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1. Full Text Depression and cardiovascular disease: Epidemiological evidence on their linking mechanisms
by Penninx, Brenda W.J.H
Neuroscience and Biobehavioral Reviews, ISSN 0149-7634, 03/2017, Volume 74, Issue Pt B, pp. 277 - 286
Depression’s burden of disease goes beyond functioning and quality of life and extends to somatic health. Results from longitudinal cohort studies converge in... 
Cardiovascular | Depression | Lifestyle | Inflammation | Cortisol | Metabolic syndrome | Cardiac autonomic control | Epidemiology | C-REACTIVE PROTEIN | MYOCARDIAL-INFARCTION | ANTIDEPRESSANT MEDICATION | CORTISOL AWAKENING RESPONSE | MAJOR DEPRESSION | NEUROSCIENCES | HEART-RATE-VARIABILITY | MENTAL-DISORDERS | BEHAVIORAL SCIENCES | ANXIETY NESDA | META-ANALYSIS | Quality of Life | Cardiovascular Diseases | Anxiety | Humans | Cardiovascular diseases | Antidepressants | Depression, Mental | Corticosteroids | Mortality | Health aspects | Patient compliance
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2. Full Text Understanding the somatic consequences of depression: biological mechanisms and the role of depression symptom profile
by Penninx, B.W.J.H and Milaneschi, Y and Lamers, F and Vogelzangs, N
BMC Medicine, ISSN 1741-7015, 2013, Volume 11, Issue 1, pp. 129 - 129
Depression is the most common psychiatric disorder worldwide. The burden of disease for depression goes beyond functioning and quality of life and extends to... 
Obesity | Treatment | Autonomic Tone | Cardiovascular | Symptom profile | Depression | Cortisol | Inflammation | Metabolic syndrome | C-REACTIVE PROTEIN | PRO-INFLAMMATORY CYTOKINES | CARDIAC VAGAL CONTROL | NERVOUS-SYSTEM | RATE-VARIABILITY | MAJOR DEPRESSION | MEDICINE, GENERAL & INTERNAL | GENERAL-POPULATION | TREATMENT RESPONSE | CORONARY-HEART-DISEASE | Metabolic Syndrome - etiology | Depression - physiopathology | Depression - pathology | Humans | Depression - complications | Metabolic Syndrome - prevention & control | Depression - therapy | Metabolic Syndrome - epidemiology | Metabolic regulation | Metabolic diseases | Corticosteroids | Depression, Mental | Mental disorders | Mortality | Mental health | Cardiovascular disease | Mental depression | Kinases | Risk factors | Morbidity | Quality of life | Meta-analysis | Studies | Confidence intervals | Body mass index | Hyperglycemia | Physical fitness | Exercise | Antidepressants | Older people | Blood pressure | Lifestyles | Public health
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3. Full Text Comprehensive Meta-Analysis of Excess Mortality in Depression in the General Community Versus Patients With Specific Illnesses
by Cuijpers, Pim and Vogelzangs, Nicole and Twisk, Jos and Kleiboer, Annet and Li, Juan and Penninx, Brenda W
American Journal of Psychiatry, ISSN 0002-953X, 04/2014, Volume 171, Issue 4, pp. 453 - 462
The mechanisms linking depression to mortality were found to be related to biological dysregulations or lifestyle factors rather than disease specific in this... 
CYTOKINES | RISK-FACTOR | MORBIDITY | PSYCHIATRY | DISORDER | MECHANISMS | SYMPTOMS | CORONARY-HEART-DISEASE | CANCER | Pulmonary Disease, Chronic Obstructive - mortality | Multivariate Analysis | Regression Analysis | Heart Diseases - mortality | Humans | Mortality | Depressive Disorder - mortality | Neoplasms - mortality | Kidney Diseases - mortality | Risk | Case-Control Studies | Development and progression | United States | Depression, Mental | Risk factors
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4. Full Text Hair cortisol, stress exposure, and mental health in humans: A systematic review
by Staufenbiel, Sabine M and Penninx, Brenda W.J.H and Spijker, Anne T and Elzinga, Bernet M and van Rossum, Elisabeth F.C
Psychoneuroendocrinology, ISSN 0306-4530, 2012, Volume 38, Issue 8, pp. 1220 - 1235
Abstract The deleterious effects of chronic stress on health and its contribution to the development of mental illness attract broad attention worldwide. An... 
Endocrinology & Metabolism | Psychiatry | Depression | Anxiety | Psychopathology | Hair cortisol | Stress | BIOMARKER | PSYCHIATRY | LONG-TERM CORTISOL | THE-ART | NEUROSCIENCES | AGE-OF-ONSET | PITUITARY-ADRENAL ACTIVITY | CUSHINGS-SYNDROME | GLUCOCORTICOID-RECEPTOR | SHIFT WORK | ENDOCRINOLOGY & METABOLISM | DIURNAL SALIVARY CORTISOL | MAJOR DEPRESSIVE DISORDER | Stress, Psychological - genetics | Pituitary-Adrenal System - metabolism | Humans | Mental Disorders - metabolism | Stress, Psychological - metabolism | Hair - metabolism | Hydrocortisone - metabolism | Research Design | Hypothalamo-Hypophyseal System - metabolism | Stress, Psychological - complications | Corticosteroids | Stress (Psychology) | Mental health | Steroids | Age
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5. Full Text Association of Symptom Network Structure With the Course of Longitudinal Depression
by van Borkulo, Claudia and Boschloo, Lynn and Borsboom, Denny and Penninx, Brenda W. J. H and Waldorp, Lourens J and Schoevers, Robert A
Jama psychiatry, ISSN 2168-622X, 12/2015, Volume 72, Issue 12, pp. 1219 - 1226
IMPORTANCE Major depressive disorder (MDD) is a heterogeneous condition in terms of symptoms, course, and underlying disease mechanisms. Current... 
HETEROGENEITY | CRITERIA | INVENTORY | PERSPECTIVE | PSYCHIATRY | FRAMEWORK | DISORDERS | PATTERNS | SELECTION | LIFE EVENTS | CENTRALITY | Symptomatology | Research | Psychology, Pathological | Depression, Mental | Analysis
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6. Full Text Is depression associated with increased oxidative stress? A systematic review and meta-analysis
by Black, Catherine N and Bot, Mariska and Scheffer, Peter G and Cuijpers, Pim and Penninx, Brenda W.J.H
Psychoneuroendocrinology, ISSN 0306-4530, 2014, Volume 51, pp. 164 - 175
Highlights • A meta-analysis on oxidative stress in depression (uni- and bipolar) was performed. • 10 studies (1308 subjects) on 8-OHdG in depression were... 
Endocrinology & Metabolism | Psychiatry | Oxidative stress | Depression | Bipolar disorder | 8-Hydroxy-2′-deoxyguanosine (8-OHdG) | F2-isoprostanes | Major depressive disorder | 8-Hydroxy-2'-deoxyguanosine (8-OHdG) | POPULATION | HUMAN-DISEASE | ANTIOXIDANTS | PSYCHIATRY | DNA-DAMAGE | SYMPTOMS | MAJOR DEPRESSION | MENTAL-HEALTH | NEUROSCIENCES | 8-Hydroxy-2 '-deoxyguanosine (8-OHdG) | CLINICAL DEPRESSION | ENDOCRINOLOGY & METABOLISM | PSYCHOSOCIAL FACTORS | Biomarkers - metabolism | Bipolar Disorder - metabolism | Depression - metabolism | Depressive Disorder, Major - metabolism | Humans | Oxidative Stress - physiology | Deoxyguanosine - metabolism | F2-Isoprostanes - metabolism | Deoxyguanosine - analogs & derivatives | Analysis | Depression, Mental
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7. Multinutrient Supplementation for Prevention of Major Depressive Disorder in Overweight Adults/Multinutrient Supplementation for Prevention of Major Depressive Disorder in Overweight Adults-Reply
by Julia J Rucklidge and Alexandra J Richardson and Ingeborg A Brouwer and Brenda W H J Penninx and Marjolein Visser
JAMA, ISSN 0098-7484, 07/2019, Volume 322, Issue 4, p. 366
Prevention | Body weight | Adults | Mental depression | Supplementation
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8. Full Text Longitudinal Association Between Depression and Inflammatory Markers: Results From the Netherlands Study of Depression and Anxiety
by Lamers, Femke and Milaneschi, Yuri and Smit, Johannes H and Schoevers, Robert A and Wittenberg, Gayle and Penninx, Brenda W.J.H
Biological Psychiatry, ISSN 0006-3223, 05/2019, Volume 85, Issue 10, pp. 829 - 837
While cross-sectional associations of inflammatory markers interleukin-6 (IL-6) and C-reactive protein with major depressive disorder are well established,... 
CRP | Depression severity | Longitudinal | Epidemiology | IL-6 | Depressive disorder | Diagnosis | Interleukins | Analysis | Depression, Mental
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9. Full Text Integrative approaches for large-scale transcriptome-wide association studies
by Gusev, A and Ko, A and Shi, H and Bhatia, G and Chung, W and Penninx, B.W.J.H and Jansen, R and de Geus, E.J.C and Boomsma, D.I and Wright, F.A and Sullivan, P.F and Nikkola, E and Alvarez, M and Civelek, M and Lusis, A.J and Lehtimäki, T and Raitoharju, E and Kähönen, M and Seppälä, I and Raitakari, O.T and Kuusisto, J and Laakso, M and Price, A.L and Pajukanta, P and Pasaniuc, B
Nature Genetics, ISSN 1061-4036, 2016, Volume 48, Issue 3, pp. 245 - 252
Many genetic variants influence complex traits by modulating gene expression, thus altering the abundance of one or multiple proteins. Here we introduce a... 
HUMAN HEIGHT | PARTITIONING HERITABILITY | STATISTICS | GENETICS & HEREDITY | GENE-EXPRESSION | BODY-MASS INDEX | YOUNG FINNS | MENDELIAN RANDOMIZATION | COMPLEX TRAITS | REGULATORY VARIATION | CARDIOVASCULAR RISK | Genetic Predisposition to Disease | Genome-Wide Association Study | Phenotype | Animals | Gene Expression Regulation - genetics | Humans | Genotype | Mice | Transcriptome - genetics | Obesity - genetics | Obesity - pathology | Quantitative Trait Loci - genetics | Genome-wide association studies | Genetic research | Research | Gene expression | Identification and classification | Methods | Studies | Genotype & phenotype | Lipids | Software | Genomes | Estimates
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10. Full Text Leptin Dysregulation Is Specifically Associated With Major Depression With Atypical Features: Evidence for a Mechanism Connecting Obesity and Depression
by Milaneschi, Yuri and Lamers, Femke and Bot, Mariska and Drent, Madeleine L and Penninx, Brenda W.J.H
Biological Psychiatry, ISSN 0006-3223, 05/2017, Volume 81, Issue 9, pp. 807 - 814
Background Obesity-related dysregulation of leptin signaling (e.g., hyperleptinemia due to central functional resistance) may affect mood. However, evidence... 
Psychiatry | Heterogeneity | Obesity | Atypical | Major depression | Epidemiology | Leptin | ANTIDEPRESSANT | SUBTYPES | PSYCHIATRY | FOOD-INTAKE | DISORDERS | SYMPTOMS | NEUROSCIENCES | METABOLISM | DISEASE | RESISTANCE | ANXIETY NESDA | NETHERLANDS | Body Mass Index | Depressive Disorder, Major - blood | Obesity - complications | Humans | Middle Aged | Depressive Disorder, Major - complications | Male | Depressive Disorder, Major - epidemiology | Obesity - blood | Young Adult | Netherlands | Leptin - blood | Adiposity | Obesity - epidemiology | Adolescent | Adult | Female | Aged | Psychological aspects | Neurosciences | Major depressive disorder | Analysis
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11. Full Text The Association between Psychiatric Disorders and Telomere Length: A Meta-Analysis Involving 14,827 Persons
by Darrow, Sabrina M and Verhoeven, Josine E and Révész, Dóra and Lindqvist, Daniel and Penninx, Brenda W.J.H and Delucchi, Kevin L and Wolkowitz, Owen M and Mathews, Carol A and Lund University and Psychiatry (Lund) and Psykiatri, Lund and Lunds universitet
Psychosomatic Medicine, ISSN 0033-3174, 09/2016, Volume 78, Issue 7, pp. 776 - 787
Objective This study examined the relationship between leukocyte telomere length (LTL), a marker of cell aging, and psychiatric disorders in adults compared... 
bipolar disorders | anxiety disorders | depressive disorders | psychosis | telomere length | posttraumatic stress disorder | PSYCHIATRY | DNA-DAMAGE | EARLY-LIFE STRESS | MECHANISMS | PSYCHOLOGY | PSYCHOLOGY, MULTIDISCIPLINARY | NAIVE PATIENTS | DISEASE | MAJOR DEPRESSIVE DISORDER | MENTAL-ILLNESS | HEALTH | SEVERITY | AGE | Young Adult | Humans | Mental Disorders - metabolism | Middle Aged | Telomere Shortening - physiology | Aged, 80 and over | Adult | Aged | Mental disorders | Ageing | Anxiety-Depression | Bipolar affective disorder | Data processing | Depression | Posttraumatic stress disorder | Associations | Cells | Meta-analysis | Psychoses | Post-traumatic stress disorder | Aging | Adults | Anxiety | Causality | Psychiatric disorders | post-traumatic stress disorder | Clinical Medicine | Psykiatri | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap | Psychiatry
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12. Full Text Comorbidity Patterns of Anxiety and Depressive Disorders in a Large Cohort Study: The Netherlands Study of Depression and Anxiety (NESDA)
by Lamers, Femke and van Oppen, Patricia and Comijs, Hannie C and Smit, Johannes H and Spinhoven, Philip and van Balkom, Anton J. L. M and Nolen, Willem A and Zitman, Frans G and Beekman, Aartjan T. F and Penninx, Brenda
Journal of Clinical Psychiatry, ISSN 0160-6689, 2011, Volume 72, Issue 3, pp. 341 - 348
Background: Comorbidity of depressive and anxiety disorders is common and has been shown to be a consistent predictor of chronicity. Comorbidity patterns among... 
CO-MORBIDITY | PSYCHOMETRIC PROPERTIES | SUBSTANCE USE DISORDERS | GENERAL-POPULATION | CHILDHOOD LIFE EVENTS | MOOD DISORDERS | PSYCHIATRY | PSYCHIATRIC-DISORDERS | MAJOR DEPRESSION | PSYCHOLOGY, CLINICAL | MENTAL-HEALTH SURVEY | SOCIAL PHOBIA | Severity of Illness Index | Comorbidity | Humans | Netherlands - epidemiology | Risk Factors | Anxiety - psychology | Anxiety Disorders - epidemiology | Logistic Models | Male | Chi-Square Distribution | Anxiety Disorders - psychology | Psychiatric Status Rating Scales | Time Factors | Personality Inventory | Age of Onset | Anxiety - epidemiology | Adult | Female | Depressive Disorder - epidemiology | Depressive Disorder - psychology | Cohort Studies
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