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Proceedings of the National Academy of Sciences, ISSN 0027-8424, 11/2013, Volume 110, Issue 45, pp. 18226 - 18231
Inhibitors of BRAF protein kinase, such as Vemurafenib and Dabrafenib, have shown remarkable antitumor activity in patients with BRAF mutant melanoma. However,... 
Vemurafenib | LKB1 | Biological Sciences
Journal Article
Cancer Research, ISSN 0008-5472, 07/2017, Volume 77, Issue 13, pp. 3513 - 3526
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 05/2018, Volume 36, Issue 15_suppl, pp. e21610 - e21610
Journal Article
Journal of Investigative Dermatology, ISSN 0022-202X, 05/2014, Volume 134, Issue 5, pp. 1359 - 1368
Journal Article
Carcinogenesis, ISSN 0143-3334, 12/2010, Volume 31, Issue 12, pp. 2127 - 2135
Pharmacological inhibitors of the transforming growth factor beta (TGF beta) type I receptor (ALK5) have shown promise in blocking growth of xenotransplanted... 
MESSENGER-RNA | ONCOLOGY | CHEMICAL CARCINOGENESIS | KINASE | STRATIFIED EPITHELIA | GENE-EXPRESSION | MICE | TRANSFORMING-GROWTH-FACTOR | SQUAMOUS-CELL CARCINOMAS | CANCER | ABERRANT EXPRESSION | Carcinogenesis
Journal Article
Carcinogenesis, ISSN 0143-3334, 02/2010, Volume 31, Issue 6, pp. 1116 - 1123
Transforming growth factor β1 (TGFβ1) expression is elevated by tumor promoters in the mouse skin, but its role in tumor promotion has not been well defined.... 
Carcinogenesis
Journal Article
Cancer research, ISSN 0008-5472, 7/2017, Volume 77, Issue 13, pp. 3513 - 3526
Rational therapeutic approaches based on synthetic lethality may improve cancer management. Based on a high-throughput drug screen, we provide preclinical... 
Journal Article
Journal of Investigative Dermatology, ISSN 0022-202X, 09/2010, Volume 130, Issue 9, pp. 2295 - 2303
Overexpression of transforming growth factor-β1 (TGFβ1) in the normal epidermis can provoke an inflammatory response, but whether this occurs within a... 
Journal Article
Cancer Research, ISSN 0008-5472, 07/2015, Volume 75, Issue 14 Supplement, pp. B09 - B09
Journal Article
Carcinogenesis, ISSN 0143-3334, 1/2008, Volume 29, Issue 1, pp. 9 - 14
Transforming growth factor β1 (TGFβ1) signaling plays a critical role in skin carcinogenesis. While most studies have focused on TGFβ1 signaling and response... 
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2013, Volume 110, Issue 45, p. 18226
  Biguanides, such as the diabetes therapeutics metformin and phenformin, have demonstrated antitumor activity both in vitro and in vivo. The energy-sensing... 
Biochemistry | Mutation | Kinases | Cells | Skin cancer | Apoptosis
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2013, Volume 110, Issue 45, pp. 18226 - 18231
Biguanides, such as the diabetes therapeutics metformin and phenformin, have demonstrated antitumor activity both in vitro and in vivo. The energy-sensing... 
Cell growth | Animal models | Medical treatment | Melanoma | Cell lines | Viability | Genetic mutation | Heterologous transplantation | Tumors | Cancer
Journal Article
Proceedings of the National Academy of Sciences of the United States, ISSN 0027-8424, 11/2013, Volume 110, Issue 45, p. 18226
Journal Article
The Journal of Investigative Dermatology, ISSN 0022-202X, 09/2010, Volume 130, Issue 9, p. 2295
  Overexpression of transforming growth factor-beta1 (TGFbeta1) in the normal epidermis can provoke an inflammatory response, but whether this occurs within a... 
Journal Article
Carcinogenesis, ISSN 0143-3334, 06/2010, Volume 31, Issue 6, pp. 1116 - 1123
Transforming growth factor b1 (TGFb1) expression is elevated by tumor promoters in the mouse skin, but its role in tumor promotion has not been well defined.... 
Journal Article
Carcinogenesis, ISSN 0143-3334, 01/2010, Volume 31, Issue 12, pp. 2127 - 2135
Pharmacological inhibitors of the transforming growth factor beta (TGF beta ) type I receptor (ALK5) have shown promise in blocking growth of xenotransplanted... 
Animal models | TPA | Tumor cells | Benign | Homeostasis | Inflammation | Transforming growth factor- beta | Tumor cell lines | Carcinogenesis | Keratin | Papilloma | Skin | Tumorigenesis | Differentiation | Apoptosis | squamous cell carcinoma
Journal Article
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