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Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2014, Volume 111, Issue 42, pp. 15072 - 15077
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 4/2007, Volume 104, Issue 15, pp. 6217 - 6222
Journal Article
Science, ISSN 0036-8075, 2/2007, Volume 315, Issue 5813, pp. 856 - 859
A central issue in the regulation of apoptosis by the Bcl-2 family is whether its BH3-only members initiate apoptosis by directly binding to the essential... 
Research fellowships | Protein isoforms | Medical research | Myeloid cells | Antibodies | Cytochromes | Ligands | Reports | Grants | Viability | Apoptosis | RESPONSES | FAMILY-MEMBERS | X-L | MULTIDISCIPLINARY SCIENCES | BIM | HELIX | MITOCHONDRIAL-MEMBRANE | PUMA | DOMAINS | BH3-ONLY PROTEINS | CELL-DEATH | bcl-2-Associated X Protein - chemistry | Humans | BH3 Interacting Domain Death Agonist Protein - genetics | Proto-Oncogene Proteins - chemistry | Neoplasm Proteins - metabolism | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Bcl-2-Like Protein 11 | Tumor Suppressor Proteins - genetics | BH3 Interacting Domain Death Agonist Protein - chemistry | Apoptosis Regulatory Proteins - genetics | bcl-Associated Death Protein - metabolism | Membrane Proteins - metabolism | BH3 Interacting Domain Death Agonist Protein - metabolism | Protein Structure, Tertiary | Proto-Oncogene Proteins - metabolism | Cell Line | Tumor Suppressor Proteins - metabolism | Membrane Proteins - genetics | Apoptosis Regulatory Proteins - chemistry | Cells, Cultured | bcl-2-Associated X Protein - metabolism | Proto-Oncogene Proteins - genetics | Apoptosis Regulatory Proteins - metabolism | Mice, Knockout | Animals | Proteins - metabolism | Membrane Proteins - chemistry | Models, Biological | Myeloid Cell Leukemia Sequence 1 Protein | Mice | Mutation | bcl-X Protein - metabolism | Research | Peptides | Analysis | Biochemistry | Cellular biology | Molecular biology | Binding sites | Index Medicus
Journal Article
Immunity, ISSN 1074-7613, 04/2012, Volume 36, Issue 4, pp. 646 - 657
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 09/2014, Volume 111, Issue 39, pp. E4076 - E4085
The pivotal step on the mitochondrial pathway to apoptosis is permeabilization of the mitochondrial outer membrane (MOM) by oligomers of the B-cell lymphoma-2... 
Cysteine-scanning mutagenesis | Mitochondrial permeabilization | Protein-membrane topology | Cell death | Membrane pores | protein-membrane topology | DOMAIN | ACTIVATION | cell death | cysteine-scanning mutagenesis | mitochondrial permeabilization | MULTIDISCIPLINARY SCIENCES | BCL-X(L) | CELL-DEATH | INTERFACE | membrane pores | X-RAY | HOMODIMERS | OLIGOMERIZATION | PROTEINS | BCL-2 FAMILY | bcl-2-Associated X Protein - chemistry | Humans | bcl-2 Homologous Antagonist-Killer Protein - genetics | Molecular Sequence Data | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Stilbenes | Mitochondrial Membranes - chemistry | Protein Structure, Quaternary | bcl-2-Associated X Protein - genetics | Protein Structure, Tertiary | Recombinant Proteins - metabolism | Amino Acid Sequence | Cell Line | Mutagenesis, Site-Directed | Protein Structure, Secondary | bcl-2-Associated X Protein - metabolism | Models, Molecular | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Cysteine - chemistry | Mitochondrial Membranes - metabolism | Animals | Mice | Apoptosis - physiology | bcl-2 Homologous Antagonist-Killer Protein - chemistry | Amino Acid Substitution | Sulfhydryl Reagents | Mitochondria | Membranes | Proteomics | Lipids | Lymphomas | Permeability | Apoptosis | Index Medicus | Biological Sciences | PNAS Plus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2014, Volume 111, Issue 39, pp. 14017 - 14017
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 06/2013, Volume 9, Issue 6, pp. 390 - 397
  The prosurvival BCL-2 family protein BCL-XL is often overexpressed in solid tumors and renders malignant tumor cells resistant to anticancer therapeutics.... 
Proteins | Gene expression | Drug therapy | Tumors | Cancer
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2015, Volume 112, Issue 27, pp. E3535 - E3544
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 1/2008, Volume 180, Issue 2, pp. 341 - 355
Journal Article
Nature Communications, ISSN 2041-1723, 12/2019, Volume 10, Issue 1, pp. 2385 - 10
Venetoclax is a first-in-class cancer therapy that interacts with the cellular apoptotic machinery promoting apoptosis. Treatment of patients suffering chronic... 
Therapy | Chronic lymphatic leukemia | Bcl-2 protein | Leukemia | Mutation | Binding sites | Crystal structure | Apoptosis | Index Medicus
Journal Article
Nature Structural and Molecular Biology, ISSN 1545-9993, 08/2015, Volume 22, Issue 8, pp. 590 - 596
Plasmepsin V, an essential aspartyl protease of malaria parasites, has a key role in the export of effector proteins to parasite-infected erythrocytes.... 
Plasmodium falciparum - enzymology | Surface Plasmon Resonance | Protozoan Proteins - antagonists & inhibitors | Humans | Molecular Sequence Data | Plasmodium vivax - genetics | Substrate Specificity | Crystallography, X-Ray | Immunoblotting | Green Fluorescent Proteins - genetics | Protein Transport - drug effects | Protozoan Proteins - genetics | Carbamates - chemistry | Carbamates - metabolism | Protease Inhibitors - pharmacology | Peptides - metabolism | Protozoan Proteins - metabolism | Plasmodium falciparum - genetics | Protozoan Proteins - chemistry | Membrane Proteins - metabolism | Molecular Structure | Oligopeptides - chemistry | Plasmodium vivax - enzymology | Carbamates - pharmacology | Protein Structure, Tertiary | Amino Acid Sequence | Aspartic Acid Endopeptidases - chemistry | Cell Line | Green Fluorescent Proteins - metabolism | Peptides - chemistry | Aspartic Acid Endopeptidases - antagonists & inhibitors | Membrane Proteins - genetics | Models, Molecular | Protease Inhibitors - chemistry | Protease Inhibitors - metabolism | Oligopeptides - metabolism | Erythrocytes - drug effects | Sequence Homology, Amino Acid | Animals | Aspartic Acid Endopeptidases - metabolism | Erythrocytes - metabolism | Protein Binding | Amino Acid Motifs - genetics | Oligopeptides - pharmacology | Plasmodium | Physiological aspects | Genetic aspects | Research | Virulence (Microbiology) | Aspartic proteinases | Health aspects | Proteins | Malaria | Parasites | Index Medicus
Journal Article