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1. Full Text The FANCM-BLM-TOP3A-RMI complex suppresses alternative lengthening of telomeres (ALT)
by Lu, Robert and O’Rourke, Julienne J and Sobinoff, Alexander P and Allen, Joshua A. M and Nelson, Christopher B and Tomlinson, Christopher G and Lee, Michael and Reddel, Roger R and Deans, Andrew J and Pickett, Hilda A
Nature Communications, ISSN 2041-1723, 12/2019, Volume 10, Issue 1, pp. 2252 - 14
The collapse of stalled replication forks is a major driver of genomic instability. Several committed mechanisms exist to resolve replication stress. These... 
Neoplasms - metabolism | DNA Topoisomerases, Type I - metabolism | RecQ Helicases - metabolism | HCT116 Cells | Humans | DNA Replication | Nuclear Proteins - metabolism | Telomere Homeostasis | DNA-Binding Proteins - metabolism | DNA Helicases - metabolism | Carrier Proteins - metabolism | HEK293 Cells | Cell Line, Tumor | Telomere - metabolism | HeLa Cells | Collapse | Complex formation | Stability | Anemia | Translocase | Fanconi syndrome | Substrates | Stress | Genomic instability | Replication forks | DNA biosynthesis | Telomeres | Depletion | Synthesis | Biomarkers | Replication | Attenuation | Bioindicators | Telomerase | Deoxyribonucleic acid--DNA | Cancer
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2. Full Text Enhanced cardiac repair by telomerase reverse transcriptase over-expression in human cardiac mesenchymal stromal cells
by Le, TL and Pickett, HA and Yang, A and Ho, JWK and Thavapalachandran, S and Igoor, S and Yang, SF and Farraha, M and Voges, HK and Hudson, JE and dos Remedios, CG and Bryan, TM and Kizana, E and Chong, JJH
SCIENTIFIC REPORTS, ISSN 2045-2322, 07/2019, Volume 9, Issue 1, pp. 10579 - 17
We have previously reported a subpopulation of mesenchymal stromal cells (MSCs) within the platelet-derived growth factor receptor-alpha (PDGFR alpha)/CD90... 
PROGENITOR CELLS | OVEREXPRESSION | STEM-CELLS | MYOCARDIAL-INFARCTION | ANGIOGENESIS | GENE | MULTIDISCIPLINARY SCIENCES | HEART-FAILURE | TISSUE-REPAIR | ASSOCIATION | FIBROBLASTS | Heart | Cell proliferation | Myocardial infarction | Heart attacks | RNA-directed DNA polymerase | Platelet-derived growth factor | Cell survival | Telomerase reverse transcriptase | Mesenchyme | Paracrine signalling | Innate immunity | Mass spectroscopy | Transplantation | Cell differentiation | CD90 antigen | Angiogenesis | Overexpression | Stromal cells | Ventricle | Telomerase
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3. Full Text Telomere sequence content can be used to determine ALT activity in tumours
by Lee, Michael and Teber, Erdahl T and Holmes, Oliver and Nones, Katia and Patch, Ann-Marie and Dagg, Rebecca A and Lau, Loretta M S and Lee, Joyce H and Napier, Christine E and Arthur, Jonathan W and Grimmond, Sean M and Hayward, Nicholas K and Johansson, Peter A and Mann, Graham J and Scolyer, Richard A and Wilmott, James S and Reddel, Roger R and Pearson, John V and Waddell, Nicola and Pickett, Hilda A
Nucleic Acids Research, ISSN 0305-1048, 06/2018, Volume 46, Issue 10, pp. 4903 - 4918
Abstract The replicative immortality of human cancer cells is achieved by activation of a telomere maintenance mechanism (TMM). To achieve this, cancer cells... 
SURVIVAL | TERT PROMOTER MUTATIONS | STEM-CELLS | MELANOMA | MECHANISM | DNA | BIOCHEMISTRY & MOLECULAR BIOLOGY | PANCREATIC NEUROENDOCRINE TUMORS | ATRX | CANCER | TUMORIGENESIS | Promoter Regions, Genetic | Computational Biology - methods | Humans | Databases, Genetic | Neoplasms - mortality | Telomere Homeostasis - genetics | Machine Learning | X-linked Nuclear Protein - genetics | Whole Exome Sequencing | Telomerase - genetics | Neoplasms - genetics | Melanoma - genetics | Adaptor Proteins, Signal Transducing - genetics | Survival Analysis | Female | Mutation | Nuclear Proteins - genetics | Melanoma - mortality | Telomere - genetics | Computational Biology
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4. Full Text DKC1 is a transcriptional target of GATA1 and drives upregulation of telomerase activity in normal human erythroblasts
by Richards, Laura A and Kumari, Ashu and Knezevic, Kathy and Thoms, Julie Ai and von Jonquieres, Georg and Napier, Christine E and Ali, Zara and O'Brien, Rosemary and Marks-Bluth, Jonathon and Maritz, Michelle F and Pickett, Hilda A and Morris, Jonathan and Pimanda, John E and MacKenzie, Karen L
Haematologica, ISSN 0390-6078, 08/2019, p. haematol.2018.215699
Telomerase is a ribonucleoprotein complex that maintains the length and integrity of telomeres to enable ongoing cellular proliferation. Understanding the... 
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5. Full Text Molecular mechanisms of activity and derepression of alternative lengthening of telomeres
by Pickett, Hilda A and Reddel, Roger R
Nature Structural and Molecular Biology, ISSN 1545-9993, 11/2015, Volume 22, Issue 11, pp. 875 - 880
Alternative lengthening of telomeres (ALT) involves homology-directed telomere synthesis. This multistep process is facilitated by loss of the ATRX or DAXX... 
IMMORTALIZED CELLS | MAMMALIAN TELOMERES | BIOCHEMISTRY & MOLECULAR BIOLOGY | ALT CELLS | VARIANT REPEATS | CELL BIOLOGY | GENOME INSTABILITY | CAENORHABDITIS-ELEGANS | BIOPHYSICS | EMBRYONIC STEM-CELLS | EPIGENETIC REGULATION | HOMOLOGOUS RECOMBINATION | BREAK-INDUCED REPLICATION | DNA Helicases - metabolism | Homologous Recombination | Nuclear Proteins - metabolism | Telomere - metabolism | Telomere Homeostasis | Cellular proteins | DNA synthesis | Research | Chromosomes | Cellular biology | Telomerase | Deoxyribonucleic acid--DNA
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6. Full Text Corrigendum: Whole-genome landscape of pancreatic neuroendocrine tumours
by Scarpa, Aldo and Chang, David K and Nones, Katia and Corbo, Vincenzo and Patch, Ann-Marie and Bailey, Peter and Lawlor, Rita T and Johns, Amber L and Miller, David K and Mafficini, Andrea and Rusev, Borislav and Scardoni, Maria and Antonello, Davide and Barbi, Stefano and Sikora, Katarzyna O and Cingarlini, Sara and Vicentini, Caterina and McKay, Skye and Quinn, Michael C J and Bruxner, Timothy J C and Christ, Angelika N and Harliwong, Ivon and Idrisoglu, Senel and McLean, Suzanne and Nourse, Craig and Nourbakhsh, Ehsan and Wilson, Peter J and Anderson, Matthew J and Fink, J Lynn and Newell, Felicity and Waddell, Nick and Holmes, Oliver and Kazakoff, Stephen H and Leonard, Conrad and Wood, Scott and Xu, Qinying and Hiriyur Nagaraj, Shivashankar and Amato, Eliana and Dalai, Irene and Bersani, Samantha and Cataldo, Ivana and Dei Tos, Angelo P and Capelli, Paola and Vittoria Davì, Maria and Landoni, Luca and Malpaga, Anna and Miotto, Marco and Whitehall, Vicki L J and Leggett, Barbara A and Harris, Janelle L and Harris, Jonathan and Jones, Marc D and Humphris, Jeremy and Chantrill, Lorraine A and Chin, Venessa and Nagrial, Adnan M and Pajic, Marina and Scarlett, Christopher J and Pinho, Andreia and Rooman, Ilse and Toon, Christopher and Wu, Jianmin and Pinese, Mark and Cowley, Mark and Barbour, Andrew and Mawson, Amanda and Humphrey, Emily S and Colvin, Emily K and Chou, Angela and Lovell, Jessica A and Jamieson, Nigel B and Duthie, Fraser and Gingras, Marie-Claude and Fisher, William E and Dagg, Rebecca A and Lau, Loretta M S and Lee, Michael and Pickett, Hilda A and Reddel, Roger R and Samra, Jaswinder S and Kench, James G and Merrett, Neil D and Epari, Krishna and Nguyen, Nam Q and Zeps, Nikolajs and Falconi, Massimo and Simbolo, Michele and Butturini, Giovanni and Van Buren, George and Partelli, Stefano and Fassan, Matteo and Khanna, Kum Kum and Gill, Anthony J and Wheeler, David A and Gibbs, Richard A and Musgrove, Elizabeth A and Bassi, Claudio and Tortora, Giampaolo and Pederzoli, Paolo and Pearson, John V and ... and Australian Pancreatic Cancer Genome Initiative
Nature, ISSN 0028-0836, 10/2017, Volume 550, Issue 7677, p. 548
This corrects the article DOI: 10.1038/nature21063. 
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7. Full Text Abstract 14799: Over-expression of Telomerase Reverse Transcriptase Increases Self-renewal, Survival and Multi-potency in Human Cardiac Progenitor Cells Derived From Aged and Diseased Hearts
by Le, Thi Y and Pickett, Hilda A and Farraha, Melad and dos Remedios, Cris and Chong, James J
Circulation, ISSN 0009-7322, 11/2016, Volume 134, Issue Suppl_1 Suppl 1, pp. A14799 - A14799
IntroductionStem cells, or their derivatives, are an exciting potential treatment for heart failure. We have recently characterised a resident cardiac... 
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8. Full Text Over-expression of telomerase reverse transcriptase increases self-renewal, survival and multi-potency in human cardiac progenitor cells derived from aged and diseased hearts
by Farraha, Melad and Remedios, Cris dos and Chong, James J and Pickett, Hilda A and Le, Thi Y
Circulation, ISSN 0009-7322, 11/2016, Volume 134, Issue 19
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9. Full Text Corrigendum: Whole-genome landscape of pancreatic neuroendocrine tumours (Nature (2017) 543 (65-71) DOI: 10.1038/nature21063)
Nature, ISSN 0028-0836, 10/2017, Volume 550, Issue 7677, p. 548
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10. Full Text Erratum: Corrigendum: Whole-genome landscape of pancreatic neuroendocrine tumours
by Scarpa, Aldo and Chang, David K and Nones, Katia and Corbo, Vincenzo and Patch, Ann-Marie and Bailey, Peter and Lawlor, Rita T and Johns, Amber L and Miller, David K and Mafficini, Andrea and Rusev, Borislav and Scardoni, Maria and Antonello, Davide and Barbi, Stefano and Sikora, Katarzyna O and Cingarlini, Sara and Vicentini, Caterina and McKay, Skye and Quinn, Michael C. J and Bruxner, Timothy J. C and Christ, Angelika N and Harliwong, Ivon and Idrisoglu, Senel and McLean, Suzanne and Nourse, Craig and Nourbakhsh, Ehsan and Wilson, Peter J and Anderson, Matthew J and Fink, J. Lynn and Newell, Felicity and Waddell, Nick and Holmes, Oliver and Kazakoff, Stephen H and Leonard, Conrad and Wood, Scott and Xu, Qinying and Hiriyur Nagaraj, Shivashankar and Amato, Eliana and Dalai, Irene and Bersani, Samantha and Cataldo, Ivana and Dei Tos, Angelo P and Capelli, Paola and Vittoria Davì, Maria and Landoni, Luca and Malpaga, Anna and Miotto, Marco and Whitehall, Vicki L. J and Leggett, Barbara A and Harris, Janelle L and Harris, Jonathan and Jones, Marc D and Humphris, Jeremy and Chantrill, Lorraine A and Chin, Venessa and Nagrial, Adnan M and Pajic, Marina and Scarlett, Christopher J and Pinho, Andreia and Rooman, Ilse and Toon, Christopher and Wu, Jianmin and Pinese, Mark and Cowley, Mark and Barbour, Andrew and Mawson, Amanda and Humphrey, Emily S and Colvin, Emily K and Chou, Angela and Lovell, Jessica A and Jamieson, Nigel B and Duthie, Fraser and Gingras, Marie-Claude and Fisher, William E and Dagg, Rebecca A and Lau, Loretta M. S and Lee, Michael and Pickett, Hilda A and Reddel, Roger R and Samra, Jaswinder S and Kench, James G and Merrett, Neil D and Epari, Krishna and Nguyen, Nam Q and Zeps, Nikolajs and Falconi, Massimo and Simbolo, Michele and Butturini, Giovanni and Van Buren, George and Partelli, Stefano and Fassan, Matteo and Khanna, Kum Kum and Gill, Anthony J and Wheeler, David A and Gibbs, Richard A and Musgrove, Elizabeth A and Bassi, Claudio and Tortora, Giampaolo and Pederzoli, Paolo and Pearson, John V and ... and Australian Pancreatic Cancer Genome Initiative
Nature, ISSN 0028-0836, 10/2017, Volume 550, Issue 7677, pp. 548 - 548
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11. Full Text Functional dissection of breast cancer risk-associated TERT promoter variants
by Helbig, S and Wockner, L and Bouendeu, A and Hille-Betz, U and McCue, K and French, JD and Edwards, SL and Pickett, HA and Reddel, RR and Chenevix-Trench, G and Dork, T and Beesley, J
ONCOTARGET, ISSN 1949-2553, 09/2017, Volume 8, Issue 40, pp. 67203 - 67217
The multi-cancer susceptibility locus at 5p15.33 includes TERT, encoding the telomerase catalytic subunit. Genome-wide association studies (GWAS) have... 
CATALYTIC SUBUNIT | CELLS | ACTIVATION | GWAS | C-MYC | HTERT GENE-EXPRESSION | CELL BIOLOGY | IN-VITRO | telomerase | SNP | breast carcinoma | SEQUENCE | MUTATIONS | CARCINOMA | GABPA | TELOMERASE-REVERSE-TRANSCRIPTASE
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12. Full Text A Common Cancer Risk-Associated Allele in the hTERT Locus Encodes a Dominant Negative Inhibitor of Telomerase
: e1005286
by Anagha Killedar and Michael D Stutz and Alexander P Sobinoff and Christopher G Tomlinson and Tracy M Bryan and Jonathan Beesley and Georgia Chenevix-Trench and Roger R Reddel and Hilda A Pickett
PLoS Genetics, ISSN 1553-7390, 06/2015, Volume 11, Issue 6
  The TERT-CLPTM1L region of chromosome 5p15.33 is a multi-cancer susceptibility locus that encodes the reverse transcriptase subunit, hTERT, of the telomerase... 
Enzymes | Genes | Cell division | Proteins | Councils | Cell cycle | Genetic engineering | Scientific imaging | Tumorigenesis | Chromosomes | Telomerase | Mass spectrometry | Deoxyribonucleic acid--DNA | Cancer
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13. Full Text Alternative Lengthening of Telomeres: DNA Repair Pathways Converge
by Sobinoff, Alexander P and Pickett, Hilda A
Trends in Genetics, ISSN 0168-9525, 12/2017, Volume 33, Issue 12, pp. 921 - 932
Telomeres shorten during each cellular division, with cumulative attrition resulting in telomeric damage and replicative senescence. Bypass of replicative... 
ALT | replication stress | recombination | break-induced telomere synthesis | DNA damage response | telomere | BLM RECQ HELICASES | GENOME INSTABILITY | ROLES | GENETICS & HEREDITY | DOUBLE-STRAND BREAKS | ALT CELLS | VARIANT REPEATS | END RESECTION | HOMOLOGOUS RECOMBINATION | BREAK-INDUCED REPLICATION | REVEALS | Animals | Humans | DNA Replication - genetics | Homologous Recombination - genetics | DNA Repair - genetics | Telomere Homeostasis - genetics | Telomere - genetics | Telomeres | DNA repair | Genomics | DNA | DNA damage
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14. Full Text NuRD-ZNF827 recruitment to telomeres creates a molecular scaffold for homologous recombination
by Conomos, Dimitri and Conomos, Dimitri and Reddel, Roger R and Reddel, Roger R and Pickett, Hilda A and Pickett, Hilda A
Nature structural & molecular biology, ISSN 1545-9993, 09/2014, Volume 21, Issue 9, pp. 760 - 770
Alternative lengthening of telomeres (ALT) is a homologous recombination (HR)-dependent mechanism for de novo synthesis of telomeric DNA in mammalian cells.... 
HUMAN-CHROMOSOMES | PML BODY | MAMMALIAN TELOMERES | DNA-DAMAGE RESPONSE | HUMAN-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | VARIANT REPEATS | ALT CELLS | CANCER | CELL BIOLOGY | BIOPHYSICS | CHROMATIN-REMODELING COMPLEX | NURD COMPLEX | DNA-Binding Proteins - metabolism | Cell Line | Cell Cycle | Humans | Chromatin Assembly and Disassembly | Homologous Recombination | Mi-2 Nucleosome Remodeling and Deacetylase Complex - metabolism | Telomere - metabolism | DNA-Binding Proteins - genetics | DNA-Binding Proteins - chemistry | Apoptosis | Gene Knockdown Techniques | Chromosome replication | Physiological aspects | Genetic research | Telomeres | Research | Genetic translation | Proteins | Chromatin | Cellular biology | Molecular biology | Index Medicus
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15. Full Text Alternative lengthening of telomeres: Remodeling the telomere architecture
by Conomos, Dimitri and Pickett, Hilda A and Reddel, Roger R
Frontiers in Oncology, ISSN 2234-943X, 2013, Volume 3, pp. 27 - 27
To escape from the normal limits on proliferative potential, cancer cells must employ a means to counteract the gradual telomere attrition that accompanies... 
Variant telomeric repeats | Chromatin | Recombination | DNA damage response (DDR) | Shelterin | Alternative lengthening of telomeres (ALT) | Nuclear receptors | Telomere | recombination | DNA damage response | Nuclear Receptors
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16. Full Text RTEL1 contributes to DNA replication and repair and telomere maintenance
by Uringa, Evert-Jan and Lisaingo, Kathleen and Pickett, Hilda A and Brind'Amour, Julie and Rohde, Jan-Henik and Zelensky, Alex and Essers, Jeroen and Lansdorp, Peter M
Molecular Biology of the Cell, ISSN 1059-1524, 07/2012, Volume 23, Issue 14, pp. 2782 - 2792
Telomere maintenance and DNA repair are important processes that protect the genome against instability. mRtel1, an essential helicase, is a dominant factor... 
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17. Full Text Whole-genome landscapes of major melanoma subtypes
by Hayward, Nicholas K and Wilmott, James S and Waddell, Nicola and Johansson, Peter A and Field, Matthew A and Nones, Katia and Patch, Ann-Marie and Kakavand, Hojabr and Alexandrov, Ludmil B and Burke, Hazel and Jakrot, Valerie and Kazakoff, Stephen and Holmes, Oliver and Leonard, Conrad and Sabarinathan, Radhakrishnan and Mularoni, Loris and Wood, Scott and Xu, Qinying and Waddell, Nick and Tembe, Varsha and Pupo, Gulietta M and De Paoli-Iseppi, Ricardo and Vilain, Ricardo E and Shang, Ping and Lau, Loretta M. S and Dagg, Rebecca A and Schramm, Sarah-Jane and Pritchard, Antonia and Dutton-Regester, Ken and Newell, Felicity and Fitzgerald, Anna and Shang, Catherine A and Grimmond, Sean M and Pickett, Hilda A and Yang, Jean Y and Stretch, Jonathan R and Behren, Andreas and Kefford, Richard F and Hersey, Peter and Long, Georgina V and Cebon, Jonathan and Shackleton, Mark and Spillane, Andrew J and Saw, Robyn P. M and López-Bigas, Núria and Pearson, John V and Thompson, John F and Scolyer, Richard A and Mann, Graham J and Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Nature, ISSN 0028-0836, 05/2017, Volume 545, Issue 7653, pp. 175 - 180
Melanoma of the skin is a common cancer only in Europeans, whereas it arises in internal body surfaces (mucosal sites) and on the hands and feet (acral sites)... 
TERT PROMOTER MUTATIONS | UVEAL MELANOMA | SEQUENCE DATA | MULTIDISCIPLINARY SCIENCES | RECURRENT MUTATIONS | FREQUENT SOMATIC MUTATIONS | MALIGNANT-MELANOMA | GENERAL FRAMEWORK | CANCER GENOMES | ACTIVATING MUTATIONS | DRIVER MUTATIONS | Membrane Proteins - genetics | Humans | X-linked Nuclear Protein | Phosphoproteins - genetics | RNA Splicing Factors - genetics | Mutation - genetics | Genes, p16 | Genome, Human - genetics | Tumor Suppressor Protein p53 - genetics | Ultraviolet Rays - adverse effects | Telomerase - genetics | Signal Transduction - drug effects | GTP Phosphohydrolases - genetics | Melanoma - genetics | Proto-Oncogene Proteins B-raf - genetics | Mitogen-Activated Protein Kinases - genetics | Neurofibromatosis 1 - genetics | Melanoma - classification | Nuclear Proteins - genetics | DNA Helicases - genetics | Telomere - genetics | Genetic research | Genetic aspects | Genomes | Research | Melanoma | Pathogenesis | Copy number | Mucosa | p53 Protein | Radiation | Security | Epidemiology | Metastases | Reproduction (copying) | Coding | Mismatch repair | Clusters | Eye (anatomy) | Fellowships | Deoxyribonucleic acid--DNA | Medical research | Breakpoints | Radiation effects | MAP kinase | Exposure | Sun | Amplification | Bridges | Pathology | Ultraviolet radiation | Mutagenesis | Computation | Skin | Mutation | Internet | Aberration | Biotechnology | Genes | DNA damage | Carcinogens | Infrastructure | Signatures | Health | U.V. radiation | Inversions | Foldback | Data processing | Energy policy | Readers | Deamination | Protein kinase | Cell lines | Gene mapping | Tumors | Cancer | Index Medicus | Biological Science | 60 APPLIED LIFE SCIENCES
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18. Full Text The role of telomere trimming in normal telomere length dynamics
by Pickett, Hilda A and Reddel, Roger R
Cell Cycle, ISSN 1538-4101, 04/2012, Volume 11, Issue 7, pp. 1309 - 1315
Telomeres consist of repetitive DNA and associated proteins that protect chromosome ends from illicit DNA repair. It is well known that telomeric DNA is... 
telomerase | Alternative Lengthening of Telomeres | telomere rapid deletion | homologous recombination | telomere trimming | telomere length | Binding | Proteins | Landes | Calcium | Bioscience | Biology | Cell | Cycle | Cancer | Organogenesis | Telomere trimming | Telomere length | Alternative lengthening of telomeres | Telomerase | Homologous recombination | Telomere rapid deletion | Chromosomes, Mammalian - physiology | Chromosomes, Mammalian - genetics | Humans | Telomere Homeostasis | Telomere Shortening - genetics | DNA - genetics | Animals | Aging - genetics | Cell Division | DNA Repair | Telomerase - metabolism | Mice | Telomere - metabolism | Telomere - genetics
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