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Organic letters, ISSN 1523-7060, 01/2020
A convergent sequence to access the indole alkaloid (±)-melokhanine E in 12-steps (8-step longest linear sequence) and an 11% overall yield is reported. The... 
Journal Article
Organic Letters, ISSN 1523-7060, 02/2015, Volume 17, Issue 4, pp. 968 - 971
Monanchocidin A is a recently isolated pentacyclic guanidinium alkaloid that contains an unusual highly oxidized morpholinone fragment. Herein we report a... 
Journal Article
Organic Letters, ISSN 1523-7060, 10/2016, Volume 18, Issue 20, pp. 5308 - 5311
Plagiogyrin A (1) was first isolated from the fronds of Plagiogyria matsumureana. Structurally, it features an α-ketoaldehyde functional group in its... 
CHEMISTRY, ORGANIC | ETHERS | ALDEHYDES | PTEROPHYTES | EFFICIENT
Journal Article
Chembiochem : a European journal of chemical biology, ISSN 1439-4227, 11/2019
The failure of frontline antibiotics in the clinic is one of the most serious threats to human health and requires a multitude of novel therapeutics and... 
Journal Article
Angewandte Chemie, ISSN 0044-8249, 07/2018, Volume 130, Issue 28, pp. 8818 - 8822
Natural products have historically been a major source of antibiotics and therefore novel scaffolds are constantly of interest. The lipoxazolidinone family of... 
Cyclisierungen | Heterocyclen | Naturstoffe | Antibiotika | Medizinische Chemie | Lead compounds
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 01/2018, Volume 59, Issue 3, pp. 277 - 279
An efficient one-pot synthesis of functionalized thiazolines via the coupling of thioamides with 4-bromocrotonate esters is described. A range of aryl- and... 
Thiazoline | Medicinal chemistry | Heterocycle | Natural products | Alkylation | THIOHYDROXIMIC ACIDS | PALLADIUM | ANALOGS | NATURAL-PRODUCTS | LARGAZOLE | CHEMISTRY, ORGANIC | COPPER | ALTHIOMYCIN | CHEMISTRY | OXIDATIVE CYCLIZATION | INHIBITOR | Esters
Journal Article
ISSN 1359-7345, 6/2017, Volume 53, Issue 53, pp. 7353 - 7356
Investigation into the biological function of 5-benzylidene-4-oxazolidinones revealed dose-dependent inhibition of biofilm formation in Methicillin-resistant... 
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 03/2019, Volume 10, Issue 3, pp. 374 - 377
The lipoxazolidinone family of marine natural products, which contains an unusual 4-oxazolidinone core, was found to possess potent antimicrobial activity... 
heterocycles | Oxazolidinones | antibiotics | MRSA | CHEMISTRY, MEDICINAL | NATURAL-PRODUCTS | ANTIBACTERIAL | BROAD | 4-OXAZOLIDINONE | SYNOXAZOLIDINONES
Journal Article
Angewandte Chemie, ISSN 1433-7851, 05/2014, Volume 53, Issue 21, p. 5401
  A five-step total synthesis of the marine natural product synoxazolidinoneA was achieved through a diastereoselective imine acylation/cyclization cascade.... 
Natural products | Antimicrobial agents
Journal Article
Angewandte Chemie, ISSN 0044-8249, 07/2018, Volume 130, Issue 28, pp. 8818 - 8822
Natural products have historically been a major source of antibiotics and therefore novel scaffolds are constantly of interest. The lipoxazolidinone family of... 
Synthesis | Antibiotics | Historical account | Natural products | Oxazolidinones | Pharmacology | Lead compounds | Scaffolds | Antiinfectives and antibacterials | Optimization | Lipophilicity
Journal Article
Organic Letters, ISSN 1523-7060, 06/2017, Volume 19, Issue 11, pp. 2961 - 2964
A facile, diastereoselective synthesis of highly substituted pyrrolidine-2,3-diones is reported, along with the one-step conversion of these heterocycles to... 
DESIGN | ALLYLATION | ALLYLIC ALKYLATION | OXINDOLES | CHEMISTRY, ORGANIC | PROCHIRAL NUCLEOPHILES | CONDENSATION | LACTAMS | INHIBITORS | DERIVATIVES | Molecular Structure | Cyclization | Stereoisomerism | Pyrrolidines - chemistry | Amino Acids
Journal Article
The Journal of Organic Chemistry, ISSN 0022-3263, 01/2018, Volume 83, Issue 1, pp. 12 - 22
An efficient synthesis of S-allyl thioimidate hydrobromide salts via coupling of thioamides with allyl bromide derivatives is described. A range of mono-, di-,... 
Thioacetamide | Usage | Chemical properties | Chemical synthesis | Heterocyclic compounds
Journal Article
Organic Letters, ISSN 1523-7060, 09/2015, Volume 17, Issue 18, pp. 4542 - 4545
Journal Article
Synthesis, ISSN 0039-7881, 11/2015, Volume 47, Issue 21, pp. 3363 - 3370
Abstract A mild and efficient silver-mediated synthesis of 2,3-dihydro-1,3-oxazin-4-ones through a formal [4+2] cycloaddition reaction of aldimines and... 
paper | ACETYLKETENE | DIKETENE | 2,2,6-TRIMETHYL-4H-1,3-DIOXIN-4-ONE | transition metals | CHEMISTRY, ORGANIC | imines | acylation | KETENE | KETONES | cycloaddition | heterocycles | TERT-BUTANESULFINAMIDE | 2,2,6-TRIMETHYL-1,3-DIOXIN-4-ONE | AEROBIC OXIDATIVE CYCLIZATION | DERIVATIVES
Journal Article
Synthesis, ISSN 0039-7881, 06/2016, Volume 48, Issue 12, pp. 1902 - 1909
Abstract An oxidative cyclization of amidoximes to form 1,2,4-oxadiazoles, mediated by 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ), is described. A range... 
special topic | oxidation | radicals | heterocycles | cyclization | medicinal chemistry | THIOHYDROXIMIC ACIDS | FUNCTIONALIZATION | ACTIVATION | REAGENTS | CHEMISTRY, ORGANIC | C-H OXIDATION | OXADIAZOLES
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 07/2018, Volume 57, Issue 28, pp. 8682 - 8686
Natural products have historically been a major source of antibiotics and therefore novel scaffolds are constantly of interest. The lipoxazolidinone family of... 
natural products | heterocycles | antibiotics | cyclization | medicinal chemistry | ANTIBACTERIAL DRUG DISCOVERY | ACIDS | RESISTANT STAPHYLOCOCCUS-AUREUS | 4-OXAZOLIDINONE | CHEMISTRY, MULTIDISCIPLINARY | Lead compounds | Synthesis | Antibiotics | Historical account | Natural products | Oxazolidinones | Pharmacology | Scaffolds | Antiinfectives and antibacterials | Optimization | Lipophilicity
Journal Article
Organic Letters, ISSN 1523-7060, 08/2005, Volume 7, Issue 16, pp. 3537 - 3540
Hydrozirconation of allenes followed by in situ transmetalation to dialkylzinc leads to the formation of an allylic zinc species that, upon addition of... 
Journal Article
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