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Archives of Toxicology, ISSN 0340-5761, 4/2017, Volume 91, Issue 4, pp. 1749 - 1762
Journal Article
Journal Article
Toxicology in Vitro, ISSN 0887-2333, 04/2020, Volume 64, p. 104463
In this paper, we evaluate the PPARα signaling network in rats, examining transcriptional responses in primary hepatocytes exposed to a PPARα specific ligand,... 
Fit-for-purpose assays | PPARα signaling network | TT21C | Gene expression profiling | PPARα ChIP-seq | In vitro risk assessment
Journal Article
TOXICOLOGICAL SCIENCES, ISSN 1096-6080, 01/2020, Volume 173, Issue 1, pp. 86 - 99
To address concerns around age-related sensitivity to pyrethroids, a life-stage physiologically based pharmacokinetic (PBPK) model, supported by in vitro to in... 
TRANS-PERMETHRIN | IN-VIVO PHARMACOKINETICS | INTERINDIVIDUAL VARIABILITY | IVIVE | CARBOXYLESTERASE 1 | HUMAN LIVER-MICROSOMES | PBPK modeling | pyrethroids | TISSUE DISTRIBUTION | BIAS ANALYSIS | EPIDEMIOLOGIC ASSOCIATIONS | TOXICOLOGY | METABOLIZING-ENZYMES | VITRO METABOLISM | enzyme ontogeny | Exposure Sciences
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 11/2017, Volume 335, p. 28
Styrene increased lung tumors in mice at chronic inhalation exposures of 20ppm and greater. MIEs, KEs and MFs were examined using gene expression in three... 
Metabolites | Lung cancer | Genes | Genomics | Cytochrome P-450 | Mice | Genetic engineering | DNA binding proteins | Tumor proteins | Gene expression | Parenting | Genetic research
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 11/2017, Volume 335, pp. 28 - 40
Styrene increased lung tumors in mice at chronic inhalation exposures of 20ppm and greater. MIEs, KEs and MFs were examined using gene expression in three... 
Molecular initiating events | Styrene inhalation | MIEs | Mouse lung tumors | Nr4 family gene downregulation | Adaptation and modulating factors | CHRONIC TOXICITY/ONCOGENICITY | RATS | DOSE-DEPENDENT TRANSITIONS | INHALED STYRENE | TOXICITY | CD-1 MICE | CANCER | CIRCADIAN CLOCK | INHALATION PHARMACOKINETICS | METABOLISM | PHARMACOLOGY & PHARMACY | TOXICOLOGY | Toxicogenetics - methods | Aryl Hydrocarbon Hydroxylases - genetics | Male | Intracellular Signaling Peptides and Proteins - metabolism | Gene Regulatory Networks - drug effects | Cytochrome P-450 CYP2B6 - metabolism | Dose-Response Relationship, Drug | Time Factors | Cytochrome P450 Family 2 - genetics | Inhalation Exposure - adverse effects | Models, Animal | Lung - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Styrenes - metabolism | Styrenes - toxicity | Cytochrome P-450 CYP2B6 - genetics | Mice, Inbred C57BL | Circadian Rhythm - genetics | Circadian Rhythm Signaling Peptides and Proteins - genetics | Gene Expression Profiling - methods | Genotype | Signal Transduction - genetics | Transcriptome - drug effects | Transcription Factors - genetics | Aryl Hydrocarbon Hydroxylases - metabolism | Mice, Knockout | Transcription Factors - metabolism | Cytochrome P-450 Enzyme System - deficiency | Phenotype | Animals | Circadian Rhythm Signaling Peptides and Proteins - metabolism | Cytochrome P450 Family 2 - metabolism | Signal Transduction - drug effects | Lung - drug effects | Cytochrome P-450 Enzyme System - genetics | Circadian Rhythm - drug effects | Index Medicus
Journal Article
Toxicological Sciences, ISSN 1096-6080, 1/2017, Volume 155, Issue 1, pp. 85 - 100
The developmental origins of obesity hypothesis posits a multifaceted contribution of factors to the fetal origins of obesity and metabolic disease. Adipocyte... 
adipogenesis | endocrine disrupting chemicals | adipose-derived stem cell | PPARG | PPAR-Gamma in ToxCast Chemicals | ToxCast | obesogens
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 10/2017, Volume 332, pp. 149 - 158
Journal Article
Journal Article