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Journal Article
Clinical Cancer Research, ISSN 1078-0432, 07/2006, Volume 12, Issue 13, pp. 4080 - 4089
Purpose: Aurora kinases play critical roles during mitosis in chromosome segregation and cell division. The aim of this study was to determine the preclinical... 
mitosis | kinase inhibitor | Aurora kinase | OVEREXPRESSION | ONCOLOGY | HISTONE H3 | PROTEIN-KINASE | ANTICANCER AGENTS | B KINASE | CHROMOSOME CONDENSATION | SPINDLE | A KINASE | MITOTIC PHOSPHORYLATION | CANCER | Pyrazoles - therapeutic use | Humans | Antineoplastic Agents - therapeutic use | Dose-Response Relationship, Drug | Aurora Kinase B | Enzyme Inhibitors - chemistry | Reverse Transcriptase Polymerase Chain Reaction - methods | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Biomarkers, Tumor - metabolism | Inhibitory Concentration 50 | Antineoplastic Agents - pharmacology | Molecular Structure | Phosphorylation - drug effects | Biomarkers, Tumor - antagonists & inhibitors | Pyrroles - therapeutic use | Protein-Serine-Threonine Kinases - metabolism | Disease Models, Animal | Mammary Neoplasms, Experimental - drug therapy | Pyrazoles - pharmacology | Recombinant Proteins - metabolism | Recombinant Proteins - antagonists & inhibitors | Enzyme Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - genetics | Mice, Transgenic | Recombinant Proteins - genetics | Aurora Kinases | Antineoplastic Agents - chemistry | Enzyme Inhibitors - therapeutic use | Phenotype | Pyrroles - pharmacology | Animals | Cell Line, Tumor | HL-60 Cells | Cell Proliferation - drug effects | Mice | HeLa Cells | Cell Cycle - drug effects | Drug Screening Assays, Antitumor
Journal Article
Apoptosis, ISSN 1360-8185, 2/2011, Volume 16, Issue 2, pp. 198 - 207
Journal Article
Molecular Oncology, ISSN 1574-7891, 12/2014, Volume 8, Issue 8, pp. 1495 - 1507
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 06/2008, Volume 4, Issue 6, pp. 357 - 365
Cdc7 is an essential kinase that promotes DNA replication by activating origins of replication. Here, we characterized the potent Cdc7 inhibitor PHA-767491 (1)... 
YEAST | IN-VITRO PHOSPHORYLATION | APOPTOSIS | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | HUMAN CDC7-RELATED KINASE | S-PHASE | AGENTS | HUMAN CANCER-CELLS | HUMAN HOMOLOG | CYCLE | Phosphorylation | DNA Replication - drug effects | Humans | Structure-Activity Relationship | Minichromosome Maintenance Complex Component 2 | Cell Cycle Proteins - antagonists & inhibitors | Cell Cycle Proteins - chemistry | Dose-Response Relationship, Drug | Protein Kinase Inhibitors - chemistry | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Cycle Proteins - genetics | DNA - biosynthesis | Antineoplastic Agents - pharmacology | Molecular Structure | Cell Death - drug effects | DNA - drug effects | Protein-Serine-Threonine Kinases - genetics | Rats | Antineoplastic Agents - chemistry | Mice, SCID | Nuclear Proteins - chemistry | Piperidones - pharmacology | Xenograft Model Antitumor Assays | Piperidones - chemistry | Pyrroles - pharmacology | Animals | Mice, Nude | Small Molecule Libraries | Fibroblasts - drug effects | Nuclear Proteins - antagonists & inhibitors | Cell Line, Tumor | Pyrroles - chemistry | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - chemistry | HeLa Cells | Cell Cycle - drug effects | Biochemistry | Inhibitor drugs | Kinases | DNA damage | Cancer
Journal Article
Fusion Engineering and Design, ISSN 0920-3796, 11/2017, Volume 124, pp. 123 - 126
ENEA, in the framework of Broader Approach program for the early realization of fusion with the construction of JT-60SA tokamak, is procuring 9 of the 18 TF... 
Satellite tokamak program | Superconducting tokamak | JT-60SA | Broader approach | NUCLEAR SCIENCE & TECHNOLOGY | Superconductors | Welding | Coils (windings) | Coils | Piping | Machining | Magnetism | Tokamak devices | Nuclear reactors | Fusion | Acceptance tests | Assembly | Cables
Journal Article
Journal of Neuro-Oncology, ISSN 0167-594X, 05/2019, Volume 142, Issue 3, pp. 455 - 462
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 04/2016, Volume 15, Issue 4, pp. 628 - 639
Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 04/2016, Volume 59, Issue 7, pp. 3392 - 3408
Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase responsible for the development of different tumor types. Despite the remarkable clinical... 
CELL LUNG-CANCER | EML4-ALK | CHEMISTRY, MEDICINAL | FUSION | GENE | RESISTANCE | NEUROBLASTOMA | GENERATION | IDENTIFICATION | REARRANGEMENTS | ACTIVATING MUTATIONS | Lung Neoplasms - drug therapy | Rats, Wistar | Humans | Lung Neoplasms - metabolism | Receptor, trkA - antagonists & inhibitors | Crystallography, X-Ray | Lung Neoplasms - pathology | Antineoplastic Agents - administration & dosage | Indazoles - administration & dosage | Benzamides - administration & dosage | Protein Kinase Inhibitors - chemistry | Anaplastic Lymphoma Kinase | Microsomes, Liver - drug effects | Receptor, trkB - antagonists & inhibitors | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Antineoplastic Agents - pharmacology | Benzamides - pharmacology | Tumor Cells, Cultured | Benzamides - chemistry | Proto-Oncogene Proteins - antagonists & inhibitors | Indazoles - chemistry | Administration, Oral | Crystallization | Receptor, trkC - antagonists & inhibitors | Rats | Antineoplastic Agents - chemistry | Mice, SCID | Blood-Brain Barrier - drug effects | Drug Discovery | Blotting, Western | Indazoles - pharmacology | Xenograft Model Antitumor Assays | Protein Kinase Inhibitors - administration & dosage | Animals | Mice, Nude | Cell Membrane Permeability - drug effects | Dogs | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Protein-Tyrosine Kinases - antagonists & inhibitors
Journal Article
Blood, ISSN 0006-4971, 04/2008, Volume 111, Issue 8, pp. 4355 - 4364
Journal Article