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1. Full Text S.03.02 - Clinical heterogeneity in major depressive disorder
by Penninx, B.W.J.H and Lamers, F and Milaneschi, Y
European Neuropsychopharmacology, ISSN 0924-977X, 03/2018, Volume 28, pp. S62 - S63
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2. Full Text Personalised medicine: From a scientific perspective
by Myin-Germeys, I and Penninx, B.W.J.H
Tijdschrift voor Psychiatrie, ISSN 0303-7339, 03/2018, Volume 60, Issue 3, pp. 210 - 214
Experience sampling method | Biomarkers | Ecological momentary interventions | Psychomarkers. sociomarkers | Symptom dimensions
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3. Full Text Associations of neighbourhood sociodemographic characteristics with depressive and anxiety symptoms in older age: Results from a 5-wave study over 15 years
by Motoc, I and Timmermans, E.J and Deeg, D and Penninx, B.W.J.H and Huisman, M
Health and Place, ISSN 1353-8292, 09/2019, Volume 59, pp. 102172 - 102172
We examined the long-term association between objective neighbourhood sociodemographic characteristics (index of socioeconomic position (SEP), average income,... 
Health technology assessment
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4. Full Text Depression and anxiety among coronary heart disease patients: can affect dimensions and theory inform diagnostic disorder-based screening?
by Tully, P.J and Penninx, B.W.J.H
Journal of Clinical Psychology, ISSN 0021-9762, 2012, Volume 68, Issue 4, pp. 448 - 461
Objectives: To examine the association between low positive affect, somatic anxiety and general distress with affective disorders, anxious misery, and visceral... 
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5. Full Text Evidence for a differential role of HPA-axis function, inflammation and metabolic syndrome in melancholic versus atypical depression
by Lamers, F and Vogelzangs, N and Merikangas, K. R and de Jonge, P and Beekman, A. T. F and Penninx, B. W. J. H
Molecular Psychiatry, ISSN 1359-4184, 06/2013, Volume 18, Issue 6, pp. 692 - 699
The hypothalamic-pituitary-adrenal (HPA) axis and the inflammatory response system have been suggested as pathophysiological mechanisms implicated in the... 
metabolic syndrome | salivary cortisol | depression | inflammation | subtypes | CYTOKINES | ASSOCIATIONS | ANXIETY | PSYCHIATRY | BIOCHEMISTRY & MOLECULAR BIOLOGY | SYMPTOMS | MAJOR DEPRESSION | NEUROSCIENCES | MOOD | ANTIDEPRESSANT USE | NETHERLANDS | Body Mass Index | Tumor Necrosis Factor-alpha - metabolism | Enzyme-Linked Immunosorbent Assay | Depression - pathology | Pituitary-Adrenal System - metabolism | Humans | Middle Aged | Depression - classification | Male | Hypothalamo-Hypophyseal System - metabolism | Young Adult | C-Reactive Protein - metabolism | Metabolic Diseases - etiology | Adolescent | Adult | Depression - complications | Female | Aged | Hydrocortisone - blood | Interleukin-6 - metabolism | Cohort Studies | Encephalitis - etiology | Physiological aspects | C-reactive protein | Depression, Mental | Analysis | Cholesterol | Index Medicus
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6. Full Text Clinical heterogeneity in major depressive disorder
by Penninx, BWJH and Lamers, F and Milaneschi, Y
EUROPEAN NEUROPSYCHOPHARMACOLOGY, ISSN 0924-977X, 03/2018, Volume 28, pp. S59 - S60
PHARMACOLOGY & PHARMACY | PSYCHIATRY | NEUROSCIENCES | CLINICAL NEUROLOGY
Conference Proceeding
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7. Full Text Depression and obesity: A meta-analysis of community-based studies
by de Wit, Leonore and Luppino, Floriana and van Straten, Annemieke and Penninx, Brenda and Zitman, Frans and Cuijpers, Pim
Psychiatry Research, ISSN 0165-1781, 2009, Volume 178, Issue 2, pp. 230 - 235
Abstract To examine the nature of the association between depression and obesity and to determine possible underlying (demographic) factors, we conducted a... 
Psychiatry | Obesity | Depression | General population | Cross-sectional | BMI | Meta-analysis | UNITED-STATES | ADOLESCENT DEPRESSION | PSYCHIATRY | SYMPTOMS | ADULT OBESITY | GENERAL-POPULATION | MENTAL-DISORDERS | OVERWEIGHT | PSYCHIATRIC-DISORDERS | HEALTH | ASSOCIATION | Residence Characteristics | Meta-Analysis as Topic | Association | Depression - epidemiology | Cross-Sectional Studies | Humans | Obesity - epidemiology | Sensitivity and Specificity | Databases, Factual - statistics & numerical data | Female | Male | Index Medicus
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8. Full Text Major depressive disorder and accelerated cellular aging: results from a large psychiatric cohort study
by Verhoeven, J.E and Revesz, D and Epel, E.S and Lin, J and Wolkowitz, O.M and Penninx, B.W.J.H
Molecular Psychiatry, ISSN 1359-4184, 2014, Volume 19, Issue 8, pp. 895 - 901
Patients with major depressive disorder (MDD) have an increased onset risk of aging-related somatic diseases such as heart disease, diabetes, obesity and... 
telomere shortening | depression | cell aging | mood disorders | LEUKOCYTE TELOMERE LENGTH | OXIDATIVE STRESS | METAANALYSIS | PSYCHIATRY | BIOCHEMISTRY & MOLECULAR BIOLOGY | HUMAN T | NEUROSCIENCES | CARDIOVASCULAR HEALTH | CHILDHOOD LIFE EVENTS | PHYSICAL-ACTIVITY | CORONARY-HEART-DISEASE | ANXIETY NESDA | PITUITARY-ADRENAL AXIS | Severity of Illness Index | Cellular Senescence - genetics | Depressive Disorder, Major - pathology | Humans | Middle Aged | Male | Case-Control Studies | Young Adult | Telomere Shortening | Depressive Disorder, Major - genetics | Adolescent | Adult | Female | Aged | Cohort Studies | Telomeres | Physiological aspects | Aging | Development and progression | Health aspects | Major depressive disorder | Risk factors | Cells | Index Medicus
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9. Full Text Dysregulation of the autonomic nervous system predicts the development of the metabolic syndrome
by Licht, C.M.M and de Geus, E.J.C and Penninx, B.W.J.H
Journal of Clinical Endocrinology and Metabolism, ISSN 0021-972X, 2013, Volume 98, Issue 6, pp. 2484 - 2493
Context: Stress is suggested to lead to metabolic dysregulations as clustered in the metabolic syndrome. Although dysregulation of the autonomic nervous system... 
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10. Full Text Telomere Length as a Marker of Cellular Aging Is Associated With Prevalence and Progression of Metabolic Syndrome
by Révész, Dóra and Milaneschi, Yuri and Verhoeven, Josine E and Penninx, Brenda W. J. H
The Journal of Clinical Endocrinology & Metabolism, ISSN 0021-972X, 12/2014, Volume 99, Issue 12, pp. 4607 - 4615
Context: Metabolic syndrome (MetS) clusters risk factors for age-related conditions including cardiovascular disease and diabetes. Shorter telomere length... 
MORTALITY | OXIDATIVE STRESS | OBESITY | INSULIN-RESISTANCE | MEN | ENDOCRINOLOGY & METABOLISM | CARDIOVASCULAR-DISEASE | GENDER | WEIGHT-GAIN | BLOOD | Prevalence | Prospective Studies | Cross-Sectional Studies | Follow-Up Studies | Humans | Middle Aged | Netherlands - epidemiology | Male | Young Adult | Telomere Shortening | Waist Circumference | Cellular Senescence | Adolescent | Triglycerides - blood | Biomarkers | Cholesterol, HDL - blood | Adult | Female | Aged | Metabolic Syndrome - pathology | Longitudinal Studies | Metabolic Syndrome - epidemiology | Cohort Studies | Index Medicus | Abridged Index Medicus
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11. Full Text Integrative approaches for large-scale transcriptome-wide association studies
by Gusev, A and Ko, A and Shi, H and Bhatia, G and Chung, W and Penninx, B.W.J.H and Jansen, R and de Geus, E.J.C and Boomsma, D.I and Wright, F.A and Sullivan, P.F and Nikkola, E and Alvarez, M and Civelek, M and Lusis, A.J and Lehtimäki, T and Raitoharju, E and Kähönen, M and Seppälä, I and Raitakari, O.T and Kuusisto, J and Laakso, M and Price, A.L and Pajukanta, P and Pasaniuc, B
Nature Genetics, ISSN 1061-4036, 2016, Volume 48, Issue 3, pp. 245 - 252
Many genetic variants influence complex traits by modulating gene expression, thus altering the abundance of one or multiple proteins. Here we introduce a... 
HUMAN HEIGHT | PARTITIONING HERITABILITY | STATISTICS | GENETICS & HEREDITY | GENE-EXPRESSION | BODY-MASS INDEX | YOUNG FINNS | MENDELIAN RANDOMIZATION | COMPLEX TRAITS | REGULATORY VARIATION | CARDIOVASCULAR RISK | Genetic Predisposition to Disease | Genome-Wide Association Study | Phenotype | Animals | Gene Expression Regulation - genetics | Humans | Genotype | Mice | Transcriptome - genetics | Obesity - genetics | Obesity - pathology | Quantitative Trait Loci - genetics | Genome-wide association studies | Genetic research | Research | Gene expression | Identification and classification | Methods | Studies | Genotype & phenotype | Lipids | Software | Genomes | Estimates | Index Medicus
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12. Full Text Psychische stress en cellulaire veroudering: De samenhang tussen depressie, angst en telomeerlengte
by Verhoeven, J.E and Van Oppen, P and Penninx, B.W.J.H
Tijdschrift voor Psychiatrie, ISSN 0303-7339, 06/2017, Volume 59, Issue 6, pp. 350 - 359
Anxiety disorder | Depression | Cellular ageing | Telomere length | Major depressive disorder
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13. Full Text Effect of variation in BDNF Val(66)Met polymorphism, smoking, and nicotine dependence on symptom severity of depressive and anxiety disorders
by Jamal, M and Van der Does, W and Penninx, B.W.J.H
Drug and Alcohol Dependence, ISSN 0376-8716, 2015, Volume 148, pp. 150 - 157
Background: Smoking, especially nicotine dependence is associated with more severe symptoms of depression and anxiety disorders. However, the mechanisms... 
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14. Full Text Mindful eating and change in depressive symptoms: Mediation by psychological eating styles
by Winkens, L.H.H and van Strien, T and Brouwer, I.A and Penninx, B.W.J.H and Visser, M
Appetite, ISSN 0195-6663, 02/2019, Volume 133, pp. 204 - 211
Earlier cross-sectional research showed that a higher level of mindful eating is associated with less depression. This study investigated associations of... 
mindful eating | Depressive symptoms | Eating styles | Mediation analysis | Prospective analysis | EFFICACY | BEHAVIOR | BODY-IMAGE | INTERVENTIONS | NUTRITION & DIETETICS | ADOLESCENTS | RESTRAINT | BEHAVIORAL SCIENCES | PEOPLE | QUESTIONNAIRE | ASSOCIATION | ANOREXIA | Research institutes | Mediation | Analysis | Food habits | Depression, Mental
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15. Full Text Leukocyte telomere length and personality: Associations with the big five and type d personality traits
by Schoormans, D and Verhoeven, J.E and Denollet, J and van de Poll-Franse, L and Penninx, B.W.J.H
Psychological Medicine, ISSN 0033-2917, 2017
Accelerated cellular ageing, which can be examined by telomere length (TL), may be an overarching mechanism underlying the association between personality and... 
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16. Full Text The specificity of childhood adversities and negative life events across the life span to anxiety and depressive disorders
by Spinhoven, Philip and Elzinga, Bernet M and Hovens, Jacqueline G.F.M and Roelofs, Karin and Zitman, Frans G and van Oppen, Patricia and Penninx, Brenda W.J.H
Journal of Affective Disorders, ISSN 0165-0327, 2010, Volume 126, Issue 1, pp. 103 - 112
Abstract Background Although several studies have shown that life adversities play an important role in the etiology and maintenance of both depressive and... 
Psychiatry | Neuroticism | Depression | Anxiety | Life events | Trauma | Emotional neglect | SUBSTANCE USE DISORDERS | SEXUAL-ABUSE | PSYCHIATRY | MAJOR DEPRESSION | THREATENING EXPERIENCES | EMOTIONAL ABUSE | ADULT PSYCHIATRIC OUTPATIENTS | CLINICAL NEUROLOGY | CO-MORBIDITY | NATIONAL-COMORBIDITY-SURVEY | COMMUNITY SAMPLE | DIAGNOSTIC INTERVIEW CIDI | Dysthymic Disorder - etiology | Dysthymic Disorder - psychology | Adult Survivors of Child Abuse - psychology | Mood Disorders - psychology | Humans | Life Change Events | Logistic Models | Depressive Disorder - etiology | Anxiety Disorders - etiology | Anxiety Disorders - psychology | Mood Disorders - etiology | Psychiatric Status Rating Scales | Retrospective Studies | Depressive Disorder - psychology | Odds Ratio | Stress, Psychological - complications | Psychic trauma | Depressive Disorders | Rape | Comorbidity | Survivors | Neglect | Longitudinal Study | Epidemiology | Child Abuse | Emotional Abuse | Anxiety Disorders | Etiology | Battery | Life Experiences | Adults | Dutch | Stressors | Index Medicus
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17. Full Text Effects of antidepressants, but not psychopathology, on cardiac sympathetic control: a longitudinal study
by Licht, C.M.M and Penninx, B.W.J.H and Geus, de, E.J.C
Neuropsychopharmacology, ISSN 0893-133X, 2012, Volume 37, Issue 11, p. 2487
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18. Full Text Effects of antidepressants, but not psychopathology, on cardiac sympathetic control: a longitudinal study
by Licht, C.M.M and Penninx, B.W.J.H and de Geus, E.J.C
Neuropsychopharmacology, ISSN 0893-133X, 2012, Volume 37, Issue 11, pp. 2487 - 2495
Increased sympathetic activity has been hypothesized to have a role in the elevated somatic disease risk in persons with depressive or anxiety disorders.... 
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19. Full Text Does self-medication predict the persistence or rather the recurrence of alcohol dependence?
by Boschloo, L and van den Brink, W and Penninx, B.W.J.H
JAMA Psychiatry, ISSN 2168-622X, 2014, Volume 71, Issue 2, pp. 205 - 205
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20. Full Text The Association of Early and Recent Psychosocial Life Stress With Leukocyte Telomere Length
by Verhoeven, J.E and van Oppen, P.C and Puterman, E and Elzinga, B and Penninx, B.W.J.H
Psychosomatic Medicine, ISSN 0033-3174, 2015, Volume 77, Issue 8, pp. 882 - 891
Objectives: Chronic exposure to psychosocial stressors is related to worse somatic health. This association applies both to stressors early in life, such as... 
cellular aging | childhood trauma | psychosocial stress | early-life stress | stressful life events | telomere length | TL = telomere length | CHILDHOOD-TRAUMA | PERCEIVED STRESS | PSYCHOLOGY | PSYCHOLOGY, MULTIDISCIPLINARY | CARDIOVASCULAR-DISEASE | BMI = body mass index | CTI = Childhood Trauma Interview | DEPRESSION | OXIDATIVE STRESS | RISK-FACTORS | PSYCHIATRY | SD = standard deviation | NESDA = Netherlands Study of Depression and Anxiety | PTSD = posttraumatic stress disorder | CTQ = Childhood Trauma Questionnaire | PSYCHIATRIC-DISORDERS | HPA AXIS | IMMUNE FUNCTION | PERSONALITY-TRAITS | PCR = polymerase chain reaction | Humans | Life Change Events | Middle Aged | Telomere Shortening - physiology | Male | Leukocytes - physiology | Young Adult | Netherlands | Time Factors | Adult Survivors of Child Adverse Events | Adolescent | Stress, Psychological | Adult | Female | Telomere - physiology | Aged | Index Medicus
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