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Diabetes, ISSN 0012-1797, 05/2018, Volume 67, Issue Supplement 1, p. 1174
Journal Article
CPT: Pharmacometrics & Systems Pharmacology, ISSN 2163-8306, 06/2019, Volume 8, Issue 6, pp. 380 - 395
Quantitative systems pharmacology (QSP), a mechanistically oriented form of drug and disease modeling, seeks to address a diverse set of problems in the... 
Parameter estimation | Simulation | Disease | Research & development--R&D | Biomarkers | Oncology | Employees | Pharmacology | Biology | Pharmaceutical industry | Drug dosages | Reviews | Review
Journal Article
by Schaum, Nicholas and Karkanias, Jim and Neff, Norma F and May, Andrew P and Quake, Stephen R and Wyss-Coray, Tony and Darmanis, Spyros and Batson, Joshua and Botvinnik, Olga and Chen, Michelle B and Chen, Steven and Green, Foad and Jones, Robert C and Maynard, Ashley and Penland, Lolita and Pisco, Angela Oliveira and Sit, Rene V and Stanley, Geoffrey M and Webber, James T and Zanini, Fabio and Baghel, Ankit S and Bakerman, Isaac and Bansal, Ishita and Berdnik, Daniela and Bilen, Biter and Brownfield, Douglas and Cain, Corey and Cho, Min and Cirolia, Giana and Conley, Stephanie D and Demers, Aaron and Demir, Kubilay and de Morree, Antoine and Divita, Tessa and du Bois, Haley and Dulgeroff, Laughing Bear Torrez and Ebadi, Hamid and Espinoza, F. Hernán and Fish, Matt and Gan, Qiang and George, Benson M and Gillich, Astrid and Genetiano, Geraldine and Gu, Xueying and Gulati, Gunsagar S and Hang, Yan and Hosseinzadeh, Shayan and Huang, Albin and Iram, Tal and Isobe, Taichi and Ives, Feather and Kao, Kevin S and Karnam, Guruswamy and Kershner, Aaron M and Kiss, Bernhard M and Kong, William and Kumar, Maya E and Lam, Jonathan Y and Lee, Davis P and Lee, Song E and Li, Guang and Li, Qingyun and Liu, Ling and Lo, Annie and Lu, Wan-Jin and Manjunath, Anoop and May, Kaia L and May, Oliver L and McKay, Marina and Metzger, Ross J and Mignardi, Marco and Min, Dullei and Nabhan, Ahmad N and Ng, Katharine M and Noh, Joseph and Patkar, Rasika and Peng, Weng Chuan and Puccinelli, Robert and Rulifson, Eric J and Sikandar, Shaheen S and Sinha, Rahul and Szade, Krzysztof and Tan, Weilun and Tato, Cristina and Tellez, Krissie and Travaglini, Kyle J and Tropini, Carolina and Waldburger, Lucas and van Weele, Linda J and Wosczyna, Michael N and Xiang, Jinyi and Xue, Soso and Youngyunpipatkul, Justin and Zardeneta, Macy E and Zhang, Fan and Zhou, Lu and Castro, Paola and Croote, Derek and DeRisi, Joseph L and Kuo, Christin S and ... and Tabula Muris Consortium and Principal investigators and Library preparation and sequencing and Computational data analysis and Logistical coordination and Supplemental text writing group and Overall coordination and Organ collection and processing and Writing group and Cell type annotation and The Tabula Muris Consortium
Nature, ISSN 0028-0836, 10/2018, Volume 562, Issue 7727, pp. 367 - 372
Here we present a compendium of single-cell transcriptomic data from the model organism Mus musculus that comprises more than 100,000 cells from 20 organs and... 
GENE-EXPRESSION | EPITHELIUM | RNA-SEQ | MULTIDISCIPLINARY SCIENCES | Cluster analysis | Flow cytometry | Transcription | Liver | Genomics | Organs | Bladder | Fluorescence | Principal components analysis | Lymphocytes T | Biology | Gene expression | Tissues | Endothelial cells | Lymphocytes | Pancreas | Bioinformatics | Methods
Journal Article
Diabetes, obesity & metabolism, 08/2019
Sodium glucose cotransporter 2 inhibitors (SGLT2i) are a class of oral glucose lowering compounds used to treat type 2 diabetes mellitus (T2DM). Paradoxically,... 
Journal Article
Frontiers in Pharmacology, 01/2012, Volume 3
The human cardiac sodium channel (hNav1.5, encoded by the SCN5A gene) is critical for action potential generation and propagation in the heart. Drug-induced... 
ECG | Sodium channel | preclinical | arrhythmia
Journal Article
Diabetes, Obesity and Metabolism, ISSN 1462-8902, 08/2018, Volume 20, Issue 8, pp. 2034 - 2038
This study aimed to quantify the effect of the immediate release (IR) of exenatide, a short‐acting glucagon‐like peptide‐1 (GLP‐1) receptor agonist (GLP‐1RA),... 
pharmacodynamics | 1 analogue | antidiabetic drug | GLP | dose–response relationship | incretin therapy | exenatide | GLP-1 analogue | GLUCAGON-LIKE PEPTIDE-1 | ENDOCRINOLOGY & METABOLISM | dose-response relationship | Incretins - blood | Humans | Intestinal Absorption - drug effects | Glucagon-Like Peptide 1 - blood | Incretins - pharmacokinetics | Diabetes Mellitus, Type 2 - metabolism | Dietary Carbohydrates - metabolism | Systems Biology | Dose-Response Relationship, Drug | Hypoglycemia - prevention & control | Hypoglycemic Agents - blood | Glucagon-Like Peptide-1 Receptor - metabolism | Hypoglycemic Agents - administration & dosage | Postprandial Period | Exenatide - pharmacokinetics | Hypoglycemic Agents - therapeutic use | Digestion - drug effects | Hyperglycemia - prevention & control | Exenatide - therapeutic use | Hypoglycemic Agents - pharmacokinetics | Blood Glucose - analysis | Drug Administration Schedule | Diabetes Mellitus, Type 2 - blood | Gastric Emptying - drug effects | Models, Biological | Drug Liberation | Exenatide - administration & dosage | Exenatide - blood | Incretins - therapeutic use | Diabetes Mellitus, Type 2 - drug therapy | Glucagon-Like Peptide-1 Receptor - agonists | Incretins - administration & dosage | Pharmacology | Hypoglycemic agents | Glucose | Glucagon | Dextrose | Gastric emptying | Glutamic acid receptors | Food intake
Journal Article
AAPS PharmSciTech, 12/2014, Volume 15, Issue 6, pp. 1490 - 1497
Typically, colonic absorption of a drug is mandatory for a sustained release formulation to hold the drug's plasma level for more than 12 or 24 h above the... 
Journal Article
Frontiers in Pharmacology, ISSN 1663-9812, 2012, Volume 3, p. 6
The human cardiac sodium channel (hNav1.5, encoded by the SCN5A gene) is critical for action potential generation and propagation in the heart. Drug-induced... 
Pre-clinical | ECG | Sodium channel | Arrhythmia | PHARMACOLOGY & PHARMACY | sodium channel | arrhythmia | pre-clinical
Journal Article
09/2014
The present invention relates to compounds of the general formula (I) that have activity as SlP receptor modulating agents and the use of such compounds to... 
METALLURGY | ORGANIC CHEMISTRY | CHEMISTRY | HETEROCYCLIC COMPOUNDS
Patent
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