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Analytical Biochemistry, ISSN 0003-2697, 12/2008, Volume 383, Issue 1, pp. 44 - 51
Although it is known that (i) O -alkylguanine-DNA alkyltransferase (AGT) confers tumor cell resistance to guanine O -targeting drugs such as cloretazine,... 
Benzene | Carmustine | alkylguanine-DNA alkyltransferase assay | melanoma | H]O | Temozolomide | Cloretazine | Drug binding to melanin | benzylguanine | AGT-positive and -negative cells | O6-alkylguanine—DNA alkyltransferase | [Benzene-3H]O6-benzylguanine | B16F10 melanoma | assay
Journal Article
Analytical Biochemistry, ISSN 0003-2697, 12/2008, Volume 383, Issue 1, pp. 44 - 51
Although it is known that (i) O super(6)-alkylguanine-DNA alkyltransferase (AGT) confers tumor cell resistance to guanine O super(6)-targeting drugs such as... 
Journal Article
British Journal of Cancer, ISSN 0007-0920, 03/2016, Volume 114, Issue 7, pp. 777 - 786
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 06/2010, Volume 79, Issue 11, pp. 1553 - 1561
1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)-2-[[1-(4-nitrophenyl)ethoxy]carbonyl]hydrazine (KS119) is a prodrug of the 1,2-bis(sulfonyl)hydrazine class of... 
O6-Alkylguanine-DNA alkyltransferase | Oxygen-deficient cells | 1,2-Bis(sulfonyl)hydrazines | KS119 | Onrigin | Alkylguanine-DNA alkyltransferase
Journal Article
Journal Article
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 10/2014, Volume 91, Issue 3, pp. 312 - 322
Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 02/2013, Volume 56, Issue 3, pp. 1355 - 1359
O 6-Alkylguanine-DNA alkyltransferase (AGT) is a DNA repair protein which removes alkyl groups from the O-6 position of guanine, thereby providing strong... 
OXYGEN | SYSTEM | CELLS | CHEMISTRY, MEDICINAL | RESISTANCE | AGENTS | DERIVATIVES | VNP40101M | CARMUSTINE | AGT
Journal Article
Chemical Biology & Drug Design, ISSN 1747-0277, 01/2018, Volume 91, Issue 1, pp. 62 - 74
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 2011, Volume 81, Issue 10, pp. 1201 - 1210
To most effectively treat cancer it may be necessary to preferentially destroy tumor tissue while sparing normal tissues. One strategy to accomplish this is to... 
O 6-alkylguanine-DNA alkyltransferase | Oxygen-deficient cells | 1,2-Bis(sulfonyl)hydrazines | KS900 | Onrigin | alkylguanine-DNA alkyltransferase | LYSYL OXIDASE | METHYLTRANSFERASE | CANCER | VNP40101M | TEMOZOLOMIDE | OXYGEN | LAROMUSTINE | PHARMACOLOGY & PHARMACY | O-6-alkylguanine-DNA alkyltransferase | INHIBITORS | Onrigin (TM) | PHASE-I | CYTOTOXICITY
Journal Article
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 11/2005, Volume 4, Issue 11, pp. 1755 - 1763
Cloretazine (VNP40101M; 101M; 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)-2-[(methylamino)carbonyl ] hydrazine) is a sulfonylhydrazine prodrug that generates... 
Journal Article
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