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physiology (9) 9
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middle aged (7) 7
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Current pharmaceutical design, 08/2019
The Endocannabinoid (eCB) system and its role in many physiological and pathological conditions is well described and accepted, and includes cardiovascular... 
Journal Article
SCIENTIFIC REPORTS, ISSN 2045-2322, 07/2018, Volume 8, Issue 1, pp. 1 - 16
Accumulating evidence supports the role of astrocytes in endocannabinoid mediated modulation of neural activity. It has been reported that some astrocytes... 
CANNABINOID RECEPTORS | SYNAPSES | ENDOCANNABINOIDS | MULTIDISCIPLINARY SCIENCES | SYNAPTIC-TRANSMISSION | NEURONS | LIPASE | GLIAL-CELLS | DORSAL-HORN | BRAIN | COMMUNICATION | Spinal cord | Calcium (intracellular) | 2-Arachidonylglycerol | Astrocytes | Diacylglycerol | Lipoprotein lipase | Receptor mechanisms | Intracellular | Cannabinoid CB1 receptors | Lipase
Journal Article
Advances in Pharmacology, ISSN 1054-3589, 2017, Volume 80, pp. 1 - 30
Identification of the two major endogenous cannabinoid ligands, known as endocannabinoids, N-arachidonoyl-ethanolamine (anandamide, AEA) and... 
Lipidomics | EC-like molecules | Mass spectrometry | Lipoamines | Endocannabinoids | Endocannabinoids - isolation & purification | Metabolomics | Animals | Amines - analysis | Endocannabinoids - analysis | Humans | Mass Spectrometry | Chemistry Techniques, Analytical - methods | Endocannabinoids - chemistry
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2011, Volume 6, Issue 9, p. e25565
Apart from its role during labor and lactation, oxytocin is involved in several other functions. Interestingly, oxytocin-and oxytocin receptor-deficient mice... 
BODY-WEIGHT | PPAR-ALPHA | TARGETED DISRUPTION | ADIPOCYTES | PLASMA | BIOLOGY | FAT | RECEPTOR GENE-EXPRESSION | DEFICIENT MICE | OLEOYLETHANOLAMIDE | MAMMARY-GLAND | Anti-Obesity Agents - blood | Oxytocin - pharmacology | Obesity - drug therapy | Diet - adverse effects | Body Weight - drug effects | Male | Dose-Response Relationship, Drug | Oleic Acids - metabolism | Adipose Tissue - metabolism | Oleic Acids - biosynthesis | Obesity - etiology | Endocannabinoids | Anti-Obesity Agents - metabolism | Anti-Obesity Agents - administration & dosage | Oxytocin - blood | Insulin Resistance | Rats | Obesity - physiopathology | PPAR alpha - genetics | Oxytocin - biosynthesis | Gene Knockout Techniques | Obesity - metabolism | Oxytocin - administration & dosage | PPAR alpha - deficiency | Animals | Mice | PPAR alpha - metabolism | Adipose Tissue - drug effects | Anti-Obesity Agents - pharmacology | Type 2 diabetes | Obesity | Enzymes | Monounsaturated fatty acids | Diet | Body weight | Physiological aspects | Insulin resistance | Adipose tissue | Lactation | Homeostasis | Body weight loss | Phospholipids | Adipocytes | Desaturase | High fat diet | Animal lactation | Infusion | Oxidation resistance | Oleic acid | Rodents | Coenzyme A | Physiology | Oxidation | Lipid metabolism | Drug dosages | Phosphatidylethanolamine | Oxytocin | Internal medicine | Diabetes mellitus | Weight loss | Triglycerides | Metabolism | Gene expression | Insulin | Body weight gain | Fatty acids | Lipolysis | Medicine | Glucose tolerance | Nutrition research | Intolerance | Weight control | Food intake | Peroxisome proliferator-activated receptors | Diabetes | Binding sites | Endocrinology
Journal Article
Journal Article
International journal of molecular sciences, ISSN 1422-0067, 09/2019, Volume 20, Issue 18, p. 4503
There is robust evidence indicating that enhancing the endocannabinoid (eCB) tone has therapeutic potential in several brain disorders. The inhibition of eCBs... 
URB597 | endocannabinoid tone | fatty acid amide hydrolase | patients’ compliance | intranasal drug delivery | PF-04457845
Journal Article
Endocrinology, ISSN 0013-7227, 10/2017, Volume 158, Issue 10, pp. 3462 - 3476
Phthalates, used as plasticizers, have become a ubiquitous contaminant and have been reported for their potential to induce toxicity in living organisms. Among... 
DANIO-RERIO | HUMAN EXPOSURE | LIPID-METABOLISM | FOOD-INTAKE | INSULIN-RESISTANCE | ENDOCRINOLOGY & METABOLISM | ADIPOCYTE DIFFERENTIATION | ACTIVATED RECEPTOR-ALPHA | DIISONONYL PHTHALATE | ACYL-COENZYME | NEUROPEPTIDE-Y | Endocannabinoids - metabolism | Plasticizers - pharmacology | Gene Expression - drug effects | Lipoprotein Lipase - drug effects | Receptor, Cannabinoid, CB2 - genetics | Brain - metabolism | Dose-Response Relationship, Drug | Arachidonic Acids - metabolism | Phospholipase D - drug effects | Endocrine Disruptors - pharmacology | Liver - drug effects | Female | Phospholipase D - genetics | Phthalic Acids - pharmacology | Lipoprotein Lipase - metabolism | Fatty Liver - metabolism | Lipoprotein Lipase - genetics | Receptor, Cannabinoid, CB2 - drug effects | Zebrafish | Glycerides - metabolism | Polyunsaturated Alkamides - metabolism | Phospholipase D - metabolism | Brain - drug effects | Receptor, Cannabinoid, CB1 - metabolism | Receptor, Cannabinoid, CB2 - metabolism | Animals | Receptor, Cannabinoid, CB1 - genetics | Lipid Metabolism - drug effects | Receptor, Cannabinoid, CB1 - drug effects | Endocrine disruptors | Neuroimaging | Brain | Infrared spectroscopy | Deregulation | Transcription | Image processing | Toxicity | Liver | Lipids | Infrared analysis | Fatty liver | Infrared imaging | Lipid metabolism | Appetite | Plasticizers | Histology | Metabolism | Infrared imagery | Phthalates | Studies | Image analysis | Contaminants | Aquatic organisms
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 1 - 1
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. 
Spinal cord | Calcium mobilization | Calcium (intracellular) | 2-Arachidonylglycerol | Astrocytes | Receptor mechanisms | Cannabinoid CB1 receptors
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 06/2012, Volume 166, Issue 4, pp. 1444 - 1460
BACKGROUND AND PURPOSE Cannabichromene (CBC) is a major non‐psychotropic phytocannabinoid that inhibits endocannabinoid inactivation and activates the... 
ileum | TRPA1 | 2‐arachydonoylglycerol | intestinal motility | cannabinoids | cannabichromene | cannabinoid receptors | anandamide | transient receptor potential (TRP) channels | gastrointestinal transit | 2-arachydonoylglycerol | TRP CHANNELS | PIG SMALL-INTESTINE | BOWEL-DISEASE | MOUSE INTESTINE | DELTA-OPIOID-RECEPTOR | EXPERIMENTAL COLITIS | NITRIC-OXIDE | PHARMACOLOGY & PHARMACY | GASTROINTESTINAL MOTILITY | POTENTIAL ANKYRIN 1 | CB1 RECEPTORS | Transient Receptor Potential Channels - antagonists & inhibitors | Gastrointestinal Motility - drug effects | Ileum - metabolism | Male | Receptor, Cannabinoid, CB2 - antagonists & inhibitors | Ileum - immunology | RNA, Messenger - metabolism | Receptor, Cannabinoid, CB2 - genetics | Jejunum - metabolism | Jejunum - drug effects | Arachidonic Acids - metabolism | Cannabis - chemistry | Ileum - drug effects | Receptor, Cannabinoid, CB1 - agonists | Jejunum - physiopathology | Duodenum - metabolism | Ileitis - physiopathology | Duodenum - physiopathology | Ileitis - metabolism | Transient Receptor Potential Channels - metabolism | Endocannabinoids | Duodenum - immunology | Ileitis - drug therapy | Jejunum - immunology | Ethanolamines | Polyunsaturated Alkamides - metabolism | Transient Receptor Potential Channels - agonists | Mice, Inbred ICR | Gene Expression Regulation - drug effects | Receptor, Cannabinoid, CB1 - metabolism | Receptor, Cannabinoid, CB2 - metabolism | Cannabinoids - therapeutic use | Gastrointestinal Agents - pharmacology | Animals | Receptor, Cannabinoid, CB1 - genetics | Ileitis - immunology | Muscle Contraction - drug effects | Transient Receptor Potential Channels - genetics | TRPA1 Cation Channel | Ileum - physiopathology | Mice | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | In Vitro Techniques | Palmitic Acids - metabolism | Duodenum - drug effects | Glycerol | Rodents | Motility | Research Papers
Journal Article
Journal Article
Molecular Pain, ISSN 1744-8069, 1/2011, Volume 7, Issue 1, pp. 7 - 7
Background: Neuropathic pain is a chronic disease resulting from dysfunction within the “pain matrix”. The basolateral amygdala (BLA) can modulate cortical... 
ANTERIOR CINGULATE CORTEX | BASOLATERAL AMYGDALA | ANION GRADIENT | N-ARACHIDONOYL-SEROTONIN | CENTRAL-NERVOUS-SYSTEM | TRPV1 RECEPTORS | CHRONIC BACK-PAIN | SYNAPTIC PLASTICITY | NEUROBLASTOMA-CELLS | NEUROSCIENCES | DORSAL-HORN | Amygdala - physiopathology | Neurons - pathology | Amygdala - drug effects | Serotonin - administration & dosage | Electric Stimulation | Rats, Wistar | Prefrontal Cortex - physiopathology | Mononeuropathies - physiopathology | Male | Carbamates - administration & dosage | RNA, Messenger - metabolism | Serotonin - pharmacology | Prefrontal Cortex - pathology | Electrodes | TRPV Cation Channels - metabolism | Benzamides - administration & dosage | Prefrontal Cortex - drug effects | Piperidines - pharmacology | Arachidonic Acids - administration & dosage | TRPV Cation Channels - antagonists & inhibitors | Benzamides - pharmacology | Neurons - metabolism | Prefrontal Cortex - enzymology | Carbamates - pharmacology | Pyrazoles - pharmacology | Amidohydrolases - metabolism | Piperidines - administration & dosage | Microinjections | Amidohydrolases - genetics | RNA, Messenger - genetics | Rats | Amidohydrolases - antagonists & inhibitors | Arachidonic Acids - pharmacology | TRPV Cation Channels - genetics | Mononeuropathies - pathology | Pyrazoles - administration & dosage | Animals | Microdialysis | Serotonin - analogs & derivatives | Nociceptors - metabolism | Mononeuropathies - enzymology | Electrophysiological Phenomena - drug effects | Enzymes | Pain | Physiological aspects | Hydrolases | Development and progression | Genetic aspects | Research | Prefrontal cortex | Fatty acids | Risk factors | Studies | Back pain | Decision making | Neurons | Rodents | Surgery | Behavior | Laboratory animals | Experiments | Animal cognition
Journal Article