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1. Full Text Aberrant expression of enzymes regulating m6A mRNA methylation: implication in cancer
by Natalia, Pinello and Stephanie, Sun and Justin, Jong-Leong Wong
Cancer Biology & Medicine, ISSN 2095-3941, 2018, Volume 15, Issue 4, pp. 323 - 334
N6-methyladenosine (m6A) is an essential RNA modification that regulates key cellular processes, including stem cell renewal,cellular differentiation, and... 
Enzymes | RNA modification | Target recognition | Leukemia | DNA damage | Breast cancer | Myc protein | Gene expression | Metabolism | Proteins | Pancreatic cancer | Medical prognosis | Stem cells | Cell cycle | DNA methylation | Tumor suppressor genes | Tumorigenesis | RNA processing | Localization | PTEN protein | Cancer | N6-methyladenosine (m6A) | tumor suppressor | cancer | Review | oncogene
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2. Full Text Targeting ASCT2‐mediated glutamine uptake blocks prostate cancer growth and tumour development
by Wang, Qian and Hardie, Rae‐Anne and Hoy, Andrew J and van Geldermalsen, Michelle and Gao, Dadi and Fazli, Ladan and Sadowski, Martin C and Balaban, Seher and Schreuder, Mark and Nagarajah, Rajini and Wong, Justin J‐L and Metierre, Cynthia and Pinello, Natalia and Otte, Nicholas J and Lehman, Melanie L and Gleave, Martin and Nelson, Colleen C and Bailey, Charles G and Ritchie, William and Rasko, John EJ and Holst, Jeff
The Journal of Pathology, ISSN 0022-3417, 07/2015, Volume 236, Issue 3, pp. 278 - 289
Glutamine is conditionally essential in cancer cells, being utilized as a carbon and nitrogen source for macromolecule production, as well as for anaplerotic... 
prostate cancer | metabolism | SLC1A5 | glutamine | ASCT2 | cell cycle | ANDROGEN RECEPTOR | ACTIVATION | COMPLEX | MECHANISM | CELL-GROWTH | PATHOLOGY | ACID TRANSPORTER ASCT2 | MTORC1 | ONCOLOGY | AMINO-ACIDS | EXPRESSION | Prostatic Neoplasms - metabolism | Cell Proliferation | TOR Serine-Threonine Kinases - metabolism | Minor Histocompatibility Antigens | Humans | Gene Expression Regulation, Neoplastic | Glutamine - metabolism | Male | Multiprotein Complexes - genetics | Oxygen - metabolism | Gene Knockdown Techniques | Mechanistic Target of Rapamycin Complex 1 | Multiprotein Complexes - metabolism | Neoplasm Metastasis | Heterografts | Prostatic Neoplasms - genetics | TOR Serine-Threonine Kinases - genetics | Biological Transport | Amino Acid Transport System ASC - genetics | Prostatic Neoplasms - prevention & control | Fatty Acids - metabolism | Prostatic Neoplasms - pathology | Down-Regulation | Amino Acid Transport System ASC - antagonists & inhibitors | Amino Acid Transport System ASC - metabolism | Animals | Cell Cycle | Mice, Nude | Cell Line, Tumor | Mice | RNA, Small Interfering | Proteins | Synthesis | Growth | Analysis | Physiological aspects | Fatty acids | Prostate cancer | Glutamine | Tumors | Original Papers | Original Paper
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3. Full Text Epigenetic modifications of splicing factor genes in myelodysplastic syndromes and acute myeloid leukemia
by Wong, Justin J.‐L and Lau, Katherine A and Pinello, Natalia and Rasko, John E. J
Cancer Science, ISSN 1347-9032, 11/2014, Volume 105, Issue 11, pp. 1457 - 1463
Somatic mutations in splicing factor genes have frequently been reported in myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). Although aberrant... 
splicing factors | DNA hypermethylation | Acute myeloid leukemia | epigenetics | myelodysplastic syndromes | Epigenetics | Splicing factors | Myelodysplastic syndromes | RING SIDEROBLASTS | METHYLATION | SPLICEOSOME | MACHINERY | U2AF1 | SF3B1 MUTATIONS | IMPACT | CANCER GENOMICS | ONCOLOGY | DIFFERENTIATION | PROTEOMIC ANALYSIS | Promoter Regions, Genetic | Epigenesis, Genetic | Humans | Middle Aged | Gene Silencing | Male | Gene Expression Regulation, Leukemic | Genetic Loci | Young Adult | DNA Methylation | Myelodysplastic Syndromes - diagnosis | RNA Splicing | Leukemia, Myeloid, Acute - diagnosis | Adolescent | Aged, 80 and over | Cell Line, Tumor | Adult | Female | Ribonucleoproteins - genetics | Aged | Myelodysplastic Syndromes - genetics | Mutation | Nuclear Proteins - genetics | Leukemia, Myeloid, Acute - genetics | Hematology | Anemia | Myeloid leukemia | Pathogenesis | Leukemia | Genes | Genomes | Gene expression | Patients | Lymphoma | Myelodysplastic syndrome | Gene silencing | Cell lines | DNA methylation | Genetic testing | Deoxyribonucleic acid--DNA | Cancer | Original
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4. Full Text Intron retention is regulated by altered MeCP2-mediated splicing factor recruitment
by Wong, Justin J.-L and Gao, Dadi and Nguyen, Trung V and Kwok, Chau-To and Van Geldermalsen, Michelle and Middleton, Rob and Pinello, Natalia and Thoeng, Annora and Nagarajah, Rajini and Holst, Jeff and Ritchie, William and Rasko, John E.J
Nature Communications, ISSN 2041-1723, 05/2017, Volume 8, Issue 1, p. 15134
While intron retention (IR) is considered a widely conserved and distinct mechanism of gene expression control, its regulation is poorly understood. Here we... 
MECP2 | TARGET | IMPACT | DNA METHYLATION | CHROMATIN | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | DIFFERENTIATION | C/EBP-EPSILON | GENOME | FAMILY | RNA Splice Sites | Alternative Splicing | Granulocyte Precursor Cells - metabolism | Introns | Cells, Cultured | Methyl-CpG-Binding Protein 2 - metabolism | RNA Polymerase II - metabolism | RNA Splicing Factors - genetics | Methyl-CpG-Binding Protein 2 - genetics | RNA Splicing Factors - metabolism | DNA Methylation | Animals | Protein Binding | RNA Polymerase II - genetics | Mice | Bioinformatics | Computer Science
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5. Full Text Intron retention enhances gene regulatory complexity in vertebrates
by Schmitz, Ulf and Pinello, Natalia and Jia, Fangzhi and Alasmari, Sultan and Ritchie, William and Keightley, Maria-Cristina and Shini, Shaniko and Lieschke, Graham J and Wong, Justin J-L and Rasko, John E.J
Genome Biology, ISSN 1474-7596, 11/2017, Volume 18, Issue 1, pp. 216 - 15
Background: While intron retention (IR) is now widely accepted as an important mechanism of mammalian gene expression control, it remains the least studied... 
Alternative splicing | Evolution | Intron retention | Granulocytes | Gene regulation | Transcriptomic complexity | LANDSCAPE | TRANSCRIPTS | BIOINFORMATICS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | INCREASE | GENETICS & HEREDITY | DIVERSITY | MESSENGER-RNA DECAY | EXPRESSION | PROGRAM | BIDIRECTIONAL PROMOTERS | Conserved Sequence - genetics | Introns - genetics | Species Specificity | Vertebrates - genetics | Humans | Gene Expression Regulation | Male | MicroRNAs - metabolism | Binding Sites - genetics | Promoter Regions, Genetic - genetics | Animals | Time Factors | MicroRNAs - genetics | Genome | Post-transcription | Genomics | MiRNA | Genomes | Leukocytes (neutrophilic) | Phylogeny | Mammals | Gene expression | Retention | Proteins | Vertebrates | Conserved sequence | Acids | 3' Untranslated regions | MicroRNAs | Leukocytes (granulocytic) | Bioinformatics | Binding sites | Life Sciences | Genetics | Computer Science
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6. Full Text Orchestrated Intron Retention Regulates Normal Granulocyte Differentiation
by Wong, Justin J.-L and Wong, Jason W.H and Ritchie, William and Ebner, Olivia A and Selbach, Matthias and Huang, Yizhou and Gao, Dadi and Pinello, Natalia and Gonzalez, Maria and Baidya, Kinsha and Thoeng, Annora and Khoo, Teh-Liane and Bailey, Charles G and Holst, Jeff and Rasko, John E.J
Cell, ISSN 0092-8674, 08/2013, Volume 154, Issue 3, pp. 583 - 595
Intron retention (IR) is widely recognized as a consequence of mis-splicing that leads to failed excision of intronic sequences from pre-messenger RNAs. Our... 
TRANSCRIPTION FACTORS | NUCLEAR-ENVELOPE | QUANTIFICATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENE-EXPRESSION | SURVEILLANCE | ABSENCE | MESSENGER-RNA DECAY | LAMIN B1 | CELL BIOLOGY | Granulocytes - cytology | Lamin Type B - genetics | Introns | Down-Regulation | Humans | Mice, Inbred C57BL | Nonsense Mediated mRNA Decay | RNA Splicing | Algorithms | Animals | Cell Nucleus - metabolism | Base Composition | Hematopoiesis | Mice | Granulocytes - metabolism | Proteins | Medical colleges | RNA | Analysis | Genes | Stem cells | Physiological aspects | Genetic translation
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7. DNA methylation/hydroxymethylation regulate gene expression and alternative splicing during terminal granulopoiesis
by Gao, Dadi and Pinello, Natalia and Nguyen, Trung V and Thoeng, Annora and Nagarajah, Rajini and Holst, Jeff and Rasko, John E.J and Wong, Justin J.-L
Epigenomics, ISSN 1750-1911, 01/2019, Volume 11, Issue 1, pp. 95 - 109
Aim: To determine whether epigenetic modifications of DNA regulate gene expression and alternative splicing during terminal granulopoiesis. Materials &... 
DNA hydroxymethylation | mRNA sequencing | whole genome bisulfite sequencing | alternative splicing | granulopoiesis | DNA methylation | gene expression | TRANSCRIPTION FACTORS | RESPIRATORY BURST | METHYLATION | NEUTROPHIL | 5-METHYLCYTOSINE | ENHANCERS | PU.1 | METHYLOME | COMMITMENT | GENETICS & HEREDITY | BLOOD
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8. Full Text Aberrant expression of enzymes regulating m 6 A mRNA methylation: implication in cancer
by Pinello, Natalia and Sun, Stephanie and Wong, Justin Jong-Leong
Cancer Biology and Medicine, ISSN 2095-3941, 11/2018, Volume 15, Issue 4, pp. 323 - 334
N -methyladenosine (m A) is an essential RNA modification that regulates key cellular processes, including stem cell renewal, cellular differentiation, and... 
RNA modification | methyladenosine (m | Tumor suppressor | Oncogene | Cancer
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9. Full Text RBM3 regulates temperature sensitive miR-142-5p and miR-143 (thermomiRs), which target immune genes and control fever
by Wong, Justin J.-L and Au, Amy Y.M and Gao, Dadi and Pinello, Natalia and Kwok, Chau-To and Thoeng, Annora and Lau, Katherine A and Gordon, Jane E.A and Schmitz, Ulf and Feng, Yue and Nguyen, Trung V and Middleton, Robert and Bailey, Charles G and Holst, Jeff and Rasko, John E.J and Ritchie, William
Nucleic Acids Research, ISSN 0305-1048, 01/2016, Volume 44, Issue 6, pp. 2888 - 2897
Fever is commonly used to diagnose disease and is consistently associated with increased mortality in critically ill patients. However, the molecular controls... 
CELLS | METAANALYSIS | REPRESSION | BIOCHEMISTRY & MOLECULAR BIOLOGY | RECEPTOR | HEAT-SHOCK | INFECTION | MICRORNAS | PROTEIN-SYNTHESIS | EXPRESSION | SEVERE SEPSIS | Leukocytes, Mononuclear - metabolism | RNA, Small Interfering - genetics | RNA-Binding Proteins - genetics | Toll-Like Receptor 2 - genetics | Cytokine Receptor gp130 - genetics | Humans | Tumor Necrosis Factor-alpha - genetics | Gene Expression Profiling | Receptors, Prostaglandin E - genetics | Leukocytes, Mononuclear - immunology | Tumor Necrosis Factor-alpha - immunology | Receptors, Prostaglandin E - immunology | Fever - immunology | Fever - pathology | Macrophages - immunology | RNA-Binding Proteins - antagonists & inhibitors | Cell Line | Interleukin-6 - genetics | Signal Transduction | RNA-Binding Proteins - immunology | Gene Expression Regulation | Cytokine Receptor gp130 - immunology | Macrophages - cytology | Body Temperature | MicroRNAs - immunology | Feedback, Physiological | Interleukin-6 - immunology | Fever - genetics | Toll-Like Receptor 2 - immunology | Leukocytes, Mononuclear - cytology | MicroRNAs - genetics | Body Temperature Regulation - genetics | Primary Cell Culture | RNA, Small Interfering - metabolism | Life Sciences | RNA
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10. Full Text An Atypical Parvovirus Drives Chronic Tubulointerstitial Nephropathy and Kidney Fibrosis
by Roediger, Ben and Lee, Quintin and Tikoo, Shweta and Cobbin, Joanna C.A and Henderson, James M and Jormakka, Mika and O’Rourke, Matthew B and Padula, Matthew P and Pinello, Natalia and Henry, Marisa and Wynne, Maria and Santagostino, Sara F and Brayton, Cory F and Rasmussen, Lorna and Lisowski, Leszek and Tay, Szun S and Harris, David C and Bertram, John F and Dowling, John P and Bertolino, Patrick and Lai, Jack H and Wu, Wengen and Bachovchin, William W and Wong, Justin J.-L and Gorrell, Mark D and Shaban, Babak and Holmes, Edward C and Jolly, Christopher J and Monette, Sébastien and Weninger, Wolfgang
Cell, ISSN 0092-8674, 10/2018, Volume 175, Issue 2, pp. 530 - 543.e24
The occurrence of a spontaneous nephropathy with intranuclear inclusions in laboratory mice has puzzled pathologists for over 4 decades, because its etiology... 
chronic kidney disease | tubulointerstitial fibrosis | inclusion body nephropathy | Parvoviridae | fibrosis | parvovirus | viral metagenomics | RENAL FIBROSIS | ALIGNMENT | TRANSCRIPTOME | BIOCHEMISTRY & MOLECULAR BIOLOGY | MICE | CELL | PROGRESSION | RANGE | CELL BIOLOGY | Mice | Kidney diseases | Analysis | Fibrosis | Resveratrol
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11. Full Text Targeting ASCT2-mediated glutamine uptake blocks prostate cancer growth and tumour development
: Regulation of glutamine transport in prostate cancer
by Wang, Qian and Hardie, Rae-Anne and Hoy, Andrew J and van Geldermalsen, Michelle and Gao, Dadi and Fazli, Ladan and Sadowski, Martin C and Balaban, Seher and Schreuder, Mark and Nagarajah, Rajini and Wong, Justin J-L and Metierre, Cynthia and Pinello, Natalia and Otte, Nicholas J and Lehman, Melanie L and Gleave, Martin and Nelson, Colleen C and Bailey, Charles G and Ritchie, William and Rasko, John EJ and Holst, Jeff
The Journal of Pathology, ISSN 0022-3417, 07/2015, Volume 236, Issue 3, pp. 278 - 289
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