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Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2014, Volume 134, Issue 1, pp. 116 - 126.e11
Background Common variable immunodeficiency (CVID) is an antibody deficiency with an equal sex distribution and a high variability in clinical presentation.... 
Allergy and Immunology | patient self-reported outcomes | treatment | Common variable immunodeficiency | primary antibody deficiency | autoimmunity | enteropathy | immunoglobulin replacement | quality of life | lymphadenopathy | granulomas | INFECTIONS | PHENOTYPES | IMMUNOLOGY | DEFICIENCY | IGM | TRIAL | B-CELL | ALLERGY | HYPOGAMMAGLOBULINEMIA | INTRAVENOUS IMMUNOGLOBULIN | DISEASE | Autoimmunity | Common Variable Immunodeficiency - immunology | Common Variable Immunodeficiency - drug therapy | Humans | Child, Preschool | Lymphoproliferative Disorders - complications | Male | Lymphoproliferative Disorders - immunology | Splenomegaly - pathology | Bronchiectasis - pathology | Common Variable Immunodeficiency - mortality | Pneumonia - mortality | Pneumonia - immunology | Adult | Female | Retrospective Studies | Child | Europe | Delayed Diagnosis | Common Variable Immunodeficiency - complications | Lymphoproliferative Disorders - mortality | Pneumonia - drug therapy | Immunoglobulins, Intravenous - therapeutic use | Adolescent | Age of Onset | Survival Analysis | Pneumonia - complications | Lymphoproliferative Disorders - drug therapy | Immunological deficiency syndromes | Care and treatment | Health aspects | Respiratory tract diseases | Studies | Pneumonia | Meningitis | Lymphomas | Multivariate analysis | Patients | Age | Data bases
Journal Article
by Coulter, Tanya I., MRCPI and Chandra, Anita, PhD, FRCPath and Bacon, Chris M., PhD, FRCPath and Babar, Judith, MRCP, FRCR and Curtis, James, PhD and Screaton, Nick, FRCP, FRCR and Goodlad, John R., MD, FRCPath and Farmer, George, MD and Steele, Cathal Laurence, MB and Leahy, Timothy Ronan, MRCPI and Doffinger, Rainer, PhD, FRCPath and Baxendale, Helen, PhD, FRCPath and Bernatoniene, Jolanta, PhD and Edgar, J. David M., FRCP, FRCPath and Longhurst, Hilary J., PhD, FRCPath and Ehl, Stephan, MD, PhD and Speckmann, Carsten, MD and Grimbacher, Bodo, MD, PhD and Sediva, Anna, MD, PhD and Milota, Tomas, MD and Faust, Saul N., PhD, FRCPCH and Williams, Anthony P., PhD, FRCPath and Hayman, Grant, FRCP, FRCPath and Kucuk, Zeynep Yesim, MD and Hague, Rosie, MRCP, FRCPH and French, Paul, MD, MRCS, DipFMS, FRCPath and Brooker, Richard, FRCPCH and Forsyth, Peter, FRCPath and Herriot, Richard, FRCP, FRCPath and Cancrini, Caterina, MD, PhD and Palma, Paolo, MD, PhD and Ariganello, Paola, MD and Conlon, Niall, PhD, FRCPath and Feighery, Conleth, PhD, FRCPath and Gavin, Patrick J., MD and Jones, Alison, PhD, FRCPCH and Imai, Kohsuke, MD, PhD and Ibrahim, Mohammad A.A., PhD, FRCP, FRCPath and Markelj, Gašper, MD and Abinun, Mario, MD, PhD and Rieux-Laucat, Frédéric, PhD and Latour, Sylvain, PhD and Pellier, Isabelle, MD, PhD and Fischer, Alain, MD, PhD and Touzot, Fabien, MD, PhD and Casanova, Jean-Laurent, MD, PhD and Durandy, Anne, MD, PhD and Burns, Siobhan O., MD, PhD and Savic, Sinisa, PhD, FRCPath and Kumararatne, D.S., FRCPath, DPhil (Oxon) and Moshous, Despina, MD, PhD and Kracker, Sven, PhD and Vanhaesebroeck, Bart, PhD, FMedSci and Okkenhaug, Klaus, PhD and Picard, Capucine, MD, PhD and Nejentsev, Sergey, MD, PhD and Condliffe, Alison M., PhD, FRCP and Cant, Andrew James, MD, FRCP, FRCPH
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2016, Volume 139, Issue 2, pp. 597 - 606.e4
Background Activated phosphoinositide 3-kinase δ syndrome (APDS) is a recently described combined immunodeficiency resulting from gain-of-function mutations in... 
Allergy and Immunology | Activated phosphoinositide 3-kinase δ syndrome | hematopoietic stem cell transplantation | phosphoinositide 3-kinase δ | immunodeficiency | phosphoinositide 3-kinase inhibitor | PIK3CD gene | bronchiectasis | p110δ-activating mutation causing senescent T cells, lymphadenopathy, and immunodeficiency | Activated phosphoinositide 3-kinase delta syndrome | IMMUNOLOGICAL FEATURES | HYPER-IGM SYNDROME | p110 delta-activating mutation causing senescent T cells | hematopoietic stem cell | COMMON VARIABLE IMMUNODEFICIENCY | PIK3CD | IMMUNOLOGY | lymphadenopathy | REFERENCE VALUES | P110-DELTA | phosphoinositide 3-kinase delta | P110 DELTA | B-CELL | ALLERGY | transplantation | MUTATIONS | Recurrence | Class I Phosphatidylinositol 3-Kinases - genetics | Herpesviridae Infections - mortality | Humans | Middle Aged | Child, Preschool | Infant | Male | Antibiotic Prophylaxis | Respiratory Tract Infections - genetics | Lymphoproliferative Disorders - therapy | Young Adult | Respiratory Tract Infections - mortality | Respiratory Tract Infections - therapy | Immunologic Deficiency Syndromes - mortality | Adult | Female | Surveys and Questionnaires | Herpesviridae Infections - genetics | Child | Immunologic Deficiency Syndromes - therapy | Hematopoietic Stem Cell Transplantation | International Cooperation | Lymphoproliferative Disorders - genetics | Mutation - genetics | Class I Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Enzyme Inhibitors - therapeutic use | Lymphoproliferative Disorders - mortality | Animals | Herpesviridae Infections - therapy | Immunoglobulins, Intravenous - therapeutic use | Adolescent | Survival Analysis | Immunologic Deficiency Syndromes - genetics | Mice | Cohort Studies | Immune Deficiencies, Infection, and Systemic Immune Disorders | HSCT, Hematopoietic stem cell transplantation | BALF, Bronchoalveolar lavage fluid | CT, Computed tomography | APDS, Activated phosphoinositide-3 kinase δ syndrome | GOF, Gain of function | PI3K, Phosphoinositide 3-kinase | HSV, Herpes simplex virus | CMV, Cytomegalovirus | OR, Odds ratio | PPV, Pneumococcal polysaccharide vaccine | CNS, Central nervous system
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2014, Volume 135, Issue 3, pp. 818 - 820.e4
  [...]long after treatment, patients with HL exhibit a persistent and dramatic alteration in CD4+ T-cell homeostasis and in thymic function, evidenced by a... 
Allergy and Immunology | CD8-Positive T-Lymphocytes - pathology | Prospective Studies | Hodgkin Disease - pathology | Humans | Middle Aged | CD4-Positive T-Lymphocytes - radiation effects | Gamma Rays - therapeutic use | Male | Antineoplastic Agents - therapeutic use | Killer Cells, Natural - pathology | CD4-Positive T-Lymphocytes - pathology | CD4-Positive T-Lymphocytes - immunology | CD8-Positive T-Lymphocytes - radiation effects | Thymus Gland - radiation effects | Thymus Gland - pathology | Killer Cells, Natural - immunology | Adult | Female | B-Lymphocytes - pathology | Lymphopoiesis - drug effects | Lymphopoiesis - radiation effects | B-Lymphocytes - radiation effects | Killer Cells, Natural - radiation effects | Immunophenotyping | Thymus Gland - drug effects | B-Lymphocytes - drug effects | B-Lymphocytes - immunology | CD8-Positive T-Lymphocytes - drug effects | Hodgkin Disease - therapy | Lymphopoiesis - immunology | Hodgkin Disease - immunology | Thymus Gland - immunology | Killer Cells, Natural - drug effects | CD8-Positive T-Lymphocytes - immunology | Neoplasm Staging | CD4-Positive T-Lymphocytes - drug effects | Antimitotic agents | Care and treatment | Lymphomas | T cells | Antineoplastic agents | Cancer | Chemotherapy | Lymphocytes | Homeostasis | Infections | Radiation therapy | Multivariate analysis | Age | Immune system | Life Sciences
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2011, Volume 128, Issue 2, pp. 382 - 389.e1
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2011, Volume 129, Issue 3, pp. 770 - 777
Background Primary immunoglobulin deficiencies lead to recurrent bacterial infections of the respiratory tract and bronchiectasis, even with adequate... 
Allergy and Immunology | infections | immunodeficiency | immunoglobulins | Haemophilus influenzae | IgM | INDUCED CYTIDINE DEAMINASE | X-LINKED AGAMMAGLOBULINEMIA | BRONCHIECTASIS | COMMON VARIABLE IMMUNODEFICIENCY | IMMUNOLOGY | MOLECULAR ANALYSIS | IMMUNIZATION | OUTER-MEMBRANE PROTEIN | ALLERGY | DISEASE | REPLACEMENT THERAPY | INFECTION | Respiratory System - pathology | Agammaglobulinemia - immunology | Antibodies, Viral - metabolism | Prospective Studies | Humans | Haemophilus Infections - epidemiology | Male | Risk | Haemophilus Infections - complications | Immunoglobulin M - immunology | Incidence | Immunoglobulin M - metabolism | Respiratory System - virology | Female | Child | Hyper-IgM Immunodeficiency Syndrome - complications | Respiratory System - immunology | Agammaglobulinemia - complications | Hyper-IgM Immunodeficiency Syndrome - epidemiology | Adolescent | Haemophilus influenzae - immunology | Hyper-IgM Immunodeficiency Syndrome - immunology | Antibodies, Viral - immunology | Haemophilus Infections - immunology | Haemophilus influenzae - pathogenicity | Agammaglobulinemia - epidemiology | Tyrosine | Care and treatment | Immunoglobulins | Bacterial infections | Hemophilus infections | Immunodeficiency | Disease susceptibility | Plasma | Antibiotics | Lymphocytes | Bacteria | Chronic obstructive pulmonary disease | Kinases | Multivariate analysis | Age | Streptococcus infections | Immunoglobulin M | Agammaglobulinemia | Respiratory System | Antibodies, Viral | Life Sciences | Microbiology and Parasitology | Haemophilus Infections | Hyper-IgM Immunodeficiency Syndrome
Journal Article
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2017, Volume 140, Issue 5, pp. 1388 - 1393.e8
Journal Article
Lancet, The, ISSN 0140-6736, 2015, Volume 386, Issue 9999, pp. 1156 - 1164
Journal Article