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1. Full Text Fluid challenges in intensive care: the FENICE study
: A global inception cohort study
by Cecconi, Maurizio and Hofer, Christoph and Teboul, Jean-Louis and Pettila, Ville and Wilkman, Erika and Molnar, Zsolt and Della Rocca, Giorgio and Aldecoa, Cesar and Artigas, Antonio and Jog, Sameer and Sander, Michael and Spies, Claudia and Lefrant, Jean-Yves and De Backer, Daniel and FENICE Investigators and ESICM Trial Grp and ESICM Trial Group and on behalf of the FENICE Investigators and the ESICM Trial Group
Intensive Care Medicine, ISSN 0342-4642, 9/2015, Volume 41, Issue 9, pp. 1529 - 1537
Fluid challenges (FCs) are one of the most commonly used therapies in critically ill patients and represent the cornerstone of hemodynamic management in... 
Pediatrics | Pain Medicine | Emergency Medicine | Pneumology/Respiratory System | Medicine & Public Health | Intensive / Critical Care Medicine | Anesthesiology | RESPONSIVENESS | TASK-FORCE | ARTERIAL-PRESSURE | CIRCULATORY SHOCK | SEPTIC SHOCK | HYDROXYETHYL STARCH 130/0.4 | OF-THE-LITERATURE | RENAL REPLACEMENT THERAPY | CRITICALLY-ILL PATIENTS | SEVERE SEPSIS | CRITICAL CARE MEDICINE | Fluid Therapy | Humans | Middle Aged | Critical Care | Female | Male | Practice Patterns, Physicians | Cohort Studies | Index Medicus | Life Sciences | Human health and pathology | Seven-Day Profile Publication
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2. Full Text 37th International Symposium on Intensive Care and Emergency Medicine (part 2 of 3)
: Brussels, Belgium. 21-24 March 2017
by Rob, D and Špunda, R and Lindner, J and Šmalcová, J and Šmíd, O and Kovárník, T and Linhart, A and Bìlohlávek, J and Marinoni, M. M and Cianchi, G and Trapani, S and Migliaccio, M. L and Gucci, L and Bonizzoli, M and Cramaro, A and Cozzolino, M and Valente, S and Peris, A and Grins, E and Kort, E and Weiland, M and Shresta, N. Manandhar and Davidson, P and Algotsson, L and Fitch, S and Marco, G and Sturgill, J and Lee, S and Dickinson, M and Boeve, T and Khaghani, A and Wilton, P and Jovinge, S and Ahmad, A. N and Loveridge, R and Vlachos, S and Patel, S and Gelandt, E and Morgan, L and Butt, S and Whitehorne, M and Kakar, V and Park, C and Hayes, M and Willars, C and Hurst, T and Best, T and Vercueil, A and Auzinger, G and Adibelli, B and Akovali, N and Torgay, A and Zeyneloglu, P and Pirat, A and Kayhan, Z and Schmidbauer, S. S and Herlitz, J and Karlsson, T and Friberg, H and Knafelj, R and Radsel, P and Duprez, F and Bonus, T and Cuvelier, G and Mashayekhi, S and Maka, M and Ollieuz, S and Reychler, G and Mosaddegh, R and Abbasi, S and Talaee, S and Zotzmann, V. Z and Staudacher, D. S and Wengenmayer, T. W and Dürschmied, D. D and Bode, C. B and Nelskylä, A and Nurmi, J and Jousi, M and Schramko, A and Mervaala, E and Ristagno, G and Skrifvars, M and Ozsoy, G and Kendirli, T and Azapagasi, E and Perk, O and Gadirova, U and Ozcinar, E and Cakici, M and Baran, C and Durdu, S and Uysalel, A and Dogan, M and Ramoglu, M and Ucar, T and Tutar, E and Atalay, S and Akar, R and Kamps, M and ...
Critical Care, ISSN 1364-8535, 03/2017, Volume 21, Issue S1
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3. Full Text Early, Goal-Directed Therapy for Septic Shock — A Patient-Level Meta-Analysis
by Rowan, Kathryn M and Angus, Derek C and Bailey, Michael and Barnato, Amber E and Bellomo, Rinaldo and Canter, Ruth R and Coats, Timothy J and Delaney, Anthony and Gimbel, Elizabeth and Grieve, Richard D and Harrison, David A and Higgins, Alisa M and Howe, Belinda and Huang, David T and Kellum, John A and Mouncey, Paul R and Music, Edvin and Peake, Sandra L and Pike, Francis and Reade, Michael C and Sadique, M. Zia and Singer, Mervyn and Yealy, Donald M and The PRISM Investigators and PRISM Investigators
The New England Journal of Medicine, ISSN 0028-4793, 06/2017, Volume 376, Issue 23, pp. 2223 - 2234
This study presents a patient-level meta-analysis of three recent trials of early, goal-directed therapy for septic shock. Results showed that EGDT did not... 
MORTALITY | TRIAL | MEDICINE, GENERAL & INTERNAL | PERSONALIZED MEDICINE | OUTCOMES | SEVERE SEPSIS | Fluid Therapy | Quality-Adjusted Life Years | Vasoconstrictor Agents - therapeutic use | Resuscitation - economics | Resuscitation - methods | Hospital Mortality | Erythrocyte Transfusion | Humans | Middle Aged | Male | Treatment Outcome | Combined Modality Therapy | Shock, Septic - mortality | Shock, Septic - therapy | Randomized Controlled Trials as Topic | Cardiotonic Agents - therapeutic use | Cost-Benefit Analysis | Survival Analysis | Female | Aged | Infusions, Intravenous | Hospitalization - economics | Practice Guidelines as Topic | Usage | Care and treatment | Therapeutics | Septic shock | Patients | Health aspects | Homeopathy | Materia medica and therapeutics | Shock | Mortality | Clinical trials | Antimicrobial agents | Statistics | Survival | Hypotension | Clinical outcomes | Meta-analysis | Hyperlactatemia | Hospitals | Reviews | Sepsis | Death | Lactic acid | Drug therapy | Index Medicus | Abridged Index Medicus
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4. Full Text ESICM LIVES 2016: part one : Milan, Italy. 1-5 October 2016
by Pizzaballa, M.L and Doronzio, A and Balicco, B and Kiers, H.D and Heijden, W.A. van der and Gerretsen, J and Mast, Q. de and El Messaoudi, S and Rongen, G.A and Gomes, M.E and Kox, M and Pickkers, P and Riksen, N.P and Kashiwagi, Y and Okada, M and Hayashi, K and Inagaki, Y and Fujita, S and Nakamae, M.N and Kang, Y.R and Souza, R.B and Liberatore, A.M and Koh, I.H and Blet, A and Sadoune, M and ARIAM-CARDIAC SURGERY PROJECT AUTHORS and Mid-Norway Sepsis Research Center and LUNG SAFE Investigators and the ESICM Trials Group and ECOCRITIC group and FINNAKI Study Group and for the Xe-HYPOTHECA study group and The Korean Chungcheong Critical Care Research Group and H1N1 SEMICYUC/GETGAG Working Group and NEFROCON Investigators and P-INFECT and KARISMA and LUNG SAFE investigators and the ESICM study group and ARIAM-SEMICYUC Registry Investigators and SICM NICER Group and for the GRAVITY-VAP TRIAL NETWORK and United States Critical Illness and Injury Trials Group/LIPS-B investigators and SIRAKI group and ARIAM Group and Apelin Group and for the Section on Ethics of the ESICM and EXODUS-investigators and The RAPIT Group and CAPCRI Study and Cardiac Arrest Group HUVR and Clinical Intensive Care Research Basel
Intensive Care Medicine Experimental, ISSN 2197-425X, 2016, Volume 4, Issue S1, pp. 27 - 27
Medicine & Public Health | Intensive / Critical Care Medicine
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5. Full Text ESICM LIVES 2016: part three : Milan, Italy. 1-5 October 2016
by Velasquez, T and Mackey, G and Lusk, J and Kyle, U.G and Rood, P.J.T and Frenzel, T and Verhage, R and Bonn, M and Pickkers, P and Hoeven, J.G. van der and Boogaard, M.H.W.A. van den and GETGAG Working Group and JSEPTIC (Japanese Society of Education for Physicians and Trainees in Intensive Care) Clinical Trial Group and PICS- HCPA: Programa Intrahospitalar de Combate à Sepse do Hospital de Clínicas de Porto Alegre and PS-ICU Group and Plug Working Group and FINNRESUSCI Study Group and IPREA Study Group and ENVIN-HELICS Study Group and Tokyo Womens Medical University and from the FROG ICU Investigators and St George’s University of London and The Rapid Diagnosis of Infections in the Critically Ill Team and On behalf of Okayama Research Investigation Organizing Network (ORION)investigators and ARIAM registry of adult cardiac surgery and Student Research Committee - Shiraz University of Medical Sciences and ARIAM-ANDALUCIA and CAPCRI Study and Japan Septic Disseminated Intravascular Coagulation (JSEPTIC DIC) study group and The WIND study group and AKI Research Group and for the ReVA Research Network and the PROVE Network Investigators and GETGAG/SEMICYUC
Intensive Care Medicine Experimental, ISSN 2197-425X, 2016, Volume 4, Issue S1, pp. 28 - 28
Medicine & Public Health | Intensive / Critical Care Medicine
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6. Full Text ESICM LIVES 2016: part one
by L Bos and L Schouten and L van Vught and M Wiewel and D Ong and O Cremer and A Artigas and I Martin-Loeches and A Hoogendijk and T van der Poll and J Horn and N Juffermans and M Schultz and N de Prost and T Pham and G Carteaux and A Mekontso Dessap and C Brun-Buisson and E Fan and G Bellani and J Laffey and A Mercat and L Brochard and B Maitre and P A Howells and D R Thickett and C Knox and D P Park and F Gao and O Tucker and T Whitehouse and D F McAuley and G D Perkins and L Pisani and J P Roozeman and F D Simonis and A Giangregorio and L R Schouten and S M Van der Hoeven and A Serpa Neto and E Festic and A M Dondorp and S Grasso and L D Bos and M J Schultz and M Koster-Brouwer and D Verboom and B Scicluna and K van de Groep and J Frencken and M Bonten and J I Ko and K S Kim and G J Suh and W Y Kwon and K Kim and J H Shin and O T Ranzani and E Prina and R Menendez and A Ceccato and R Mendez and C Cilloniz and A Gabarrus and M Ferrer and A Torres and A Urbano and L A Zhang and D Swigon and F Pike and R S Parker and G Clermont and C Scheer and S O Kuhn and A Modler and M Vollmer and C Fuchs and K Hahnenkamp and S Rehberg and M Gründling and A Taggu and N Darang and N Öveges and I László and K Tánczos and M Németh and G Lebák and B Tudor and D Érces and J Kaszaki and W Huber and D Trásy and Z Molnár and G Ferrara and V S Kanoore Edul and H S Canales and E Martins and C Canullán and G Murias and M O Pozo and ...
Intensive Care Medicine Experimental, 09/2016, Volume 4, Issue 1, pp. 1 - 203
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7. Full Text DALI: Defining Antibiotic Levels in Intensive Care Unit Patients: Are Current beta-Lactam Antibiotic Doses Sufficient for Critically Ill Patients?
by Roberts, JA and Paul, SK and Akova, M and Bassetti, M and De Waele, JJ and Dimopoulos, G and Kaukonen, KM and Koulenti, D and Martin, C and Montravers, P and Rello, J and Rhodes, A and Starr, T and Wallis, SC and Lipman, J and DALI Study
CLINICAL INFECTIOUS DISEASES, ISSN 1058-4838, 04/2014, Volume 58, Issue 8, pp. 1072 - 1083
Background. Morbidity and mortality for critically ill patients with infections remains a global healthcare problem. We aimed to determine whether beta-lactam... 
SURVIVAL | INFECTIOUS DISEASES | MULTICENTER | pharmacodynamics | continuous infusion | extended infusion | MICROBIOLOGY | INFUSION | adverse events | PREVALENCE | IMMUNOLOGY | CEFTAZIDIME | IMPACT | pharmacokinetics | RESISTANCE | SEVERITY | Intensive Care Units | beta-Lactams - pharmacokinetics | Prospective Studies | Blood Chemical Analysis | Bacterial Infections - drug therapy | Humans | Middle Aged | Critical Illness | Male | Treatment Outcome | International Cooperation | Models, Statistical | Microbial Sensitivity Tests | Anti-Bacterial Agents - pharmacokinetics | Female | Aged | Anti-Bacterial Agents - administration & dosage | beta-Lactams - administration & dosage | Logistic regression | Usage | Antibiotics | Pharmacokinetics | Health aspects | Index Medicus
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8. Full Text ESICM LIVES 2016: part two : Milan, Italy. 1-5 October 2016
by Sivakumar, S and Taccone, F.S and Desai, K.S and Rood, P.J.T and Schoor, F. van de and Tertholen, K. van and Pickkers, P and Boogaard, M.H.W.A. van den and TAVeM study group and The FINNAKI Study Group and POPC-CB investigators and DESIRE (DExmedetomidine for Sepsis in ICU Randomized Evaluation) Trial Investigators and PLUG Working group and SIRAKI group and on behalf of Department of Professional Development, ESICM and Nurses of the Central and General ICUs of Shiraz Namazi Hospital and Renal Transplantation HUVR and Grupo ESBAGA and GEMINI and SPACeR group (Surrey Peri-operative, Anaesthesia and Critical Care Collaborative Research Group) and Sedation an Delirium Group Hospital Universitari de Bellvitge and Queen Square Neuroanaesthesia and Neurocritical Care Resreach Group and for the PRoVENT investigators and the PROVE Network and SEMICYUC/GETGAG Working Group and Critical Care Research Group and EDISVAL Group and Bioethics work group of SEMICYUC
Intensive Care Medicine Experimental, ISSN 2197-425X, 2016, Volume 4, Issue S1, pp. 30 - 30
Medicine & Public Health | Intensive / Critical Care Medicine
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9. Full Text ESICM LIVES 2016 : part two : Milan, Italy. 1-5 October 2016
by Sivakumar, S and Taccone, F S and Desai, K A and Lazaridis, C and Skarzynski, M and Sekhon, M and Henderson, W and Griesdale, D and Chapple, L and Deane, A and Williams, L and Strickland, R and Lange, K and Heyland, D and Chapman, M and Rowland, M J and Garry, P and Westbrook, J and Corkill, R and Antoniades, C A and Pattinson, K T and Fatania, G and Strong, A J and Myers, R B and Jermaine, C M and Robertson, C S and Rusin, C G and Hofmeijer, J and Sondag, L and Tjepkema-Cloostermans, M C and Beishuizen, A and Bosch, F H and van Putten, M J A M and Carteron, L and Patet, C and Solari, D and Oddo, M and Dias, C and Almeida, R and Vaz-Ferreira, A and Silva, J and Monteiro, E and Cerejo, A and Rocha, A P and Elsayed, A A and Abougabal, A M and Beshey, B N and Alzahaby, K M and Pozzebon, S and Ortiz, A Blandino and Cristallini, S and Lheureux, O and Brasseur, A and Vincent, J L and Creteur, J and Hravnak, M and Yousef, K and Chang, Y and Crago, E and Friedlander, R M and Abdelmonem, S A and Tahon, S A and Helmy, T A and Meligy, H S and Puig, F and Dunn-Siegrist, I and Pugin, J and Gupta, S and Govil, D and Srinivasan, S and Patel, S J and N, J K and Gupta, A and Tomar, D S and Shafi, M and Harne, R and Arora, D P and Talwar, N and Mazumdar, S and Papakrivou, E E and Makris, D and Manoulakas, E and Tsolaki, B and Karadodas, B and Zakynthinos, E and Garcia, I Palacios and Martin, A Diaz and Encinares, V Sanchez and Ibañez, M Pachón and Montero, J Garnacho and Labrador, G and Cangueiro, T Cebrero and Poulose, V and Koh, J and Kam, J W and Yeter, H and Kara, A and Aktepe, O and Topeli, A and Tsolakoglou, I and ...
Intensive Care Medicine Experimental, ISSN 2197-425X, 09/2016, Volume 4, Issue Suppl 1
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10. Full Text Acute kidney injury in patients with severe sepsis in Finnish Intensive Care Units
by POUKKANEN, M and VAARA, S. T and PETTILÄ, V and KAUKONEN, K.‐M and KORHONEN, A.‐M and HOVILEHTO, S and INKINEN, O and LARU‐SOMPA, R and KAMINSKI, T and REINIKAINEN, M and LUND, V and KARLSSON, S and FINNAKI Study Grp and FINNAKI study group
Acta Anaesthesiologica Scandinavica, ISSN 0001-5172, 08/2013, Volume 57, Issue 7, pp. 863 - 872
BackgroundSevere sepsis is one of the leading causes of acute kidney injury (AKI). Patients with sepsis-associated AKI demonstrate high-hospital mortality. We... 
90-DAY MORTALITY | HYDROXYETHYL STARCH | GUIDELINES | SEPTIC SHOCK | ANESTHESIOLOGY | SURVIVING SEPSIS | ORGAN FAILURE | INFLAMMATORY RESPONSE | CRITICALLY-ILL PATIENTS | EPIDEMIOLOGY | CAMPAIGN | Prospective Studies | Hospital Mortality | Comorbidity | Humans | Middle Aged | Sepsis - epidemiology | Colloids - therapeutic use | Intensive Care Units - statistics & numerical data | Male | Sepsis - complications | Treatment Outcome | Incidence | Multiple Organ Failure - epidemiology | Renal Replacement Therapy - utilization | Mass Screening | Creatinine - blood | Female | Acute Kidney Injury - therapy | Aged | Acute Kidney Injury - epidemiology | Finland - epidemiology | Acute Kidney Injury - etiology | Length of Stay - statistics & numerical data | Sepsis - microbiology | Mortality | Confidence intervals | Sepsis | Intensive care | Index Medicus
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11. Full Text Variability in protein binding of teicoplanin and achievement of therapeutic drug monitoring targets in critically ill patients: Lessons from the DALI Study
by Roberts, J.A and Stove, V and De Waele, J.J and Sipinkoski, B and McWhinney, B and Ungerer, J.P.J and Akova, M and Bassetti, M and Dimopoulos, G and Kaukonen, K.-M and Koulenti, D and Martin, C and Montravers, P and Rello, J and Rhodes, A and Starr, T and Wallis, S.C and Lipman, J and DALI Study Authors
International Journal of Antimicrobial Agents, ISSN 0924-8579, 2014, Volume 43, Issue 5, pp. 423 - 430
Abstract The aims of this study were to describe the variability in protein binding of teicoplanin in critically ill patients as well as the number of patients... 
Infectious Disease | Hypoalbuminaemia | ICU | Antibiotics | Pharmacokinetics | Glycopeptides | Critically ill patients | INFECTIOUS DISEASES | MICROBIOLOGY | PREVALENCE | IMPACT | VANCOMYCIN | AUGMENTED RENAL CLEARANCE | INTENSIVE-CARE-UNIT | PHARMACOLOGY & PHARMACY | STAPHYLOCOCCUS-AUREUS | Humans | Middle Aged | Critical Illness | Anti-Bacterial Agents - metabolism | Male | International Cooperation | Chromatography | Young Adult | Teicoplanin - administration & dosage | Plasma - chemistry | Anti-Bacterial Agents - pharmacokinetics | Protein Binding | Adult | Female | Aged | Teicoplanin - metabolism | Drug Monitoring | Teicoplanin - pharmacokinetics | Anti-Bacterial Agents - administration & dosage | Medicine, Experimental | Medical research | Health aspects | Analysis | Protein binding | Index Medicus | Life Sciences | Human health and pathology | Microbiology and Parasitology | Pharmacology | Infectious diseases | Pharmaceutical sciences
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12. Full Text Comparison of the efficacy and safety of FP-1201-lyo (intravenously administered recombinant human interferon beta-1a) and placebo in the treatment of patients with moderate or severe acute respiratory distress syndrome: Study protocol for a randomized controlled trial
by Bellingan, Geoff and Brealey, David and Mancebo, Jordi and Mercat, Alain and Patroniti, Nicolò and Pettilä, Ville and Quintel, Michael and Vincent, Jean-Louis and Maksimow, Mikael and Jalkanen, Markku and Piippo, Ilse and Ranieri, V.Marco
Trials, ISSN 1745-6215, 11/2017, Volume 18, Issue 1, pp. 536 - 536
Background: Acute respiratory distress syndrome (ARDS) results in vascular leakage, inflammation and respiratory failure. There are currently no approved... 
CD73 | Interferon | Vascular leakage | ARDS | MORTALITY | MEDICINE, RESEARCH & EXPERIMENTAL | COSTS | ACUTE LUNG INJURY | MECHANISMS | OUTCOMES | CARE | Acute respiratory distress syndrome | Medical research | Respiratory distress syndrome | Mortality | Interferon beta | Clinical trials | Medicine, Experimental | Drug therapy | Comparative analysis | Biological response modifiers | Viral antigens | Nucleotidases | Index Medicus
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