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Immunology, ISSN 0019-2805, 07/2017, Volume 151, Issue 3, pp. 340 - 348
Summary T regulatory (Treg) cells are critical for preventing autoimmunity and suppressing immune responses during cancer and chronic infection. However, the... 
simian immunodeficiency virus | interleukin‐2 | interferon‐γ | lymphocytic choriomeningitis virus | Tregs | tumour necrosis factor‐α | tumour necrosis factor-α | interferon-γ | interleukin-2 | PERSISTENCE | CHRONIC LCMV INFECTION | IMMUNOLOGY | interferon | VIRAL-INFECTION | EFFECTOR | BET | MEMORY | tumour necrosis factor | MICE | DIFFERENTIATION | TRANSCRIPTION FACTOR | EXPRESSION | Diphtheria Toxin - administration & dosage | Lymphocytic choriomeningitis virus - immunology | Antigens, Viral - administration & dosage | Cercopithecus aethiops | Lymphocytic choriomeningitis virus - drug effects | Immunologic Memory - drug effects | Lymphocytic Choriomeningitis - immunology | Antibodies, Viral - blood | T-Lymphocytes, Regulatory - immunology | CD4-Positive T-Lymphocytes - immunology | Time Factors | Female | Vero Cells | Disease Models, Animal | Simian Immunodeficiency Virus - immunology | Lymphocytic Choriomeningitis - virology | Mice, Transgenic | Diphtheria Toxin - immunology | Viral Vaccines - administration & dosage | Antigens, Viral - immunology | Adaptive Immunity - drug effects | Animals | Lymphocytic Choriomeningitis - prevention & control | Lymphocyte Activation - drug effects | CD8-Positive T-Lymphocytes - drug effects | Cell Proliferation - drug effects | CD8-Positive T-Lymphocytes - immunology | Viral Vaccines - immunology | CD4-Positive T-Lymphocytes - drug effects | Autoimmunity | Interferon | Vaccines | Biological response modifiers | T cells | Health aspects | CD8 antigen | Impairment | Differentiation (biology) | Chronic infection | Effector cells | Viruses | Lymphocytes T | Infections | Control | Lymphocytes | Recall | Expansion | Retarding | Pathogens | Immunological memory | Memory cells | Immune response | Immunoregulation | Markers | T cell receptors | Maintenance | Cell differentiation | CD4 antigen | Depletion | Mice | Intracellular | Cancer | Original
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 512, Issue 1, pp. 74 - 77
The viral reservoir represents a critical challenge for human immunodeficiency virus type 1 (HIV-1) eradication strategies(1-5). However, it remains unclear... 
LATENT INFECTION | REPLICATION | INITIATION | MULTIDISCIPLINARY SCIENCES | ACTIVE ANTIRETROVIRAL THERAPY | VACCINE | PREVENTION | DYNAMICS | IMMUNODEFICIENCY VIRUS-INFECTION | DEPENDS | HIV-1 INFECTION | DNA, Viral - biosynthesis | Macaca mulatta - immunology | Simian Immunodeficiency Virus - growth & development | DNA, Viral - analysis | Male | RNA, Viral - blood | Rectum - virology | Macaca mulatta - virology | Simian Acquired Immunodeficiency Syndrome - virology | Proviruses - genetics | Time Factors | Treatment Failure | Female | Disease Models, Animal | Simian Immunodeficiency Virus - immunology | Virus Replication - drug effects | Anti-Retroviral Agents - therapeutic use | Anti-Retroviral Agents - pharmacology | Viremia - drug therapy | Simian Immunodeficiency Virus - physiology | DNA, Viral - blood | Carrier State - virology | Animals | Simian Acquired Immunodeficiency Syndrome - drug therapy | Simian Acquired Immunodeficiency Syndrome - immunology | Viremia - virology | Anti-Retroviral Agents - administration & dosage | Carrier State - drug therapy | Kinetics | Viral Load - drug effects | Simian Immunodeficiency Virus - drug effects | Physiological aspects | Simian immunodeficiency virus | Virulence (Microbiology) | Studies | Antiretroviral drugs | Lymphocytes | Human immunodeficiency virus--HIV | Infections | Monkeys & apes | Deoxyribonucleic acid--DNA
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 06/2013, Volume 123, Issue 6, pp. 2604 - 2615
The inhibitory receptor programmed cell death 1 (PD-1) plays a major role in functional exhaustion of T cells during chronic infections and cancer, and recent... 
MEDICINE, RESEARCH & EXPERIMENTAL | HIV-INFECTION | IMMUNODEFICIENCY-VIRUS | NEGATIVE FEEDBACK-REGULATION | INTERLEUKIN-2 THERAPY | GENE-EXPRESSION | ANTIRETROVIRAL THERAPY | CHRONIC VIRAL-INFECTION | LOW-DOSE IL-2 | TUMOR-IMMUNOTHERAPY | IMMUNE EVASION | Lymphocytic choriomeningitis virus - immunology | Arenaviridae Infections - virology | Humans | Lymphocytic choriomeningitis virus - drug effects | T-Lymphocytes, Regulatory - immunology | Interleukin-2 - administration & dosage | Immunotherapy | Hyaluronan Receptors - metabolism | CD8-Positive T-Lymphocytes - metabolism | Female | Arenaviridae Infections - immunology | Antiviral Agents - pharmacology | Lymphocyte Activation | Mice, Inbred C57BL | Immunologic Factors - administration & dosage | Programmed Cell Death 1 Receptor - metabolism | Mice, Transgenic | Viremia - drug therapy | Antiviral Agents - administration & dosage | B7-H1 Antigen - immunology | Antibodies - pharmacology | Drug Synergism | Antibodies - administration & dosage | T-Lymphocytes, Regulatory - drug effects | Animals | B7-H1 Antigen - antagonists & inhibitors | Arenaviridae Infections - drug therapy | Viremia - virology | CD8-Positive T-Lymphocytes - virology | CD8-Positive T-Lymphocytes - drug effects | Interleukin-7 Receptor alpha Subunit - metabolism | Interleukin-2 - pharmacology | Viremia - immunology | Mice | CD8-Positive T-Lymphocytes - immunology | Viral Load - drug effects | Chronic Disease | Immunologic Factors - pharmacology | Care and treatment | Interleukin-2 | Genetic aspects | Research | T cells | Health aspects | Apoptosis | Cancer | Studies | Antiretroviral drugs | Cytokines | Lymphocytes | Infections | T cell receptors | Drug dosages | Cancer therapies | Viral infections | Immune system
Journal Article
European Journal of Immunology, ISSN 0014-2980, 12/2013, Volume 43, Issue 12, pp. 3219 - 3232
CD4+ T follicular helper (TFH) cells are central for generation of long‐term B‐cell immunity. A defining phenotypic attribute of TFH cells is the expression of... 
Folate R 4 | CD73 | B cells | CD4+ T cells | Viral infection | FOLATE RECEPTOR | IMMUNOLOGY | VIRAL-INFECTION | DEFICIENCY | CUTTING EDGE | CXC CHEMOKINE RECEPTOR-5 | EFFECTOR | IMMUNE-RESPONSES | DIFFERENTIATION | CD4(+) T cells | EXPRESSION | 5'-Nucleotidase - genetics | Inducible T-Cell Co-Stimulator Protein - biosynthesis | T-Lymphocytes, Helper-Inducer - immunology | 5'-Nucleotidase - immunology | Inducible T-Cell Co-Stimulator Protein - genetics | Programmed Cell Death 1 Receptor - biosynthesis | T-Lymphocytes, Helper-Inducer - cytology | Receptors, Cell Surface - biosynthesis | Virus Diseases - genetics | Inducible T-Cell Co-Stimulator Protein - immunology | 5'-Nucleotidase - biosynthesis | Acute Disease | DNA-Binding Proteins - immunology | T-Lymphocytes, Helper-Inducer - metabolism | Virus Diseases - immunology | Receptors, CXCR5 - genetics | Gene Expression Regulation - genetics | Gene Expression Regulation - immunology | Mice, Transgenic | Virus Diseases - metabolism | DNA-Binding Proteins - genetics | Receptors, CXCR5 - immunology | Receptors, Cell Surface - immunology | Animals | Receptors, CXCR5 - biosynthesis | Mice | Programmed Cell Death 1 Receptor - immunology | DNA-Binding Proteins - biosynthesis | Programmed Cell Death 1 Receptor - genetics | Proto-Oncogene Proteins c-bcl-6 | Receptors, Cell Surface - genetics | Gene expression | Medical research | T cell receptors | CD4 T cells | viral infection | folate receptor 4
Journal Article
Immunology, ISSN 0019-2805, 10/2017, Volume 152, Issue 2, pp. 328 - 343
Summary CD4 T cells help immune responses, but knowledge of how memory CD4 T cells are regulated and how they regulate adaptive immune responses and induce... 
CD4 T cell proliferation | gene regulation | inflammation | T cell | CD4 T cell differentiation | ANTIBODIES | CD8(+) | IMMUNOLOGY | IDENTIFICATION | LYMPHOCYTIC CHORIOMENINGITIS VIRUS | RESPONSES | EPITOPE | EXPANSION | DIFFERENTIATION | FOLLICULAR HELPER | ANTIGEN | Lymphocytic choriomeningitis virus - immunology | Cell Proliferation | Adoptive Transfer | Interferon Type I - immunology | Lymphocytic Choriomeningitis - immunology | CD4-Positive T-Lymphocytes - immunology | Lymphocytic Choriomeningitis - metabolism | Inflammation - metabolism | Immunity, Humoral | Time Factors | Lymphocytic choriomeningitis virus - pathogenicity | Interferon Type I - metabolism | Receptors, Antigen, T-Cell - immunology | CD4-Positive T-Lymphocytes - virology | Disease Models, Animal | Lymphocytic Choriomeningitis - genetics | Adaptive Immunity | Lymphocytic Choriomeningitis - virology | Receptors, Antigen, T-Cell - metabolism | Signal Transduction | Lymphocyte Activation | Mice, Inbred C57BL | CD4-Positive T-Lymphocytes - metabolism | Inflammation - virology | Genotype | Mice, Transgenic | Inflammation - immunology | Host-Pathogen Interactions | Phenotype | Animals | CD4-Positive T-Lymphocytes - transplantation | Immunologic Memory | Receptors, Antigen, T-Cell - genetics | Cytotoxicity, Immunologic | Antigens | Medical research | AIDS vaccines | Analysis | Medicine, Experimental | Interferon | Inflammation | Biological response modifiers | T cells | Cell differentiation | Health aspects | Cell proliferation | Memory cells | Immunological memory | Immune response | Viruses | Infections | T cell receptors | Lymphocytes T | Adoptive transfer | CD4 antigen | Lymphocytes | Expansion | Viral infections | Original
Journal Article