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1. Full Text Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk
by Dunlop, Malcolm G and Dobbins, Sara E and Farrington, Susan Mary and Jones, Angela M and Palles, Claire and Whiffin, Nicola and Tenesa, Albert and Spain, Sarah and Broderick, Peter and Ooi, Li-Yin and Domingo, Enric and Smillie, Claire and Henrion, Marc and Frampton, Matthew and Martin, Lynn and Grimes, Graeme and Gorman, Maggie and Semple, Colin and Ma, Yusanne P and Barclay, Ella and Prendergast, James and Cazier, Jean-Baptiste and Olver, Bianca and Penegar, Steven and Lubbe, Steven and Chander, Ian and Carvajal-Carmona, Luis G and Ballereau, Stephane and Lloyd, Amy and Vijayakrishnan, Jayaram and Zgaga, Lina and Rudan, Igor and Theodoratou, Evropi and Thomas, Huw and Maher, Eamonn and Evans, Gareth and Walker, Lisa and Halliday, Dorothy and Lucassen, Anneke and Paterson, Joan and Hodgson, Shirley and Homfray, Tessa and Side, Lucy and Izatt, Louise and Donaldson, Alan and Tomkins, Susan and Morrison, Patrick and Brewer, Carole and Henderson, Alex and Davidson, Rosemarie and Murday, Victoria and Cook, Jaqueline and Haites, Neva and Bishop, Timothy and Sheridan, Eamonn and Green, Andrew and Marks, Christopher and Carpenter, Sue and Broughton, Mary and Greenhalge, Lynn and Suri, Mohnish and Starr, John M and Deary, Ian and Kirac, Iva and Kovacevia, Dujo and Aaltonen, Lauri A and Renkonen-Sinisalo, Laura and Mecklin, Jukka-Pekka and Matsuda, Koichi and Nakamura, Yusuke and Okada, Yukinori and Gallinger, Steven and Duggan, David J and Conti, David and Newcomb, Polly and Hopper, John and Jenkins, Mark A and Schumacher, Fredrick and Casey, Graham and Easton, Douglas and Shah, Mitul and Pharoah, Paul and Lindblom, Annika and Liu, Tao and Edler, David and Lenander, Claes and Dalén, Johan and Hjern, Fredrik and Lundqvist, Nils and Lindforss, Ulrik and Påhlman, Lars and Smedh, Kennet and Törnqvist, Anders and Holm, Jörn and Janson, Martin and Andersson, Magnus and Ekelund, Susanne and Olsson, Louise and Smith, Christopher G and West, Hannah and ... and Colorectal Tumour Gene Identificat and Coin Collaborative Grp and Swedish Low-Risk Colorectal Canc and COIN Collaborative Group and Swedish Low-Risk Colorectal Cancer Study Group and Colorectal Tumour Gene Identification (CORGI) Consortium and The Swedish Low-Risk Colorectal Cancer Study Group and The COIN Collaborative Group and The Colorectal Tumour Gene Identification (CORGI) Consortium and Inst för molekylär medicin och kirurgi and Karolinska Institutet and Dept of Molecular Medicine and Surgery
Nature Genetics, ISSN 1061-4036, 07/2012, Volume 44, Issue 7, pp. 770 - 776
We performed a meta-analysis of five genome-wide association studies to identify common variants influencing colorectal cancer (CRC) risk comprising 8,682... 
METAANALYSIS | VARIANTS | MICROSATELLITE INSTABILITY | GENETICS & HEREDITY | SUSCEPTIBILITY LOCI | GENE-EXPRESSION | X-CHROMOSOME INACTIVATION | MUTATIONS | GENOME-WIDE ASSOCIATION | Genetic Variation | Genetic Predisposition to Disease | Cyclin-Dependent Kinase Inhibitor p21 - genetics | DNA Polymerase III - genetics | Membrane Proteins - genetics | Colorectal Neoplasms - genetics | Humans | Genetic Loci | Genome-Wide Association Study - methods | Case-Control Studies | Genetic aspects | Research | Gene mutations | Health aspects | Risk factors | Colorectal cancer | Studies | Confidence intervals | Cyclin-dependent kinases | Genomes | Arrays | Bioinformatics | DNA repair | Deoxyribonucleic acid--DNA | Recruitment | Meta-analysis | Index Medicus | MEDICIN OCH HÄLSOVETENSKAP | MEDICAL AND HEALTH SCIENCES
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2. Full Text Multiple common susceptibility variants near BMP pathway loci GREM1, BMP4, and BMP2 explain part of the missing heritability of colorectal cancer
by Tomlinson, Ian P. M and Carvajal-Carmona, Luis G and Dobbins, Sara E and Tenesa, Albert and Jones, Angela M and Howarth, Kimberley and Palles, Claire and Broderick, Peter and Jaeger, Emma E. M and Farrington, Susan and Lewis, Annabelle and Prendergast, James G. D and Pittman, Alan M and Theodoratou, Evropi and Olver, Bianca and Walker, Marion and Penegar, Steven and Barclay, Ella and Whiffin, Nicola and Martin, Lynn and Ballereau, Stephane and Lloyd, Amy and Gorman, Maggie and Lubbe, Steven and Howie, Bryan and Marchini, Jonathan and Ruiz-Ponte, Clara and Fernandez-Rozadilla, Ceres and Castells, Antoni and Carracedo, Angel and Castellvi-Bel, Sergi and Duggan, David and Conti, David and Cazier, Jean-Baptiste and Campbell, Harry and Sieber, Oliver and Lipton, Lara and Gibbs, Peter and Martin, Nicholas G and Montgomery, Grant W and Young, Joanne and Baird, Paul N and Gallinger, Steven and Newcomb, Polly and Hopper, John and Jenkins, Mark A and Aaltonen, Lauri A and Kerr, David J and Cheadle, Jeremy and Pharoah, Paul and Casey, Graham and Houlston, Richard S and Dunlop, Malcolm G and EPICOLON Consortium and COGENT Consortium and CORGI Collaborators and The EPICOLON Consortium and The COGENT Consortium and The CORGI Collaborators
PLoS Genetics, ISSN 1553-7390, 06/2011, Volume 7, Issue 6, pp. e1002105 - e1002105
Genome-wide association studies (GWAS) have identified 14 tagging single nucleotide polymorphisms (tagSNPs) that are associated with the risk of colorectal... 
GENETIC-VARIANTS | METAANALYSIS | MUTATIONS | GENETICS & HEREDITY | GENOME-WIDE ASSOCIATION | Bone Morphogenetic Protein 2 - genetics | Genetic Predisposition to Disease | Genome-Wide Association Study | Quantitative Trait, Heritable | Signal Transduction | Bone Morphogenetic Protein 4 - genetics | Colorectal Neoplasms - genetics | Gene Frequency | Humans | Middle Aged | Intercellular Signaling Peptides and Proteins - genetics | Male | Bone Morphogenetic Protein 4 - metabolism | Case-Control Studies | Genetic Variation | Bone Morphogenetic Protein 2 - metabolism | Aged | Polymorphism, Single Nucleotide | Colorectal Neoplasms - metabolism | Colorectal cancer | Physiological aspects | Bone morphogenetic proteins | Genetic aspects | Cellular signal transduction | Disease susceptibility | Research | Risk factors | Index Medicus | Studies | Medical research | Genetics | Genes
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3. Full Text Cumulative impact of common genetic variants and other risk factors on colorectal cancer risk in 42 103 individuals
by Dunlop, Malcolm G and Tenesa, Albert and Farrington, Susan M and Ballereau, Stephane and Brewster, David H and Koessler, Thibaud and Pharoah, Paul and Schafmayer, Clemens and Hampe, Jochen and Völzke, Henry and Chang-Claude, Jenny and Hoffmeister, Michael and Brenner, Hermann and von Holst, Susanna and Picelli, Simone and Lindblom, Annika and Jenkins, Mark A and Hopper, John L and Casey, Graham and Duggan, David and Newcomb, Polly A and Abulí, Anna and Bessa, Xavier and Ruiz-Ponte, Clara and Castellví-Bel, Sergi and Niittymäki, Iina and Tuupanen, Sari and Karhu, Auli and Aaltonen, Lauri and Zanke, Brent and Hudson, Tom and Gallinger, Steven and Barclay, Ella and Martin, Lynn and Gorman, Maggie and Carvajal-Carmona, Luis and Walther, Axel and Kerr, David and Lubbe, Steven and Broderick, Peter and Chandler, Ian and Pittman, Alan and Penegar, Steven and Campbell, Harry and Tomlinson, Ian and Houlston, Richard S
Gut, ISSN 0017-5749, 06/2013, Volume 62, Issue 6, pp. 871 - 881
Objective Colorectal cancer (CRC) has a substantial heritable component. Common genetic variation has been shown to contribute to CRC risk. A study was... 
DISEASE RISK | SUSCEPTIBILITY LOCI | SURVEILLANCE | TYPE-2 DIABETES RISK | MUTATIONS | FAMILY-HISTORY | GASTROENTEROLOGY & HEPATOLOGY | CARRIERS | GENOME-WIDE ASSOCIATION | ADENOMATOUS POLYPS | PREDICTION | Colorectal Neoplasms - epidemiology | Genetic Predisposition to Disease - genetics | Colorectal Neoplasms - ethnology | Risk Assessment | Colorectal Neoplasms - genetics | Humans | Risk Factors | Genotype | Logistic Models | Male | Scotland - epidemiology | Case-Control Studies | Feasibility Studies | Alleles | Female | Genetic Variation - genetics | Genetic variation | Colorectal cancer | Genetic aspects | Models | Research | Health risk assessment | Risk factors | Health care | Biomedical research | Funding | Colorectal carcinoma | Population studies | Genomes | Family medical history | Gender | Population genetics | Ethics | Prediction models | Population | Age | Public health | Genotypes | Medical research | Genealogy | Feasibility studies | Whites | Genetic diversity | Grants | Regression analysis | Genetic variance | Councils | Surveillance | Collaboration | Index Medicus | Abridged Index Medicus
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4. Full Text A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21
by Tomlinson, Ian and Thomas, Huw and Chandler, Ian and Hubner, Richard and Wild, Ruth and Johnstone, Elaine and Silver, Andrew and Barclay, Ella and Houlston, Richard and Sieber, Oliver and Wood, Wendy and Gorman, Maggie and Broderick, Peter and Howarth, Kimberley and Sellick, Gabrielle and Webb, Emily and Penegar, Steven and Muir, Kenneth and Kemp, Zoe and Martin, Lynn and Fielding, Sarah and Kerr, David and Atkin, Wendy and Gray, Richard and Cazier, Jean-Baptiste and Rowan, Andrew and Lubbe, Steven and Logan, Richard and Carvajal-Carmona, Luis and Peto, Julian and Jaeger, Emma and Spain, Sarah and CORGI Consortium and the CORGI Consortium
Nature Genetics, ISSN 1061-4036, 08/2007, Volume 39, Issue 8, pp. 984 - 988
Much of the variation in inherited risk of colorectal cancer (CRC) is probably due to combinations of common low risk variants. We conducted a genome-wide... 
RISK | METAANALYSIS | TUMORS | PROSTATE-CANCER | GENETICS & HEREDITY | Genetic Predisposition to Disease | Colorectal Neoplasms - genetics | Humans | Middle Aged | Female | Genotype | Male | Aged | Chromosomes, Human, Pair 8 | Polymorphism, Single Nucleotide | Physiological aspects | Genetic aspects | Diagnosis | Research | Single nucleotide polymorphisms | Colorectal cancer | Population genetics | Genomics | Risk factors | Tumors | Index Medicus
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5. Full Text A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3
by Koessler, Thibaud and Chandler, Ian and Caldés, Trinidad and Agúndez, Jose AG and Buch, Stephan and Howarth, Kimberley and Ladero, Jose M and Walther, Axel and Morreau, Hans and Giles, Graham G and Cazier, Jean-Baptiste and Castells, Antoni and Maher, Eamonn R and Wood, Wendy and Försti, Asta and Southey, Melissa C and Broderick, Peter and de la Hoya, Miguel and Hopper, John L and Webb, Emily and Wijnen, Juul T and Aaltonen, Lauri and Dunlop, Malcolm G and John, Ulrich and Fielding, Sarah and Barnetson, Rebecca A and Barclay, Ella and Martin, Lynn and Bishop, D Timothy and Tuupanen, Sari and Tenesa, Albert and Cheng, K K and Jaeger, Emma and Niittymäki, Iina and Karhu, Auli and Schreiber, Stefan and Peto, Julian and Völzke, Henry and Luk, J and Schafmayer, Clemens and Vodicka, Pavel and Carracedo, Angel and Vijayakrishnan, Jayaram and Houlston, Richard S and Rowan, Andrew and Tomlinson, Ian PM and Ruiz-Ponte, Clara and Ho, Judy WC and Kemp, Zoe and Lipton, Lara and Sullivan, Kate and Penegar, Steven and Prendergast, James GD and Carvajal-Carmona, Luis and Hampe, Jochen and Sham, Pak C and Kerr, David and Pharoah, Paul and Campbell, Harry and Severi, Gianluca and Gray, Richard and Pittman, Alan M and Castellví-Bel, Sergi and Spain, Sarah and Domingo, Enric and Hemminki, Kari and Lubbe, Steven and Thomas, Huw and Naccarati, Alessio and van Wezel, Tom and Gorman, Maggie and Lucassen, Anneke and Farrington, Susan M and Qureshi, Mobshra and Evans, D Gareth R and EPICOLON Consortium and CORGI Consortium and The EPICOLON Consortium and The CORGI Consortium
Nature Genetics, ISSN 1061-4036, 05/2008, Volume 40, Issue 5, pp. 623 - 630
To identify colorectal cancer (CRC) susceptibility alleles, we conducted a genome-wide association study. In phase 1, we genotyped 550,163 tagSNPs in 940... 
BREAST-CANCER | EIF3S3 | METAANALYSIS | PROSTATE-CANCER | GENES | GENETICS & HEREDITY | RISK | SCAN | VARIANT | TUMORS | Chromosomes, Human, Pair 8 - genetics | Genetic Predisposition to Disease | Colorectal Neoplasms - genetics | Humans | Middle Aged | Male | Pedigree | Alleles | Eukaryotic Initiation Factor-3 - genetics | Adult | Female | Aged | Polymorphism, Single Nucleotide | Chromosomes, Human, Pair 10 - genetics | Genome, Human | Genetic Linkage | Quality control | Colorectal cancer | Genetic research | Histology | Gene loci | Regression analysis | Genetic testing | Chromosomes | Index Medicus
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6. Full Text Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer
by Houlston, Richard S and Webb, Emily and Broderick, Peter and Pittman, Alan M and Di Bernardo, Maria Chiara and Lubbe, Steven and Chandler, Ian and Vijayakrishnan, Jayaram and Sullivan, Kate and Penegar, Steven and Carvajal-Carmona, Luis and Howarth, Kimberley and Jaeger, Emma and Spain, Sarah L and Walther, Axel and Barclay, Ella and Martin, Lynn and Gorman, Maggie and Domingo, Enric and Teixeira, Ana S and Kerr, David and Cazier, Jean-Baptiste and Niittymäki, Iina and Tuupanen, Sari and Karhu, Auli and Aaltonen, Lauri A and Tomlinson, Ian P. M and Farrington, Susan M and Tenesa, Albert and Prendergast, James G. D and Barnetson, Rebecca A and Cetnarskyj, Roseanne and Porteous, Mary E and Pharoah, Paul D. P and Koessler, Thibaud and Hampe, Jochen and Buch, Stephan and Schafmayer, Clemens and Tepel, Jurgen and Schreiber, Stefan and Völzke, Henry and Chang-Claude, Jenny and Hoffmeister, Michael and Brenner, Hermann and Zanke, Brent W and Montpetit, Alexandre and Hudson, Thomas J and Gallinger, Steven and Campbell, Harry and Dunlop, Malcolm G and Int Colorectal Canc Genetic Assoc and CoRGI Consortium and COGENT Study and Colorectal Canc Assoc Study Consor and Colorectal Cancer Association Study Consortium
Nature Genetics, ISSN 1061-4036, 12/2008, Volume 40, Issue 12, pp. 1426 - 1435
Genome-wide association (GWA) studies have identified multiple loci at which common variants modestly influence the risk of developing colorectal cancer (CRC).... 
BREAST-CANCER | 8Q24 | CADHERIN GENE CDH1 | PROSTATE-CANCER | GENETICS & HEREDITY | GERMLINE MUTATIONS | RISK | JUVENILE POLYPOSIS | BETA-CATENIN | SAMPLE-SIZE | FAMILIAL GASTRIC-CANCER | Genetic Predisposition to Disease | Genome-Wide Association Study | Colorectal Neoplasms - genetics | Humans | Middle Aged | Female | Male | Aged | Genome, Human | Case-Control Studies | Genetic aspects | Disease susceptibility | Research | Genetic variation | Risk factors | Colorectal cancer | Medical research | Inflation | Genomics | Risk assessment | Quality control | Genetics | Gene loci | Meta-analysis | Index Medicus
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7. Full Text A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk
by Chandler, Ian and Teixeira, Ana and Howarth, Kimberley and Martin, Lynn and Cazier, Jean-Baptiste and Vijayakrishnan, Jayaram and Sieber, Oliver and Houlston, Richard S and Wood, Wendy and Rowan, Andrew and Tomlinson, Ian and Carvajal-Carmona, Luis and Broderick, Peter and Kemp, Zoe and Sellick, Gabrielle and Peto, Julian and Webb, Emily and Sullivan, Kate and Penegar, Steven and Papaemmanuil, Elli and Fielding, Sarah and Kerr, David and Gray, Richard and Pittman, Alan M and Barclay, Ella and Spain, Sarah and Domingo, Enric and Lubbe, Steven and Gorman, Maggie and Jaeger, Emma and Qureshi, Mobshra and CORGI Consortium and members of the CORGI Consortium
Nature Genetics, ISSN 1061-4036, 11/2007, Volume 39, Issue 11, pp. 1315 - 1317
To identify risk variants for colorectal cancer (CRC), we conducted a genome-wide association study, genotyping 550,163 tag SNPs in 940 individuals with... 
GENETICS & HEREDITY | Genetic Predisposition to Disease | Colorectal Neoplasms - genetics | Humans | Risk Factors | Alleles | Genotype | Polymorphism, Single Nucleotide | Genome, Human | Smad7 Protein - genetics | Case-Control Studies | Genetic Linkage | Colorectal cancer | Physiological aspects | Genetic aspects | Diagnosis | Research | Single nucleotide polymorphisms | Identification and classification | Risk factors | Genetic research | Genotype & phenotype | Genomics | Index Medicus
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8. Full Text Association analyses identify 31 new risk loci for colorectal cancer susceptibility
by Law, Philip J and Timofeeva, Maria and Fernandez-Rozadilla, Ceres and Broderick, Peter and Studd, James and Fernandez-Tajes, Juan and Farrington, Susan and Svinti, Victoria and Palles, Claire and Orlando, Giulia and Sud, Amit and Holroyd, Amy and Penegar, Steven and Theodoratou, Evropi and Vaughan-Shaw, Peter and Campbell, Harry and Zgaga, Lina and Hayward, Caroline and Campbell, Archie and Harris, Sarah and Deary, Ian J and Starr, John and Gatcombe, Laura and Pinna, Maria and Briggs, Sarah and Martin, Lynn and Jaeger, Emma and Sharma-Oates, Archana and East, James and Leedham, Simon and Arnold, Roland and Johnstone, Elaine and Wang, Haitao and Kerr, David and Kerr, Rachel and Maughan, Tim and Kaplan, Richard and Al-Tassan, Nada and Palin, Kimmo and Hänninen, Ulrika A and Cajuso, Tatiana and Tanskanen, Tomas and Kondelin, Johanna and Kaasinen, Eevi and Sarin, Antti-Pekka and Eriksson, Johan G and Rissanen, Harri and Knekt, Paul and Pukkala, Eero and Jousilahti, Pekka and Salomaa, Veikko and Ripatti, Samuli and Palotie, Aarno and Renkonen-Sinisalo, Laura and Lepistö, Anna and Böhm, Jan and Mecklin, Jukka-Pekka and Buchanan, Daniel D and Win, Aung-Ko and Hopper, John and Jenkins, Mark E and Lindor, Noralane M and Newcomb, Polly A and Gallinger, Steven and Duggan, David and Casey, Graham and Hoffmann, Per and Nöthen, Markus M and Jöckel, Karl-Heinz and Easton, Douglas F and Pharoah, Paul D. P and Peto, Julian and Canzian, Federico and Swerdlow, Anthony and Eeles, Rosalind A and Kote-Jarai, Zsofia and Muir, Kenneth and Pashayan, Nora and Henderson, Brian E and Haiman, Christopher A and Schumacher, Fredrick R and Al Olama, Ali Amin and Benlloch, Sara and Berndt, Sonja I and Conti, David V and Wiklund, Fredrik and Chanock, Stephen and Gapstur, Susan and Stevens, Victoria L and Tangen, Catherine M and Batra, Jyotsna and Clements, Judith and Gronberg, Henrik and Schleutker, Johanna and Albanes, Demetrius and Wolk, Alicja and West, Catharine and Mucci, Lorelei and Cancel-Tassin, Géraldine and Koutros, Stella and ... and PRACTICAL Consortium and PRACTICAL consortium and The PRACTICAL consortium
Nature Communications, ISSN 2041-1723, 12/2019, Volume 10, Issue 1, pp. 2154 - 15
Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide, and has a strong heritable basis. We report a genome-wide association analysis of... 
COHORT PROFILE | TRANSCRIPTION FACTOR-BINDING | IMPUTATION | METAANALYSIS | GWAS | CHROMATIN | MULTIDISCIPLINARY SCIENCES | IDENTIFICATION | HERITABILITY | GENOME-WIDE ASSOCIATION | Target recognition | Wnt protein | Identification methods | Genes | Colorectal carcinoma | Colorectal cancer | Health risks | Association analysis | Risk | Genomes | Single-nucleotide polymorphism | Gene expression | Loci | Annotations | Pathways | Cancer | Index Medicus
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