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Public Budgeting & Finance, ISSN 0275-1100, 2013, Volume 33, Issue 3, pp. 96 - 114
  This paper reviews the main conceptual issues regarding the notion of Opportunity Cost of Public Funds (OCPF) and its use in normative economics. Despite the... 
Government spending | Opportunity costs | Public sector | Pension funds
Journal Article
Nature Communications, ISSN 2041-1723, 12/2017, Volume 8, Issue 1, pp. 2176 - 15
Microbial nucleic acid recognition serves as the major stimulus to an antiviral response, implying a requirement to limit the misrepresentation of self nucleic... 
AICARDI-GOUTIERES-SYNDROME | SYSTEMIC-LUPUS-ERYTHEMATOSUS | ACTIVE ENZYME | MAMMALIAN DNA | MULTIDISCIPLINARY SCIENCES | ALPHA | INFLAMMATORY DISEASE | DEOXYRIBONUCLEASE-II | MUTATIONS | EXONUCLEASE TREX1 | NUCLEIC-ACIDS | Endodeoxyribonucleases - immunology | Phosphorylation | Deoxyribonucleases - deficiency | Humans | RNA, Messenger - analysis | Male | Gene Expression Profiling | Erythroblasts - immunology | Signal Transduction - immunology | Deoxyribonucleases - immunology | STAT1 Transcription Factor - metabolism | Female | Endodeoxyribonucleases - deficiency | Child | STAT3 Transcription Factor - metabolism | Interferon-alpha - metabolism | Antiviral Agents - pharmacology | Hereditary Autoinflammatory Diseases - blood | Hereditary Autoinflammatory Diseases - enzymology | Hereditary Autoinflammatory Diseases - immunology | Interferon-alpha - immunology | Up-Regulation - drug effects | Deoxyribonucleases - genetics | Hematopoiesis - immunology | Endodeoxyribonucleases - genetics | Sequence Analysis, RNA | Interferon-alpha - blood | Adolescent | Mutation | Hereditary Autoinflammatory Diseases - genetics | Glomerulonephritis | Neonates | Deformation | Liver | Antibodies | α-Interferon | Microorganisms | Lymphocytes | Hematopoiesis | Peripheral blood | Anti-DNA antibodies | Stat1 protein | Enzyme-linked immunosorbent assay | Deoxyribonucleic acid--DNA | Deoxyribonuclease | Hematology | Anemia | Stat3 protein | Nucleic acids | Ribonucleic acid--RNA | Hemopoiesis | Signaling | Monocytes | Erythroblasts | Fibrosis | Interferon | Endonuclease | Life Sciences | Immunology
Journal Article
Nature Communications, ISSN 2041-1723, 12/2019, Volume 10, Issue 1, pp. 2198 - 12
Many gene fusions are reported in tumours and for most their role remains unknown. As fusions are used for diagnostic and prognostic purposes, and are targets... 
DRUG-SENSITIVITY | ONCOPROTEIN | EFFICACY | PATHWAY | LANDSCAPE | MULTIDISCIPLINARY SCIENCES | KINASE | RESISTANCE | MARKERS | INHIBITOR | ROS1 | CRISPR | Pharmacology | Tumor cell lines | Ribonucleic acid--RNA | Carcinogenesis | Gene sequencing | Yes-associated protein | Carcinogens | Cell lines | Diagnostic systems | Cancer | Tumors | Fitness
Journal Article
Cancer Research, ISSN 0008-5472, 07/2017, Volume 77, Issue 13 Supplement, pp. 3151 - 3151
Journal Article
EMBO Molecular Medicine, ISSN 1757-4676, 03/2017, Volume 9, Issue 3, pp. 293 - 303
In colorectal cancer (CRC), WNT pathway activation by genetic rearrangements of RSPO3 is emerging as a promising target. However, its low prevalence severely... 
Flow cytometry | Data analysis | Wnt protein | Transcription | RNA-mediated interference | Colorectal carcinoma | Colorectal cancer | Stroma | Genomes | Gene expression | Hypotheses | Cell lines | Stem cells | Mutation | Bioinformatics
Journal Article
Cancer Discovery, ISSN 2159-8274, 05/2017, Volume 7, Issue 5, pp. 456 - 458
A study by Pauli and colleagues in this issue of Cancer Discovery describes the creation of a precision cancer platform for patients with advanced disease,... 
ONCOLOGY | Heterografts | Organoids | Sequence Analysis, DNA | Humans | Neoplasms | Precision Medicine
Journal Article
Cancer Research, ISSN 0008-5472, 07/2016, Volume 76, Issue 14 Supplement, pp. LB-213 - LB-213
Journal Article
Scientific Reports, ISSN 2045-2322, 09/2015, Volume 5, Issue 1, p. 14721
We developed a selectable marker rendering human cells resistant to Diphtheria Toxin (DT). The marker (DTR) consists of a primary microRNA sequence engineered... 
CANCER CELLS | EGF | DIPHTHAMIDE BIOSYNTHESIS | MULTIDISCIPLINARY SCIENCES | GROWTH | TUMOR-TISSUE | RECEPTOR | GENE-TRANSFER | VIRAL VECTORS | EXPRESSION | MOUSE MODELS | Cell Line | Gene Expression | Transduction, Genetic | Humans | Gene Silencing | Diphtheria Toxin - toxicity | Proteins - genetics | Drug Resistance - genetics | Animals | Heterografts | Transfection | Mice | MicroRNAs - genetics | Genetic Vectors | Transgenes
Journal Article
Clinical cancer research : an official journal of the American Association for Cancer Research, ISSN 1078-0432, 08/2019
Patient-derived xenograft (PDX) models accurately recapitulate the tumor of origin in terms of histopathology, genomic landscape, and therapeutic response, but... 
Journal Article
Cancer Research, ISSN 0008-5472, 08/2015, Volume 75, Issue 15 Supplement, pp. 583 - 583
Journal Article
Cancer Research, ISSN 0008-5472, 08/2015, Volume 75, Issue 15 Supplement, pp. 916 - 916
Journal Article
Journal of the National Cancer Institute, ISSN 0027-8874, 2017, Volume 109, Issue 2, p. djw209
Background: The NEDD8 conjugation pathway modulates the ubiquitination and activity of a wide range of intracellular proteins, and its blockade by pevonedistat... 
GROWTH-FACTOR RECEPTOR | NAE INHIBITOR | ONCOLOGY | NEDDYLATION | NEDD8-ACTIVATING ENZYME-INHIBITOR | ANTI-EGFR THERAPY | CHECKPOINT ACTIVATION | PEVONEDISTAT MLN4924 | TNF-ALPHA | CELL-LINES | UP-REGULATION | Neoplasm Transplantation | Adenocarcinoma, Mucinous - pathology | Apoptosis - drug effects | DNA Replication - drug effects | Proto-Oncogene Proteins p21(ras) - genetics | Colorectal Neoplasms - genetics | Humans | Transcriptome | Antineoplastic Agents - therapeutic use | Cetuximab - therapeutic use | CDX2 Transcription Factor - genetics | Keratin-20 - genetics | Neoplasm Grading | Colorectal Neoplasms - drug therapy | Female | Antineoplastic Agents - pharmacology | Adenocarcinoma, Mucinous - drug therapy | Cadherins - genetics | Ubiquitins - metabolism | NEDD8 Protein | Cyclopentanes - pharmacology | Pyrimidines - pharmacology | Homeodomain Proteins - genetics | Disease-Free Survival | Drug Resistance, Neoplasm - genetics | Animals | Signal Transduction - drug effects | Proto-Oncogene Proteins B-raf - genetics | Pyrimidines - therapeutic use | Cell Line, Tumor | Cyclopentanes - therapeutic use | Cell Proliferation - drug effects | Mice | Adenocarcinoma, Mucinous - genetics | Colorectal Neoplasms - pathology | Ubiquitins - antagonists & inhibitors | Care and treatment | Colorectal cancer | Development and progression | Genetic aspects | Cellular signal transduction | Ubiquitin-proteasome system | Health aspects
Journal Article
Journal Article