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PLoS ONE, ISSN 1932-6203, 03/2016, Volume 11, Issue 3, pp. e0152471 - e0152471
In Down syndrome (DS) or trisomy of chromosome 21, the beta-amyloid (A beta) peptide product of the amyloid precursor protein (APP) is present in excess.... 
PATHOGENESIS | IMMUNIZATION | TRANSPORT | DEMENTIA | ABNORMALITIES | ALZHEIMERS-DISEASE | MULTIDISCIPLINARY SCIENCES | RECEPTOR | NEURODEGENERATION | PEPTIDE | TRANSGENIC MICE | Inflammation - pathology | Antibodies - metabolism | Memory | Septal Nuclei - pathology | Vaccination | Male | Vaccines - therapeutic use | Atrophy | Behavior, Animal | Brain - metabolism | Amyloid beta-Peptides - genetics | Down Syndrome - complications | Disease Models, Animal | Animals, Newborn | Biomarkers - metabolism | Cholinergic Neurons - metabolism | Gene Expression Regulation | Mice, Transgenic | Cognition Disorders - drug therapy | Cognition Disorders - complications | Animals | Brain - pathology | Down Syndrome - drug therapy | Amyloid beta-Peptides - immunology | Hemorrhage - pathology | Brain | Neurosciences | Neuropathology | Pathogenesis | Immunoglobulin G | Medical services | Cognitive ability | Forebrain | Antibodies | Vaccines | Hemorrhage | Lipid A | Reduction | Down's syndrome | Neurodegeneration | Proteolysis | Rodents | Immunotherapy | Dementia disorders | Monophosphoryl lipid A | Drug dosages | Alzheimer's disease | Age | Immunization | Immunological memory | Neurodegenerative diseases | Medical treatment | Pattern recognition | Down syndrome | Object recognition | Forebrain (basal) | Immunological tolerance | Amyloid precursor protein | Fear conditioning | Medicine | Neurology | Chromosome 21 | β-Amyloid | Cholinergic nerves | Mice | Infiltration | Liposomes | Alzheimers disease | Dementia | Index Medicus
Journal Article
PloS one, ISSN 1932-6203, 2013, Volume 8, Issue 8, pp. e72301 - e72301
Progressive aggregation of protein Tau into oligomers and fibrils correlates with cognitive decline and synaptic dysfunction, leading to neurodegeneration in... 
NEUROFIBRILLARY TANGLES | IMMUNOTHERAPY | ALZHEIMERS-DISEASE | MULTIDISCIPLINARY SCIENCES | AMYLOID-BETA-PEPTIDE | MOUSE MODEL | PATHOLOGY | CONFORMATION | PASSIVE-IMMUNIZATION | BRAIN | DEGENERATION | Phosphoproteins - immunology | Phosphorylation | Tauopathies - immunology | tau Proteins - immunology | Humans | Vaccination | Peptides - administration & dosage | Phosphoproteins - chemical synthesis | Peptides - chemical synthesis | tau Proteins - genetics | Tauopathies - physiopathology | tau Proteins - antagonists & inhibitors | Alzheimer Vaccines - immunology | Disease Models, Animal | Brain - physiopathology | Peptides - immunology | Alzheimer Vaccines - administration & dosage | Mice, Transgenic | Treatment Outcome | Psychomotor Performance - drug effects | Brain - drug effects | Liposomes - chemistry | Animals | Mice | Tauopathies - drug therapy | Brain - immunology | Antibodies, Neutralizing - blood | Phosphoproteins - administration & dosage | Oligomers | Medical research | Peptides | Medicine, Experimental | Disease susceptibility | Vaccines | Alzheimer's disease | Antigenic determinants | Brain | Neurosciences | Cognitive ability | Clinical trials | Lipids | Antisera | Proteins | Neurodegeneration | Transgenic animals | Immunotherapy | Rodents | Genetics | Neurodegenerative diseases | Medical treatment | Fibrils | Pharmacology | Pathology | Tau protein | Liposomes | Mutation | Alzheimers disease | Animal cognition | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2007, Volume 104, Issue 23, pp. 9810 - 9815
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 1 - 15
The aggregation of intracellular tau protein is a major hallmark of Alzheimer’s disease (AD). The extent and the stereotypical spread of tau pathology in the... 
Brain | Oligomerization | Tau protein | Site selection | Proteolysis | Edman degradation | Cognitive ability | Mass spectroscopy | Calpain | Alzheimer's disease
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 07/2012, Volume 32, Issue 28, pp. 9677 - 9689
Passive immunization against beta-amyloid (A beta) has become an increasingly desirable strategy as a therapeutic treatment for Alzheimer's disease (AD).... 
APP TRANSGENIC MICE | NATURAL OLIGOMERS | HUMAN IGG1 | ALZHEIMERS-DISEASE | PROTEIN-KINASE | LONG-TERM POTENTIATION | SYNAPTIC PLASTICITY | NEUROSCIENCES | PASSIVE-IMMUNIZATION | SECRETED OLIGOMERS | P38 MAP KINASE | Microglia - metabolism | Humans | Middle Aged | Male | Green Fluorescent Proteins - genetics | Neuroprotective Agents - metabolism | Alzheimer Disease - pathology | Neuroprotective Agents - pharmacology | Time Factors | Protein Binding - drug effects | Amyloid beta-Peptides - metabolism | Statistics, Nonparametric | Aged, 80 and over | Neurons - metabolism | p38 Mitogen-Activated Protein Kinases - metabolism | Alzheimer Disease - immunology | Receptors, Chemokine - genetics | Plaque, Amyloid - immunology | Disease Models, Animal | Animals, Newborn | Rats | Mice, Transgenic | Mutation - genetics | Rats, Sprague-Dawley | Microscopy, Confocal | Plaque, Amyloid - metabolism | Mice | CX3C Chemokine Receptor 1 | Alzheimer Disease - blood | Immunoglobulin G - metabolism | Tumor Necrosis Factor-alpha - metabolism | Dose-Response Relationship, Immunologic | Cerebral Cortex - cytology | Dose-Response Relationship, Drug | Immunoglobulin G - pharmacology | Female | Neurons - drug effects | Peptide Fragments - metabolism | Double-Blind Method | Enzyme-Linked Immunosorbent Assay | Microglia - drug effects | Plaque, Amyloid - pathology | Gene Expression Regulation - genetics | Gene Expression Regulation - immunology | Alzheimer Disease - therapy | Cells, Cultured | Presenilin-1 - genetics | Hippocampus - cytology | Gene Expression Regulation - drug effects | Amyloid beta-Protein Precursor - genetics | Animals | Amyloid beta-Peptides - immunology | Aged | Index Medicus
Journal Article
Journal of Alzheimer's Disease, ISSN 1387-2877, 2017, Volume 56, Issue 2, pp. 585 - 599
Journal Article
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, ISSN 1552-5260, 07/2017, Volume 13, Issue 7, pp. P957 - P957
Journal Article
Blood, ISSN 0006-4971, 01/2013, Volume 121, Issue 1, pp. 85 - 94
Immunoglobulin class switching from IgM to IgG in response to peptides is generally T cell-dependent and vaccination in T cell-deficient individuals is... 
MONOPHOSPHORYL-LIPID-A | AMYLOID-BETA PEPTIDE | IMMUNE-RESPONSE | IMMUNIZATION | ALZHEIMERS-DISEASE | MOUSE MODEL | TOLL-LIKE RECEPTORS | ANTIGENS | ANTIBODY-RESPONSES | HEMATOLOGY | INNATE IMMUNITY | CD28 Antigens - deficiency | Ovalbumin - immunology | Germinal Center - immunology | Humans | Vaccination | Adaptor Proteins, Vesicular Transport - deficiency | Adaptor Proteins, Vesicular Transport - genetics | Immunoglobulin Class Switching - immunology | Molecular Sequence Data | Adoptive Transfer | CD40 Ligand - immunology | Antigen Presentation | Immunoglobulin G - biosynthesis | Toll-Like Receptor 4 - deficiency | Peptide Fragments - immunology | Amyloid beta-Peptides - administration & dosage | B-Lymphocytes - metabolism | Amino Acid Sequence | Adaptor Proteins, Vesicular Transport - physiology | CD40 Ligand - deficiency | Mice, Inbred C57BL | Peptide Fragments - administration & dosage | Toll-Like Receptor 4 - genetics | Lipopolysaccharide Receptors - immunology | CD28 Antigens - immunology | Vaccines, Subunit - immunology | Receptors, Antigen, B-Cell - immunology | Mice, Knockout | Toll-Like Receptor 4 - physiology | Animals | B-Lymphocytes - immunology | Histocompatibility Antigens Class II - immunology | Ovalbumin - administration & dosage | Mice, Nude | Vaccines, Subunit - administration & dosage | Amyloid beta-Peptides - immunology | T-Lymphocytes - immunology | Mice | Liposomes | Immunoglobulin M - biosynthesis | Index Medicus | Abridged Index Medicus
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2016, Volume 6, Issue 1, pp. 39374 - 39374
Accumulation of amyloid-beta (A beta) peptides and amyloid plaque deposition in brain is postulated as a cause of Alzheimer's disease (AD). The precise... 
PROTEIN | FIBRILS | ATOMIC-RESOLUTION STRUCTURE | ALZHEIMERS-DISEASE | AMYLOID-BETA | MULTIDISCIPLINARY SCIENCES | X-RAY-DIFFRACTION | ANTIBODY | CONFORMATION | OLIGOMERS | PEPTIDE
Journal Article