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Journal Article
Oncology Letters, ISSN 1792-1074, 2015, Volume 9, Issue 4, pp. 1907 - 1911
The development of acquired resistance to chemotherapy is a major obstacle in the successful treatment of cancer. In breast cancer cells, B-cell lymphoma-extra... 
Resistance | Let-7b | Breast cancer | Single nucleotide polymorphism | B-cell lymphoma-extra large | POTENTIAL APPLICATIONS | POLYMORPHISMS | ONCOLOGY | single nucleotide polymorphism | breast cancer | TARGETS | MICRORNAS | let-7b | EXPRESSION | resistance | CHEMOTHERAPY
Journal Article
Cellular Physiology and Biochemistry, ISSN 1015-8987, 07/2017, Volume 42, Issue 4, pp. 1540 - 1549
Background/Aims: The injury and apoptotic cell death of endothelial cells hallmark the development of atherosclerosis (AS), characterized by dysregulation of... 
Endothelial cell apoptosis | ApoE (-/-) | Bcl-Xl | Atherosclerosis | High fat diet (HFD) | ox-LDL | miR-876 | ACTIVATION | PHYSIOLOGY | KINASE | APOLIPOPROTEIN | LESIONS | CELL BIOLOGY | INHIBITION | DYSFUNCTION | E-DEFICIENT MICE | Protein Biosynthesis | MicroRNAs - antagonists & inhibitors | Platelet Endothelial Cell Adhesion Molecule-1 - genetics | Apolipoproteins E - deficiency | Atherosclerosis - genetics | Humans | bcl-X Protein - genetics | Diet, High-Fat - adverse effects | Apoptosis - genetics | MicroRNAs - metabolism | Aorta - metabolism | RNA, Messenger - metabolism | Atherosclerosis - etiology | Platelet Endothelial Cell Adhesion Molecule-1 - metabolism | Oligoribonucleotides, Antisense - metabolism | Binding Sites | Disease Models, Animal | Cell Line | Atherosclerosis - pathology | Signal Transduction | Endothelial Cells - metabolism | Aorta - drug effects | RNA, Messenger - genetics | Gene Expression Regulation | Lipoproteins, LDL - pharmacology | Atherosclerosis - metabolism | Mice, Knockout | Aorta - pathology | Animals | Apolipoproteins E - genetics | Oligoribonucleotides, Antisense - genetics | Mice | MicroRNAs - genetics | Primary Cell Culture | Endothelial Cells - pathology | bcl-X Protein - metabolism | Endothelial Cells - drug effects | Proteins | Flow cytometry | Cell growth | MicroRNAs | Genes | Kinases | Apolipoproteins | Laboratory animals | Apoptosis
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 09/2017, Volume 16, Issue 9, pp. 1806 - 1818
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 06/2006, Volume 281, Issue 23, pp. 16034 - 16042
PUMA is a BH3-only Bcl-2 family protein that plays an essential role in DNA damage-induced apoptosis. PUMA interacts with anti-apoptotic Bcl-2 and Bcl-X L and... 
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 12/2018, Volume 59, Issue 52, pp. 4566 - 4570
The application of an OSMAC approach on an endophytic fungus sp. XL 029 has yielded four novel polyketides, emericelactones A-D ( – ). The structures and... 
Panax notoginseng | Polyketide | Antimicrobial activity | Emericella sp | Fungi | Bacteria | Information management | Analysis
Journal Article
Cancer Chemotherapy and Pharmacology, ISSN 0344-5704, 10/2018, Volume 82, Issue 4, pp. 593 - 605
The mainstay of treatment for advanced bladder cancer (BC) is cisplatin (CDDP)-based systematic chemotherapy. However, acquired chemoresistance induced by as... 
Bcl-xL | Medicine & Public Health | Chemoresistance | Oncology | Cancer Research | GRIM19 | Pharmacology/Toxicology | Bladder cancer | Cisplatin | MITOCHONDRIAL FUSION | PROTEIN | STAT3 | PROLIFERATION | KAPPA-B | LUNG-CANCER | INHIBITION | ONCOLOGY | GRIM-19 | RESISTANCE | PHARMACOLOGY & PHARMACY | CARCINOMA | NADH, NADPH Oxidoreductases - genetics | Protein Subunits | Apoptosis - drug effects | Humans | Neoplasm Recurrence, Local | Gene Expression Profiling | Cisplatin - pharmacology | Urinary Bladder Neoplasms - drug therapy | Down-Regulation - drug effects | Apoptosis Regulatory Proteins - metabolism | Xenograft Model Antitumor Assays | Drug Resistance, Neoplasm - genetics | Animals | Ubiquitination - drug effects | Signal Transduction - drug effects | Urinary Bladder Neoplasms - pathology | Cell Line, Tumor | Antineoplastic Agents - pharmacology | Mice | NADH, NADPH Oxidoreductases - metabolism | Neoplasm Staging | bcl-X Protein - metabolism | Drug Resistance, Neoplasm - drug effects | Ubiquitin | Antimitotic agents | Chemotherapy | Analysis | Genetic research | DNA polymerases | Development and progression | Biological response modifiers | Antineoplastic agents | Cancer | Immunoprecipitation | Pathogenesis | Xenotransplantation | Medical services | Bladder | Immunoblotting | mRNA | Chemosensitization | Subgroups | Degradation | Mitochondria | Ubiquitination | Bcl-x protein | Xenografts | Attenuation | Inhibition | Pretreatment | Enzyme-linked immunosorbent assay | Cell survival | Medical treatment | MAP kinase | Gene expression | Molecular chains | Inhibitors | Interferon | Viability | Apoptosis
Journal Article
by Huang, TL and Ding, XW and Xu, GF and Chen, G and Cao, Y and Peng, CY and Shen, SS and Lv, Y and Wang, L and Zou, XP
CELL DEATH & DISEASE, ISSN 2041-4889, 08/2019, Volume 10, Issue 8, pp. 602 - 14
Journal Article
Journal Article
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 2008, Volume 18, Issue 21, pp. 5771 - 5773
Discovery of a stable and soluble Bcl-xl inhibitor derived from kendomycin has been disclosed. The cytotoxic macrolide kendomycin was identified as a ligand of... 
High-throughput screening | Kendomycin | Ketal | Bcl-2, Bcl-xl | Apoptotic | Semi-synthetic | CHEMISTRY, MEDICINAL | NATURAL-PRODUCTS | CHEMISTRY, ORGANIC | FAMILY PROTEINS | CANCER | DRUGS | CHEMISTRY | INHIBITOR | Rifabutin - chemistry | bcl-X Protein - chemistry | Rifabutin - pharmacology | Apoptosis - drug effects | Humans | Rifabutin - analogs & derivatives | Cell Line, Tumor | Heterocyclic compounds
Journal Article
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 06/2004, Volume 113, Issue 12, pp. 1763 - 1773
Deregulated expression of both Myc and Bcl-X L are consistent features of human plasma cell neoplasms (PCNs). To investigate whether targeted expression of Myc... 
Journal Article
AMERICAN JOURNAL OF CANCER RESEARCH, ISSN 2156-6976, 2019, Volume 9, Issue 3, pp. 546 - 561
Sphingosine kinase 2 (SPHK2) is a key factor within sphingolipid metabolism, responsible for the conversion of pro-apoptotic sphingosine to the pro-survival... 
APOPTOSIS | EFFICACY | ACUTE MYELOGENOUS LEUKEMIA | COMBINATION | NOXA | obatoclax | ONCOLOGY | ACUTE LYMPHOBLASTIC-LEUKEMIA | THERAPEUTIC TARGETS | ABC294640 | ABT-263 | EXPRESSION | Cholangiocarcinoma |