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humans (5) 5
female (4) 4
male (4) 4
aged (3) 3
older people (3) 3
[ sdv ] life sciences [q-bio] (2) 2
adult (2) 2
analysis (2) 2
clinical trials (2) 2
cognitive ability (2) 2
decline (2) 2
disability (2) 2
docosahexaenoic acid (2) 2
double-blind method (2) 2
eicosapentaenoic acid (2) 2
fatty acids (2) 2
gait (2) 2
gait speed (2) 2
geriatrics & gerontology (2) 2
geriatrics/gerontology (2) 2
index medicus (2) 2
life sciences (2) 2
memory (2) 2
middle aged (2) 2
pharmacology & pharmacy (2) 2
physical activity (2) 2
physical performance (2) 2
polyunsaturated fatty acids (2) 2
studies (2) 2
[ sdv.aen ] life sciences [q-bio]/food and nutrition (1) 1
[ sdv.bbm ] life sciences [q-bio]/biochemistry, molecular biology (1) 1
abdominal-surgery (1) 1
activities of daily living (1) 1
adenosine triphosphate - metabolism (1) 1
adults (1) 1
aged, 80 and over (1) 1
aging (1) 1
alfentanil (1) 1
alzheimer's disease (1) 1
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alzheimers-disease (1) 1
anesthesia, general - adverse effects (1) 1
anesthetics, intravenous - adverse effects (1) 1
animals (1) 1
anti-association activity (1) 1
anti-hiv agents (1) 1
anti-hiv agents - therapeutic use (1) 1
antiviral agents (1) 1
antiviral agents - therapeutic use (1) 1
biochemistry, molecular biology (1) 1
biomarkers, tumor - genetics (1) 1
biomarkers, tumor - metabolism (1) 1
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cd4-positive t-lymphocytes - physiology (1) 1
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cohort (1) 1
comparative analysis (1) 1
consciousness (1) 1
controlled infusion (1) 1
coronary-heart-disease (1) 1
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cryoglobulinemia - drug therapy (1) 1
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dementia (1) 1
depression, mental (1) 1
dietary supplements (1) 1
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disease prevention (1) 1
eif6 phosphorylation (1) 1
elderly (1) 1
endpoint determination (1) 1
enzastaurin (1) 1
enzastaurin; malignant pleural mesothelioma; pkcbeta; anti-association activity; eif6 phosphorylation (1) 1
eukaryotic initiation factors - genetics (1) 1
eukaryotic initiation factors - metabolism (1) 1
exercise (1) 1
exercise therapy (1) 1
extubation time (1) 1
fatty acids, omega-3 - therapeutic use (1) 1
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1. Full Text Effect of long-term omega 3 polyunsaturated fatty acid supplementation with or without multidomain intervention on cognitive function in elderly adults with memory complaints (MAPT): a randomised, placebo-controlled trial
by Andrieu, Sandrine, Prof and Guyonnet, Sophie, PhD and Coley, Nicola, PhD and Cantet, Christelle, MSc and Bonnefoy, Marc, Prof and Bordes, Serge, MD and Bories, Lawrence, MD and Cufi, Marie-Noëlle, MD and Dantoine, Thierry, Prof and Dartigues, Jean-François, Prof and Desclaux, Françoise, MD and Gabelle, Audrey, Prof and Gasnier, Yannick, MD and Pesce, Alain, MD and Sudres, Kristel, MD and Touchon, Jacques, Prof and Robert, Philippe, Prof and Rouaud, Olivier, MD and Legrand, Philippe, Prof and Payoux, Pierre, Prof and Caubere, Jean-Paul, PharmD and Weiner, Michael, Prof and Carrié, Isabelle, PhD and Ousset, Pierre-Jean, MD and Vellas, Bruno, Prof and MAPT Study Grp and MAPT Study Group
Lancet Neurology, The, ISSN 1474-4422, 2017, Volume 16, Issue 5, pp. 377 - 389
Summary Background No large trials have been done to investigate the efficacy of an intervention combining a specific compound and several lifestyle... 
Neurology | DEMENTIA | PLASMA | ALZHEIMERS-DISEASE | PERFORMANCE | PREVENTION | RISK | GAIT SPEED | BRAIN | CLINICAL NEUROLOGY | DECLINE | Double-Blind Method | Humans | Male | Treatment Outcome | Cognition - drug effects | Exercise Therapy | Neuropsychological Tests | Memory Disorders - prevention & control | Aged, 80 and over | Fatty Acids, Omega-3 - therapeutic use | Cognitive Therapy | Female | Aged | Dietary Supplements | Clinical trials | Fatty acids | Intervention | Physical training | Physical activity | Gait | Polyunsaturated fatty acids | Memory | Cognitive ability | Docosahexaenoic acid | Exercise | Motivation | Older people | Supplementation | Fish oils | Dietary supplements | Medical screening | Disease prevention | Studies | Physical fitness | Cognition & reasoning | Lifestyles | Alzheimers disease | Eicosapentaenoic acid | Geriatrics | Dementia | Life Sciences | Food and Nutrition | Biochemistry, Molecular Biology
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2. Full Text Comparison of the time to extubation after use of remifentanil or sufentanil in combination with propofol as anesthesia in adults undergoing nonemergency intracranial surgery: A prospective, randomized, double-blind trial
by Djian, Marie-Christine and Blanchet, Benoit and Pesce, Florence and Sermet, Alain and Disdet, Monique and Vazquez, Vincent and Gury, Charles and Roux, François-Xavier and Raggueneau, Jean-Loup and Coste, Joel and Joly, Luc-Marie
Clinical Therapeutics, ISSN 0149-2918, 2006, Volume 28, Issue 4, pp. 560 - 568
Anesthetics with a short context-sensitive half-time (ie, the time required for the effect-site concentration of an IV drug to decrease by 50% at steady... 
sufentanil | extubation time | remifentanil | intracranial surgery | cost analysis | CONSCIOUSNESS | ABDOMINAL-SURGERY | ALFENTANIL | RECOVERY | PHARMACOKINETICS | CONTROLLED INFUSION | SUPRATENTORIAL CRANIOTOMY | NEUROSURGICAL PROCEDURES | PHARMACOLOGY & PHARMACY | FENTANYL | RATIONAL OPIOID SELECTION | Anesthetics, Intravenous - adverse effects | Costs and Cost Analysis | Prospective Studies | Double-Blind Method | Humans | Meningioma - surgery | Middle Aged | Male | Anesthesia, General - adverse effects | Supratentorial Neoplasms - surgery | Neurosurgical Procedures | Piperidines - adverse effects | Endpoint Determination | Adult | Brain - surgery | Craniotomy | Female | Aged | Hemodynamics | Glioma - surgery | Intubation, Intratracheal | Sufentanil - adverse effects | Monitoring, Intraoperative | Propofol - adverse effects | Clinical trials | Adults | Comparative analysis | Surgery
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3. Full Text Omega-3 fatty acid levels in red blood cell membranes and physical decline over 3 years: longitudinal data from the MAPT study
by Fougère, Bertrand and Goisser, Sabine and Cantet, Christelle and Soriano, Gaëlle and Guyonnet, Sophie and De Souto Barreto, Philipe and Cesari, Matteo and Andrieu, Sandrine and Vellas, Bruno and MAPT Study Grp and MAPT Study Group
GeroScience, ISSN 2509-2715, 8/2017, Volume 39, Issue 4, pp. 429 - 437
Studies have shown that omega-3 polyunsaturated fatty acids (PUFAs) are associated with brain, cardiovascular, and immune function, as well as physical... 
Life Sciences | Gait speed | Physical performance | Geriatrics/Gerontology | Omega-3 polyunsaturated fatty acids | SPPB | Molecular Medicine | MAPT | Cell Biology | OLDER-ADULTS | LOWER-EXTREMITY FUNCTION | DIETARY-INTAKE | OMEGA-3 INDEX | GERIATRICS & GERONTOLOGY | RISK-FACTOR | DISABILITY | POLYUNSATURATED FATTY-ACIDS | FISH-OIL | CORONARY-HEART-DISEASE | Membranes | Immune response | Physical activity | Gait | Polyunsaturated fatty acids | Memory | Cognitive ability | Cell membranes | Docosahexaenoic acid | Fatty acids | Studies | Body mass index | Older people | Eicosapentaenoic acid
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4. Full Text Effect of indinavir and higher CD4+ T-cell count on viral load response after 6 months of highly active Antiretroviral Therapy
by Pradier, Christian and Pesce, Alain and Carrieri, Patrizia and Cottalorda, Jacqueline and Boyer, Patrice and Senesi, Christian and Fuzibet, Jean-Gabriel and Dellamonica, Pierre and Cassuto, Jill-Patrice
Clinical Therapeutics, ISSN 0149-2918, 1999, Volume 21, Issue 8, pp. 1313 - 1320
This retrospective, unmasked chart review was undertaken to determine which HIV-infected patients receiving protease inhibitors (PIs) for the first time were... 
protease inhibitors | indinavir | highly active antiretroviral therapy | viral load | HIV | Highly active antiretroviral therapy | Protease inhibitors | Viral load | Indinavir | PROTEASE INHIBITOR THERAPY | VIROLOGICAL TREATMENT FAILURE | PREDICTORS | IMMUNODEFICIENCY-VIRUS INFECTION | PHARMACOLOGY & PHARMACY | COHORT | HIV-1 INFECTION | Antiviral Agents - therapeutic use | Humans | Male | Clinical Trials as Topic | Data Collection | Saquinavir - therapeutic use | CD4-Positive T-Lymphocytes - physiology | Retroviridae - drug effects | Viral Load | Polymerase Chain Reaction | Lymphocyte Count | Ritonavir - therapeutic use | Adult | Anti-HIV Agents - therapeutic use | Female | Retrospective Studies | Protease Inhibitors - therapeutic use | Indinavir - therapeutic use | Antiviral agents | Proteases | Analysis | HIV patients | T cells | Anti-HIV agents
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5. Full Text Low-dose interferon-α for mixed cryoglobulinemia associated with hepatitis C virus
by Taillan, Bruno and Ferrari, Emile and Garnier, Georges and Pesce, Alain and Fuzibet, Jean-Gabriel and Dujardin, Pierre
The American Journal of Medicine, ISSN 0002-9343, 1992, Volume 93, Issue 4, pp. 476 - 476
MEDICINE, GENERAL & INTERNAL | Interferon-alpha - administration & dosage | Cryoglobulinemia - drug therapy | Humans | Middle Aged | Interferon alpha-2 | Female | Hepatitis C - complications | Male | Recombinant Proteins | Cryoglobulinemia - microbiology
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6. Full Text Expression and activity of eIF6 trigger malignant pleural mesothelioma growth in vivo
by Miluzio, Annarita and Oliveto, Stefania and Pesce, Elisa and Mutti, Luciano and Murer, Bruno and Grosso, Stefano and Ricciardi, Sara and Brina, Daniela and Biffo, Stefano
Oncotarget, ISSN 1949-2553, 2015, Volume 6, Issue 35, pp. 37471 - 37485
eIF6 is an antiassociation factor that regulates the availability of active 80S. Its activation is driven by the RACK1/PKCβ axis, in a mTORc1 independent... 
EIF6 phosphorylation | Malignant pleural mesothelioma | PKCbeta | Enzastaurin | Anti-association activity | Up-Regulation | Phosphorylation | Pleural Neoplasms - genetics | Cell Proliferation | Mesothelioma - pathology | Humans | Gene Expression Regulation, Neoplastic | Pleural Neoplasms - metabolism | Transfection | RNA Interference | Time Factors | Adenosine Triphosphate - metabolism | Biomarkers, Tumor - metabolism | Indoles - pharmacology | Protein Stability | Pleural Neoplasms - pathology | Eukaryotic Initiation Factors - genetics | Eukaryotic Initiation Factors - metabolism | Mesothelioma - therapy | Signal Transduction | Mesothelioma - genetics | Tumor Burden | Mice, SCID | Pleural Neoplasms - therapy | Xenograft Model Antitumor Assays | Animals | Mesothelioma - metabolism | Cell Line, Tumor | Glycolysis | Mice, Inbred NOD | Protein Kinase C beta - metabolism | Biomarkers, Tumor - genetics | Protein Kinase Inhibitors - pharmacology | RNAi Therapeutics | Protein Kinase C beta - antagonists & inhibitors
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7. Full Text Defining Vitality: Associations of Three Operational Definitions of Vitality with Disability in Instrumental Activities of Daily Living and Frailty among Elderly Over a 3-Year Follow-Up (MAPT Study)
by Giudici, Kelly Virecoulon and de Souto Barreto, P and Soriano, G and Rolland, Y and Vellas, B and MAPT DSA Grp and MAPT/DSA Group
The journal of nutrition, health & aging, ISSN 1279-7707, 4/2019, Volume 23, Issue 4, pp. 386 - 392
This study aimed to examine the associations of three operational definitions of vitality with variation in instrumental activities of daily living (IADL) and... 
frailty | Neurosciences | Medicine & Public Health | Nutrition | cognition | Geriatrics/Gerontology | elderly | activities of daily living | Aging | Quality of Life Research | Primary Care Medicine | Vitality | PHYSICAL PERFORMANCE | GRIP STRENGTH | COGNITIVE FUNCTION | DECLINE | GERIATRICS & GERONTOLOGY | NUTRITION & DIETETICS | HANDGRIP STRENGTH | QUALITY-OF-LIFE | HEALTH | INCIDENT DISABILITY | Reservoirs | Aged | Activities of daily living | Alzheimer's disease | Analysis | Depression, Mental
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