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Chembiochem : a European journal of chemical biology, ISSN 1439-4227, 07/2019
NMR measurements of rotational and translational diffusion are used to characterize the solution behavior of a wide variety of therapeutic proteins and... 
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 11/2016, Volume 124, p. 36
The design, synthesis, SAR, and biological profile of a substituted 4-morpholine sulfonamide series of [gamma]-secretase inhibitors (GSIs) were described. In... 
Genetically modified animals | Liability (Law) | Sulfonamides | Analysis | Cytochrome P-450 | Animal genetic engineering | Alzheimer's disease | Bonds | Carbamates
Journal Article
Journal Article
Bioorganic and Medicinal Chemistry Letters, ISSN 0960-894X, 01/2013, Volume 23, Issue 2, pp. 466 - 471
In an attempt to further improve overall profiles of the oxadiazine series of GSMs, in particular the hERG activity, conformational modifications of the core... 
Journal Article
International Journal of Alzheimer's Disease, ISSN 2090-8024, 01/2013, Volume 2013, pp. 1 - 14
Substantial evidence implicates -amyloid (A) peptides in the etiology of Alzheimer’s disease (AD). A is produced by the proteolytic cleavage of the amyloid... 
Physiological aspects | Enzyme inhibitors | Research | Peptides | Analysis | Amyloid beta-protein | Chemical properties | Alzheimer's disease | Health aspects | Risk factors | Proteins | Studies | Pathology | Plasma | Brain research | Rodents | Biomarkers | Drug dosages
Journal Article
SCIENCE CHINA Chemistry, ISSN 1674-7291, 11/2011, Volume 54, Issue 11, p. 1688
Novel tricyclic sulfones as I3-secretase inhibitors have been reported by this laboratory for the treatment of Alzheimer's disease. Compounds in this series... 
Carbocyclic compounds | Sulfonamides | Heterocyclic compounds | Cyclohexane | Alzheimer's disease
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 02/2000, Volume 122, Issue 4, pp. 619 - 631
A stereoselective total synthesis of natural levorotatory polycavernoside A (1) has been achieved. Initial investigations produced the properly activated... 
SECONDARY ALCOHOLS | SYSTEM | GLYCOSIDES | OLIGOSACCHARIDES | RING PART | PROTECTION | CONVERSION | CONSTRUCTION | RELATIVE CONFIGURATION | LACTONIZATION | CHEMISTRY, MULTIDISCIPLINARY | fucose | Polycavernoside A | glycosidation | xylose
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 11/2016, Volume 24, Issue 21, pp. 5534 - 5545
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 01/2012, Volume 55, Issue 1, pp. 489 - 502
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 10/2017, Volume 8, Issue 10, pp. 1002 - 1006
The design and synthesis of a new series of tetrahydrobenzisoxazoles as modulators of γ-secretase activity and their structure–activity relationship (SAR) will... 
γ-secretase modulators | Alzheimer's disease | tetrahydrobenzisoxazole | CHEMISTRY, MEDICINAL | y-secretase modulators | OXADIAZINES | A-BETA-42 | ALZHEIMERS-DISEASE | IDENTIFICATION | BETA | POTENT | IN-VIVO | AGGREGATION | BRAIN
Journal Article
Journal Article
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 2005, Volume 15, Issue 9, pp. 2365 - 2369
Journal Article
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