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1. Full Text The molecular logic of endocannabinoid signalling
by Piomelli, Daniele
Nature Reviews Neuroscience, ISSN 1471-003X, 11/2003, Volume 4, Issue 11, pp. 873 - 884
The endocannabinoids are a family of lipid messengers that engage the cell surface receptors that are targeted by Delta(9)-tetrahydrocannabinol, the active... 
CB1 CANNABINOID RECEPTORS | ENDOGENOUS CANNABINOIDS | CEREBELLAR PURKINJE-CELLS | ACID AMIDE HYDROLASE | LONG-TERM DEPRESSION | DEPOLARIZATION-INDUCED SUPPRESSION | SYNAPTIC-TRANSMISSION | SR 141716A | CENTRAL-NERVOUS-SYSTEM | RAT-BRAIN | NEUROSCIENCES | Cannabinoid Receptor Modulators - metabolism | Hallucinogens - pharmacology | Humans | Neurotransmitter Agents - metabolism | Glutamic Acid - physiology | Receptor, Cannabinoid, CB1 - physiology | gamma-Aminobutyric Acid - physiology | Cannabinoid Receptor Modulators - physiology | Cannabis - chemistry | Animals | Signal Transduction - drug effects | Receptor, Cannabinoid, CB1 - drug effects | Cannabinoid Receptor Modulators - chemical synthesis | Signal Transduction - physiology | Synaptic Transmission - drug effects | Glutamic Acid - metabolism | Dronabinol - pharmacology | Neurotransmitter Agents - physiology | Endocannabinoids
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2. Full Text A fatty gut feeling
by Piomelli, Daniele
Trends in Endocrinology & Metabolism, ISSN 1043-2760, 2013, Volume 24, Issue 7, pp. 332 - 341
The absorptive epithelium of the proximal small intestine converts oleic acid released during fat digestion into oleoylethanolamide (OEA), an endogenous... 
Endocrinology & Metabolism | MOLECULAR CHARACTERIZATION | BODY-WEIGHT | HYDROLYZING ACID AMIDASE | N-ACYLPHOSPHATIDYLETHANOLAMINE | FOOD-INTAKE | GASTROINTESTINAL-TRACT | ENDOCRINOLOGY & METABOLISM | SMALL-INTESTINE | OLEOYLETHANOLAMIDE | TRANSPORTER FAT | PEPTIDE-1 SECRETION | Dietary Fats - metabolism | Intestinal Mucosa - metabolism | Satiety Response | Intestinal Mucosa - innervation | Signal Transduction | Humans | Feeding Behavior | Digestion | Sympathetic Nervous System - metabolism | Intestinal Absorption | Oleic Acids - metabolism | Gastrointestinal Motility | Animals | Hypothalamus - metabolism | Intestine, Small - innervation | PPAR alpha - agonists | Neurons - metabolism | Intestine, Small - metabolism | PPAR alpha - metabolism | Parasympathetic Nervous System - metabolism | Endocannabinoids | Dietary fat | Monounsaturated fatty acids
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3. Full Text More surprises lying ahead. The endocannabinoids keep us guessing
by Piomelli, Daniele
Neuropharmacology, ISSN 0028-3908, 01/2014, Volume 76, pp. 228 - 234
The objective of this review is to point out some important facts that about endogenous cannabinoids — lipid-derived signaling molecules that activate CB... 
Cocaine | Drugs of abuse | Endocannabinoid | Cannabinoid receptor | Anandamide | ENDOGENOUS CANNABINOID PRECURSOR | ANANDAMIDE HYDROLYSIS | MONOACYLGLYCEROL LIPASE | NEUROSCIENCES | ANTIDEPRESSANT-LIKE ACTIVITY | VENTRAL TEGMENTAL AREA | ACID AMIDE HYDROLASE | GLUTAMATERGIC SYNAPSES | PHARMACOLOGY & PHARMACY | RAT-BRAIN | DIACYLGLYCEROL-LIPASE | N-ACYL ETHANOLAMINE | Amidohydrolases - metabolism | Endocannabinoids - metabolism | Substance-Related Disorders - metabolism | Endocannabinoids - pharmacology | Humans | Polyunsaturated Alkamides - metabolism | Receptors, Cannabinoid - metabolism | Arachidonic Acids - metabolism | Endocannabinoids - physiology | Animals | Substance-Related Disorders - drug therapy | Endocannabinoids - therapeutic use | Receptors, Cannabinoid - genetics | Glycerin | Enzymes | Cannabinoids | Illegal drugs | Glycerol | Hydrolases | Fatty acids
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4. Arachidonic acid in cell signaling
by Piomelli, Daniele, 1958
1996, Molecular biology intelligence unit (Unnumbered), ISBN 9781570593949, 199
Cellular signal transduction | Arachidonic acid | Metabolism | Physiological effect
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5. Full Text Peripheral gating of pain signals by endogenous lipid mediators
by Piomelli, Daniele and Sasso, Oscar
Nature Neuroscience, ISSN 1097-6256, 02/2014, Volume 17, Issue 2, pp. 164 - 174
Primary sensory afferents and their neighboring host-defense cells are a rich source of lipid-derived mediators that contribute to the sensation of pain caused... 
PPAR-ALPHA | N-ACYLETHANOLAMINES | ACID AMIDE HYDROLASE | MECHANICAL HYPERALGESIA | INHIBITION REVEALS | THERAPEUTIC TARGET | DORSAL-ROOT GANGLIA | 2-ARACHIDONOYL GLYCEROL | INFLAMMATORY RESPONSE | NEUROSCIENCES | CANNABINOID CB2 RECEPTORS | Humans | Neurotransmitter Agents - metabolism | Nociceptors - physiology | Lipid Metabolism | Pain - metabolism | Pain - pathology | Peripheral Nerves - pathology | Peripheral Nerves - physiopathology | Inflammation - complications | Animals | Neurotransmitter Agents - therapeutic use | Afferent Pathways - physiology | Pain - etiology | Nociception | Physiological aspects | Lipids | Physiological research | Cellular signal transduction | Research | Properties
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6. Full Text Intestinal lipid-derived signals that sense dietary fat
by DiPatrizio, NV and Plomelli, D
JOURNAL OF CLINICAL INVESTIGATION, ISSN 0021-9738, 03/2015, Volume 125, Issue 3, pp. 891 - 898
Fat is a vital macronutrient, and its intake is closely monitored by an array of molecular sensors distributed throughout the alimentary canal. In the mouth,... 
MEDICINE, RESEARCH & EXPERIMENTAL | GLOSSOPHARYNGEAL NERVE | LONG-CHAIN FATTY | CORN-OIL | FOOD-INTAKE | LINGUAL LIPASE | ENDOCANNABINOID SYSTEM | ATTENUATES SUPPRESSION | OROSENSORY DETECTION | PEPTIDE-1 SECRETION | NUCLEUS-ACCUMBENS | Dietary Fats - metabolism | Eating | Solitary Nucleus - physiology | Endocannabinoids - physiology | Animals | Appetite Regulation | Humans | Intestines - innervation | Taste | Intestines - physiology | Satiation | Dietary fat | Physiological aspects | Physiological research | Eating (Physiology) | Research | Obesity | Anorexia | Peptides | Glycerol | Lipids | Nervous system | Hormones | Fatty acids | Small intestine | Weight control | Rodents | Oils & fats | Behavior | Food | Review Series
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7. Full Text Erratum: Blockade of nicotine reward and reinstatement by activation of alpha-type peroxisome proliferator-activated receptors (Biological Psychiatry (2011) 69 (633-644))
by Piomelli, Daniele
Biological Psychiatry, ISSN 0006-3223, 06/2011, Volume 69, Issue 12, p. 1212
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8. Full Text Endocannabinoid signal in the gut controls dietary fat intake
by Nicholas V. DiPatrizio and Giuseppe Astarita and Gary Schwartz and Xiaosong Li and Daniele Piomelli
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2011, Volume 108, Issue 31, pp. 12904 - 12908
Oral sensory signals drive dietary fat intake, but the neural mechanisms underlying this process are largely unknown. The endocannabinoid system has gained... 
Fat intake | Stomach | Receptors | Liquids | Corn oil | Diet | Rats | Lipids | Cannulae | Endocannabinoids | SYSTEM | BODY-WEIGHT | ANTAGONIST | CORN-OIL | FOOD-INTAKE | MULTIDISCIPLINARY SCIENCES | ANANDAMIDE | DEGRADATION | LIPASE | BRAIN | Cannabinoid Receptor Modulators - metabolism | Dietary Fats - metabolism | Male | Eating - physiology | Brain - metabolism | Piperidines - pharmacology | Dietary Fats - administration & dosage | Pyrazoles - pharmacology | Amidohydrolases - metabolism | Gastrointestinal Tract - drug effects | Phospholipase D - metabolism | Rats, Sprague-Dawley | Vagotomy | Gastrointestinal Tract - metabolism | Brain - drug effects | Eating - drug effects | Receptor, Cannabinoid, CB1 - metabolism | Pyrroles - pharmacology | Animals | Benzyl Compounds - pharmacology | Signal Transduction - drug effects | Intestine, Small - drug effects | Signal Transduction - physiology | Intestine, Small - metabolism | Lipids - analysis | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | Dietary fat | Physiological aspects | Neural circuitry | Health aspects | Biological Sciences
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9. Full Text A neuroscientist's guide to lipidomics
by Piomelli, Daniele and Rapaka, Rao and Astarita, Giuseppe
Nature Reviews Neuroscience, ISSN 1471-003X, 10/2007, Volume 8, Issue 10, pp. 743 - 754
Nerve cells mould the lipid fabric of their membranes to ease vesicle fusion, regulate ion fluxes and create specialized microenvironments that contribute to... 
ENDOGENOUS CANNABINOIDS | PHOSPHATIDYLSERINE RECEPTOR | DOCOSAHEXAENOIC ACID | METABOTROPIC GLUTAMATE RECEPTORS | CANNABINOID CB1 RECEPTOR | CENTRAL-NERVOUS-SYSTEM | PLATELET-ACTIVATING-FACTOR | LONG-TERM POTENTIATION | ARACHIDONIC-ACID | RAT-BRAIN | NEUROSCIENCES | Animals | Neurons - chemistry | Humans | Neurons - physiology | Neurosciences - methods | Membrane Lipids - physiology | Lipid Bilayers - chemistry | Lipid Bilayers - metabolism | Medical Laboratory Personnel | Membrane Lipids - chemistry | Physiological aspects | Membrane lipids | Research | Exocytosis
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10. Full Text Corrigendum to "The FAAH inhibitor URB-597 interferes with cisplatin- and nicotine-induced vomiting in the Suncus murinus (house musk shrew)" [Physiology & Behavior. Volume (97) 121-124]
by Piomelli, Daniele
Physiology and Behavior, ISSN 0031-9384, 10/2011, Volume 104, Issue 5, p. 1082
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11. Full Text Combining galantamine and memantine in multitargeted, new chemical entities potentially useful in Alzheimer's disease
by Simoni, Elena and Daniele, Simona and Bottegoni, Giovanni and Pizzirani, Daniela and Trincavelli, Maria L and Goldoni, Luca and Tarozzo, Glauco and Reggiani, Angelo and Martini, Claudia and Piomelli, Daniele and Melchiorre, Carlo and Rosini, Michela and Cavalli, Andrea
Journal of Medicinal Chemistry, ISSN 0022-2623, 11/2012, Volume 55, Issue 22, pp. 9708 - 9721
Herein we report on a novel series of multitargeted compounds obtained by linking together galantamine and memantine. The Compounds were designed by taking... 
SITE | BETA-AMYLOID AGGREGATION | TARGET-DIRECTED LIGANDS | NMDA RECEPTOR | CHEMISTRY, MEDICINAL | COMBINATION THERAPY | DOCKING | D-ASPARTATE RECEPTORS | SYNAPTIC-TRANSMISSION | DRUG DESIGN | ACETYLCHOLINESTERASE INHIBITORS | Memantine - pharmacology | Humans | Receptors, N-Methyl-D-Aspartate - metabolism | Rats | Male | Acetylcholinesterase - chemistry | Rats, Sprague-Dawley | Cerebral Cortex - metabolism | Feasibility Studies | Galantamine - pharmacology | Animals | Neuroprotective Agents - pharmacology | Cholinesterase Inhibitors - pharmacology | Alzheimer Disease - prevention & control | Computer Simulation | Neuroblastoma - drug therapy | Drug Design | Cell Proliferation - drug effects | Cerebral Cortex - drug effects | Drug Combinations | Index Medicus
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12. Full Text A second endogenous cannabinoid that modulates long-term potentiation
by Piomelli, Daniele and Schweitzer, Paul and Stella, Nephi
Nature, ISSN 0028-0836, 08/1997, Volume 388, Issue 6644, pp. 773 - 778
Cannabinoid receptors are molecular targets for marijuana and hashish, the widespread drugs of abuse. These receptors are expressed in areas of the central... 
SLICES | BINDS | INHIBITION | MULTIDISCIPLINARY SCIENCES | ANANDAMIDE | NEURONS | RECEPTOR | K RO MULTIDISCIPLINARY SCIENCES | ARACHIDONIC-ACID | IDENTIFICATION | BRAIN | Electric Stimulation | Gas Chromatography-Mass Spectrometry | Brain - physiology | Brain - metabolism | Diglycerides - biosynthesis | Polyunsaturated Alkamides | Arachidonic Acids - analysis | Calcium - physiology | Glycerides - analysis | Neurons - metabolism | Endocannabinoids | Arachidonic Acids - physiology | Cells, Cultured | Rats | Glycerides - biosynthesis | Receptors, Drug - metabolism | Hippocampus - metabolism | Animals | Glycerides - physiology | Long-Term Potentiation | Ligands | Receptors, Cannabinoid | Brain Chemistry | Hippocampus - physiology | In Vitro Techniques | Cannabinoids - analysis | Astrocytes - metabolism | Cannabinoids | Research | Drug receptors | Drugs | Medical research | Nervous system | Biochemistry
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