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1. Full Text Association of Symptom Network Structure With the Course of Longitudinal Depression
by van Borkulo, Claudia and Boschloo, Lynn and Borsboom, Denny and Penninx, Brenda W. J. H and Waldorp, Lourens J and Schoevers, Robert A
Jama psychiatry, ISSN 2168-622X, 12/2015, Volume 72, Issue 12, pp. 1219 - 1226
IMPORTANCE Major depressive disorder (MDD) is a heterogeneous condition in terms of symptoms, course, and underlying disease mechanisms. Current... 
HETEROGENEITY | CRITERIA | INVENTORY | PERSPECTIVE | PSYCHIATRY | FRAMEWORK | DISORDERS | PATTERNS | SELECTION | LIFE EVENTS | CENTRALITY | Symptomatology | Research | Psychology, Pathological | Depression, Mental | Analysis
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2. Full Text Comorbidity Patterns of Anxiety and Depressive Disorders in a Large Cohort Study: The Netherlands Study of Depression and Anxiety (NESDA)
by Lamers, Femke and van Oppen, Patricia and Comijs, Hannie C and Smit, Johannes H and Spinhoven, Philip and van Balkom, Anton J. L. M and Nolen, Willem A and Zitman, Frans G and Beekman, Aartjan T. F and Penninx, Brenda
Journal of Clinical Psychiatry, ISSN 0160-6689, 2011, Volume 72, Issue 3, pp. 341 - 348
Background: Comorbidity of depressive and anxiety disorders is common and has been shown to be a consistent predictor of chronicity. Comorbidity patterns among... 
CO-MORBIDITY | PSYCHOMETRIC PROPERTIES | SUBSTANCE USE DISORDERS | GENERAL-POPULATION | CHILDHOOD LIFE EVENTS | MOOD DISORDERS | PSYCHIATRY | PSYCHIATRIC-DISORDERS | MAJOR DEPRESSION | PSYCHOLOGY, CLINICAL | MENTAL-HEALTH SURVEY | SOCIAL PHOBIA | Severity of Illness Index | Comorbidity | Humans | Netherlands - epidemiology | Risk Factors | Anxiety - psychology | Anxiety Disorders - epidemiology | Logistic Models | Male | Chi-Square Distribution | Anxiety Disorders - psychology | Psychiatric Status Rating Scales | Time Factors | Personality Inventory | Age of Onset | Anxiety - epidemiology | Adult | Female | Depressive Disorder - epidemiology | Depressive Disorder - psychology | Cohort Studies
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3. Full Text Identifying Depressive Subtypes in a Large Cohort Study: Results From the Netherlands Study of Depression and Anxiety (NESDA)
by Lamers, Femke and de Jonge, Peter and Nolen, Willem A and Smit, Johannes H and Zitman, Frans G and Beekman, Aartjan T. F and Penninx, Brenda
Journal of Clinical Psychiatry, ISSN 0160-6689, 2010, Volume 71, Issue 12, pp. 1582 - 1589
Objective: The heterogeneity of depression in the current classification system remains a point of discussion in the psychiatric field, despite previous... 
DSM-V | MOOD DISORDERS | PSYCHIATRY | ATYPICAL DEPRESSION | HYPOTHESIS | VALIDATION | CLASSIFICATION | SYMPTOMS | MAJOR DEPRESSION | SYMPTOMATOLOGY IDS | PSYCHOLOGY, CLINICAL | COMORBIDITY | Prevalence | Adult Survivors of Child Abuse - psychology | Humans | Middle Aged | Netherlands - epidemiology | Male | Depressive Disorder, Major - epidemiology | Anxiety - classification | Stress, Psychological - epidemiology | Adult | Female | Surveys and Questionnaires | Metabolic Syndrome - epidemiology | Metabolic Syndrome - psychology | Body Mass Index | Severity of Illness Index | Diagnostic and Statistical Manual of Mental Disorders | Depression - epidemiology | Comorbidity | Life Change Events | Risk Factors | Anxiety - psychology | Depression - classification | Depression - diagnosis | Depressive Disorder, Major - psychology | Adolescent | Sex Factors | Depression - psychology | Depressive Disorder, Major - classification | Aged | Depressive Disorder, Major - diagnosis | Adult Survivors of Child Abuse - statistics & numerical data | Stress, Psychological - complications | Cohort Studies
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4. Full Text Attentional bias for negative, positive, and threat words in current and remitted depression
by Elgersma, Hermien J and Koster, Ernst H.W and Van Tuijl, Lonneke A and Hoekzema, A and Penninx, Brenda W.J.H and Bockting, Claudi L.H and De Jong, Peter J
PLoS ONE, ISSN 1932-6203, 10/2018, Volume 13, Issue 10, p. e0205154
Background The aim of this study was to improve our understanding of the underlying mechanisms in the maintenance of depression. We examined attentional bias... 
INDIVIDUAL-DIFFERENCES | COGNITIVE VULNERABILITY | ANXIETY | INFORMATION | MULTIDISCIPLINARY SCIENCES | SELECTIVE ATTENTION | IMPAIRED DISENGAGEMENT | TIME-COURSE | MAJOR DEPRESSION | EMOTIONAL FACES | ANGRY FACES | Complications and side effects | Care and treatment | Anxiety | Research | Diagnosis | Major depressive disorder | Risk factors | Cognition & reasoning | Anxieties | Bias | Clinical trials | Mental depression | Risk analysis | Emotions
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5. Full Text Effect of Multinutrient Supplementation and Food-Related Behavioral Activation Therapy on Prevention of Major Depressive Disorder Among Overweight or Obese Adults With Subsyndromal Depressive Symptoms The MooDFOOD Randomized Clinical Trial
by Bot, M and Brouwer, IA and Roca, M and Kohls, E and Penninx, BWJH and Watkins, E and van Grootheest, G and Cabout, M and Hegerl, U and Gili, M and Owens, M and Visser, M and Verkerk, B and Paans, N and Thesing, C and Gibson-Smith, D and Horsfall, M and Weiss, L and Romijn, A and Bunce, H and Winfield, O and Bunker-Smith, H and Durbridge, F and Molinares, CV and Sapar, A and Tortella, M and Covas, CH and Perez-Ara, MA and Gracia, AC and Reig, JL and Hoesel, J and Dogan, E and Baldofski, S and Mauche, N and MooDFOOD Prevention Trial and MooDFOOD Prevention Trial Investigators and for the MooDFOOD Prevention Trial Investigators
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, ISSN 0098-7484, 03/2019, Volume 321, Issue 9, pp. 858 - 868
IMPORTANCE Effects of nutritional interventions on the prevention of major depressive disorder (MDD) in overweight adults are unknown. OBJECTIVE To examine the... 
MEDICINE, GENERAL & INTERNAL | INTERVENTIONS | IMPACT | QUALITY | ANXIETY | PATTERNS | RISK | QUESTIONNAIRE | FOLIC-ACID | VALIDITY | ONSET | Obesity - diet therapy | Behavior Therapy | Depressive Disorder, Major - prevention & control | Follow-Up Studies | Obesity - psychology | Humans | Middle Aged | Male | Combined Modality Therapy | Overweight - diet therapy | Overweight - therapy | Analysis of Variance | Treatment Failure | Obesity - therapy | Adult | Female | Psychotherapy, Group | Overweight - psychology | Dietary Supplements | Psychological aspects | Placebos | Overweight persons | Care and treatment | Usage | Major depressive disorder | Intervention | Therapy | Vitamin D3 | Signs and symptoms | Calcium | Body weight | Dietary supplements | Clinical trials | Activation | Mental depression | Fatty acids | Patients | Folic acid | Prevention | Body mass index | Randomization | Body mass | Body size | Adults | Selenium | Supplementation | Food | Original Investigation | Research
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6. Full Text A 6-year longitudinal study of predictors for suicide attempts in major depressive disorder
by Eikelenboom, Merijn and Beekman, Aartjan T. F and Penninx, Brenda W. J. H and Smit, Johannes H
Psychological Medicine, ISSN 0033-2917, 06/2018, Volume 49, Issue 6, pp. 1 - 11
Background. Major depressive disorder (MDD), represent a major source of risk for suicidality. However, knowledge about risk factors for future suicide... 
follow-up | Depression | suicide attempt | mood disorder | major depressive disorder | risk factor | RISK-FACTORS | PSYCHIATRY | BEHAVIOR | UNIPOLAR | PSYCHOLOGY, CLINICAL | BIPOLAR | PSYCHOLOGY | MOOD | CHILDHOOD SEXUAL-ABUSE | SUBJECTIVE SLEEP QUALITY | PRIMARY-CARE PATIENTS | TOWER-OF-BABEL | VALIDITY | Measurement | Low income groups | Depressive personality disorders | Mental disorders | Demographic aspects | Attempted | Economic aspects | Mental depression | Suicidal ideation | Suicide | Risk factors | Mental health care | Sleep disorders | Suicides & suicide attempts | Lifestyle | Anxiety | Clinical risk factors | Interviews | Antidepressant drugs | Research & development--R&D | Anxiety-Depression | Personality | Unemployment | Primary care | Studies | Anxieties | Insomnia | Socioeconomic factors
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7. Full Text A characterization of postzygotic mutations identified in monozygotic twins
by Ouwens, Klaasjan G and Jansen, Rick and Tolhuis, Bas and Slagboom, P. Eline and Penninx, Brenda W.J.H and Boomsma, Dorret I
Human Mutation, ISSN 1059-7794, 10/2018, Volume 39, Issue 10, pp. 1393 - 1401
Postzygotic mutations are DNA changes acquired from the zygote stage onwards throughout the lifespan. These changes lead to differences in DNA sequence among... 
postzygotic mutations | somatic mosaicism | genetics | mutations | next‐generation sequencing | next-generation sequencing | DISCORDANT | HUMAN-DISEASE | ALPORT-SYNDROME | CANCER | SOMATIC MUTATIONS | POINT MUTATIONS | CHIMERISM | HEMATOPOIESIS | GENE | GENETICS & HEREDITY | DETECTABLE CLONAL MOSAICISM | Computational Biology - methods | Twins, Monozygotic - genetics | Humans | Molecular Sequence Annotation | Genotype | Male | Phenotype | DNA Mutational Analysis | Aged, 80 and over | Adult | Female | High-Throughput Nucleotide Sequencing | Mutation | Genomics - methods | Gene Ontology | Analysis | Genomics | Genetic research | Genetic aspects | Nucleotide sequencing | Twins | DNA sequencing | Alternative splicing | Life span | Nucleotide sequence | Etiology | Mosaicism | Genomes | Regulatory sequences | Genetic testing | Deoxyribonucleic acid--DNA | Guanosinetriphosphatase
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8. Full Text Comorbidity and risk indicators for alcohol use disorders among persons with anxiety and/or depressive disorders: findings from the Netherlands Study of Depression and Anxiety (NESDA)
by Boschloo, Lynn and Vogelzangs, Nicole and Smit, Johannes H and van den Brink, Wim and Veltman, Dick J and Beekman, Aartjan T. F and Penninx, Brenda W. J. H
Journal of affective disorders, ISSN 0165-0327, 2011, Volume 131, Issue 1-3, pp. 233 - 242
This study examines comorbidity of alcohol abuse and alcohol dependence as well as its risk indicators among anxious and/or depressed persons, also considering... 
Alcohol dependence | Alcohol abuse | Comorbidity | Risk-indicators | Anxiety disorder | Depressive disorder | R PSYCHIATRIC-DISORDERS | UNITED-STATES | PSYCHOMETRIC PROPERTIES | SUBSTANCE USE DISORDERS | NATIONAL EPIDEMIOLOGIC SURVEY | PSYCHIATRY | MAJOR DEPRESSION | MENTAL-HEALTH SURVEY | CLINICAL NEUROLOGY | DEPENDENCE | GENERAL-POPULATION | ABUSE | Age Factors | Humans | Middle Aged | Netherlands - epidemiology | Risk Factors | Anxiety Disorders - epidemiology | Logistic Models | Male | Chi-Square Distribution | Marital Status | Alcoholism - epidemiology | Anxiety Disorders - psychology | Young Adult | Adolescent | Sex Factors | Adult | Female | Aged | Depressive Disorder - epidemiology | Depressive Disorder - psychology | Interview, Psychological | Alcoholism - psychology | Cohort Studies
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9. Full Text Anxiety sensitivity, its stability and longitudinal association with severity of anxiety symptoms
by Hovenkamp-Hermelink, Johanna H. M and van der Veen, Date C and Oude Voshaar, Richard C and Batelaan, Neeltje M and Penninx, Brenda W.J.H and Jeronimus, Bertus F and Schoevers, Robert A and Riese, Harriëtte
Scientific Reports, ISSN 2045-2322, 12/2019, Volume 9, Issue 1, pp. 4314 - 7
Anxiety sensitivity is associated with the onset of panic attacks, anxiety, and other common mental disorders. Anxiety sensitivity is usually seen as a... 
TRAIT ANXIETY | DEPRESSION | CONSTRUCT | METAANALYSIS | MOOD DISORDERS | MULTIDISCIPLINARY SCIENCES | MENTAL-DISORDERS | TRAJECTORIES | DSM-IV ANXIETY | NETHERLANDS | 2-YEAR COURSE | Anxiety | Panic attacks | Mental disorders | Anxieties | Correlation analysis
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10. Full Text A methylation study of long-term depression risk
by Clark, Shaunna L and Hattab, Mohammad W and Chan, Robin F and Shabalin, Andrey A and Han, Laura K M and Zhao, Min and Smit, Johannes H and Jansen, Rick and Milaneschi, Yuri and Xie, Lin Ying and van Grootheest, Gerard and Penninx, Brenda W J H and Aberg, Karolina A and van den Oord, Edwin J C G
Molecular psychiatry, ISSN 1359-4184, 09/2019
Recurrent and chronic major depressive disorder (MDD) accounts for a substantial part of the disease burden because this course is most prevalent and typically... 
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11. Full Text Biomarker-based subtyping of depression and anxiety disorders using Latent Class Analysis. A NESDA study
by Beijers, Lian and Wardenaar, Klaas J and Bosker, Fokko J and Lamers, Femke and Van Grootheest, Gerard and De Boer, Marrit K and Penninx, Brenda W.J.H and Schoevers, Robert A
Psychological Medicine, ISSN 0033-2917, 03/2019, Volume 49, Issue 4, pp. 617 - 627
Background Etiological research of depression and anxiety disorders has been hampered by diagnostic heterogeneity. In order to address this, researchers have... 
Anxiety | depression | latent class analysis | biomarkers | subtyping | METABOLIC SYNDROME | METAANALYSIS | PSYCHIATRY | MAJOR DEPRESSION | PSYCHOLOGY, CLINICAL | PSYCHOLOGY | ADULT DEPRESSION | HETEROGENEITY | OBESITY | PERSONALIZED MEDICINE | ANTIDEPRESSANT USE | NETHERLANDS | ASSOCIATION | Sociodemographic aspects | Drugs | Brain | Body weight | Mental depression | Hormones | Latent class analysis | Heterogeneity | Etiology | Classification | Psychopathology | Biological markers | Obesity | Research & development--R&D | Anxiety-Depression | Tryptophan | Severity | Metabolism | Patients | Studies | Cohort analysis | Brain-derived neurotrophic factor | Anxieties | Leptin | Internalization | Biomarkers | Original
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12. Full Text Involvement of inflammatory gene expression pathways in depressed patients with hyperphagia
by de Kluiver, H and Jansen, R and Milaneschi, Y and Penninx, BWJH
TRANSLATIONAL PSYCHIATRY, ISSN 2158-3188, 08/2019, Volume 9, Issue 1, pp. 193 - 11
The pathophysiology of major depressive disorder (MDD) is highly heterogeneous. Previous evidence at the DNA level as well as on the serum protein level... 
C-REACTIVE PROTEIN | ATYPICAL FEATURES | OBESITY | IMMUNE-SYSTEM | METAANALYSIS | MECHANISM | ANXIETY | PSYCHIATRY | NECROSIS-FACTOR-ALPHA | SYMPTOMS | MAJOR DEPRESSION | Gene expression
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13. Full Text Depression and cardiovascular disease: Epidemiological evidence on their linking mechanisms
by Penninx, Brenda W.J.H
Neuroscience and Biobehavioral Reviews, ISSN 0149-7634, 03/2017, Volume 74, Issue Pt B, pp. 277 - 286
Depression’s burden of disease goes beyond functioning and quality of life and extends to somatic health. Results from longitudinal cohort studies converge in... 
Cardiovascular | Depression | Lifestyle | Inflammation | Cortisol | Metabolic syndrome | Cardiac autonomic control | Epidemiology | C-REACTIVE PROTEIN | MYOCARDIAL-INFARCTION | ANTIDEPRESSANT MEDICATION | CORTISOL AWAKENING RESPONSE | MAJOR DEPRESSION | NEUROSCIENCES | HEART-RATE-VARIABILITY | MENTAL-DISORDERS | BEHAVIORAL SCIENCES | ANXIETY NESDA | META-ANALYSIS | Quality of Life | Cardiovascular Diseases | Anxiety | Humans | Cardiovascular diseases | Antidepressants | Depression, Mental | Corticosteroids | Mortality | Health aspects | Patient compliance
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14. Full Text Major depression and enhanced molecular senescence abnormalities in young and middle-aged adults
by Diniz, BS and Reynolds, CF and Sibille, E and Bot, M and Penninx, BWJH
TRANSLATIONAL PSYCHIATRY, ISSN 2158-3188, 08/2019, Volume 9, Issue 1, pp. 198 - 10
Recent evidence suggests a significant overlap in biological changes between major depression and aging across the lifespan. We aim to evaluate the impact of a... 
SECRETORY PHENOTYPE | METAANALYSIS | ANXIETY | PSYCHIATRY | OLDER-ADULTS | DISEASE | DYSFUNCTION | LATE-LIFE DEPRESSION | LUNG CARCINOGENESIS | CELLULAR SENESCENCE | ASSOCIATION | Senescence | Middle age | Mental depression
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