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Aging Cell, ISSN 1474-9718, 06/2019, Volume 18, Issue 3, pp. e12950 - n/a
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2015, Volume 112, Issue 46, pp. E6301 - E6310
Journal Article
Journal Article
Aging Cell, ISSN 1474-9718, 06/2016, Volume 15, Issue 3, pp. 428 - 435
Journal Article
Aging Cell, ISSN 1474-9718, 08/2015, Volume 14, Issue 4, pp. 644 - 658
Summary The healthspan of mice is enhanced by killing senescent cells using a transgenic suicide gene. Achieving the same using small molecules would have a... 
dasatinib | plasminogen‐activated inhibitor | dependence receptors | quercetin | ephrins | PI3K delta | p21 | Dasatinib | Dependence receptors | Ephrins | Plasminogen-activated inhibitor | Quercetin | P21 | ENDOTHELIAL DYSFUNCTION | PLASMINOGEN-ACTIVATOR INHIBITOR-1 | EXPRESSION PROFILES | plasminogen-activated inhibitor | CELLULAR SENESCENCE | CANCER-THERAPY | CELL BIOLOGY | GERIATRICS & GERONTOLOGY | LUNG-CANCER | SET ENRICHMENT ANALYSIS | GENE-EXPRESSION | IONIZING-RADIATION | TUMOR-GROWTH | Carotid Arteries - drug effects | Endonucleases - genetics | Plasminogen Activator Inhibitor 2 - genetics | Transcriptome | Gene Expression Profiling | Adipocytes - drug effects | Aging - genetics | Osteoporosis - metabolism | Ephrins - metabolism | Plasminogen Activator Inhibitor 2 - metabolism | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Osteoporosis - genetics | Intervertebral Disc - pathology | Fibroblasts - metabolism | Endothelial Cells - metabolism | Intervertebral Disc - chemistry | Fibroblasts - pathology | Mesenchymal Stem Cells - pathology | Mice, Knockout | Dasatinib - pharmacology | Osteoporosis - pathology | Ephrins - genetics | Fibroblasts - drug effects | Mice | Endothelial Cells - pathology | bcl-X Protein - metabolism | Aging - metabolism | Aging - drug effects | bcl-X Protein - genetics | Cellular Senescence - drug effects | Phosphatidylinositol 3-Kinases - metabolism | Endonucleases - metabolism | DNA-Binding Proteins - metabolism | Cyclin-Dependent Kinase Inhibitor p21 - genetics | Mesenchymal Stem Cells - drug effects | Mesenchymal Stem Cells - metabolism | Heart - physiopathology | Cellular Senescence - genetics | Osteoporosis - prevention & control | DNA-Binding Proteins - genetics | Adipocytes - pathology | Aging - pathology | Phosphatidylinositol 3-Kinases - genetics | Animals | Quercetin - pharmacology | Adipocytes - metabolism | Heart - drug effects | Carotid Arteries - pathology | Intervertebral Disc - drug effects | Drug Combinations | Endothelial Cells - drug effects | Original
Journal Article
Nature Medicine, ISSN 1078-8956, 08/2018, Volume 24, Issue 8, pp. 1246 - 1256
Journal Article
Nature Medicine, ISSN 1078-8956, 09/2017, Volume 23, Issue 9, pp. 1072 - 1079
Aging is associated with increased cellular senescence, which is hypothesized to drive the eventual development of multiple comorbidities(1). Here we... 
MEDICINE, RESEARCH & EXPERIMENTAL | CELLS | SECRETORY PHENOTYPE | BIOCHEMISTRY & MOLECULAR BIOLOGY | MATURE | IDENTIFICATION | CELL BIOLOGY | OSTEOCLASTOGENESIS | ACTIVATOR | MASS | ESTROGEN | FRACTURES | DYSFUNCTION | Osteocytes - drug effects | Cancellous Bone - metabolism | beta-Galactosidase | Cellular Senescence - drug effects | Apoptosis - genetics | Cancellous Bone - drug effects | Gene Expression Profiling | Osteoclasts - cytology | Bone and Bones - drug effects | Caspase 8 - genetics | Flow Cytometry | Osteoporosis - metabolism | Bone and Bones - metabolism | Osteoporosis - genetics | Cell Differentiation | Osteoblasts - cytology | Real-Time Polymerase Chain Reaction | Pyrazoles - pharmacology | Cellular Senescence - genetics | Osteoblasts - drug effects | Mice, Transgenic | Absorptiometry, Photon | Cortical Bone - metabolism | Janus Kinases - antagonists & inhibitors | Culture Media, Conditioned | Animals | Cortical Bone - drug effects | Weight-Bearing | Mice | In Vitro Techniques | Osteoclasts - drug effects | Prevention | Osteoporosis | Aging | Physiological aspects | Genetic aspects | Research | Cells | Senescence | Bone (trabecular) | Suicide | Bone resorption | Bone growth | Biomedical materials | Mineralization | Rodents | Computer architecture | Biocompatibility | Inhibition | Conditioning | Bone loss | Bone (cortical) | Suicide genes | Age | Cardiovascular system | Cell survival | Aging (artificial) | Caspase | Pharmacology | Secretome | Inflammation | Insulin | Osteoclastogenesis | Caspase-8 | Bone mass | Cellular biology | Sensitivity enhancement | Bone | In vitro methods and tests | Osteogenesis | Disease prevention | Osteoclast | Drug therapy | Osteocyte
Journal Article