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Science, ISSN 0036-8075, 05/2016, Volume 352, Issue 6289, pp. aad7993 - aad7993
The host innate immune response is the first line of defense against pathogens and is orchestrated by the concerted expression of genes induced by microbial... 
RNA-POLYMERASE-II | BROMODOMAINS | VIRUS | CAMPTOTHECIN | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION | DISEASE | INFLUENZA | RIG-I | CPG ISLANDS | EXPRESSION | Transcription, Genetic - drug effects | Interferon-beta - immunology | Sendai virus | Humans | Positive Transcriptional Elongation Factor B - antagonists & inhibitors | Host-Pathogen Interactions - drug effects | RNA Polymerase II - metabolism | Flavonoids - therapeutic use | Topoisomerase I Inhibitors - pharmacology | Piperidines - pharmacology | Inflammation - drug therapy | HEK293 Cells | Flavonoids - pharmacology | Hemorrhagic Fever, Ebola - drug therapy | Staphylococcus aureus | Triazoles - therapeutic use | Ebolavirus | Inflammation - microbiology | Staphylococcal Infections - drug therapy | Camptothecin - therapeutic use | DNA Topoisomerases, Type I - metabolism | Mice, Inbred C57BL | Immunity, Innate | Topotecan - therapeutic use | Azepines - therapeutic use | Azepines - pharmacology | Gene Expression Regulation - drug effects | Triazoles - pharmacology | Animals | Host-Pathogen Interactions - genetics | Influenza A virus | Piperidines - therapeutic use | Topoisomerase I Inhibitors - therapeutic use | Inflammation - genetics | Mice | Camptothecin - pharmacology | Pathogens | Inflammation | Gene expression | Immune system | Winding | Genes | Deoxyribonucleic acid | Bacteria | Viruses | Pharmacology | Inhibition
Journal Article
Journal Article
FRONTIERS IN MICROBIOLOGY, ISSN 1664-302X, 09/2019, Volume 10
Ebola virus (EBOV) is a non-segmented negative-sense RNA virus that causes a severe human disease. The ongoing EBOV outbreak in the Eastern part of Democratic... 
protein painting | small molecule EBOV inhibitor | SPECIFICITY | MICROBIOLOGY | protein phosphatase-1 | Ebola virus | TRIAL | PP1 | surface plasmon resonance | SUBSTRATE | split NanoBiT | DEPHOSPHORYLATION | mass spectrometry
Journal Article
Journal of Infectious Diseases, ISSN 0022-1899, 11/2018, Volume 218, Issue 5, pp. S627 - S635
We identified a protein phosphatase 1 (PP1)-targeting compound, C31, that inhibited Ebola virus transcription and replication. C31 bound to the PP1 C-terminal... 
Ebola virus | protein phosphatase 1 | transcription inhibitor | INFECTIOUS DISEASES | MICROBIOLOGY | GENERATION | IMMUNOLOGY
Journal Article
Antiviral Research, ISSN 0166-3542, 02/2018, Volume 150, pp. 193 - 201
Ebola virus (EBOV) is an enveloped negative-sense, single-stranded RNA virus of the filovirus family that causes severe disease in humans. Approved therapies... 
Ebola virus | Vesicular stomatitis virus | Antiviral | Zika virus | Filovirus | Marburg virus | DRUG | MARBURG-VIRUS | TRANSCRIPTION | REVERSE GENETICS SYSTEMS | POTENT ACTIVITY | VIROLOGY | ANTIVIRAL ACTIVITY | PHARMACOLOGY & PHARMACY | INFECTION | T-705 FAVIPIRAVIR | DENGUE VIRUS | MYCOPHENOLIC-ACID | Antiviral agents | Synthesis | RNA | Microbiology | Marburg virus disease
Journal Article
Journal Article
Journal of Virology, ISSN 0022-538X, 2013, Volume 87, Issue 22, pp. 12506 - 12506
Journal Article
PLoS Neglected Tropical Diseases, ISSN 1935-2727, 12/2013, Volume 7, Issue 12
  Background Junín virus (JUNV), the etiologic agent of Argentine hemorrhagic fever (AHF), is classified by the NIAID and CDC as a Category A priority... 
Plasma | Cell culture | Disease | Mortality | Viruses | Infections | RNA polymerase | Fever | Studies | Drug therapy | Laboratory animals | Drug dosages | Public health
Journal Article
ACS Infectious Diseases, ISSN 2373-8227, 01/2016, Volume 1, Issue 8, pp. 380 - 387
Ebola virus (EBOV), a member of the family Filoviridae, is a nonsegmented negative-sense RNA virus that causes severe, often lethal, disease in humans. EBOV... 
Ebola virus | translation | high-throughput screen | RNA polymerase | filovirus | antiviral | INFECTIOUS DISEASES | CHEMISTRY, MEDICINAL | PHOSPHORYLATION | TRANSCRIPTION | MARBURG | REVERSE GENETICS SYSTEMS | PROTEIN-SYNTHESIS
Journal Article
Journal Article
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