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Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study
Lancet, The, ISSN 0140-6736, 08/2012, Volume 380, Issue 9841, pp. 572 - 580
Summary Background High plasma HDL cholesterol is associated with reduced risk of myocardial infarction, but whether this association is causal is unclear....
Internal Medicine | ENDOTHELIAL LIPASE | METAANALYSIS | BLOOD CHOLESTEROL | ATHEROSCLEROSIS | GENETIC-VARIANTS | LOCI | CORONARY-HEART-DISEASE | UMCG Approved | HIGH-DENSITY-LIPOPROTEIN | ISCHEMIC CARDIOVASCULAR-DISEASE | ARTERY-DISEASE | MEDICINE, GENERAL & INTERNAL | CONTRIBUTE | SUSCEPTIBILITY | CARDIOVASCULAR-DISEASE | ASSOCIATION | Mendelian Randomization Analysis - methods | Myocardial Infarction - blood | Myocardial Infarction - genetics | Genetic Predisposition to Disease | Myocardial Infarction - epidemiology | Prospective Studies | Gene Frequency | Humans | Risk Factors | Biomarkers - blood | Case-Control Studies | Cholesterol, HDL - blood | Cholesterol, LDL - blood | Polymorphism, Single Nucleotide | Myocardial Infarction - etiology | Lipase - genetics | Genetic aspects | High density lipoproteins | Health aspects | Heart attack | Risk factors | Studies | Plasma | Heart attacks | Diet | Cardiovascular disease | Lipids | Cholesterol | Medical and Health Sciences | Medicin och hälsovetenskap
Internal Medicine | ENDOTHELIAL LIPASE | METAANALYSIS | BLOOD CHOLESTEROL | ATHEROSCLEROSIS | GENETIC-VARIANTS | LOCI | CORONARY-HEART-DISEASE | UMCG Approved | HIGH-DENSITY-LIPOPROTEIN | ISCHEMIC CARDIOVASCULAR-DISEASE | ARTERY-DISEASE | MEDICINE, GENERAL & INTERNAL | CONTRIBUTE | SUSCEPTIBILITY | CARDIOVASCULAR-DISEASE | ASSOCIATION | Mendelian Randomization Analysis - methods | Myocardial Infarction - blood | Myocardial Infarction - genetics | Genetic Predisposition to Disease | Myocardial Infarction - epidemiology | Prospective Studies | Gene Frequency | Humans | Risk Factors | Biomarkers - blood | Case-Control Studies | Cholesterol, HDL - blood | Cholesterol, LDL - blood | Polymorphism, Single Nucleotide | Myocardial Infarction - etiology | Lipase - genetics | Genetic aspects | High density lipoproteins | Health aspects | Heart attack | Risk factors | Studies | Plasma | Heart attacks | Diet | Cardiovascular disease | Lipids | Cholesterol | Medical and Health Sciences | Medicin och hälsovetenskap
Journal Article
JACC (Journal of the American College of Cardiology), ISSN 0735-1097, 2016, Volume 67, Issue 22, pp. 2578 - 2589
Abstract Background Approximately 7% of American adults have severe hypercholesterolemia (untreated low-density lipoprotein [LDL] cholesterol ≥190 mg/dl),...
Cardiovascular | Internal Medicine | coronary artery disease | gene sequencing | genetics | low-density lipoprotein cholesterol | POPULATION | CARDIAC & CARDIOVASCULAR SYSTEMS | VARIANTS | AUTOSOMAL-DOMINANT HYPERCHOLESTEROLEMIA | PREVALENCE | GUIDANCE | HEART | MUTATIONS | SPECTRUM | ASSOCIATION | LDLR | Receptors, LDL - genetics | Humans | Middle Aged | Hyperlipoproteinemia Type II - diagnosis | Male | Proprotein Convertase 9 - genetics | Apolipoprotein B-100 - genetics | Case-Control Studies | Genetic Variation | Cholesterol, LDL - blood | Female | Heterozygote | Coronary Artery Disease - epidemiology | Sequence Analysis | Cohort Studies | Hypercholesterolemia - epidemiology | Hyperlipoproteinemia Type II - genetics | Medical colleges | Care and treatment | Low density lipoproteins | Genes | Coronary heart disease | Population genetics | Epidemiology | Blood | Hypercholesterolemia | Analysis and chemistry | Atherosclerosis | Genetic research | Genetic aspects | Diagnosis | Research institutes | Cardiology | Trans fatty acids | Heart attacks | Cardiovascular disease | Lipids | Apolipoproteins | Low density lipoprotein | Cholesterol | Proteins | Studies | Confidence intervals | Consortia | Algorithms | Coronary vessels | Population | Mutation | Deoxyribonucleic acid--DNA
Cardiovascular | Internal Medicine | coronary artery disease | gene sequencing | genetics | low-density lipoprotein cholesterol | POPULATION | CARDIAC & CARDIOVASCULAR SYSTEMS | VARIANTS | AUTOSOMAL-DOMINANT HYPERCHOLESTEROLEMIA | PREVALENCE | GUIDANCE | HEART | MUTATIONS | SPECTRUM | ASSOCIATION | LDLR | Receptors, LDL - genetics | Humans | Middle Aged | Hyperlipoproteinemia Type II - diagnosis | Male | Proprotein Convertase 9 - genetics | Apolipoprotein B-100 - genetics | Case-Control Studies | Genetic Variation | Cholesterol, LDL - blood | Female | Heterozygote | Coronary Artery Disease - epidemiology | Sequence Analysis | Cohort Studies | Hypercholesterolemia - epidemiology | Hyperlipoproteinemia Type II - genetics | Medical colleges | Care and treatment | Low density lipoproteins | Genes | Coronary heart disease | Population genetics | Epidemiology | Blood | Hypercholesterolemia | Analysis and chemistry | Atherosclerosis | Genetic research | Genetic aspects | Diagnosis | Research institutes | Cardiology | Trans fatty acids | Heart attacks | Cardiovascular disease | Lipids | Apolipoproteins | Low density lipoprotein | Cholesterol | Proteins | Studies | Confidence intervals | Consortia | Algorithms | Coronary vessels | Population | Mutation | Deoxyribonucleic acid--DNA
Journal Article
Heart Rhythm, ISSN 1547-5271, 2012, Volume 9, Issue 10, pp. 1627 - 1634
Background The early repolarization pattern (ERP) is common and associated with risk of sudden cardiac death. ERP is heritable, and mutations have been...
Cardiovascular | Early repolarization | GWAS | Arrhythmia | Sudden cardiac death | Electrocardiogram | Meta-analysis | J-POINT ELEVATION | COMMON VARIANTS | CARDIAC & CARDIOVASCULAR SYSTEMS | VENTRICULAR-FIBRILLATION | KV4.3 | QT INTERVAL DURATION | J-WAVE SYNDROMES | ATRIAL-FIBRILLATION | TRANSIENT OUTWARD CURRENT | CHANNEL | MUTATIONS | Genetic Predisposition to Disease | Genome-Wide Association Study | Humans | Risk Factors | Male | Death, Sudden, Cardiac | Phenotype | Heart Conduction System - physiopathology | Electrocardiography | Female | Polymorphism, Single Nucleotide | Mutation | Arrhythmias, Cardiac - genetics | Medical colleges | Genomics | Environmental health | Chronic diseases | Population genetics | Endowments | Biometry | Physiological aspects | Cardiology | Medical informatics
Cardiovascular | Early repolarization | GWAS | Arrhythmia | Sudden cardiac death | Electrocardiogram | Meta-analysis | J-POINT ELEVATION | COMMON VARIANTS | CARDIAC & CARDIOVASCULAR SYSTEMS | VENTRICULAR-FIBRILLATION | KV4.3 | QT INTERVAL DURATION | J-WAVE SYNDROMES | ATRIAL-FIBRILLATION | TRANSIENT OUTWARD CURRENT | CHANNEL | MUTATIONS | Genetic Predisposition to Disease | Genome-Wide Association Study | Humans | Risk Factors | Male | Death, Sudden, Cardiac | Phenotype | Heart Conduction System - physiopathology | Electrocardiography | Female | Polymorphism, Single Nucleotide | Mutation | Arrhythmias, Cardiac - genetics | Medical colleges | Genomics | Environmental health | Chronic diseases | Population genetics | Endowments | Biometry | Physiological aspects | Cardiology | Medical informatics
Journal Article
Journal of the American College of Cardiology, ISSN 0735-1097, 2017, Volume 69, Issue 7, pp. 823 - 836
Abstract Background Genome-wide association studies have so far identified 56 loci associated with risk of coronary artery disease (CAD). Many CAD loci show...
Cardiovascular | Internal Medicine | expression quantitative trait loci | genetics | genome-wide association | single nucleotide polymorphism | cholesteryl ester transfer protein | SR-BI | CARDIAC & CARDIOVASCULAR SYSTEMS | METAANALYSIS | CETP MASS | SUSCEPTIBILITY | RISK | PHOSPHOLIPASE A | VARIANT | SCAVENGER RECEPTOR | ABDOMINAL AORTIC-ANEURYSM | Genome-Wide Association Study | Gene Frequency | Humans | Coronary Artery Disease - genetics | Female | Male | Coronary Artery Disease - epidemiology | Genetic Pleiotropy | Polymorphism, Single Nucleotide | Genetic Loci | Odds Ratio | Case-Control Studies | Coronary heart disease | Analysis | Genealogy | Cardiovascular disease | Genomes | Metabolism | Gene expression | Blood | Risk factors | Studies | Celiac disease | Lipoproteins | Coronary vessels | Rheumatoid arthritis | Quality control | Calcification | Diabetes | Bioinformatics | LD, linkage disequilibrium | CETP, cholesteryl ester transfer protein | eQTL, expression quantitative trait locus | CAD, coronary artery disease | GWAS, genome-wide association study | BMI, body mass index | SNP, single nucleotide polymorphism | HDL, high-density lipoprotein | LDL, low-density lipoprotein | Original Investigation | Basic Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | Klinisk medicin | Kardiologi | Medical Genetics | Medicinsk genetik | Clinical Medicine | Cardiac and Cardiovascular Systems | Medicinska och farmaceutiska grundvetenskaper
Cardiovascular | Internal Medicine | expression quantitative trait loci | genetics | genome-wide association | single nucleotide polymorphism | cholesteryl ester transfer protein | SR-BI | CARDIAC & CARDIOVASCULAR SYSTEMS | METAANALYSIS | CETP MASS | SUSCEPTIBILITY | RISK | PHOSPHOLIPASE A | VARIANT | SCAVENGER RECEPTOR | ABDOMINAL AORTIC-ANEURYSM | Genome-Wide Association Study | Gene Frequency | Humans | Coronary Artery Disease - genetics | Female | Male | Coronary Artery Disease - epidemiology | Genetic Pleiotropy | Polymorphism, Single Nucleotide | Genetic Loci | Odds Ratio | Case-Control Studies | Coronary heart disease | Analysis | Genealogy | Cardiovascular disease | Genomes | Metabolism | Gene expression | Blood | Risk factors | Studies | Celiac disease | Lipoproteins | Coronary vessels | Rheumatoid arthritis | Quality control | Calcification | Diabetes | Bioinformatics | LD, linkage disequilibrium | CETP, cholesteryl ester transfer protein | eQTL, expression quantitative trait locus | CAD, coronary artery disease | GWAS, genome-wide association study | BMI, body mass index | SNP, single nucleotide polymorphism | HDL, high-density lipoprotein | LDL, low-density lipoprotein | Original Investigation | Basic Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | Klinisk medicin | Kardiologi | Medical Genetics | Medicinsk genetik | Clinical Medicine | Cardiac and Cardiovascular Systems | Medicinska och farmaceutiska grundvetenskaper
Journal Article
Journal of the American College of Cardiology, ISSN 0735-1097, 12/2016, Volume 68, Issue 25, pp. 2761 - 2772
Abstract Background Genomic analyses have suggested that the LPA gene and its associated plasma biomarker, lipoprotein(a) (Lp[a]), represent a causal risk...
Cardiovascular | Internal Medicine | coronary heart disease | genetics | phenome-wide association study | single nucleotide polymorphism | BIOLOGICAL PATHWAYS | CARDIAC & CARDIOVASCULAR SYSTEMS | MYOCARDIAL-INFARCTION | ELEVATED LIPOPROTEIN(A) | LARGE-SCALE | ATHEROSCLEROSIS RISK | APOLIPOPROTEIN(A) | CARDIOVASCULAR-DISEASE | GENOME-WIDE | CORONARY-HEART-DISEASE | ASSOCIATION | Coronary Disease - blood | Prognosis | Humans | Risk Factors | Male | DNA - genetics | Phenotype | Coronary Disease - genetics | Coronary Disease - therapy | Biomarkers | Female | Polymorphism, Single Nucleotide | Lipoprotein(a) - blood | Genome-Wide Association Study - methods | Lipoprotein(a) - genetics | Genetic Therapy - methods | Analysis | Lipoprotein A | Heart failure | Stroke | Genealogy | Fasting | Genes | Cardiovascular disease | Genomes | Glucose | Apolipoproteins | Epidemiology | Estimates | Cholesterol | Studies | Consortia | Lipoproteins | Coronary vessels | Genetics | Diabetes | Kidney diseases | Arrays | Deoxyribonucleic acid--DNA
Cardiovascular | Internal Medicine | coronary heart disease | genetics | phenome-wide association study | single nucleotide polymorphism | BIOLOGICAL PATHWAYS | CARDIAC & CARDIOVASCULAR SYSTEMS | MYOCARDIAL-INFARCTION | ELEVATED LIPOPROTEIN(A) | LARGE-SCALE | ATHEROSCLEROSIS RISK | APOLIPOPROTEIN(A) | CARDIOVASCULAR-DISEASE | GENOME-WIDE | CORONARY-HEART-DISEASE | ASSOCIATION | Coronary Disease - blood | Prognosis | Humans | Risk Factors | Male | DNA - genetics | Phenotype | Coronary Disease - genetics | Coronary Disease - therapy | Biomarkers | Female | Polymorphism, Single Nucleotide | Lipoprotein(a) - blood | Genome-Wide Association Study - methods | Lipoprotein(a) - genetics | Genetic Therapy - methods | Analysis | Lipoprotein A | Heart failure | Stroke | Genealogy | Fasting | Genes | Cardiovascular disease | Genomes | Glucose | Apolipoproteins | Epidemiology | Estimates | Cholesterol | Studies | Consortia | Lipoproteins | Coronary vessels | Genetics | Diabetes | Kidney diseases | Arrays | Deoxyribonucleic acid--DNA
Journal Article
Heart Rhythm, ISSN 1547-5271, 2012, Volume 9, Issue 7, pp. 1099 - 1103
Background T-peak to T-end (TPE) interval on the electrocardiogram is a measure of myocardial dispersion of repolarization and is associated with an increased...
Cardiovascular | Repolarization | T wave | Gene | Electrocardiogram | Polymorphism | FINNISH POPULATION | CARDIAC & CARDIOVASCULAR SYSTEMS | DISPERSION | LEFT-VENTRICULAR HYPERTROPHY | HYPERTENSIVE PATIENTS | SUDDEN CARDIAC DEATH | POSTMYOCARDIAL INFARCTION PATIENTS | LONG-QT-SYNDROME | WAVE MORPHOLOGY | TEND INTERVAL | Genetic Predisposition to Disease - genetics | Genome-Wide Association Study | Humans | Middle Aged | Asian Continental Ancestry Group - genetics | Male | Potassium Channels, Inwardly Rectifying - genetics | DNA Methylation | Heart Conduction System - physiopathology | GC Rich Sequence - genetics | Finland | Electrocardiography | Long QT Syndrome - genetics | Adult | Female | Polymorphism, Single Nucleotide | Electrophysiologic Techniques, Cardiac | Arrhythmia | Genes | Genetic research | Genetic aspects | Cardiology | Population genetics | Genetics | Epidemiology
Cardiovascular | Repolarization | T wave | Gene | Electrocardiogram | Polymorphism | FINNISH POPULATION | CARDIAC & CARDIOVASCULAR SYSTEMS | DISPERSION | LEFT-VENTRICULAR HYPERTROPHY | HYPERTENSIVE PATIENTS | SUDDEN CARDIAC DEATH | POSTMYOCARDIAL INFARCTION PATIENTS | LONG-QT-SYNDROME | WAVE MORPHOLOGY | TEND INTERVAL | Genetic Predisposition to Disease - genetics | Genome-Wide Association Study | Humans | Middle Aged | Asian Continental Ancestry Group - genetics | Male | Potassium Channels, Inwardly Rectifying - genetics | DNA Methylation | Heart Conduction System - physiopathology | GC Rich Sequence - genetics | Finland | Electrocardiography | Long QT Syndrome - genetics | Adult | Female | Polymorphism, Single Nucleotide | Electrophysiologic Techniques, Cardiac | Arrhythmia | Genes | Genetic research | Genetic aspects | Cardiology | Population genetics | Genetics | Epidemiology
Journal Article
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Association of Triglyceride-Related Genetic Variants With Mitral Annular Calcification
JACC (Journal of the American College of Cardiology), ISSN 0735-1097, 2017, Volume 69, Issue 24, pp. 2941 - 2948
Abstract Background Mitral annular calcium (MAC), commonly identified by cardiac imaging, is associated with cardiovascular events and predisposes to the...
Cardiovascular | Internal Medicine | mitral valve | lipids | Mendelian randomization | single nucleotide polymorphism | prevention | LONG-TERM | VITAMIN-D | CARDIAC & CARDIOVASCULAR SYSTEMS | RISK-FACTORS | SECONDARY HYPERPARATHYROIDISM | ANULAR CALCIUM | ALL-CAUSE | PARATHYROID-HORMONE LEVELS | HEART-DISEASE | VALVE CALCIFICATION | PLASMA TRIGLYCERIDES | Calcinosis - genetics | Calcinosis - diagnosis | Genetic Predisposition to Disease | Prospective Studies | Follow-Up Studies | Humans | Middle Aged | Risk Factors | Male | Tomography, X-Ray Computed | Incidence | Mitral Valve Insufficiency - diagnosis | Mitral Valve Insufficiency - genetics | Polymorphism, Genetic | Genetic Variation | Mitral Valve - diagnostic imaging | Triglycerides - blood | Female | Aged | Triglycerides - genetics | Calcinosis - metabolism | Mitral Valve Insufficiency - metabolism | Medical colleges | Pharmacogenetics | Genetic research | Triglycerides | Research institutes | Cardiology | Epidemiology | Biometry | Public health | Analysis | Calcification (ectopic) | Heart | Calcium | Hispanic Americans | Stenosis | Lipids | Cardiovascular disease | Risk factors | Consortia | Randomization | Imaging | Atherosclerosis | Regurgitation | Genetics | Robustness | Rheumatic heart disease | Heart diseases | Age | Mitral valve | Sensitivity analysis | Medical imaging | Health | Metabolism | Gene expression | Apolipoproteins | Minority & ethnic groups | Estimates | Low density lipoprotein | Cholesterol | Studies | Pleiotropy | Sensitivity | Ethnicity | Womens health | Arteriosclerosis | Calcification | Determinants | Replication | Health risk assessment
Cardiovascular | Internal Medicine | mitral valve | lipids | Mendelian randomization | single nucleotide polymorphism | prevention | LONG-TERM | VITAMIN-D | CARDIAC & CARDIOVASCULAR SYSTEMS | RISK-FACTORS | SECONDARY HYPERPARATHYROIDISM | ANULAR CALCIUM | ALL-CAUSE | PARATHYROID-HORMONE LEVELS | HEART-DISEASE | VALVE CALCIFICATION | PLASMA TRIGLYCERIDES | Calcinosis - genetics | Calcinosis - diagnosis | Genetic Predisposition to Disease | Prospective Studies | Follow-Up Studies | Humans | Middle Aged | Risk Factors | Male | Tomography, X-Ray Computed | Incidence | Mitral Valve Insufficiency - diagnosis | Mitral Valve Insufficiency - genetics | Polymorphism, Genetic | Genetic Variation | Mitral Valve - diagnostic imaging | Triglycerides - blood | Female | Aged | Triglycerides - genetics | Calcinosis - metabolism | Mitral Valve Insufficiency - metabolism | Medical colleges | Pharmacogenetics | Genetic research | Triglycerides | Research institutes | Cardiology | Epidemiology | Biometry | Public health | Analysis | Calcification (ectopic) | Heart | Calcium | Hispanic Americans | Stenosis | Lipids | Cardiovascular disease | Risk factors | Consortia | Randomization | Imaging | Atherosclerosis | Regurgitation | Genetics | Robustness | Rheumatic heart disease | Heart diseases | Age | Mitral valve | Sensitivity analysis | Medical imaging | Health | Metabolism | Gene expression | Apolipoproteins | Minority & ethnic groups | Estimates | Low density lipoprotein | Cholesterol | Studies | Pleiotropy | Sensitivity | Ethnicity | Womens health | Arteriosclerosis | Calcification | Determinants | Replication | Health risk assessment
Journal Article
JACC (Journal of the American College of Cardiology), ISSN 0735-1097, 2012, Volume 60, Issue 23, pp. 2364 - 2371
Objectives This study evaluated the association of timing of lipid levels and lipid genetic risk score (GRS) with subclinical atherosclerosis. Background...
Cardiovascular | Internal Medicine | genetic risk score | lipids | coronary artery calcium | YOUNG-ADULTS | CARDIAC & CARDIOVASCULAR SYSTEMS | LOW-DENSITY-LIPOPROTEIN | ATHEROSCLEROSIS | LOCI | COMPUTED-TOMOGRAPHY | PREDICTION | DISEASE | CALCIFICATION | CARDIOVASCULAR RISK | GENOME-WIDE ASSOCIATION | Calcinosis - genetics | Genetic Predisposition to Disease | Prevalence | Prospective Studies | Follow-Up Studies | Atherosclerosis - genetics | Coronary Artery Disease - metabolism | Humans | Middle Aged | Risk Factors | Multidetector Computed Tomography - methods | Calcinosis - diagnostic imaging | Male | Atherosclerosis - epidemiology | Massachusetts - epidemiology | Atherosclerosis - metabolism | Coronary Vessels - metabolism | Coronary Angiography | Coronary Artery Disease - diagnostic imaging | Time Factors | Lipids - blood | Coronary Artery Disease - genetics | Female | Calcinosis - metabolism | Medical colleges | Low density lipoproteins | Genomics | Atherosclerosis | Physiological aspects | Genetic research | Triglycerides | Cardiology | Risk factors | Cholesterol | Public health | Confidence intervals | Cardiovascular disease | Lipids | Veins & arteries | Coronary artery calcium | Genetic risk score
Cardiovascular | Internal Medicine | genetic risk score | lipids | coronary artery calcium | YOUNG-ADULTS | CARDIAC & CARDIOVASCULAR SYSTEMS | LOW-DENSITY-LIPOPROTEIN | ATHEROSCLEROSIS | LOCI | COMPUTED-TOMOGRAPHY | PREDICTION | DISEASE | CALCIFICATION | CARDIOVASCULAR RISK | GENOME-WIDE ASSOCIATION | Calcinosis - genetics | Genetic Predisposition to Disease | Prevalence | Prospective Studies | Follow-Up Studies | Atherosclerosis - genetics | Coronary Artery Disease - metabolism | Humans | Middle Aged | Risk Factors | Multidetector Computed Tomography - methods | Calcinosis - diagnostic imaging | Male | Atherosclerosis - epidemiology | Massachusetts - epidemiology | Atherosclerosis - metabolism | Coronary Vessels - metabolism | Coronary Angiography | Coronary Artery Disease - diagnostic imaging | Time Factors | Lipids - blood | Coronary Artery Disease - genetics | Female | Calcinosis - metabolism | Medical colleges | Low density lipoproteins | Genomics | Atherosclerosis | Physiological aspects | Genetic research | Triglycerides | Cardiology | Risk factors | Cholesterol | Public health | Confidence intervals | Cardiovascular disease | Lipids | Veins & arteries | Coronary artery calcium | Genetic risk score
Journal Article