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Science, ISSN 0036-8075, 12/2017, Volume 358, Issue 6367, p. eaan4368
Kinase inhibitors are important cancer therapeutics. Polypharmacology is commonly observed, requiring thorough target deconvolution to understand drug... 
REFINEMENT | PROTEIN | CHEMICAL PROTEOMICS | INHIBITOR SELECTIVITY | DATA QUALITY | QUANTIFICATION | MULTIDISCIPLINARY SCIENCES | INTEGRATIVE GENOMICS VIEWER | SALT-INDUCIBLE KINASES | CANCER | COMPREHENSIVE ANALYSIS | fms-Like Tyrosine Kinase 3 - antagonists & inhibitors | Lung Neoplasms - drug therapy | Lung Neoplasms - enzymology | Cytokines - metabolism | Humans | Drug Discovery - methods | Antineoplastic Agents - chemistry | Molecular Targeted Therapy | Xenograft Model Antitumor Assays | Leukemia, Myeloid, Acute - enzymology | Protein Kinase Inhibitors - chemistry | Animals | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Line, Tumor | Leukemia, Myeloid, Acute - drug therapy | Antineoplastic Agents - pharmacology | Mice | Protein Kinase Inhibitors - pharmacology | Proteomics - methods | Salts | Target recognition | Lung cancer | Selectivity | Drug development | Cancer therapies | Signal transduction | Biomolecules | Protein-tyrosine kinase | Tyrosine | Medical research | Imatinib | Decision making | Medical treatment | Mass spectroscopy | Tumor necrosis factor-α | Embryos | Bruton's tyrosine kinase | Mode of action | Side effects | Inhibitors | Interleukin 10 | Affinity | Drug discovery | Mass spectrometry | Acute myeloid leukemia | Drugs | Deregulation | Leukemia | Interleukin | Clinical trials | Leucine | Kinases | Biological effects | Epidermal growth factor | Salt-inducible kinase | Xenografts | Cell survival | Epidermal growth factor receptors | Research & development--R&D | Therapeutic applications | Myeloid leukemia | Markers | Data processing | Lead compounds | Leucine zipper proteins | Signaling | Proteomics | Cancer
Journal Article
Journal Article
Molecular Systems Biology, ISSN 1744-4292, 02/2019, Volume 15, Issue 2, pp. e8503 - n/a
Journal Article
Analytical Chemistry, ISSN 0003-2700, 09/2017, Volume 89, Issue 17, pp. 8884 - 8891
Offline two-dimensional chromatography is a common means to achieve deep proteome coverage. To reduce sample complexity and dynamic range and to utilize mass... 
MULTIDIMENSIONAL LIQUID-CHROMATOGRAPHY | CHEMISTRY, ANALYTICAL | BOTTOM-UP PROTEOMICS | SHOTGUN PROTEOMICS | SENSITIVITY | SEPARATION | IDENTIFICATION | EXCHANGE HSAX CHROMATOGRAPHY | GO EXTRACTION TIPS | MASS-SPECTROMETRY | HYDROPHILIC-INTERACTION CHROMATOGRAPHY | Chemical reactions | Usage | Cations | Chemistry, Analytic | Chemical properties | Research
Journal Article
Analytical Chemistry, ISSN 0003-2700, 09/2017, Volume 89, Issue 17, p. 8884
Offline two-dimensional chromatography is a common means to achieve deep proteome coverage. To reduce sample complexity and dynamic range and to utilize mass... 
Cation exchange | Solvents | Fractionation | Automation | Peptides | Workflow | Cation exchanging | Tumor cell lines | Orthogonality | pH effects | Chromatography | Proteins | Anion exchange | Pancreatic cancer | Desalination | Acetonitrile | Anion exchanging | Proteomes | Two dimensional analysis
Journal Article
Cellular Signalling, ISSN 0898-6568, 04/2020, Volume 68, p. 109525
The ERBB1/2/4 inhibitor neratinib causes plasma membrane-associated K-RAS to mislocalize into intracellular vesicles; this effect is enhanced by HDAC... 
HDAC inhibitor | Copanlisib | ERBB3 | PI3K | RAS | Neratinib | CANCERS | INHIBITORS | CELL BIOLOGY
Journal Article
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