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Nature Genetics, ISSN 1061-4036, 07/2012, Volume 44, Issue 7, pp. 751 - 759
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 02/2016, Volume 55, Issue 8, pp. 2787 - 2791
Journal Article
Molecular Biology Reports, ISSN 0301-4851, 10/2019, Volume 46, Issue 5, pp. 5063 - 5071
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2014, Volume 111, Issue 46, pp. 16538 - 16543
Why different species are predisposed to different tumor spectra is not well understood. In particular, whether the physical location of tumor suppressor genes... 
Kidneys | Cysts | Renal cell carcinoma | Alleles | Tumor suppressor genes | Kidney cells | Lesions | Genetic mutation | Tumors | Cancer | HIF | MULTIDISCIPLINARY SCIENCES | HIPPEL-LINDAU-DISEASE | kidney stem cells | CELL CARCINOMA | LESIONS | kidney cancer | INACTIVATION | Six2-Cre | EVOLUTION | GENE | TUMOR-SUPPRESSOR | VHL | MUTATIONS | EXPRESSION | BAP1 | Kidney Neoplasms - genetics | Species Specificity | Tumor Suppressor Proteins - antagonists & inhibitors | Humans | Multipotent Stem Cells - metabolism | Carcinoma, Renal Cell - genetics | Male | Kidney Failure, Chronic - pathology | Tumor Suppressor Proteins - genetics | Kidney Diseases, Cystic - genetics | Female | Precancerous Conditions - pathology | Von Hippel-Lindau Tumor Suppressor Protein - genetics | Von Hippel-Lindau Tumor Suppressor Protein - antagonists & inhibitors | Genes, Tumor Suppressor | Ubiquitin Thiolesterase - antagonists & inhibitors | Genes, Reporter | Disease Models, Animal | Genetic Predisposition to Disease | Mice, Inbred C57BL | Genes, Synthetic | Von Hippel-Lindau Tumor Suppressor Protein - physiology | Mice, Transgenic | Chromosome Mapping | Ubiquitin Thiolesterase - physiology | Ubiquitin Thiolesterase - genetics | Precancerous Conditions - genetics | Kidney Diseases, Cystic - pathology | Mice, Knockout | Kidney Failure, Chronic - genetics | Cell Lineage | Tumor Suppressor Proteins - physiology | Multipotent Stem Cells - pathology | Phenotype | Animals | Kidney Failure, Chronic - blood | Age of Onset | Mice | Models, Genetic | Mutation | Physiological aspects | Carcinoma | Kidney cancer | Biological Sciences
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 08/2019, Volume 58, Issue 35, pp. 12076 - 12080
Enhancing tumor targeting of nanocarriers has been a major strategy for advancing clinical translation of cancer nanomedicines. Herein, we report a... 
intratumoral transport | drug delivery | vascular permeability | gold nanoparticles | therapeutic index | RETENTION | SILICA NANOPARTICLES | TUMOR | NANOMEDICINE | POLYMERIC MICELLES | CHEMISTRY, MULTIDISCIPLINARY | Drugs | Anthracyclines | Drug delivery systems | Permeability | Analysis | Vehicles | Nanoparticles | Gold | Kidneys | Drug delivery | Retention | Doxorubicin | Blood | Cancer | Tumors | Index Medicus
Journal Article
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 01/2018, Volume 57, Issue 1, pp. 266 - 271
While dose dependencies in pharmacokinetics and clearance are often observed in clinically used small molecules, very few studies have been dedicated to the... 
nanoparticles | renal clearance | biocompatibility | non-human primates | dose dependencies | PARTICLES | EFFICACY | SAFETY | RATS | CHEMISTRY, MULTIDISCIPLINARY | PHARMACOKINETICS | VASCULATURE | KINETICS | Nanoparticles | Primates | Gold | Excretion | Intravenous administration | Renal function | Kidneys | Toxicity | Pharmacology | Injection | Biocompatibility | Transport | Pharmacokinetics | Kidney transplantation | Index Medicus
Journal Article
Critical Reviews in Oncogenesis, ISSN 0893-9675, 2012, Volume 17, Issue 4, pp. 361 - 367
Over the past couple of decades, with discovery of novel targeted therapies, and expansion of our understanding of the molecular biology of rectal cancer,... 
Biomarker | Rectal adenocarcinoma | Prognostic | Predictive | Colorectal Neoplasms - mortality | Colorectal Neoplasms - therapy | Adenocarcinoma - metabolism | Prognosis | Adenocarcinoma - therapy | Humans | Biomarkers, Tumor - metabolism | Neoadjuvant Therapy | Survival Rate | Colorectal Neoplasms - metabolism | Adenocarcinoma - mortality
Journal Article
Nature, ISSN 0028-0836, 2016, Volume 539, Issue 7627, pp. 112 - 117
Clear cell renal cell carcinoma (ccRCC) is characterized by inactivation of the von Hippel-Lindau tumour suppressor gene (VHL)(1,2). Because no other gene is... 
HIF-2-ALPHA | INHIBITION | RNA | GENE | PAS-B DOMAIN | DNA | MULTIDISCIPLINARY SCIENCES | HIF2-ALPHA | HYPOXIA-INDUCIBLE FACTOR-2 | TRANSCRIPTION FACTOR | EXPRESSION | Sulfones - therapeutic use | Kidney Neoplasms - genetics | Humans | Gene Expression Regulation, Neoplastic | Carcinoma, Renal Cell - genetics | Male | Kidney Neoplasms - metabolism | Aryl Hydrocarbon Receptor Nuclear Translocator - metabolism | Molecular Targeted Therapy | Sulfones - pharmacology | Indans - therapeutic use | Erythropoietin - blood | Sunitinib | Basic Helix-Loop-Helix Transcription Factors - metabolism | Female | Indoles - pharmacology | Indans - administration & dosage | Carcinoma, Renal Cell - drug therapy | Pyrroles - therapeutic use | Binding Sites | Reproducibility of Results | Basic Helix-Loop-Helix Transcription Factors - genetics | Carcinoma, Renal Cell - pathology | Basic Helix-Loop-Helix Transcription Factors - antagonists & inhibitors | Mice, SCID | Xenograft Model Antitumor Assays | Carcinoma, Renal Cell - metabolism | Pyrroles - pharmacology | Animals | Cell Transformation, Neoplastic | Cell Line, Tumor | Erythropoietin - antagonists & inhibitors | Indoles - therapeutic use | Kidney Neoplasms - pathology | Mice, Inbred NOD | Aryl Hydrocarbon Receptor Nuclear Translocator - genetics | Mice | Mutation | Kidney Neoplasms - drug therapy | Drug Resistance, Neoplasm - drug effects | Indans - pharmacology | Sulfones - administration & dosage | Physiological aspects | Molecular targeted therapy | Transcription factors | Carcinoma, Renal cell | Methods | kidney cancer | HIF-1β (F446L) | RCC | patient-derived xenograft | EPAS1 | HIF-2α (G323E) | renal cancer | ARNT
Journal Article