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BIOCONJUGATE CHEMISTRY, ISSN 1043-1802, 05/2019, Volume 30, Issue 5, pp. 1356 - 1370
Journal Article
Drug metabolism and disposition: the biological fate of chemicals, ISSN 0090-9556, 05/2019, Volume 47, Issue 10, pp. 1156 - 1163
Catalytic disulfide cleavage is an essential mechanism in cells for protein folding and synthesis; however, the detailed enzymatic mechanism of disulfide bond... 
Drugs | Reductases | Conjugates | Disulfide bonds | Prodrugs | Antibodies | Protein biosynthesis | Thioredoxin | Chemical compounds | Benzodiazepines | Organic chemistry | Protein folding | Glutaredoxin | Chemical bonds | Cleavage | NADP | Xenobiotics | Chemical synthesis | Glutathione | Reductase
Journal Article
Bioconjugate Chemistry, ISSN 1043-1802, 04/2018, Volume 29, Issue 4, p. 1155
Previous investigations on antibody-drug conjugate (ADC) stability have focused on drug release by linker-deconjugation due to the relatively stable payloads... 
Systems stability | Immunoglobulins | Drug delivery systems | Deactivation | Stability | Toxicity | Antibodies | Cytotoxicity | Pharmacology | Metabolism | Inactivation | Optimization | Drug metabolism | Biocompatibility | Conjugation | Pharmacokinetics | Payloads
Journal Article
Drug Metabolism and Pharmacokinetics, ISSN 1347-4367, 01/2019, Volume 34, Issue 1, pp. S13 - S13
Journal Article
Drug Metabolism and Pharmacokinetics, ISSN 1347-4367, 01/2019, Volume 34, Issue 1, pp. S9 - S9
Journal Article
Journal Article
DRUG METABOLISM AND DISPOSITION, ISSN 0090-9556, 08/2019, Volume 47, Issue 8, pp. 884 - 889
Carfilzomib (CFZ) is a proteasome inhibitor used for oncology indications including treating multiple myeloma. CFZ is a potent cytotoxic agent with an IC50... 
HYDROLASES | PHARMACOLOGY & PHARMACY | POTENT | PROTEASOME INHIBITORS | LINKER | Enzymes | Conjugates | Deactivation | Multiple myeloma | Antibodies | Lysosomes | Cytotoxicity | Citrulline | Tumor cell lines | Metabolism | Inactivation | ErbB-2 protein | Proteasome inhibitors | CD22 antigen | Stability criteria | Valine | Lysosomal enzymes | Internalization | Cell lines | Cathepsin B | Payloads
Journal Article
Drug metabolism and disposition: the biological fate of chemicals, ISSN 0090-9556, 07/2019, Volume 47, Issue 10, pp. 1146 - 1155
Antibody-drug conjugates (ADCs) contain a disease-receptor antibody and a payload drug connected via a linker. The rate and extent of payload delivery depend... 
Conjugates | Correlation | Drug delivery systems | Xenotransplantation | Antibodies | Alkylation | Anticancer properties | Xenografts | Drug dosages | Deoxyribonucleic acid--DNA | Antigens | Fractionation | Effectiveness | Alkylating agents | Exposure | Stability analysis | ErbB-2 protein | Benzodiazepines | Magnetohydrodynamic stability | CD22 antigen | Trend analysis | Antitumor activity | Models | Dimers | Tumors | Payloads
Journal Article
Journal Article
Cancer Research, ISSN 0008-5472, 2017, Volume 77, Issue 24, pp. 7027 - 7037
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 05/2017, Volume 16, Issue 5, pp. 871 - 878
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 03/2018, Volume 17, Issue 3, pp. 677 - 685
Journal Article