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Nature Medicine, ISSN 1078-8956, 12/2016, Volume 22, Issue 12, pp. 1428 - 1438
Aging is associated with an increased risk of cardiovascular disease and death. Here we show that oral supplementation of the natural polyamine spermidine... 
MEDICINE, RESEARCH & EXPERIMENTAL | PRESSURE-OVERLOAD | BIOCHEMISTRY & MOLECULAR BIOLOGY | MITOCHONDRIAL AUTOPHAGY | PRESERVED EJECTION FRACTION | TANDEM MASS-SPECTROMETRY | DIASTOLIC HEART-FAILURE | ROBUST QUANTIFICATION | ARGININE BIOAVAILABILITY | CELL BIOLOGY | SALT-SENSITIVE RATS | AMINO-ACIDS | MYOCARDIAL HYPERTROPHY | Mitochondria, Heart - metabolism | Prospective Studies | Diastole | Gene Expression - drug effects | Longevity - drug effects | Humans | Middle Aged | Aging - drug effects | Immunoblotting | Male | Autophagy-Related Protein 5 - genetics | Chromatography, High Pressure Liquid | Mitochondria, Heart - drug effects | Autophagy - drug effects | Aging - immunology | Mass Spectrometry | Cardiovascular Diseases - epidemiology | Heart Failure | Adult | Female | Surveys and Questionnaires | Blood Pressure - drug effects | Rats, Inbred Dahl | Phosphorylation - drug effects | Cytokines - immunology | Glucose Tolerance Test | Echocardiography | Diet - statistics & numerical data | Connectin - drug effects | Cardiomegaly - diagnostic imaging | Rats | Inflammation | Cardiotonic Agents - pharmacology | Heart - diagnostic imaging | Animals | Myocytes, Cardiac - drug effects | Connectin - metabolism | Cytokines - drug effects | Mitochondrial Degradation - drug effects | Spermidine - pharmacology | Heart - drug effects | Aged | Mice | Aging - metabolism | Cardiovascular diseases | Polyamines | Research | Aging | Cardiomyocytes | Mitochondria | Kardiologi | Biological Sciences | Clinical Medicine | Cardiac and Cardiovascular Systems | Naturvetenskap | Medical and Health Sciences | Medicin och hälsovetenskap | Biologiska vetenskaper | Natural Sciences | Klinisk medicin
Journal Article
Nature Communications, ISSN 2041-1723, 12/2019, Volume 10, Issue 1, pp. 651 - 17
Journal Article
Molecular Cell, ISSN 1097-2765, 03/2014, Volume 53, Issue 5, pp. 710 - 725
Journal Article
JOURNAL OF BIOLOGICAL CHEMISTRY, ISSN 0021-9258, 08/2019, Volume 294, Issue 32, pp. 12020 - 12039
Autophagy, a membrane-dependent catabolic process, ensures survival of aging cells and depends on the cellular energetic status. Acetyl-CoA carboxylase 1... 
CHEMICAL INHIBITION | oleate | Snf1 | HOMEOSTASIS | autophagy | FATTY-ACID SYNTHESIS | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | lipid metabolism | STRESS-RESPONSE | lipogenesis | DIETARY RESTRICTION | METABOLIC-CONTROL | yeast | BUDDING YEAST LIFE | Acc1 | CELL-DEATH | acetate | acetyl-CoA carboxylase 1 | VACUOLE FUSION | AMPK | aging | acetyl coenzyme A (acetyl-CoA) | Cell Biology
Journal Article
CELL METABOLISM, ISSN 1550-4131, 09/2019, Volume 30, Issue 3, pp. 462 - 462
Caloric restriction and intermittent fasting are known to prolong life- and healthspan in model organisms, while their effects on humans are less well studied.... 
MORTALITY | LIFE-SPAN | D-BETA-HYDROXYBUTYRATE | KETONE-BODIES | METABOLISM | CALORIC RESTRICTION | ENDOCRINOLOGY & METABOLISM | WEIGHT-LOSS | TIME | BODY-COMPOSITION | CORONARY-HEART-DISEASE | CELL BIOLOGY | Physiological aspects | Obesity | Fasting | Thyroid hormones | Low density lipoproteins | Analysis
Journal Article
Cell Metabolism, ISSN 1550-4131, 03/2014, Volume 19, Issue 3, pp. 431 - 444
Journal Article
Stroke, ISSN 0039-2499, 02/2013, Volume 44, Issue 2, pp. 340 - 349
Journal Article
Journal Article
Frontiers in Molecular Neuroscience, ISSN 1662-5099, 09/2018, Volume 11
Huntington’s disease (HD) is a neurodegenerative disorder that leads to progressive neuronal loss, provoking impaired motor control, cognitive decline, and... 
Chorea Huntington | Huntingtin | Neurodegeneration | Aging | Drug discovery | Apoptosis | Disease model | neurodegeneration | apoptosis | drug discovery | huntingtin | disease model
Journal Article