X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
index medicus (80) 80
humans (65) 65
oncology (48) 48
female (40) 40
male (36) 36
middle aged (35) 35
cancer (34) 34
adult (29) 29
pharmacokinetics (29) 29
aged (28) 28
article (26) 26
pharmacology & pharmacy (24) 24
analysis (23) 23
animals (18) 18
treatment outcome (14) 14
pharmacology (13) 13
research (13) 13
chemistry (12) 12
chemistry, analytical (11) 11
chemotherapy (11) 11
expression (10) 10
heterocyclic compounds (10) 10
organic chemistry (10) 10
therapy (10) 10
tumors (10) 10
care and treatment (9) 9
human necessities (9) 9
hygiene (9) 9
mass spectrometry (9) 9
medical or veterinary science (9) 9
metallurgy (9) 9
mice (9) 9
neoplasms - drug therapy (9) 9
preparations for medical, dental, or toilet purposes (9) 9
aged, 80 and over (8) 8
antineoplastic agents - pharmacokinetics (8) 8
breast cancer (8) 8
cell line, tumor (8) 8
medicine & public health (8) 8
metabolites (8) 8
reproducibility of results (8) 8
tandem mass spectrometry - methods (8) 8
toxicity (8) 8
young adult (8) 8
antimitotic agents (7) 7
antineoplastic agents (7) 7
antineoplastic combined chemotherapy protocols - therapeutic use (7) 7
chromatography, high pressure liquid - methods (7) 7
drug administration schedule (7) 7
genotype (7) 7
pharmacodynamics (7) 7
prostate cancer (7) 7
sensitivity and specificity (7) 7
specific therapeutic activity of chemical compounds ormedicinal preparations (7) 7
tandem mass spectrometry (7) 7
adolescent (6) 6
antineoplastic agents - therapeutic use (6) 6
antineoplastic combined chemotherapy protocols - adverse effects (6) 6
antitumor-activity (6) 6
apoptosis (6) 6
biochemical research methods (6) 6
cancer research (6) 6
drugs (6) 6
health aspects (6) 6
inhibitors (6) 6
metastasis (6) 6
methods (6) 6
patients (6) 6
pharmacogenetics (6) 6
pharmacology/toxicology (6) 6
proteins (6) 6
thalidomide - analogs & derivatives (6) 6
vascular endothelial growth factor (6) 6
administration, oral (5) 5
angiogenesis (5) 5
antineoplastic agents - pharmacology (5) 5
antineoplastic combined chemotherapy protocols - administration & dosage (5) 5
area under curve (5) 5
cell proliferation - drug effects (5) 5
cells (5) 5
combination (5) 5
dexamethasone (5) 5
dosage and administration (5) 5
dose-response relationship, drug (5) 5
drug stability (5) 5
genetic aspects (5) 5
glucuronosyltransferase - genetics (5) 5
histone deacetylase inhibitor (5) 5
identification (5) 5
in-vitro (5) 5
journal club (5) 5
linear models (5) 5
models, biological (5) 5
multicenter (5) 5
neoplasms - metabolism (5) 5
ovarian cancer (5) 5
pharmacogenomics (5) 5
solid tumors (5) 5
toxicology (5) 5
trial (5) 5
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Clinical Cancer Research, ISSN 1078-0432, 12/2017, Volume 23, Issue 24, pp. 7437 - 7439
Determining the penetration of drugs across the blood-brain barrier is a significant challenge in central nervous system drug development. The use of a... 
ONCOLOGY | EXPLOITATION | Adult | Pyrimidines | Pyrazoles | Humans | Glioblastoma | Blood-Brain Barrier | Drugs | Brain | Penetration | Barriers | Central nervous system | Pharmacology | Jumping | Drug development | Blood | Cancer | Index Medicus
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 05/2019, Volume 37, Issue 15_suppl, pp. 3115 - 3115
Journal Article
Cancer Chemotherapy and Pharmacology, ISSN 0344-5704, 07/2017, Volume 80, Issue 1, pp. 217 - 221
Journal Article
Cancer Chemotherapy and Pharmacology, ISSN 0344-5704, 07/2019, pp. 1 - 12
Purpose Seviteronel is an orally-administered selective cytochrome P450c17a 17,20-lyase and androgen receptor inhibitor with anti-tumor activity in vitro and... 
Women | Cytochrome | Dexamethasone | Parameters | Computer simulation | Body weight | Sex | Oral administration | Breast cancer | Pharmacology | Prednisone | Metastases | Anticancer properties | Androgens | Inhibitors | Antitumor agents | Castration | Covariance | Men | Breast | Cytochromes | Pharmacokinetics | Prostate cancer | Prostate | Index Medicus
Journal Article
Clinical cancer research : an official journal of the American Association for Cancer Research, ISSN 1078-0432, 05/2019
The first-in-human clinical trial with human bolus i.v. infusion IL-15 (rhIL-15) was limited by treatment-associated toxicity. Here, we report toxicity,... 
Journal Article
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 01/2015, Volume 33, Issue 1, pp. 74 - 82
Journal Article
Journal of Chromatography B, ISSN 1570-0232, 06/2012, Volume 898, pp. 32 - 37
Tegafur is a 5-fluorouracil (5-FU) prodrug widely used outside the United States to treat colorectal cancer as well as cancers of the head and neck. The... 
API | Human | Utilization | Materials recovery | Uracil | Patients | Necks | Cancer
Journal Article
Journal of Chromatography B, ISSN 1570-0232, 06/2012, Volume 898, p. 32
a* Published analytic methods for tegafur are suboptimal for pharmacokinetic studies. a* An analytic method was developed for the anticancer drug tegafur and... 
Radiation | Clinical trials | Leucovorin | Liquid chromatography | Radiotherapy | Antineoplastic agents | Chromatography | Antimitotic agents | Pyrimidines | Metabolites | Nuclear radiation | Mass spectrometry | Methods | Fluorouracil
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 2018, Volume 36, Issue 14, pp. 1389 - 1395
PurposeAbiraterone acetate (AA) is a standard of care for metastatic castration-resistant prostate cancer (CRPC). Despite a large food effect, AA was... 
SURVIVAL | TRIALS | SOLID TUMORS | ONCOLOGY | PHARMACOKINETICS | KETOCONAZOLE | INHIBITORS | ACETATE | CHEMOTHERAPY | ENZALUTAMIDE | ORIGINAL REPORTS
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 07/2017, Volume 35, Issue 19, pp. 2193 - 2202
Purpose Data suggest that DNA damage by poly (ADP-ribose) polymerase inhibition and/or reduced vascular endothelial growth factor signaling by vascular... 
SENSITIVE OVARIAN-CANCER | MULTICENTER | ANTI-PD-1 | ONCOLOGY | ANTITUMOR-ACTIVITY | NIVOLUMAB | Piperazines - administration & dosage | Vascular Endothelial Growth Factor Receptor-1 - antagonists & inhibitors | Phthalazines - pharmacokinetics | Humans | Middle Aged | Antibodies, Monoclonal - adverse effects | Antineoplastic Combined Chemotherapy Protocols - pharmacokinetics | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Quinazolines - pharmacokinetics | Protein Kinase Inhibitors - adverse effects | Dose-Response Relationship, Drug | Genital Neoplasms, Female - drug therapy | Adult | Female | Quinazolines - administration & dosage | Piperazines - pharmacokinetics | Phthalazines - administration & dosage | Antibodies, Monoclonal - pharmacokinetics | Genital Neoplasms, Female - immunology | B7-H1 Antigen - immunology | Piperazines - adverse effects | Poly(ADP-ribose) Polymerase Inhibitors - administration & dosage | Genital Neoplasms, Female - metabolism | Protein Kinase Inhibitors - administration & dosage | B7-H1 Antigen - antagonists & inhibitors | Antibodies, Monoclonal - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | B7-H1 Antigen - biosynthesis | Quinazolines - adverse effects | Aged | Genital Neoplasms, Female - pathology | Phthalazines - adverse effects | Lymphocytes, Tumor-Infiltrating - immunology | Index Medicus | Phase I and Clinical Pharmacology | Combined Modality | Breast Cancer | ORIGINAL REPORTS
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 2705 - 18
Brain metastases are devastating complications of cancer. The blood-brain barrier (BBB), which protects the normal brain, morphs into an inadequately... 
CELL LUNG-CANCER | ISCHEMIA-REPERFUSION INJURY | MULTIPLE-SCLEROSIS | CNS METASTASES | MULTIDISCIPLINARY SCIENCES | ENDOTHELIAL-CELLS | PHASE-II | THERAPEUTIC TARGETS | CENTRAL-NERVOUS-SYSTEM | CHEMOKINE CCL2 | HER2-POSITIVE BREAST-CANCER | Antibiotics, Antineoplastic - pharmacology | Humans | Astrocytes - pathology | Gene Expression Regulation, Neoplastic | Triple Negative Breast Neoplasms - drug therapy | Brain Neoplasms - metabolism | Brain Neoplasms - secondary | Xanthenes - metabolism | Triple Negative Breast Neoplasms - pathology | Receptors, Lysosphingolipid - genetics | Female | Fluorescent Dyes - pharmacology | Chemokine CCL2 - metabolism | Antibiotics, Antineoplastic - pharmacokinetics | Receptors, Lysosphingolipid - metabolism | Interleukin-6 - metabolism | Fluorescent Dyes - chemistry | Interleukin-6 - genetics | Signal Transduction | Xanthenes - chemistry | Brain Neoplasms - genetics | Chemokine CCL2 - genetics | Injections, Intramuscular | Permeability | Brain Neoplasms - drug therapy | Doxorubicin - pharmacokinetics | Blood-Brain Barrier - metabolism | Blood-Brain Barrier - pathology | Animals | Triple Negative Breast Neoplasms - genetics | Mice, Nude | Triple Negative Breast Neoplasms - metabolism | Cell Line, Tumor | Myocardium | Doxorubicin - pharmacology | Astrocytes - metabolism | Brain | Toxicity | Complications | Secretion | Brain tumors | Breast cancer | Inflammation | Metastasis | Gene expression | Blood | Endothelial cells | Metastases | Cell adhesion & migration | Interleukin 6 | Dextran | Blood-brain barrier | Cell adhesion | Lesions | Monocyte chemoattractant protein 1 | Cancer | Tumors | Index Medicus
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 02/2009, Volume 296, Issue 2, pp. 359 - 369
Journal Article
Cancer Biology & Therapy, ISSN 1538-4047, 07/2017, Volume 18, Issue 7, pp. 470 - 472
A lack of appropriate diagnostic tools for prostate cancer has led to overdiagnosis and over treatment. In a recent publication in the New England Journal of... 
prostate cancer | genetic testing | mathematical oncology | HSD3B1 | Biomarkers | microRNA | gene expression signature | ONCOLOGY | DISEASE | ANTIGEN | Index Medicus
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 08/2017, Volume 23, Issue 16, pp. 4633 - 4641
Endoglin (CD105) is an endothelial cell membrane receptor highly expressed on proliferating tumor vasculature, including that of hepatocellular carcinoma... 
Niacinamide - analogs & derivatives | Humans | Middle Aged | Antibodies, Monoclonal - adverse effects | Antineoplastic Combined Chemotherapy Protocols - pharmacokinetics | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Young Adult | Carcinoma, Hepatocellular - drug therapy | Phenylurea Compounds - adverse effects | Niacinamide - pharmacokinetics | Adult | Female | Phenylurea Compounds - pharmacokinetics | Headache - chemically induced | Liver Neoplasms - drug therapy | Niacinamide - adverse effects | Antibodies, Monoclonal - pharmacokinetics | Epistaxis - chemically induced | Treatment Outcome | Niacinamide - administration & dosage | Disease-Free Survival | Animals | Liver Neoplasms, Experimental - drug therapy | Phenylurea Compounds - administration & dosage | Antibodies, Monoclonal - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Adolescent | Cell Line, Tumor | Aged | Mice, Inbred BALB C | Myocardial infarction | Drugs | Toxicity | Immunoglobulin G | Stenosis | Cytotoxicity | Hepatocellular carcinoma | Dosage | Hemorrhage | B7 antigen | Recruitment | Confidence intervals | Infusion | Angiogenesis | Liver cancer | Endoglin | Quality | Bioindicators | Vascular endothelial growth factor | CD105 antigen | Pharmacology | Patients | Survival | Endothelial cells | Endothelium | Cirrhosis | Magnetic resonance imaging | Experimental design | Medical prognosis | Monoclonal antibodies | Biomarkers | Hypoxia | Infarction | Plasma levels | Pharmacokinetics | Apoptosis | Cancer | Index Medicus
Journal Article
Cancer Biology & Therapy, ISSN 1538-4047, 11/2018, Volume 19, Issue 11, pp. 953 - 955
Surgical intervention is a common treatment modality for localized cancer. Post-operative analysis involves evaluation of surgical margins to assess whether... 
mass spectrometry | diagnostics | cancer | biomarker | biochemical recurrence | surgical margin | MASTECTOMY | ONCOLOGY | MITOCHONDRIA | SPECTROMETRY
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 03/2017, Volume 23, Issue 6, pp. 1397 - 1406
Purpose: Our preclinical studies showed that the PARP inhibitor, olaparib, prior to carboplatin attenuated carboplatin cytotoxicity. We evaluated... 
EXCISION-REPAIR | BREAST-CANCER | ONCOLOGY | PLATINUM | SENSITIVE OVARIAN-CANCER | DNA-REPAIR | COMBINATION | MAINTENANCE THERAPY | DAMAGE | CHEMOTHERAPY | PARP INHIBITOR | Piperazines - administration & dosage | Drug-Related Side Effects and Adverse Reactions - blood | Phthalazines - pharmacokinetics | Uterine Neoplasms - pathology | Humans | Middle Aged | Ovarian Neoplasms - pathology | Carboplatin - pharmacokinetics | Drug-Related Side Effects and Adverse Reactions - pathology | Carboplatin - adverse effects | Neoplasm Recurrence, Local - pathology | Adult | Female | Piperazines - pharmacokinetics | DNA Adducts - blood | Neoplasm Recurrence, Local - blood | Ovarian Neoplasms - drug therapy | Leukocytes, Mononuclear - drug effects | Phthalazines - administration & dosage | Drug Administration Schedule | Carboplatin - administration & dosage | Ovarian Neoplasms - blood | Breast Neoplasms - drug therapy | Piperazines - adverse effects | Leukocytes, Mononuclear - pathology | Maximum Tolerated Dose | Breast Neoplasms - pathology | Uterine Neoplasms - drug therapy | Breast Neoplasms - blood | Aged | Phthalazines - adverse effects | Uterine Neoplasms - blood | Tablets | Toxicity | Cytotoxicity | Comet assay | Metastases | Platinum | Safety engineering | Deoxyribonucleic acid--DNA | Adducts | Neutropenia | Thrombocytopenia | Bioassay | Bioassays | Poly(ADP-ribose) polymerase | Pharmacology | Breast cancer | Bioavailability | Patients | Carriers | Damage detection | Experimental design | Carboplatin | DNA adducts | Intracellular | Uterine cancer | Pharmacokinetics | Cancer | Index Medicus
Journal Article