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Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 02/2018, Volume 28, Issue 3, pp. 319 - 329
Treatment of cancer by activation of an antitumor immune response is now a widely practiced and well-accepted approach to therapy. However, despite dramatic... 
NINCPJHFIWWUAZ-CDRJQVBSSA-N | BEDXOYXWXUCQNA-IPJVBHEBSA-N | KRESAFFTFXNKOO-UHFFFAOYSA-N | HWDKOBHGPXRKJJ-HMZIZCGUSA-J | UATCGUSLBHISQR-ALSSIMQBSA-N | WUDIWKVIWHAQIO-UHFFFAOYSA-N | JWVAXOHLLDJSHF-QMJXVMRNSA-N | VDNKHSAOWUDCRM-ACSVFZNHSA-N | Immuno-oncology | FAVUUGQWYAJEGA-UHFFFAOYSA-N | HUVQZTCJKOXROE-RPXLBNRVSA-N | UBQQSDUBSSXCEW-DZHBTMGUSA-N | RBFLMTFTTMGEPS-UHFFFAOYSA-N | MFZUODXFGTXTIW-GBEGKXJTSA-N | Small molecule | ARAQTZDRSNRIIK-UHFFFAOYSA-N | FVWQPAOQPHOQRR-UHFFFAOYSA-N | Cancer | CHEMISTRY, MEDICINAL | ROR-GAMMA-T | ECTO-5'-NUCLEOTIDASE INHIBITORS | ALKALINE-PHOSPHATASE | MODULATORS | INDOLEAMINE 2,3-DIOXYGENASE | CHEMISTRY, ORGANIC | CANCER-IMMUNOTHERAPY | AGONISTS | ARGINASE INHIBITORS | TOLL-LIKE RECEPTORS | HIGHLY POTENT | Small Molecule Libraries - pharmacology | Immunologic Factors - chemistry | Apoptosis - drug effects | Humans | Programmed Cell Death 1 Receptor - metabolism | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Structure-Activity Relationship | Antineoplastic Agents - chemistry | Dose-Response Relationship, Drug | Small Molecule Libraries - chemistry | Animals | Cell Cycle Checkpoints - drug effects | Antineoplastic Agents - pharmacology | Cell Proliferation - drug effects | Mice | Molecular Structure | Immunologic Factors - pharmacology | Drug Screening Assays, Antitumor | Cell death | Health aspects
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 11/2004, Volume 3, Issue 11, pp. 1427 - 1437
Journal Article
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 09/2015, Volume 11, Issue 9, p. 741
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Nature Chemical Biology, ISSN 1552-4450, 02/2015, Volume 11, Issue 2, p. 141
  Retinoic acid receptorrelated orphan receptor g (RORgt) controls the differentiation of naive CD4+ T cells into the TH17 lineage, which are critical cells in... 
Sterols | Neurons | Pathogenesis | Metabolism
Journal Article
Journal Article
Chemistry & Biology, ISSN 1074-5521, 2005, Volume 12, Issue 10, pp. 1057 - 1058
Mechanism of action studies are essential to link observable effects on cells with molecular targets of small molecules. Caligiuri and coworkers describe how... 
SYSTEM | TARGETS | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROTEIN-KINASE INHIBITORS | Two-Hybrid System Techniques | Yeasts - genetics | Animals | Humans | Drug Design | Substrate Specificity | Antineoplastic Agents - pharmacology | Phosphotransferases - antagonists & inhibitors | Drug Screening Assays, Antitumor | Cell research
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Journal of Medicinal Chemistry, ISSN 0022-2623, 04/2005, Volume 48, Issue 7, pp. 2388 - 2406
Journal Article
Journal Article
Journal Article
OncoImmunology, ISSN 2162-4011, 12/2016, Volume 5, Issue 12, p. e1254854
RORγt is the key transcription factor controlling the development and function of CD4 + Th17 and CD8 + Tc17 cells. Across a range of human tumors, about 15% of... 
co-stimulatory receptors | Tc17 | immunotherapy | RORγ | co-inhibitory receptors | Adoptive cell therapy | PD-1 | Th17 | ROR gamma | CANCER-IMMUNOTHERAPY | IMMUNOLOGY | T-CELL EXHAUSTION | MOLECULAR SIGNATURE | THERAPY | ONCOLOGY | CO-STIMULATION | T(H)17 | DIFFERENTIATION | RECEPTORS | BLOCKADE | TH17 CELLS
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Nature Chemical Biology, ISSN 1552-4450, 09/2015, Volume 11, Issue 9, pp. 741 - 741
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 02/2015, Volume 11, Issue 2, pp. 141 - 147
Journal Article
Chemistry - A European Journal, ISSN 0947-6539, 11/2008, Volume 14, Issue 34, pp. 10683 - 10704
Journal Article