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Journal Article
Journal Article
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 07/2011, Volume 286, Issue 29, pp. 26016 - 26027
ADAMTS5 has been implicated in the degradation of cartilage aggrecan in human osteoarthritis. Here, we describe a novel role for the enzyme in the regulation... 
Sequence Deletion | Receptors, Transforming Growth Factor beta - genetics | Epithelioid Cells - drug effects | Humans | Transforming Growth Factor beta1 - metabolism | Cell Aggregation - drug effects | Male | Stem Cells - metabolism | Dermis - drug effects | Phosphorylation - genetics | Hyaluronan Receptors - metabolism | Phosphorylation - drug effects | Wound Healing - genetics | Wound Healing - drug effects | Protein-Serine-Threonine Kinases - metabolism | Transforming Growth Factor beta1 - pharmacology | Epithelioid Cells - pathology | Fibroblasts - metabolism | Animals, Newborn | ADAMTS5 Protein | Smad Proteins, Receptor-Regulated - genetics | Dermis - metabolism | Dermis - physiopathology | Protein-Serine-Threonine Kinases - genetics | ADAM Proteins - deficiency | Smad Proteins, Receptor-Regulated - metabolism | Activin Receptors, Type I - metabolism | Genotype | Signal Transduction - genetics | Transforming Growth Factor beta1 - genetics | Aggrecans - metabolism | Fibroblasts - pathology | Activin Receptors, Type I - genetics | Aggrecans - genetics | Epithelioid Cells - metabolism | Gene Expression Regulation - drug effects | Animals | Receptors, Transforming Growth Factor beta - metabolism | Signal Transduction - drug effects | Fibroblasts - drug effects | Fibrosis | Stem Cells - drug effects | Stem Cells - pathology | Dermis - pathology | Mice | ADAM Proteins - genetics | Index Medicus | Proteoglycan Structure | ADAM ADAMTS | Glycobiology and Extracellular Matrices | Transforming Growth Factor beta (TGFbeta) | Connective Tissue | Proteoglycan Synthesis
Journal Article
Journal of Orthopaedic Research, ISSN 0736-0266, 07/2017
Journal Article
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2016, Volume 11, Issue 11, p. e0167069
Equine degenerative suspensory ligament desmitis (DSLD) in Peruvian Paso horses typically presents at 7-15 years and is characterized by lameness, focal... 
Horses | Genetic aspects | Research | Transforming growth factors | Collagen | Genes
Journal Article
Journal of Orthopaedic Research, ISSN 0736-0266, 12/2017, Volume 35, Issue 12, pp. 2740 - 2748
The thinness of mouse articular cartilage presents a significant imaging challenge, however contrast enhanced (µCT) can be utilized to map structural and... 
articular cartilage | mouse | micro‐computed tomography | contrast agent | micro-computed tomography | Cartilage, Articular - diagnostic imaging | Trypsin | Animals | Contrast Media | Mice, Inbred C57BL | Female | Drug Evaluation, Preclinical | Ioxaglic Acid | X-Ray Microtomography | Index Medicus
Journal Article
Journal of Orthopaedic Research, ISSN 0736-0266, 10/2018, Volume 36, Issue 10, pp. 2622 - 2632
Journal Article
Connective tissue research, ISSN 0300-8207, 9/2018, Volume 59, Issue 5, pp. 458 - 471
Healthy tendons are maintained in homeostasis through controlled usage of glucose for energy and redox equilibrium. Tendon cell stress imposed by overuse... 
Transforming growth factor beta 1 | Glucose Metabolism | Tendinopathy | Hypoxia | Metabolic Reprogramming
Journal Article
Journal of Orthopaedic Research, ISSN 0736-0266, 01/2018, Volume 36, Issue 1, pp. 365 - 376
Pirfenidone (PFD)—an anti‐inflammatory, anti‐fibrotic drug—has shown efficacy in lung and kidney fibrosis, while synovial inflammation and joint fibrosis are... 
joint fibrosis | hyaluronan synthase 1 | subchondral bone | Pirfenidone | cartilage injury | LUNG FIBROSIS | MODEL | GENE-EXPRESSION ANALYSIS | HYALURONIC-ACID | ZOLEDRONIC ACID | PHASE-II TRIAL | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | ARTICULAR-CARTILAGE | INFLAMMATION | OSTEOARTHRITIS | ORTHOPEDICS | Knee | Hyaluronic acid | Osteoarthritis | Analysis | Injuries | Fibrosis | Index Medicus | Cartilage injury
Journal Article
2000, ISBN 6610105324, 424
This book provides a comprehensive, up-to-date review of the structure, biology, and molecular interactions of proteoglycans, consolidating into a single... 
Proteoglycans | Biology, life sciences
eBook