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PLoS ONE, ISSN 1932-6203, 04/2012, Volume 7, Issue 4, p. e35009
Background: The Manila clam (Ruditapes philippinarum) is a worldwide cultured bivalve species with important commercial value. Diseases affecting this species... 
OYSTER CRASSOSTREA-GIGAS | HEAT-SHOCK PROTEINS | TNF-ALPHA FACTOR | PROTEINASE-INHIBITOR GENE | MESSENGER-RNA EXPRESSION | MULTIDISCIPLINARY SCIENCES | MOLECULAR-CLONING | ZHIKONG SCALLOP | SCALLOP CHLAMYS-FARRERI | PACIFIC OYSTER | DUPLEX-SPECIFIC NUCLEASE | Receptors, Pattern Recognition - immunology | Vibrio - immunology | Hemocytes - immunology | Apoptosis - genetics | DNA, Bacterial - immunology | Transcriptome - immunology | Peptidoglycan - immunology | Signal Transduction - immunology | Bivalvia - genetics | Bivalvia - immunology | Expressed Sequence Tags | Poly I-C - pharmacology | Vibrio - genetics | Molecular Sequence Annotation | Signal Transduction - genetics | Sequence Analysis, DNA | Complement Activation - genetics | Animals | Apoptosis - immunology | Immune System - metabolism | Hemocytes - drug effects | Lipopolysaccharides - pharmacology | Receptors, Pattern Recognition - genetics | High-Throughput Nucleotide Sequencing | Immunologic Factors - pharmacology | Technology application | Genetic markers | Immunotherapy | Analysis | Communicable diseases | Genes | Gene expression | Ontology | Taxonomy | Genomics | Mollusks | Genomes | Gene sequencing | Consortia | Signal transduction | Next-generation sequencing | Databases | Immune system | Automation | Immune response | Ribonucleic acid--RNA | Signaling | Infectious diseases | Molecular modelling | DNA microarrays | Acids | Economic impact | Hemocytes | Apoptosis | Cloïsses | Malalties infeccioses en els animals | RNA | Communicable diseases in animals | Clams | Resposta immunitària | Ribonucleic acid
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 2012, Volume 7, Issue 2, p. e31219
AMPK, a master metabolic switch, mediates the observed increase of glucose uptake in locomotory muscle of mammals during exercise. AMPK is activated by changes... 
glut4 translocation | insulin sensitivity | intracellular pool | aicar treatment | signaling pathways | glycogen-synthase | rat muscles | gene-expression | metformin action | messenger-rna expression | GLYCOGEN-SYNTHASE | METFORMIN ACTION | SIGNALING PATHWAYS | MESSENGER-RNA EXPRESSION | GLUT4 TRANSLOCATION | MULTIDISCIPLINARY SCIENCES | INTRACELLULAR POOL | GENE-EXPRESSION | RAT MUSCLES | INSULIN SENSITIVITY | AICAR TREATMENT | AMP-Activated Protein Kinases - physiology | Insulin - pharmacology | Fishes - metabolism | Muscle, Skeletal - enzymology | Animals | Glucose Transporter Type 4 | Muscle Fibers, Skeletal | Trout | Metformin - pharmacology | Muscle, Skeletal - drug effects | Glucose - metabolism | Evolution, Molecular | Enzymes | RNA | Glycogen | Muscles | Glucose | Research | Insulin | Dextrose | Glucose metabolism | Synthesis | Fishes | Physiological aspects | Protein kinases | Cell culture | Glycogen synthase | Pyruvic acid | mRNA | Kinases | AMP-activated protein kinase | Cell surface | Synergistic effects | Mitochondria | Evolutionary conservation | Rodents | Fish | Phosphofructokinase | Myotubes | Pyruvate kinase | AMP | Zebrafish | Mammals | Metabolism | Glucose transport | Muscle contraction | Hexokinase | Skeletal muscle | Vertebrates | Metformin | ATP | 6-Phosphofructokinase | Musculoskeletal system | Aparell locomotor | Biological transport | Metabolisme | Peixos | Transport biològic
Journal Article
PLoS ONE, ISSN 1932-6203, 2013, Volume 8, Issue 1, p. e53171
Journal Article
PLoS ONE, ISSN 1932-6203, 2010, Volume 5, Issue 12, p. e14483
Journal Article
PLoS ONE, ISSN 1932-6203, 2015, Volume 10, Issue 9, p. e0137404
Reproductive homing migration of salmonids requires accurate interaction between the reception of external olfactory cues for navigation to the spawning... 
LR - Genomica | LR - Animal Breeding & Genomics | WIAS | Animal Breeding & Genomics | IMARES | Aquacultuur | IMARES Aquaculture | Fokkerij & Genomica | Fokkerij en Genetica | Animal Breeding and Genetics | IMARES Aquacultuur | Wageningen Marine Research | Aquaculture | MATURING SOCKEYE-SALMON | IN-VITRO | LIFE-HISTORIES | PACIFIC SALMON | GONADOTROPIN-RELEASING-HORMONE | MULTIDISCIPLINARY SCIENCES | ANALOG IMPLANTATION | GENE-EXPRESSION PROFILES | LAKE SHIKOTSU | GNRH | LUTEINIZING-HORMONE | Receptors, Odorant - metabolism | Follicle Stimulating Hormone - metabolism | Luteinizing Hormone - genetics | Oncorhynchus keta - metabolism | Pituitary Gland - metabolism | Gonadotropin-Releasing Hormone - genetics | Oncorhynchus keta - growth & development | Transcriptome | Fish Proteins - metabolism | Male | Luteinizing Hormone - metabolism | Organ Specificity | Olfactory Receptor Neurons - metabolism | Smell | Fish Proteins - genetics | Animals | Gonadotropins - metabolism | Gonadotropin-Releasing Hormone - metabolism | Receptors, Odorant - genetics | Female | Gonadotropins - genetics | Follicle Stimulating Hormone - genetics | Sexual Maturation | Salmon | Physiological aspects | Genetic aspects | Behavior | Research | Genetic transcription | Rhinencephalon | Brain | Homing behavior | Spawning grounds | Ecosystems | Migration | Genomics | Genes | 17β-Estradiol | Estradiol | Coastal zone | Gene sequencing | Olfactory stimuli | Homing | Animal reproduction | Luteinizing hormone | Fish | Salmonids | Pituitary-gonadal axis | Navigation | Maturation | Spawning | Gonadotropins | Zebrafish | Pituitary (anterior) | Rivers | Gene expression | Ribonucleic acid--RNA | Sex hormones | Testosterone | Brain research | Pituitary | Gonadotropin-releasing hormone | Laboratory animals | River ecology | Peixos marins | Animal orientation | Marine fishes | Expressió gènica | Orientació animal | RNA | Ribonucleic acid
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2013, Volume 8, Issue 11, p. e80628
The glucose transporter 4 (GLUT4) plays a key role in glucose uptake in insulin target tissues. This transporter has been extensively studied in many species... 
GLUCOSE-TRANSPORTER GLUT4 | GENE PROMOTER | PHYSIOLOGICAL REGULATION | PROLIFERATOR-ACTIVATED RECEPTORS | MULTIDISCIPLINARY SCIENCES | PPAR-GAMMA | ADIPOCYTE DIFFERENTIATION | MEDIATES REPRESSION | TRANSGENIC MICE | RAT GLUT4 | ADIPOSE-TISSUE | Electric Stimulation | Glucose Transporter Type 4 - metabolism | Takifugu | Regulatory Sequences, Nucleic Acid | Molecular Sequence Data | Muscle Fibers, Skeletal - metabolism | PPAR gamma - metabolism | Base Sequence | Cloning, Molecular | Conserved Sequence | Transcription, Genetic | Genes, Reporter | Cell Line | Insulin - pharmacology | Promoter Regions, Genetic | Computational Biology - methods | Gene Expression | Glucose Transporter Type 4 - genetics | Rats | Sequence Analysis, DNA | Biological Evolution | Gene Expression Regulation - drug effects | Insulin - metabolism | Animals | Transcription Initiation Site | 5' Flanking Region | Glucose metabolism | Promoters (Genetics) | Codon | Genes | Muscles | Genetic aspects | Genetic transcription | DNA binding proteins | Glucose | Dextrose | Regulations | Transcription factors | Research parks | Homeostasis | Genomes | Nucleotides | CCAAT/enhancer-binding protein | Gene deletion | Kinases | Proteins | Myocyte-specific enhancer-binding factor 2 | Clonal deletion | Rodents | Animal tissues | Sterol regulatory element-binding protein | Fish | Tata box | CpG islands | Glucose transporter | Cloning | GLUT4 gene | Zebrafish | Metabolism | Gene expression | Retinoid X receptors | Sp1 protein | Insulin | Muscle contraction | Skeletal muscle | Vertebrates | Musculoskeletal system | Ligands | Hypoxia | Transporter | Binding sites | Músculs | Vertebrats | Transcripció genètica | Glucosa
Journal Article
Nature Medicine, ISSN 1078-8956, 07/2017, Volume 23, Issue 7, pp. 850 - 858
Metformin is widely used in the treatment of type 2 diabetes (T2D), but its mechanism of action is poorly defined. Recent evidence implicates the gut... 
MEDICINE, RESEARCH & EXPERIMENTAL | POPULATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | AKKERMANSIA-MUCINIPHILA | BACTERIAL | DIET-INDUCED OBESITY | CELL BIOLOGY | GLUCOSE-HOMEOSTASIS | EXTRACTION | GLUCONEOGENESIS | RESISTANCE | ASSOCIATION | MODULATION | Hypoglycemic Agents - therapeutic use | Metagenomics | Glucose Tolerance Test | Metformin - therapeutic use | Diabetes Mellitus, Type 2 - microbiology | Double-Blind Method | Humans | Middle Aged | Bile Acids and Salts - metabolism | Male | Gastrointestinal Microbiome - genetics | Fatty Acids, Volatile - metabolism | Fecal Microbiota Transplantation | Feces - microbiology | Animals | Feces - chemistry | Germ-Free Life | DNA, Bacterial - analysis | Female | Mice | Diabetes Mellitus, Type 2 - drug therapy | In Vitro Techniques | Type 2 diabetes | Care and treatment | Microbiota (Symbiotic organisms) | Analysis | Dosage and administration | Glucose | Metformin | Drug therapy | Health aspects | Dextrose | Glucose tolerance | Gnotobiotics | Pathways | Coding | Diabetes mellitus | Rodents | Diabetes | Digestive tract | Life Sciences | Human health and pathology | Hépatology and Gastroenterology | chain fatty-acids | Klinisk medicin | gluconeogenesis | diet-induced obesity | hepatic glucose-production | akkermansia-muciniphila | Cell Biology | metabolic syndrome | Medicine | Clinical Medicine | homeostasis | Biochemistry & Molecular Biology | Research & Experimental | bacterial | gastrointestinal-tract | germ-free mice
Journal Article
Journal Article