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Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 12793 - 15
Anemic Nan mice carry a mutation (E339D) in the second zinc finger of erythroid transcription factor KLF1. Nan-KLF1 fails to bind a subset of normal KLF1... 
TERMINAL ERYTHROID-DIFFERENTIATION | EKLF | GLOBAL ROLE | MULTIDISCIPLINARY SCIENCES | IN-VIVO | STRESS-RESPONSE | KRUPPEL-LIKE FACTOR | BETA-THALASSEMIA | IDENTIFICATION | EXPRESSION | SEQ | Spleen | Erythropoiesis | Flow cytometry | Anemia | Liver | Fetuses | Gene expression | DNA repair | Rodents | Cell cycle | Bone marrow | Zinc finger proteins | Mutation
Journal Article
Nature, ISSN 0028-0836, 06/2015, Volume 522, Issue 7557, p. 474
Many acute and chronic anaemias, including haemolysis, sepsis and genetic bone marrow failure diseases such as Diamond- Blackfan anaemia, are not treatable... 
Physiological aspects | Physiological research | Corticosteroids | Regeneration (Biology) | Research | Anemia | Drugs | Transcription factors | Rodents | Blood
Journal Article
Frontiers in physiology, ISSN 1664-042X, 2018, Volume 9, p. 689
RASA3 is a Ras GTPase activating protein that plays a critical role in blood formation. The autosomal recessive mouse model (severe combined anemia and... 
Journal Article
Frontiers in physiology, ISSN 1664-042X, 2014, Volume 5, p. 375
The lengths of the sarcomeric thin filaments vary in a skeletal muscle-specific manner and help specify the physiological properties of skeletal muscle. Since... 
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 02/2010, Volume 285, Issue 7, p. 4757
Spectrin and protein 4.1 cross-link F-actin protofilaments into a network called the membrane skeleton. Actin and 4.1 bind to one end of β-spectrin. The... 
Journal Article
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 04/2015, Volume 125, Issue 4, pp. 1419 - 1432
The small GTPase RAP1 is critical for platelet activation and thrombus formation. RAP1 activity in platelets is controlled by the GEF CalDAG-GEFI and an... 
GENE-MUTATIONS | MEDICINE, RESEARCH & EXPERIMENTAL | PROTEIN-KINASE-C | ADENOSINE-DIPHOSPHATE | ALPHA-IIB-BETA-3 ACTIVATION | MICE | CALDAG-GEFI | PLASMA-MEMBRANE | ADENYLATE-CYCLASE | ADP | MOUSE MODELS | Thrombopoiesis | Ticlopidine - pharmacology | rap1 GTP-Binding Proteins - antagonists & inhibitors | Platelet Activation - physiology | Thrombocytopenia - surgery | Splenectomy | Thrombocytopenia - genetics | Cellular Senescence | Hemostasis | Platelet Aggregation Inhibitors - pharmacology | GTPase-Activating Proteins - physiology | Guanine Nucleotide Exchange Factors - deficiency | Mice, Inbred C57BL | Receptors, Purinergic P2Y12 - physiology | Proto-Oncogene Proteins c-akt - physiology | Ticlopidine - analogs & derivatives | Mice, Knockout | Platelet Activation - genetics | Animals | rap1 GTP-Binding Proteins - physiology | Saphenous Vein - injuries | Clopidogrel | Mice | Mice, Inbred BALB C | Platelet Activation - drug effects | GTPase-Activating Proteins - genetics | Lymphopenia - genetics | Cell receptors | Development and progression | Cellular signal transduction | Genetic aspects | Properties | Health aspects | Blood platelet disorders | Heart attacks | Laboratories | Cloning | Thrombosis | Embryos | Proteins | Studies | Blood platelets | Rodents | Technological change | Protein expression | Mutation | Infrared imaging systems | Veins & arteries | Index Medicus | Abridged Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2010, Volume 107, Issue 34, pp. 15151 - 15156
Studies of mouse models of anemia have long provided fundamental insights into red blood cell formation and function. Here we show that the semidominant mouse... 
Phenotypes | Anemia | DNA | Genes | Erythrocytes | Heterozygotes | Cell membranes | Genetic mutation | Zinc | Blood | Mouse model | Red blood cells | Zinc finger mutation | Neonatal anemia | red blood cells | mouse model | HEMOGLOBIN-STABILIZING PROTEIN | MULTIDISCIPLINARY SCIENCES | CONGENITAL DYSERYTHROPOIETIC ANEMIA | neonatal anemia | HUMAN GAMMA-GLOBIN | BETA-GLOBIN LOCUS | HEMOLYTIC-ANEMIA | GENE | zinc finger mutation | CELL-CYCLE | MICE | EXPRESSION | TRANSCRIPTION FACTOR EKLF | Humans | Transcriptional Activation | Male | Mutation, Missense | Anemia - genetics | Kruppel-Like Transcription Factors - metabolism | Mice, Mutant Strains | Base Sequence | Female | Genes, Reporter | Disease Models, Animal | Promoter Regions, Genetic | Gene Expression | Mutant Proteins - genetics | Models, Molecular | Hemoglobins - genetics | Mutant Proteins - metabolism | Chromosome Mapping | Binding Sites - genetics | DNA - metabolism | Kruppel-Like Transcription Factors - chemistry | Mice, Inbred C3H | DNA - genetics | Pregnancy | Anemia - metabolism | Phenotype | Animals | Mutant Proteins - chemistry | Erythrocytes - metabolism | K562 Cells | Heterozygote | Zinc Fingers - genetics | Mice | Kruppel-Like Transcription Factors - genetics | Amino Acid Substitution | Infants (Newborn) | Transcription factors | Genetic aspects | Research | Health aspects | Mutation (Biology) | Diseases | Amino acids | Mutation | Rodents | Deoxyribonucleic acid--DNA | Index Medicus | Biological Sciences
Journal Article
Blood, ISSN 0006-4971, 04/2007, Volume 109, Issue 8, pp. 3133 - 3134
Journal Article
Journal Article
Journal of Applied Physiology, ISSN 8750-7587, 04/2003, Volume 94, Issue 4, pp. 1650 - 1659
The Jackson Laboratory, Bar Harbor, Maine 04609 The mouse is a proven model for studying human disease. Many strains exist that exhibit either natural or... 
Mouse Phenome Project | LEPTIN | SPORT SCIENCES | METABOLIC SYNDROME | SLEEP | PHYSIOLOGY | ATHEROSCLEROSIS | mutagenesis | VASCULAR-DISEASE | PLASMA | SYNDROME-X | INSULIN-RESISTANCE | MICE
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/1998, Volume 95, Issue 24, pp. 14158 - 14163
Spectrin is an important structural component of the plasma membrane skeleton. Heretofore-unidentified isoforms of spectrin also associate with Golgi and other... 
Maps | Databases | Complementary DNA | Genes | Liver | Antibodies | Spectroscopic analysis | Cell membranes | Genomes | Chromosomes | RAT-LIVER | IN-VITRO | COMPLEX | BINDS | GENE | MULTIDISCIPLINARY SCIENCES | MUSCLE | ENDOPLASMIC-RETICULUM | ISOFORM | IDENTIFICATION | MEMBRANE-TRANSPORT | Biological Sciences
Journal Article
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