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Nature, ISSN 0028-0836, 04/2016, Volume 532, Issue 7598, pp. 255 - 258
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 03/2014, Volume 10, Issue 3, pp. 181 - 187
Journal Article
Nature Communications, ISSN 2041-1723, 2015, Volume 6, Issue 1, pp. 7645 - 7645
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 11/2015, Volume 11, Issue 11, pp. 878 - 886
Neomorphic mutations in isocitrate dehydrogenase 1 (IDH1) are driver mutations in acute myeloid leukemia (AML) and other cancers. We report the development of... 
ISOCITRATE DEHYDROGENASE 1 | SELECTIVE-INHIBITION | PROGENITOR CELLS | DNA METHYLATION | SMALL-MOLECULE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CLINICAL-IMPLICATIONS | KINASE INHIBITORS | CELL-DIFFERENTIATION | MYELODYSPLASTIC SYNDROMES | ACUTE PROMYELOCYTIC LEUKEMIA | Neoplastic Stem Cells - drug effects | Allosteric Regulation | Humans | Crystallography, X-Ray | Male | Isocitrate Dehydrogenase - antagonists & inhibitors | Dose-Response Relationship, Drug | Leukemia, Myeloid, Acute - enzymology | Pyrazoles - chemistry | Enzyme Inhibitors - pharmacokinetics | Granulocytes - drug effects | Cytosine - metabolism | Dihydropyridines - pharmacokinetics | Enzyme Inhibitors - chemistry | Leukemia, Myeloid, Acute - drug therapy | Neoplastic Stem Cells - pathology | Granulocytes - pathology | Pyrazoles - pharmacokinetics | Pyrazoles - pharmacology | Dihydropyridines - chemistry | Leukemia, Myeloid, Acute - pathology | Enzyme Inhibitors - pharmacology | Models, Molecular | Isocitrate Dehydrogenase - genetics | Cytosine - chemistry | Granulocytes - enzymology | Xenograft Model Antitumor Assays | Animals | Cell Differentiation - drug effects | Isocitrate Dehydrogenase - chemistry | Allosteric Site | Cell Line, Tumor | CpG Islands | Dihydropyridines - pharmacology | Protein Binding | Isocitrate Dehydrogenase - metabolism | Mice | Kinetics | Mutation | Primary Cell Culture | DNA Methylation - drug effects | Neoplastic Stem Cells - enzymology | Leukemia, Myeloid, Acute - genetics | Index Medicus
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2006, Volume 103, Issue 47, pp. 17967 - 17972
Rare familial forms of Alzheimer's disease (AD) are thought to be caused by elevated proteolytic production of the Aβ42 peptide from the β-amyloid-precursor... 
Proteins | Transfection | HEK293 cells | Complementary DNA | Secretion | Neurons | Genes | Small interfering RNA | Chromosomes | Genetic screening | RNAi | siRNA | NogoR | Chromosome 10 | BETA-SECRETASE | A-BETA-42 | MULTIDISCIPLINARY SCIENCES | LOCUS | PEDIGREES | A beta | ENHANCE | chromosome 10 | CHROMOSOME-10 | MUTATIONS | TRANSMEMBRANE PROTEINS | EXPRESSION | T CATENIN GENE | Amyloid Precursor Protein Secretases - genetics | RNA, Small Interfering - genetics | Humans | Neurons - cytology | Aspartic Acid Endopeptidases - genetics | Amyloid beta-Peptides - metabolism | Amyloid beta-Protein Precursor - metabolism | Membrane Proteins - metabolism | Neurons - metabolism | Peptide Fragments - metabolism | Membrane Proteins - genetics | Cells, Cultured | Receptors, Cell Surface - metabolism | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Proteins - genetics | Carrier Proteins - genetics | Amyloid Precursor Protein Secretases - metabolism | Animals | Carrier Proteins - metabolism | Proteins - metabolism | Aspartic Acid Endopeptidases - metabolism | Alzheimer Disease - metabolism | Mice | Enzyme Activation | Alzheimer Disease - genetics | Chromosomes, Human, Pair 10 | RNA, Small Interfering - metabolism | Receptors, Cell Surface - genetics | Prevention | Research | Alzheimer's disease | Amyloid beta-protein | Alzheimers disease | Proteomics | Index Medicus | Biological Sciences |
Journal Article
Molecular Cancer Research, ISSN 1541-7786, 01/2016, Volume 14, Issue 1 Supplement, pp. A35 - A35
Journal Article
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 01/2009, Volume 328, Issue 1, pp. 131 - 140
Journal Article
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 11/2015, Volume 25, Issue 21, pp. 4812 - 4819
Journal Article