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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2007, Volume 104, Issue 41, pp. 16158 - 16163
Side-population (SP) cells within cancers and cell lines are rare cell populations known to enrich cancer stem-like cells. In this study, we characterized SP... 
Tumor cell line | Cytometry | Phenotypes | Stem cells | Cell lines | Cell cycle | Breast cancer | Cells | Cancer | Tumors | cDNA microarray | Side population cells | Reverse-phase protein array | Signaling pathway | INITIATING CELLS | SURVIVAL | PHASE PROTEIN MICROARRAYS | MULTIDISCIPLINARY SCIENCES | STAT3 | signaling pathway | PTEN | side population cells | ACUTE MYELOID-LEUKEMIA | IDENTIFICATION | SIDE-POPULATION | reverse-phase protein array | SUBPOPULATION | EXPRESSION | Protein Kinases - metabolism | Neoplasm Transplantation | Protein Kinases - genetics | Oligonucleotide Array Sequence Analysis | Humans | Breast Neoplasms - metabolism | Neoplastic Stem Cells - metabolism | STAT3 Transcription Factor - deficiency | Neoplastic Stem Cells - pathology | Female | Protein Kinases - deficiency | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Signal Transduction | Cell Survival | PTEN Phosphohydrolase - metabolism | Animals | Breast Neoplasms - genetics | Cell Cycle | Breast Neoplasms - pathology | Mice, Nude | Models, Biological | Cell Line, Tumor | Mice | TOR Serine-Threonine Kinases | DNA microarrays | Genetic aspects | Rapamycin | Cellular signal transduction | Genetic transcription | Research | Properties | Studies | Proteins | Mammals | Gene expression | Deoxyribonucleic acid--DNA | Index Medicus | Biological Sciences
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2011, Volume 108, Issue 31, pp. 12845 - 12850
Human tumors often contain slowly proliferating cancer cells that resist treatment, but we do not know precisely how these cells arise. We show that rapidly... 
Cell growth | HCT116 cells | Mitosis | Cell lines | Cell cycle | Stem cells | Cell division | Daughter cells | Cancer | Tumors | Epigenetics | Drug resistance | Cell signaling | Quiescence | BREAST-CANCER | TRANSITION | STEM-CELLS | OXIDATIVE STRESS | ACTIVATION | INHIBITION | MULTIDISCIPLINARY SCIENCES | SELF-RENEWAL | STATE | QUIESCENT | LYMPHOCYTES | Neoplasms - metabolism | Reactive Oxygen Species - metabolism | Oligonucleotide Array Sequence Analysis | Heterocyclic Compounds, 3-Ring - pharmacology | Humans | Gene Expression Regulation, Neoplastic | Gene Expression Profiling | Resting Phase, Cell Cycle | Proto-Oncogene Proteins c-akt - genetics | Breast Neoplasms - metabolism | Dose-Response Relationship, Drug | Neoplasms - genetics | Time Factors | Cell Division | Female | Molecular Structure | Proto-Oncogene Proteins c-akt - metabolism | Cell Survival - drug effects | HCT116 Cells | Blotting, Western | Microscopy, Confocal | Breast Neoplasms - genetics | Signal Transduction - drug effects | Breast Neoplasms - pathology | Models, Biological | Heterocyclic Compounds, 3-Ring - chemistry | Cell Line, Tumor | Luminescent Proteins - genetics | Neoplasms - pathology | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Luminescent Proteins - metabolism | Physiological aspects | Research | Protein kinases | Health aspects | Cancer cells | Signal transduction | Chemotherapy | Kinases | Index Medicus | Biological Sciences | quiescence | drug resistance | epigenetics | cell signaling
Journal Article
Cancer Cell, ISSN 1535-6108, 01/2016, Volume 29, Issue 1, pp. 75 - 89
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 8, pp. e23780 - e23780
Background: There is an urgent need to measure phosphorylated cell signaling proteins in cancer tissue for the individualization of molecular targeted kinase... 
BREAST-CANCER | PARAFFIN-EMBEDDED TISSUE | FORMALIN FIXATION | PHASE PROTEIN MICROARRAYS | MULTIDISCIPLINARY SCIENCES | EPIDERMAL-GROWTH-FACTOR | DECALCIFICATION | HUMAN SKIN WOUNDS | IMMUNOHISTOCHEMICAL DETECTION | AMERICAN-SOCIETY | PATHOLOGISTS GUIDELINE RECOMMENDATIONS | Tissue Preservation - methods | Cats | Reproducibility of Results | Temperature | Humans | Mice, Inbred C57BL | Middle Aged | Specimen Handling - methods | Male | Mice, SCID | Frozen Sections - methods | Mice, Inbred ICR | Immunohistochemistry - methods | Paraffin Embedding - methods | Animals | Phosphoproteins - analysis | Aged, 80 and over | Adult | Biomedical Research | Female | Mice, Inbred DBA | Mice, Inbred NOD | Aged | Mice | Immunohistochemistry | Evaluation | Chromatin | Progesterone | Phosphoproteins | Formaldehyde | Phosphorylation | Liver | Estrogens | Mucosa | Preserves | Biology | Kinases | Paraffin | Phosphatase | Tissues | Freezing | Confidence intervals | Proteins | Quality standards | Acetyl-CoA carboxylase | Ischemia | Bioindicators | Colon | Localization | Procurement | Enzymes | Antigens | Preservation | Extracellular signal-regulated kinase | MAP kinase | Histology | Breast cancer | ErbB-2 protein | Medicine | Pathology | Signaling | Fixation | Microscopy | Equivalence | Biopsy | Morphology | Quality control | Proteomics | Biomarkers | Hypoxia | Diagnostic systems | Initiation factor eIF-4G | Cancer | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2009, Volume 4, Issue 3, pp. e4763 - e4763
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2014, Volume 9, Issue 5, pp. e96778 - e96778
Journal Article
PLoS ONE, ISSN 1932-6203, 2010, Volume 5, Issue 11, pp. e13805 - e13805
Rift valley fever virus (RVFV) infection is an emerging zoonotic disease endemic in many countries of sub-Saharan Africa and in Egypt. In this study we show... 
TARGET | PROTEIN-KINASE PATHWAY | ACTIVATION | INDUCED APOPTOSIS | TRANSCRIPTION | BIOLOGY | TRANSDUCTION | MAP KINASES | DEATH | EXPRESSION | PROPAGATION | Epithelial Cells - metabolism | Signal Transduction | Humans | Rift Valley fever virus - isolation & purification | Cells, Cultured | Rift Valley fever virus - physiology | Proteome - analysis | Phosphoproteins - metabolism | Respiratory System - cytology | Blotting, Western | Host-Pathogen Interactions | Transcription Factors - metabolism | Caspases - metabolism | Phosphoproteins - analysis | Epithelial Cells - virology | X-Linked Inhibitor of Apoptosis Protein - metabolism | HSP27 Heat-Shock Proteins - metabolism | Female | Proteomics - methods | Proto-Oncogene Proteins c-akt - metabolism | Child | Proteome - metabolism | Rift Valley Fever - virology | Mitogen-Activated Protein Kinases - metabolism | Infection | Rift Valley fever | Heat shock proteins | Virulence (Microbiology) | Tumor proteins | Health aspects | Political aspects | Phosphotransferases | Zoonoses | Cell culture | Transcription factors | p53 Protein | Lung | AKT protein | Caspase-3 | Proteins | Signal transduction | Cell activation | Cell growth | Medical research | NF-κB protein | MAP kinase | JNK protein | RNA polymerase | Cyclic AMP response element-binding protein | Gene expression | Epithelium | Survival | Infectious diseases | Inhibitors | Caspase-9 | Aerosols | Phagocytosis | Phosphorylation | Transcription | Propagation | Laboratories | Epithelial cells | Viruses | Genomes | Infections | Activation | Kinases | Phase transitions | Respiratory tract | Pathways | Coccidioidomycosis | Cell cycle | Vector-borne diseases | Extracellular signal-regulated kinase | Caspase | Fever | Virology | Signaling | Hsp27 protein | Influenza | Adenoviruses | Proteomics | Viral infections | Apoptosis | Index Medicus
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 2010, Volume 5, Issue 4, pp. e10240 - e10240
Journal Article