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Gastroenterology, ISSN 0016-5085, 2015, Volume 149, Issue 4, pp. 907 - 917.e7
Background & Aims More than 20% of patients with inflammatory bowel disease (IBD) discontinue thiopurine therapy because of severe adverse drug reactions... 
Gastroenterology and Hepatology | Side Effect | Pharmacogenetic | Leukocyte | Adverse Event | CROHNS-DISEASE | RANDOMIZED-TRIAL | TOXICITY | AMINOSALICYLATES | MYELOSUPPRESSION | INOSINE TRIPHOSPHATE PYROPHOSPHATASE | S-METHYLTRANSFERASE ACTIVITY | AZATHIOPRINE THERAPY | GENES | PHARMACOGENETICS | GASTROENTEROLOGY & HEPATOLOGY | Crohn Disease - genetics | Predictive Value of Tests | Azathioprine - administration & dosage | Colitis, Ulcerative - enzymology | Genetic Testing | Prospective Studies | Humans | Methyltransferases - metabolism | Middle Aged | Colitis, Ulcerative - genetics | Gastrointestinal Agents - administration & dosage | Methyltransferases - genetics | Male | Anti-Inflammatory Agents - metabolism | Genetic Variation | Young Adult | Drug Dosage Calculations | Netherlands | Anti-Inflammatory Agents - adverse effects | Crohn Disease - diagnosis | Leukopenia - chemically induced | Mercaptopurine - metabolism | Adult | Anti-Inflammatory Agents - administration & dosage | Female | Colitis, Ulcerative - drug therapy | Leukopenia - prevention & control | Crohn Disease - enzymology | Pharmacogenetics | Azathioprine - metabolism | Risk Factors | Mercaptopurine - administration & dosage | Mercaptopurine - adverse effects | Treatment Outcome | Thrombocytopenia - chemically induced | Homozygote | Phenotype | Colitis, Ulcerative - diagnosis | Crohn Disease - drug therapy | Thrombocytopenia - prevention & control | Heterozygote | Gastrointestinal Agents - adverse effects | Azathioprine - adverse effects | Gastrointestinal Agents - metabolism | Enzymes | Care and treatment | Metabolites | Analysis | Gastrointestinal diseases | Index Medicus | Abridged Index Medicus
Journal Article
Proceedings of the National Academy of Sciences USA, ISSN 0027-8424, 2019, Volume 116, Issue 48, pp. 24296 - 24302
Coevolution of viruses and their hosts may lead to viral strategies to avoid, evade, or suppress antiviral immunity. An example is antiviral RNA interference... 
DEFENSE | SUPPRESSOR | RNAi | DOUBLE-STRANDED-RNA | PROTEIN | MULTIDISCIPLINARY SCIENCES | BINDING DOMAIN | DISTINCT ROLES | insect immunity | insect virus | PATHWAY | RESISTANCE | INTERFERENCE | viral suppressor of RNAi | antiviral defense | MICRORNA
Journal Article
Alimentary Pharmacology & Therapeutics, ISSN 0269-2813, 2017, Volume 45, Issue 3, pp. 391 - 402
BACKGROUND: Hepatotoxicity, gastrointestinal complaints and general malaise are common limiting adverse reactions of azathioprine and mercaptopurine in IBD... 
6-MERCAPTOPURINE | ALLOPURINOL | MERCAPTOPURINE | THERAPY | S-METHYLTRANSFERASE ACTIVITY | PHARMACOKINETICS | AZATHIOPRINE | PHARMACOLOGY & PHARMACY | PHARMACOGENETICS | 6-THIOGUANINE | GASTROENTEROLOGY & HEPATOLOGY | INDUCED LIVER-INJURY | Prognosis | Humans | Methyltransferases - metabolism | Middle Aged | Inflammatory Bowel Diseases - diagnosis | Male | Inflammatory Bowel Diseases - metabolism | Young Adult | Inflammatory Bowel Diseases - genetics | Aged, 80 and over | Adult | Female | Mercaptopurine - analogs & derivatives | Inflammatory Bowel Diseases - drug therapy | Thioinosine - metabolism | Risk Factors | Mercaptopurine - adverse effects | Genotype | Thioinosine - analogs & derivatives | Treatment Outcome | Chemical and Drug Induced Liver Injury - genetics | Chemical and Drug Induced Liver Injury - diagnosis | Thionucleotides - metabolism | Chemical and Drug Induced Liver Injury - metabolism | Aged | Azathioprine - adverse effects | Early Diagnosis | Cohort Studies | Complications and side effects | Phosphatases | Metabolites | Gastrointestinal diseases | Risk factors | Alkaline phosphatase | Alanine | Inflammatory bowel diseases | Liver | Erythrocytes | Methyltransferase | Risk analysis | Disease control | Patients | Inflammatory bowel disease | Side effects | Body mass | Intestine | Predictions | Determinants | Thiopurine S-methyltransferase | Pretreatment | Azathioprine | Hepatotoxicity | Index Medicus
Journal Article
The American Journal of Human Genetics, ISSN 0002-9297, 06/2013, Volume 92, Issue 6, pp. 946 - 954
Journal Article
Toxicological Sciences, ISSN 1096-6080, 09/2010, Volume 117, Issue 1, pp. 81 - 89
Journal Article
The American Journal of Human Genetics, ISSN 0002-9297, 07/2018, Volume 103, Issue 1, pp. 74 - 88
Journal Article
Hearing Research, ISSN 0378-5955, 09/2016, Volume 339, pp. 60 - 68
Journal Article
Human Genetics, ISSN 0340-6717, 2018, Volume 137, Issue 5, pp. 389 - 400
Journal Article
Journal Article
Toxicology, ISSN 0300-483X, 2007, Volume 237, Issue 1-3, pp. 35 - 48
Journal Article