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Science, ISSN 0036-8075, 5/2013, Volume 340, Issue 6132, pp. 622 - 626
A number of human cancers harbor somatic point mutations in the genes encoding isocitrate dehydrogenases 1 and 2 (IDH1 and IDH2). These mutations alter... 
Molecules | Enzymes | Dehydrogenases | Blasts | Myeloid leukemia | REPORTS | Stem cells | Bone marrow cells | Cellular differentiation | Hematopoietic stem cells | Mesenchymal stem cells | ISOCITRATE DEHYDROGENASE | ONCOMETABOLITE 2-HYDROXYGLUTARATE | SUFFICIENT | MULTIDISCIPLINARY SCIENCES | HEMATOPOIETIC PROGENITORS | MUTATION | Cell Proliferation | Humans | Protein Multimerization | Crystallography, X-Ray | Erythropoiesis - drug effects | Isocitrate Dehydrogenase - antagonists & inhibitors | Molecular Targeted Therapy | Hematopoiesis - drug effects | Antineoplastic Agents - metabolism | Leukemia, Myeloid, Acute - enzymology | Phenylurea Compounds - chemistry | Enzyme Inhibitors - chemistry | Leukemia, Myeloid, Acute - drug therapy | Antineoplastic Agents - pharmacology | Phenylurea Compounds - metabolism | Mutant Proteins - antagonists & inhibitors | Catalytic Domain | Enzyme Inhibitors - metabolism | Protein Structure, Secondary | Sulfonamides - chemistry | Leukemia, Myeloid, Acute - pathology | Cells, Cultured | Enzyme Inhibitors - pharmacology | Isocitrate Dehydrogenase - genetics | Mutant Proteins - metabolism | Gene Expression Regulation, Leukemic | Antineoplastic Agents - chemistry | Sulfonamides - pharmacology | Point Mutation | Isocitrate Dehydrogenase - chemistry | Small Molecule Libraries | Mutant Proteins - chemistry | Allosteric Site | Sulfonamides - metabolism | Cell Line, Tumor | Isocitrate Dehydrogenase - metabolism | Glutarates - metabolism | Phenylurea Compounds - pharmacology | Leukemia, Erythroblastic, Acute | Leukemia, Myeloid, Acute - genetics | Leukemia | Cancer cells | Physiological aspects | Research | Oxidoreductases | Cell differentiation | Health aspects | Mutation | Cellular biology | Drug therapy | Cells
Journal Article
Journal Article
Nature Medicine, ISSN 1078-8956, 08/2018, Volume 24, Issue 8, pp. 1167 - 1177
Journal Article
Journal Article
Blood, ISSN 0006-4971, 08/2017, Volume 130, Issue 6, pp. 732 - 741
Journal Article
Cancer Cell, ISSN 1535-6108, 09/2016, Volume 30, Issue 3, pp. 501 - 501
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Nature Medicine, ISSN 1078-8956, 10/2011, Volume 17, Issue 10, pp. 1283 - 1289
Journal Article
Cancer Cell, ISSN 1535-6108, 08/2016, Volume 30, Issue 2, pp. 192 - 194
IDH mutants cause aberrant DNA and histone methylation and contribute to hematological and neural malignancies. In this issue of Cancer Cell, Inoue et al.... 
MUTANT | CELLS | ONCOLOGY | TET2 | ATM | DNA-REPAIR | CELL BIOLOGY | DNA Methylation | Histones - genetics | Neoplasms - genetics | Humans | Isocitrate Dehydrogenase - genetics | Mutation | Methylation
Journal Article
Journal of Inherited Metabolic Disease, ISSN 0141-8955, 11/2016, Volume 39, Issue 6, pp. 807 - 820
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NATURE, ISSN 0028-0836, 10/2019, Volume 574, Issue 7777, pp. 273 - 273
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2003, Volume 100, Issue 6, pp. 3455 - 3460
Journal Article
Cancer Cell, ISSN 1535-6108, 09/2016, Volume 30, Issue 3, p. 501
In the originally published version of this paper, the authors mistakenly used the word “neuronal” when referring to glioma in four instances. The word... 
Journal Article
Cancer Discovery, ISSN 2159-8274, 05/2017, Volume 7, Issue 5, pp. 478 - 493
Journal Article