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1. Full Text Sirt1 Protects against High-Fat Diet-Induced Metabolic Damage
by Paul T. Pfluger and Daniel Herranz and Susana Velasco-Miguel and Manuel Serrano and Matthias H. Tschöp
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2008, Volume 105, Issue 28, pp. 9793 - 9798
The identification of new pharmacological approaches to effectively prevent, treat, and cure the metabolic syndrome is of crucial importance. Excessive... 
Energy metabolism | Cellular metabolism | Transgenic animals | Liver | Insulin resistance | Lipids | Mice | Inflammation | Lipid metabolism | High fat diet | Sirtuins | NFκB | Metabolism | Steatosis | OXIDATIVE STRESS | DEPENDENT TRANSCRIPTION | sirtuins | MULTIDISCIPLINARY SCIENCES | IKK-BETA | NONALCOHOLIC STEATOHEPATITIS | LIVER-DISEASE | STIMULATED INSULIN-SECRETION | inflammation | IN-VIVO | RESISTANCE | metabolism | steatosis | NF-KAPPA-B | NF kappa B | CALORIE RESTRICTION | Dietary Fats - adverse effects | Superoxide Dismutase - genetics | Protective Agents | Gene Expression Regulation | Insulin Resistance | Sirtuins - physiology | Mice, Transgenic | Nuclear Respiratory Factor 1 - genetics | Fatty Liver | Animals | Diet | Sirtuin 1 | Proteins | Usage | Metabolic syndrome X | Drug therapy | Properties | Health aspects | Ketogenic diet | Biological Sciences
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2. Full Text Profound weight loss induces reactive astrogliosis in the arcuate nucleus of obese mice
by Harrison, Luke and Pfuhlmann, Katrin and Schriever, Sonja C and Pfluger, Paul T
Molecular Metabolism, ISSN 2212-8778, 06/2019, Volume 24, pp. 149 - 155
Objective: Obesity has been linked to an inflammation like state in the hypothalamus, mainly characterized by reactive gliosis (RG) of astrocytes and... 
Reactive gliosis | Obesity | Inflammation | Astrocyte | Hypothalamus | Weight loss
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3. Full Text CNS-targeting pharmacological interventions for the metabolic syndrome
by Stemmer, Kerstin and Müller, Timo D and DiMarchi, Richard D and Pfluger, Paul T and Tschöp, Matthias H
Journal of Clinical Investigation, ISSN 0021-9738, 10/2019, Volume 129, Issue 10, pp. 4058 - 4071
The metabolic syndrome (MetS) encompasses medical conditions such as obesity, hyperglycemia, high blood pressure, and dyslipidemia that are major drivers for... 
Drugs | Peptides | Dyslipidemia | Body weight loss | Metabolic syndrome | Hyperglycemia | Energy | Metabolites | Surgery | Blood pressure | Diabetes mellitus (non-insulin dependent) | Food | Hypertension | Appetite | Obesity | Dopamine | Complications | Diabetes mellitus | Insulin | Weight control | Diabetes | Gastrointestinal surgery | Alzheimers disease | Cardiovascular diseases | Metabolic disorders
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4. Full Text Sirtuin 1 and sirtuin 3: Physiological modulators of metabolism
by Nogueiras, Ruben and Habegger, Kirk M and Chaudhary, Nilika and Finan, Brian and Banks, Alexander S and Dietrich, Marcelo O and Horvath, Tamas L and Sinclair, David A and Pfluger, Paul T and Tschöp, Matthias H
Physiological Reviews, ISSN 0031-9333, 07/2012, Volume 92, Issue 3, pp. 1479 - 1514
Nogueiras R, Habegger KM, Chaudhary N, Finan B, Banks AS, Dietrich MO, Horvath TL, Sinclair DA, Pfluger PT, Tschop MH. Sirtuin 1 and Sirtuin 3: Physiological... 
LIFE-SPAN EXTENSION | PHYSIOLOGY | ACTIVATED PROTEIN-KINASE | STIMULATED INSULIN-SECRETION | FATTY-ACID OXIDATION | DNA-DAMAGE RESPONSE | PANCREATIC BETA-CELLS | FOXO TRANSCRIPTION FACTORS | SUPRACHIASMATIC NUCLEUS LESIONS | SMALL-MOLECULE ACTIVATORS | DEPENDENT HISTONE DEACETYLASE | Enzyme Activators - pharmacology | Sirtuin 1 - metabolism | Genetic Predisposition to Disease | Sirtuin 3 - genetics | Sirtuin 3 - metabolism | Humans | Homeostasis | Models, Molecular | Metabolic Diseases - drug therapy | Signal Transduction - genetics | Structure-Activity Relationship | Circadian Rhythm | Sirtuin 1 - genetics | Polymorphism, Genetic | Phenotype | Animals | Metabolic Diseases - metabolism | Signal Transduction - drug effects | Metabolic Diseases - genetics | Protein Conformation | Enzyme Activation | Energy Metabolism - genetics | Energy Metabolism - drug effects | Enzymes | Cell metabolism | Causes of | Metabolic diseases | NAD (Coenzyme) | Regulation | Research | Health aspects
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5. Full Text A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents
by Finan, Brian and Yang, Bin and Ottaway, Nickki and Smiley, David L and Ma, Tao and Clemmensen, Christoffer and Chabenne, Joe and Zhang, Lianshan and Habegger, Kirk M and Fischer, Katrin and Campbell, Jonathan E and Sandoval, Darleen and Seeley, Randy J and Bleicher, Konrad and Uhles, Sabine and Riboulet, William and Funk, Jürgen and Hertel, Cornelia and Belli, Sara and Sebokova, Elena and Conde-Knape, Karin and Konkar, Anish and Drucker, Daniel J and Gelfanov, Vasily and Pfluger, Paul T and Müller, Timo D and Perez-Tilve, Diego and DiMarchi, Richard D and Tschöp, Matthias H
Nature Medicine, ISSN 1078-8956, 12/2014, Volume 21, Issue 1, pp. 27 - 36
We report the discovery of a new monomeric peptide that reduces body weight and diabetic complications in rodent models of obesity by acting as an agonist at... 
MEDICINE, RESEARCH & EXPERIMENTAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | WEIGHT-LOSS | ADULTS | GLP-1 RECEPTOR ACTIVATION | CONTROLLED-RELEASE PHENTERMINE/TOPIRAMATE | GLUCAGON RECEPTORS | CELL BIOLOGY | HYBRID PEPTIDE | LEPTIN RESPONSIVENESS | GLUCOSE | TRIPLE-ACTING AGONIST | FAT-FED MICE | Obesity - drug therapy | Diabetes Mellitus, Type 2 - genetics | Humans | Diabetes Mellitus, Type 2 - metabolism | Receptors, Gastrointestinal Hormone - metabolism | Body Weight - genetics | Insulin - biosynthesis | Obesity - genetics | Receptors, Gastrointestinal Hormone - agonists | Peptides - administration & dosage | Peptides - chemical synthesis | Peptides - metabolism | Glucagon-Like Peptide 1 - agonists | HEK293 Cells | Diabetes Complications - genetics | Receptors, Glucagon - agonists | Glucagon-Like Peptide 1 - metabolism | Diabetes Complications - metabolism | Rodentia | Rats | Receptors, Glucagon - metabolism | Diabetes Complications - drug therapy | Obesity - metabolism | Blood Glucose - drug effects | Insulin - metabolism | Animals | Mice | Diabetes Mellitus, Type 2 - drug therapy | Prevention | Obesity | Complications and side effects | Care and treatment | Peptides | Physiological aspects | Diabetes | Research | Risk factors | Pharmacology | Rodents
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6. Full Text Metabolic benefits from Sirt1 and Sirt1 activators
by Chaudhary, Nilika and Pfluger, Paul T
Current Opinion in Clinical Nutrition and Metabolic Care, ISSN 1363-1950, 07/2009, Volume 12, Issue 4, pp. 431 - 437
PURPOSE OF REVIEWTo evaluate the role of mammalian Sirt1 and Sirt1 activators in the protection from metabolic disorders such as diet-induced obesity, diabetes... 
Metabolic disorder | Sirt1 | Sirtuin | Nicotinamide adenine dinucleotide (NAD | Resveratrol | nicotinamide adenine dinucleotide (NAD(+)) | LIFE-SPAN | FATTY LIVER-DISEASE | MITOCHONDRIAL-FUNCTION | SACCHAROMYCES-CEREVISIAE | NUTRITION & DIETETICS | STIMULATED INSULIN-SECRETION | sirtuin | metabolic disorder | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION | PANCREATIC BETA-CELLS | resveratrol | NF-KAPPA-B | SMALL-MOLECULE ACTIVATORS | CALORIE RESTRICTION | AMP-Activated Protein Kinases - metabolism | Stilbenes - therapeutic use | Caloric Restriction | Humans | Mice, Transgenic | Animals | Diet | Sirtuin 1 | Trans-Activators - genetics | Trans-Activators - metabolism | Transcription, Genetic | Mice | Diabetes Mellitus, Type 2 - drug therapy | Energy Metabolism - genetics | Energy Metabolism - physiology | Sirtuins - genetics | Sirtuins - metabolism | NAD - metabolism | Disease Models, Animal
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7. Full Text A guide to analysis of mouse energy metabolism
by Tschöp, Matthias H and Speakman, John R and Arch, Jonathan R. S and Auwerx, Johan and Brüning, Jens C and Chan, Lawrence and Eckel, Robert H and Farese Jr, Robert V and Galgani, Jose E and Hambly, Catherine and Herman, Mark A and Horvath, Tamas L and Kahn, Barbara B and Kozma, Sara C and Maratos-Flier, Eleftheria and Müller, Timo D and Münzberg, Heike and Pfluger, Paul T and Plum, Leona and Reitman, Marc L and Rahmouni, Kamal and Shulman, Gerald I and Thomas, George and Kahn, C Ronald and Ravussin, Eric
Nature Methods, ISSN 1548-7091, 01/2012, Volume 9, Issue 1, pp. 57 - 63
We present a consolidated view of the complexity and challenges of designing studies for measurement of energy metabolism in mouse models, including a... 
BEHAVIOR | TISSUE | BIOCHEMICAL RESEARCH METHODS | FAT-FREE MASS | MALE-MICE | BODY-COMPOSITION | DIET-INDUCED OBESITY | STRESS | EXPENDITURE | CALORIMETER | AGE | Body Composition | Phenotype | Animals | Energy Metabolism | Housing, Animal | Environment | Obesity - etiology | Energy Intake | Mice, Mutant Strains - genetics | Mice - physiology | Usage | Energy metabolism | Bioenergetics | Body weight | Practice guidelines (Medicine) | Research | Statistical analysis | Metabolism | Rodents
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8. Full Text Astrocytic Insulin Signaling Couples Brain Glucose Uptake with Nutrient Availability
by García-Cáceres, Cristina and Quarta, Carmelo and Varela, Luis and Gao, Yuanqing and Gruber, Tim and Legutko, Beata and Jastroch, Martin and Johansson, Pia and Ninkovic, Jovica and Yi, Chun-Xia and Le Thuc, Ophelia and Szigeti-Buck, Klara and Cai, Weikang and Meyer, Carola W and Pfluger, Paul T and Fernandez, Ana M and Luquet, Serge and Woods, Stephen C and Torres-Alemán, Ignacio and Kahn, C. Ronald and Götz, Magdalena and Horvath, Tamas L and Tschöp, Matthias H
Cell, ISSN 0092-8674, 08/2016, Volume 166, Issue 4, pp. 867 - 880
We report that astrocytic insulin signaling co-regulates hypothalamic glucose sensing and systemic glucose metabolism. Postnatal ablation of insulin receptors... 
astrocytes | insulin receptor | glucose uptake | hypothalamus | LEPTIN | CIRCUITS | BODY-WEIGHT | CELLS | TRANSPORTER | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | BARRIER | MICE | ENERGY-METABOLISM | NEURONAL DYSFUNCTION | CELL BIOLOGY | Glial Fibrillary Acidic Protein - genetics | Signal Transduction | Endoplasmic Reticulum - metabolism | Homeostasis | Amino Acid Transport System X-AG - genetics | Neurons - cytology | Mitochondria - metabolism | Glial Fibrillary Acidic Protein - metabolism | Pro-Opiomelanocortin - metabolism | Insulin - metabolism | Amino Acid Transport System X-AG - metabolism | Animals | Hypothalamus - metabolism | Receptor, Insulin - genetics | Glucose - metabolism | Receptor, Insulin - metabolism | Mice | Neurons - metabolism | Astrocytes - metabolism | Blood-Brain Barrier | Glucose metabolism | Stem cell research | Medical colleges | Blood sugar monitoring | Neurons | Stem cells | Glucose | Glutamate | Intermediate filament proteins | Insulin | Dextrose | Neurophysiology
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9. Full Text Regulation of the endosomal SNX27-retromer by OTULIN
by Stangl, A and Elliott, PR and Pinto-Fernandez, A and Bonham, S and Harrison, L and Schaub, A and Kutzner, K and Keusekotten, K and Pfluger, PT and El Oualid, F and Kessler, BM and Komander, D and Krappmann, D
NATURE COMMUNICATIONS, ISSN 2041-1723, 09/2019, Volume 10, Issue 1, pp. 1 - 18
OTULIN (OTU Deubiquitinase With Linear Linkage Specificity) specifically hydrolyzes methionine1 (Met1)-linked ubiquitin chains conjugated by LUBAC (linear... 
MET1-LINKED UBIQUITINATION | RETROMER | PROTEIN | PDZ DOMAIN | GLUCOSE | MULTIDISCIPLINARY SCIENCES | LUBAC | BINDING | REVEALS | Ubiquitin | Cargo | Homeostasis | Chains | Catalytic activity | Cell surface | Spectrometry | Membrane trafficking | Recycling | Catalysis | Protein transport | Nexin | Assembly | Binding sites
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10. Full Text Synaptic input organization of the melanocortin system predicts diet-induced hypothalamic reactive gliosis and obesity
by Tamas L. Horvath and Beatrix Sarman and Cristina García-Cáceres and Pablo J. Enriori and Peter Sotonyi and Marya Shanabrough and Erzsebet Borok and Jesus Argente and Julie A. Chowen and Diego Perez-Tilve and Paul T. Pfluger and Hella S. Brönneke and Barry E. Levin and Sabrina Diano and Michael A. Cowley and Matthias H. Tschöp and Jeffrey M. Friedman
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2010, Volume 107, Issue 33, pp. 14875 - 14880
The neuronal circuits involved in the regulation of feeding behavior and energy expenditure are soft-wired, reflecting the relative activity of the... 
Obesity | Gliosis | Neurons | Neuroglia | Arcuate nucleus | Body weight | Rats | Melanocortins | Mice | Synapses | Brain | Inflammation | Vulnerability | High-fat diet | Synaptic plasticity | Immunohistochemistry | Synaptic Transmission - physiology | Melanocortins - metabolism | Male | Neuropeptide Y - metabolism | Neurons - ultrastructure | Synapses - metabolism | Female | Obesity - etiology | Neurons - metabolism | Arcuate Nucleus of Hypothalamus - pathology | Gliosis - etiology | Dietary Fats - adverse effects | Arcuate Nucleus of Hypothalamus - metabolism | Gliosis - metabolism | Mice, Inbred C57BL | Mice, Transgenic | Arcuate Nucleus of Hypothalamus - physiopathology | Hypothalamus - pathology | Microscopy, Electron | Hypothalamus - physiopathology | Rats, Sprague-Dawley | Obesity - metabolism | Pro-Opiomelanocortin - metabolism | Animals | Hypothalamus - metabolism | Diet | DEFENSE | MECHANISM | FOOD-INTAKE | GHRELIN | MULTIDISCIPLINARY SCIENCES | NPY/AGRP NEURONS | RATS | vulnerability | brain | ARCUATE NUCLEUS | BODY-WEIGHT | inflammation | high-fat diet | synaptic plasticity | LEPTIN RESISTANCE | FEEDING CIRCUITS | Neuroplasticity | Physiological aspects | Hypothalamus | Research | Properties | Neuropeptide Y | Brain architecture | Feeding behavior | Circuits | Blood vessels | Energy expenditure | Melanocortin | Data processing | Proopiomelanocortin | Neuronal-glial interactions | High fat diet | Diets | Blood-brain barrier | Dendrites | Cell body | Biological Sciences
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11. Full Text Obesity: Will withaferin win the war?
by Pfluger, Paul T and Tschöp, Matthias H
Nature Medicine, ISSN 1078-8956, 09/2016, Volume 22, Issue 9, pp. 970 - 971
A new study shows that withaferin A, a steroidal lactone isolated from Withania somnifera, can exert profound metabolic benefits in mice, including body-weight... 
CELASTROL | MEDICINE, RESEARCH & EXPERIMENTAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | Withanolides | Obesity | Humans | Care and treatment | Usage | Leptin | Analysis | Surgery | Drug therapy | Steroids
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12. Full Text GOAT links dietary lipids with the endocrine control of energy balance
by Willency, Jill A and Czyzyk, Traci A and Joost, Hans-Georg and Jandacek, Ronald J and Solenberg, Patricia J and Heiman, Mark L and Kirchner, Henriette and Hale, John E and Schürmann, Annette and Tschöp, Matthias H and Pfluger, Paul T and Gutierrez, Jesus A
Nature Medicine, ISSN 1078-8956, 07/2009, Volume 15, Issue 7, pp. 741 - 745
Central nervous system nutrient sensing and afferent endocrine signaling have been established as parallel systems communicating metabolic status and energy... 
MEDICINE, RESEARCH & EXPERIMENTAL | HORMONE | METABOLISM | CHAIN FATTY-ACIDS | FOOD-INTAKE | GHRELIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | SECRETION | IDENTIFICATION | PEPTIDE | CELL BIOLOGY | Acyltransferases - physiology | Ghrelin - physiology | Mice, Inbred C57BL | Ghrelin - genetics | RNA, Messenger - analysis | Acyltransferases - genetics | Mice, Knockout | Ghrelin - blood | Animals | Energy Metabolism | Dietary Fats - administration & dosage | Signal Transduction - physiology | Triglycerides - therapeutic use | Mice | Energy metabolism | Bioenergetics | Ghrelin | Central nervous system | Physiological aspects | Dietary fat | Research | Lipids | Neurosciences | Hormones | Metabolism | Endocrinology
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