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Nature Genetics, ISSN 1061-4036, 07/2012, Volume 44, Issue 7, pp. 751 - 759
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2014, Volume 111, Issue 46, pp. 16538 - 16543
Why different species are predisposed to different tumor spectra is not well understood. In particular, whether the physical location of tumor suppressor genes... 
Kidneys | Cysts | Renal cell carcinoma | Alleles | Tumor suppressor genes | Kidney cells | Lesions | Genetic mutation | Tumors | Cancer | HIF | MULTIDISCIPLINARY SCIENCES | HIPPEL-LINDAU-DISEASE | kidney stem cells | CELL CARCINOMA | LESIONS | kidney cancer | INACTIVATION | Six2-Cre | EVOLUTION | GENE | TUMOR-SUPPRESSOR | VHL | MUTATIONS | EXPRESSION | BAP1 | Kidney Neoplasms - genetics | Species Specificity | Tumor Suppressor Proteins - antagonists & inhibitors | Humans | Multipotent Stem Cells - metabolism | Carcinoma, Renal Cell - genetics | Male | Kidney Failure, Chronic - pathology | Tumor Suppressor Proteins - genetics | Kidney Diseases, Cystic - genetics | Female | Precancerous Conditions - pathology | Von Hippel-Lindau Tumor Suppressor Protein - genetics | Von Hippel-Lindau Tumor Suppressor Protein - antagonists & inhibitors | Genes, Tumor Suppressor | Ubiquitin Thiolesterase - antagonists & inhibitors | Genes, Reporter | Disease Models, Animal | Genetic Predisposition to Disease | Mice, Inbred C57BL | Genes, Synthetic | Von Hippel-Lindau Tumor Suppressor Protein - physiology | Mice, Transgenic | Chromosome Mapping | Ubiquitin Thiolesterase - physiology | Ubiquitin Thiolesterase - genetics | Precancerous Conditions - genetics | Kidney Diseases, Cystic - pathology | Mice, Knockout | Kidney Failure, Chronic - genetics | Cell Lineage | Tumor Suppressor Proteins - physiology | Multipotent Stem Cells - pathology | Phenotype | Animals | Kidney Failure, Chronic - blood | Age of Onset | Mice | Models, Genetic | Mutation | Physiological aspects | Carcinoma | Kidney cancer | Rodents | Genes | Index Medicus | Biological Sciences
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2014, Volume 111, Issue 11, pp. 4251 - 4256
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 08/2019, Volume 58, Issue 35, pp. 12076 - 12080
Enhancing tumor targeting of nanocarriers has been a major strategy for advancing clinical translation of cancer nanomedicines. Herein, we report a... 
intratumoral transport | drug delivery | vascular permeability | gold nanoparticles | therapeutic index | Drugs | Anthracyclines | Drug delivery systems | Permeability | Analysis | Vehicles | Nanoparticles | Gold | Kidneys | Drug delivery | Retention | Doxorubicin | Blood | Cancer | Tumors | Index Medicus
Journal Article
by Weinstein, John N and Akbani, Rehan and Broom, Bradley M and Wang, Wenyi and Verhaak, Roeland G. W and McConkey, David and Lerner, Seth and Morgan, Margaret and Creighton, Chad J and Smith, Carolyn and Cherniack, Andrew D and Kim, Jaegil and Pedamallu, Chandra Sekhar and Noble, Michael S and Al-Ahmadie, Hikmat A and Reuter, Victor E and Rosenberg, Jonathan E and F.Bajorin, Dean and Bochner, Bernard H and Solit, David B and Koppie, Theresa and Robinson, Brian and Gordenin, Dmitry A and Fargo, David and Klimczak, Leszek J and Roberts, Steven A and Au, Jessie and Laird, Peter W and Hinoue, Toshinori and Schultz, Nikolaus and Ramirez, Ricardo and Hansel, Donna and Hoadley, Katherine A and Kim, William Y and Damrauer, Jeffrey S and Baylin, Stephen B and Mungall, Andrew J and Robertson, A. Gordon and Chu, Andy and Kwiatkowski, David J and Sougnez, Carrie and Cibulskis, Kristian and Lichtenstein, Lee and Sivachenko, Andrey and Stewart, Chip and Lawrence, Michael S and Getz, Gad and Lander, Eric and Gabrie, Stacey B and Donehower, Lawrence and Carter, Scott L and Saksena, Gordon and Schumacher, Steven E and Freeman, Samuel S and Jung, Joonil and Bhatt, Ami S and Pugh, Trevor and Beroukhim, Rameen and Meyerson, Matthew and Ally, Adrian and Balasundaram, Miruna and Butterfield, Yaron S. N and Dhalla, Noreen and Hirst, Carrie and Holt, Robert A and Jones, Steven J. M and Lee, Darlene and Li, Haiyan I and Marra, Marco A and Mayo, Michael and Moore, Richard A and Schein, Jacqueline E and Sipahimalani, Payal and Tam, Angela and Thiessen, Nina and Wong, Tina and Wye, Natasja and Bowlby, Reanne and Chuah, Eric and Guin, Ranabir and Shen, Hui and Bootwalla, Moiz S and Triche Jr, Timothy and Lai, Phillip H and Van Den Berg, David J and Weisenberger, Daniel J and Balu, Saianand and Bodenheimer, Tom and Hoyle, Alan P and Jefferys, Stuart R and Meng, Shaowu and Mose, Lisle E and Simons, Janae V and Soloway, Mathew G and Wu, Junyuan and Parker, Joel S and Hayes, D. Neil and Roach, Jeffrey and Buda, Elizabeth and Jones, Corbin D and ... and Canc Genome Atlas Res Network and Cancer Genome Atlas Research Network and The Cancer Genome Atlas Research Network
Nature, ISSN 0028-0836, 2014, Volume 507, Issue 7492, pp. 315 - 322
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 01/2018, Volume 57, Issue 1, pp. 266 - 271
While dose dependencies in pharmacokinetics and clearance are often observed in clinically used small molecules, very few studies have been dedicated to the... 
nanoparticles | renal clearance | biocompatibility | non-human primates | dose dependencies | PARTICLES | EFFICACY | SAFETY | RATS | CHEMISTRY, MULTIDISCIPLINARY | PHARMACOKINETICS | VASCULATURE | KINETICS | Nanoparticles | Primates | Gold | Excretion | Intravenous administration | Renal function | Kidneys | Toxicity | Pharmacology | Injection | Biocompatibility | Transport | Pharmacokinetics | Kidney transplantation | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 2016, Volume 539, Issue 7627, pp. 112 - 117
Clear cell renal cell carcinoma (ccRCC) is characterized by inactivation of the von Hippel-Lindau tumour suppressor gene (VHL)(1,2). Because no other gene is... 
HIF-2-ALPHA | INHIBITION | RNA | PAS-B DOMAIN | MULTIDISCIPLINARY SCIENCES | IN-VIVO | TUMOR-SUPPRESSOR GENE | HIF2-ALPHA | HYPOXIA-INDUCIBLE FACTOR-2 | TRANSCRIPTION FACTOR | EXPRESSION | Sulfones - therapeutic use | Kidney Neoplasms - genetics | Humans | Gene Expression Regulation, Neoplastic | Carcinoma, Renal Cell - genetics | Male | Kidney Neoplasms - metabolism | Aryl Hydrocarbon Receptor Nuclear Translocator - metabolism | Molecular Targeted Therapy | Sulfones - pharmacology | Indans - therapeutic use | Erythropoietin - blood | Sunitinib | Basic Helix-Loop-Helix Transcription Factors - metabolism | Female | Indoles - pharmacology | Indans - administration & dosage | Carcinoma, Renal Cell - drug therapy | Pyrroles - therapeutic use | Binding Sites | Reproducibility of Results | Basic Helix-Loop-Helix Transcription Factors - genetics | Carcinoma, Renal Cell - pathology | Basic Helix-Loop-Helix Transcription Factors - antagonists & inhibitors | Mice, SCID | Xenograft Model Antitumor Assays | Carcinoma, Renal Cell - metabolism | Pyrroles - pharmacology | Animals | Cell Transformation, Neoplastic | Cell Line, Tumor | Erythropoietin - antagonists & inhibitors | Indoles - therapeutic use | Kidney Neoplasms - pathology | Mice, Inbred NOD | Aryl Hydrocarbon Receptor Nuclear Translocator - genetics | Mice | Mutation | Kidney Neoplasms - drug therapy | Drug Resistance, Neoplasm - drug effects | Indans - pharmacology | Sulfones - administration & dosage | Physiological aspects | Molecular targeted therapy | Transcription factors | Carcinoma, Renal cell | Methods | Index Medicus | kidney cancer | HIF-1β (F446L) | RCC | patient-derived xenograft | EPAS1 | HIF-2α (G323E) | renal cancer | ARNT
Journal Article