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Journal Article
Molecules, ISSN 1420-3049, 2018, Volume 23, Issue 5, p. 1209
Journal Article
International Journal of Nanomedicine, ISSN 1176-9114, 2018, Volume 13, pp. 7771 - 7787
Purpose: Anticancer drug delivery systems are often limited by hurdles, such as off-target distribution, slow cellular internalization, limited lysosomal... 
Nanoparticles | SMA-tDodSNO | Biologic barriers | Doxorubicin | Nitric oxide | Synergistic cytotoxicity | ACRIDINE-ORANGE | nitric oxide | DESIGN | SOLID TUMORS | PERMEABILITY | NANOSCIENCE & NANOTECHNOLOGY | MODEL | biologic barriers | MACROMOLECULAR THERAPEUTICS | LYSOSOMES | nanoparticles | RESISTANCE | PHARMACOLOGY & PHARMACY | doxorubicin | synergistic cytotoxicity | DRUG-DELIVERY SYSTEMS | CELL | Doxorubicin - therapeutic use | Nanoparticles - chemistry | Apoptosis - drug effects | Nitric Oxide - pharmacology | Humans | Triple Negative Breast Neoplasms - drug therapy | Maleates - chemical synthesis | Polystyrenes - chemistry | Polystyrenes - chemical synthesis | Endocytosis | Lysosomes - metabolism | S-Nitrosothiols - chemistry | Injections, Subcutaneous | Triple Negative Breast Neoplasms - pathology | Female | Antineoplastic Agents - pharmacology | Doxorubicin - administration & dosage | Lysosomes - drug effects | Cell Survival - drug effects | S-Nitrosothiols - chemical synthesis | Mitochondria - metabolism | Maleates - chemistry | Mitochondria - drug effects | Permeability | Animals | Cell Line, Tumor | Drug Liberation | Cell Proliferation - drug effects | Mice, Inbred BALB C | Cell Cycle - drug effects | Doxorubicin - pharmacology | Drugs | Drug delivery systems | Anthracyclines | Care and treatment | Analysis | Drug resistance | Apoptosis | Cancer | Vehicles | Medicine | Chemotherapy | Acids | Breast cancer | Cancer therapies | Autophagy | Molecular weight | Tumors | Index Medicus | Biological barriers
Journal Article
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, ISSN 1422-0067, 05/2019, Volume 20, Issue 10, p. 2593
High levels of heme oxygenase (HO)-1 have been frequently reported in different human cancers, playing a major role in drug resistance and regulation of cancer... 
heme oxygenase | TRANSLOCATION | HO-1 activity inhibitor | BIOCHEMISTRY & MOLECULAR BIOLOGY | ER stress | metformin | apoptosis | SIRT1 | CHEMISTRY, MULTIDISCIPLINARY | GLYCOLYSIS | prostate cancer | IN-VITRO | UNFOLDED PROTEIN RESPONSE | RESISTANCE | STRESS | CONTRIBUTES | MODULATION
Journal Article
ChemMedChem, ISSN 1860-7179, 07/2018, Volume 13, Issue 13, pp. 1336 - 1342
A 3D quantitative structure–activity relationship (3D‐QSAR) model for predicting the activity of heme oxygenase 1 (HO‐1) inhibitors was constructed with the... 
heme oxygenase | HO-1 inhibitors | 3D-QSAR | virtual screening | scaffold hopping | Analysis | Heme | Lead compounds | Pharmacology | Hydrophobicity | Structure-activity relationships | Optimization | Design optimization | Oxygenase | Organic chemistry | Inhibitors | Mathematical models | Three dimensional models | Scaffolds | Index Medicus
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 03/2018, Volume 148, pp. 54 - 62
Here we report the design, synthesis, and molecular modeling of new potent and selective imidazole-based HO-1 inhibitors in which the imidazole nucleus and the... 
Heme oxygenase-1 western region | Docking studies | In silico profiling | ADME-Toxicity | HO-1 imidazole inhibitors | BINDING MODE | CHEMISTRY, MEDICINAL | PROTEIN | HO-1 INHIBITORS | RAY CRYSTAL-STRUCTURE | DIOXOLANE COMPOUNDS | METALLOPORPHYRINS | AZALANSTAT | DERIVATIVES | EXPRESSION | INSIGHTS | Analysis | Heme | Index Medicus
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 09/2013, Volume 21, Issue 17, pp. 5145 - 5153
Journal Article
Journal Article