | BAX | CYTOCHROME-C RELEASE | Cell Line | Tumor Suppressor Proteins - metabolism | Humans | Oxidative Stress - physiology | Cell Cycle Proteins - metabolism | Oncogene Proteins - metabolism | Tumor Suppressor Protein p53 - metabolism | Ataxia Telangiectasia Mutated Proteins | Cyclin-Dependent Kinase Inhibitor p16 | DNA-Binding Proteins - metabolism | Animals | Mice | Apoptosis - physiology | Tumor Suppressor Protein p14ARF - metabolism | Protein-Serine-Threonine Kinases - metabolism | Fibroblasts - metabolism | Aircraft industry | Tumor proteins | Phosphotransferases | DNA | ONCOGENES | APOPTOSIS | NEOPLASMS | CELL PROLIFERATION | ARGON FLUORIDES | 60 APPLIED LIFE SCIENCES | STRAND BREAKS | DNA REPAIR | PHOSPHOTRANSFERASES | GENE REGULATION | VIRUSES
Journal Article
20.
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A role for the RNA pol II–associated PAF complex in AID-induced immune diversification
The Journal of Cell Biology, ISSN 0021-9525, 10/2012, Volume 199, Issue 1, pp. i1 - i1
Journal Article
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