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Gut, ISSN 0017-5749, 02/2018, Volume 67, Issue 2, pp. 320 - 332
ObjectiveLimited efficacy of immune checkpoint inhibitors in pancreatic ductal adenocarcinoma (PDAC) has prompted investigation into combination therapy. We... 
INTERLEUKINS | IMMUNOTHERAPY | PANCREATIC CANCER | MULTIPLE-MYELOMA | INTERFERON-ALPHA | ACTIVATION | ADENOCARCINOMA | SILTUXIMAB | MONOCLONAL-ANTIBODY | MICE | SUPPRESSOR-CELLS | INTERLEUKIN-6 | GASTROENTEROLOGY & HEPATOLOGY | T-CELLS | Antineoplastic Agents, Immunological - administration & dosage | Interleukin-6 - antagonists & inhibitors | Pancreatic Neoplasms - metabolism | Humans | Actins - metabolism | Carcinoma, Pancreatic Ductal - metabolism | STAT Transcription Factors - metabolism | Janus Kinases - metabolism | L-Selectin - metabolism | Pancreatic Neoplasms - drug therapy | Th1 Cells - metabolism | Pancreatic Stellate Cells - immunology | Hyaluronan Receptors - metabolism | Female | Lymphocytes, Tumor-Infiltrating - metabolism | Carcinoma, Pancreatic Ductal - immunology | Interleukin-6 - metabolism | Disease Models, Animal | Mice, Inbred C57BL | Survival Rate | B7-H1 Antigen - immunology | Disease Progression | Tumor Microenvironment - immunology | Xenograft Model Antitumor Assays | Carcinoma, Pancreatic Ductal - drug therapy | B7-H1 Antigen - metabolism | Animals | B7-H1 Antigen - antagonists & inhibitors | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Pancreatic Neoplasms - immunology | Interleukin-6 - immunology | Mice | Pancreatic Stellate Cells - metabolism | Adenocarcinoma | Immunohistochemistry | Flow cytometry | Animal models | Transcription | CD8 antigen | Multiple myeloma | Smooth muscle | Lymphocytes T | Kinases | Metastases | Interleukin 6 | Lymphocytes | Actin | CD44 antigen | Immunotherapy | Fibroblasts | BRCA2 protein | Stellate cells | Cytokines | Secretion | Stroma | CD62L protein | CD4 antigen | Immune checkpoint | Antibiotics | Pancreatic cancer | Medical prognosis | PD-L1 protein | Cell lines | Ligands | Genetic engineering | Apoptosis | PD-L1 | pancreatic cancer | IL-6
Journal Article
Cancer Research, ISSN 0008-5472, 08/2016, Volume 76, Issue 15 Supplement, pp. A40 - A40
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2017, Volume 12, Issue 9, p. e0184984
Journal Article
Journal Article
JOURNAL OF IMMUNOLOGY, ISSN 0022-1767, 10/2017, Volume 199, Issue 7, pp. 2333 - 2342
Journal Article
Cancer Research, ISSN 0008-5472, 05/2018, Volume 78, Issue 10 Supplement, pp. PR04 - PR04
Journal Article
Cell Cycle, ISSN 1538-4101, 12/2011, Volume 10, Issue 23, pp. 4128 - 4137
Previous studies have demonstrated that curcumin induces mitochondria-mediated apoptosis. However, understanding of the molecular mechanisms underlying... 
Binding | Proteins | Landes | Calcium | Bioscience | Biology | Cell | Cycle | Cancer | Organogenesis | Cytochrome c | Caspase | Mitochondria | Apaf-1 | Curcumin | p21 | CARCINOMA-CELLS | GLIOMA-CELLS | P53-DEPENDENT APOPTOSIS | BCL-XL | mitochondria | DOWN-REGULATION | MEDIATED APOPTOSIS | caspase | CELL BIOLOGY | COLON-CANCER CELLS | ECTOPIC EXPRESSION | BAX | cytochrome c | CYTOCHROME-C RELEASE | curcumin | RNA, Small Interfering - genetics | Humans | Caspase 3 - metabolism | Cytosol - drug effects | Gene Expression Regulation, Neoplastic | Cytochromes c - genetics | Apoptotic Protease-Activating Factor 1 - genetics | RNA, Messenger - metabolism | Gene Knockdown Techniques | Dose-Response Relationship, Drug | Lentivirus - metabolism | Mitochondrial Membranes - drug effects | Cyclin-Dependent Kinase Inhibitor p21 - genetics | Mitochondria - genetics | Amino Acid Chloromethyl Ketones - pharmacology | Caspase 3 - genetics | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Lentivirus - genetics | bcl-2-Associated X Protein - genetics | Jurkat Cells | Cytochromes c - metabolism | HCT116 Cells | RNA, Messenger - genetics | Curcumin - pharmacology | Enzyme Inhibitors - pharmacology | bcl-2-Associated X Protein - metabolism | Mitochondria - metabolism | Mitochondria - drug effects | Caspase Inhibitors | Apoptotic Protease-Activating Factor 1 - metabolism | Mitochondrial Membranes - metabolism | Fluorescent Antibody Technique | Cytosol - metabolism | Enzyme Activation | Apoptosis | RNA, Small Interfering - metabolism | Report
Journal Article
Developmental Dynamics, ISSN 1058-8388, 06/2018, Volume 247, Issue 6, pp. 854 - 866
Journal Article
Gastroenterology, ISSN 0016-5085, 04/2017, Volume 152, Issue 5, pp. S275 - S275
Journal Article
Gastroenterology, ISSN 0016-5085, 2017, Volume 152, Issue 5, pp. S275 - S275
Journal Article
Cancer Research, ISSN 0008-5472, 07/2015, Volume 75, Issue 13 Supplement, pp. B01 - B01
Journal Article
Neoplasia, ISSN 1476-5586, 2016, Volume 18, Issue 9, pp. 541 - 552
Journal Article