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Science, ISSN 0036-8075, 12/2017, Volume 358, Issue 6367, p. eaan4368
Kinase inhibitors are important cancer therapeutics. Polypharmacology is commonly observed, requiring thorough target deconvolution to understand drug... 
REFINEMENT | PROTEIN | CHEMICAL PROTEOMICS | INHIBITOR SELECTIVITY | DATA QUALITY | QUANTIFICATION | MULTIDISCIPLINARY SCIENCES | INTEGRATIVE GENOMICS VIEWER | SALT-INDUCIBLE KINASES | CANCER | COMPREHENSIVE ANALYSIS | fms-Like Tyrosine Kinase 3 - antagonists & inhibitors | Lung Neoplasms - drug therapy | Lung Neoplasms - enzymology | Cytokines - metabolism | Humans | Drug Discovery - methods | Antineoplastic Agents - chemistry | Molecular Targeted Therapy | Xenograft Model Antitumor Assays | Leukemia, Myeloid, Acute - enzymology | Protein Kinase Inhibitors - chemistry | Animals | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Line, Tumor | Leukemia, Myeloid, Acute - drug therapy | Antineoplastic Agents - pharmacology | Mice | Protein Kinase Inhibitors - pharmacology | Proteomics - methods | Salts | Target recognition | Lung cancer | Selectivity | Drug development | Cancer therapies | Signal transduction | Biomolecules | Protein-tyrosine kinase | Tyrosine | Medical research | Imatinib | Decision making | Medical treatment | Mass spectroscopy | Tumor necrosis factor-α | Embryos | Bruton's tyrosine kinase | Mode of action | Side effects | Inhibitors | Interleukin 10 | Affinity | Drug discovery | Mass spectrometry | Acute myeloid leukemia | Drugs | Deregulation | Leukemia | Interleukin | Medical services | Clinical trials | Leucine | Kinases | Biological effects | Epidermal growth factor | Salt-inducible kinase | Xenografts | Cell survival | Epidermal growth factor receptors | Research & development--R&D | Therapeutic applications | Myeloid leukemia | Markers | Data processing | Lead compounds | Leucine zipper proteins | Signaling | Proteomics | Cancer
Journal Article
Molecular and Cellular Proteomics, ISSN 1535-9476, 09/2017, Volume 16, Issue 9, pp. 1563 - 1577
Preserving the native phenotype of primary cells in vitro is a complex challenge. Recently, hydrogel-based cellular matrices have evolved as alternatives to... 
BLOOD-VESSEL MATURATION | UMBILICAL VEIN | IN-VITRO | BIOCHEMICAL RESEARCH METHODS | GENE-EXPRESSION | CDNA ENDS | REGENERATIVE MEDICINE | EXTRACELLULAR-MATRIX | MESENCHYMAL TRANSITION | MASSIVE ANALYSIS | VON-WILLEBRAND-FACTOR | Human Umbilical Vein Endothelial Cells - drug effects | Human Umbilical Vein Endothelial Cells - metabolism | Cell Separation | Humans | RNA, Messenger - genetics | Cells, Cultured | Gene Expression Profiling | Transcriptome - genetics | RNA, Messenger - metabolism | Cell Differentiation - drug effects | Human Umbilical Vein Endothelial Cells - cytology | Proteomics | Collagen - pharmacology | Cellulose - pharmacology | Proteome - metabolism | Cluster Analysis | Cluster analysis | Cell culture | Hydrogels | Cellulose | Differentiation (biology) | Biosynthesis | Culture techniques | Biomaterials | Proteins | Genotype & phenotype | Network analysis | Cell cycle | Bacteria | Protein-tyrosine kinase receptors | Protein-tyrosine kinase | Tyrosine | Biodegradation | CD34 antigen | Polystyrene resins | Statistical analysis | Cultivation | Vector quantization | Extracellular signal-regulated kinase | Protein biosynthesis | Inflammation | Gene expression | Clustering | Cell differentiation | Polystyrene | Endothelial cells | 1-Phosphatidylinositol 3-kinase | Signaling | Collagen | Plastics | Umbilical vein | Research
Journal Article
Journal Article
Analytical Chemistry, ISSN 0003-2700, 09/2017, Volume 89, Issue 17, p. 8884
Offline two-dimensional chromatography is a common means to achieve deep proteome coverage. To reduce sample complexity and dynamic range and to utilize mass... 
Cation exchange | Solvents | Fractionation | Automation | Peptides | Workflow | Cation exchanging | Tumor cell lines | Orthogonality | pH effects | Chromatography | Proteins | Anion exchange | Pancreatic cancer | Desalination | Acetonitrile | Anion exchanging | Two dimensional analysis | Cancer
Journal Article
Biometals, ISSN 0966-0844, 2015, Volume 28, Issue 3, p. 577
After Ctr1-mediated copper ion (Cu) entry into the human cytoplasm, chaperones Atox1 and CCS deliver Cu to P1B-type ATPases and to superoxide dismutase,... 
Biological Sciences | Biofysik | Molecular Chaperones | Humans | Biophysics | Chromatography | Gel | Biokemi och molekylärbiologi | Biologiska vetenskaper | Metallochaperones | Protein Binding | Biochemistry and Molecular Biology | metabolism | Copper | Cytoplasm
Journal Article
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