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by Capper, David and Jones, David T. W and Sill, Martin and Hovestadt, Volker and Schrimpf, Daniel and Sturm, Dominik and Koelsche, Christian and Sahm, Felix and Chavez, Lukas and Reuss, David E and Kratz, Annekathrin and Wefers, Annika K and Huang, Kristin and Pajtler, Kristian W and Schweizer, Leonille and Stichel, Damian and Olar, Adriana and Engel, Nils W and Lindenberg, Kerstin and Harter, Patrick N and Braczynski, Anne K and Plate, Karl H and Dohmen, Hildegard and Garvalov, Boyan K and Coras, Roland and Hölsken, Annett and Hewer, Ekkehard and Bewerunge-Hudler, Melanie and Schick, Matthias and Fischer, Roger and Beschorner, Rudi and Schittenhelm, Jens and Staszewski, Ori and Wani, Khalida and Varlet, Pascale and Pages, Melanie and Temming, Petra and Lohmann, Dietmar and Selt, Florian and Witt, Hendrik and Milde, Till and Witt, Olaf and Aronica, Eleonora and Giangaspero, Felice and Rushing, Elisabeth and Scheurlen, Wolfram and Geisenberger, Christoph and Rodriguez, Fausto J and Becker, Albert and Preusser, Matthias and Haberler, Christine and Bjerkvig, Rolf and Cryan, Jane and Farrell, Michael and Deckert, Martina and Hench, Jürgen and Frank, Stephan and Serrano, Jonathan and Kannan, Kasthuri and Tsirigos, Aristotelis and Brück, Wolfgang and Hofer, Silvia and Brehmer, Stefanie and Seiz-Rosenhagen, Marcel and Hänggi, Daniel and Hans, Volkmar and Rozsnoki, Stephanie and Hansford, Jordan R and Kohlhof, Patricia and Kristensen, Bjarne W and Lechner, Matt and Lopes, Beatriz and Mawrin, Christian and Ketter, Ralf and Kulozik, Andreas and Khatib, Ziad and Heppner, Frank and Koch, Arend and Jouvet, Anne and Keohane, Catherine and Mühleisen, Helmut and Mueller, Wolf and Pohl, Ute and Prinz, Marco and Benner, Axel and Zapatka, Marc and Gottardo, Nicholas G and Driever, Pablo Hernáiz and Kramm, Christof M and Müller, Hermann L and Rutkowski, Stefan and Von Hoff, Katja and Frühwald, Michael C and Gnekow, Astrid and Fleischhack, Gudrun and Tippelt, Stephan and Calaminus, Gabriele and Monoranu, Camelia-Maria and Perry, Arie and Jones, Chris and ...
Nature, ISSN 0028-0836, 03/2018, Volume 555, Issue 7697, pp. 469 - 474
Journal Article
Lancet Oncology, The, ISSN 1470-2045, 2012, Volume 13, Issue 7, pp. 707 - 715
Journal Article
Nature Medicine, ISSN 1078-8956, 08/2018, Volume 24, Issue 8, pp. 1192 - 1203
The oncometabolite (R)-2-hydroxyglutarate (R-2-HG) produced by isocitrate dehydrogenase (IDH) mutations promotes gliomagenesis via DNA and histone methylation.... 
GLIOMA-CELLS | MEDICINE, RESEARCH & EXPERIMENTAL | ACTIVATED PROTEIN-KINASE | ACID | DNA METHYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | ISOCITRATE DEHYDROGENASE MUTATIONS | CANCER | CELL BIOLOGY | IN-VIVO | DIFFERENTIATION | EXPRESSION | 2-HYDROXYGLUTARATE | Cell Proliferation | Calcium - metabolism | Humans | RNA, Messenger - metabolism | Immunity | Glioma - genetics | Lymphocyte Activation - immunology | Brain Neoplasms - immunology | Adenosine Triphosphate - metabolism | Paracrine Communication | Receptors, Antigen, T-Cell - metabolism | Signal Transduction | Mice, Inbred C57BL | NFATC Transcription Factors - metabolism | RNA, Messenger - genetics | Brain Neoplasms - genetics | Glioma - immunology | Isocitrate Dehydrogenase - genetics | Mutation - genetics | Polyamines - metabolism | Animals | Cell Line, Tumor | Isocitrate Dehydrogenase - metabolism | T-Lymphocytes - immunology | Glutarates - metabolism | Apoptosis | Molecular genetics | Gliomas | Dosage and administration | Genetic aspects | Research | Genetic transcription | T cells | Drug therapy | Immunosuppressive agents | Transcription factors | Calcium | Transcription | Biosynthesis | Lymphocytes T | NF-AT protein | Calcium signalling | Cancer vaccines | Lymphocytes | DNA methylation | Inhibition | Mutation | Methylation | Isocitrate dehydrogenase | Deoxyribonucleic acid--DNA | Tumors | Index Medicus
Journal Article
Journal Article
Nature, ISSN 0028-0836, 09/2018, Volume 561, Issue 7723, pp. 319 - 320
Immunotherapies activate T cells to destroy tumours, but the approach has failed in some brain cancers. A strategy to improve migration of T cells across the... 
Brain | Immunology | Cancer | Care and treatment | Research | T cells | Tissue engineering | Brain cancer
Journal Article
Nature, ISSN 0028-0836, 09/2018, Volume 561, Issue 7723, pp. 1 - 2
Samaha et al. engineered T cells to express an antigen receptor that was designed to bind to human epidermal growth factor receptor 2 (HER2) - an antigen... 
Encephalitis | Medical research | Brain | Antigens | Brain tumors | Brain cancer | T cell receptors | Lymphocytes T | Proteins | Researchers | Blood-brain barrier | Lymphocytes | Immunotherapy | Ligands | Tumors
Journal Article
Lancet Oncology, The, ISSN 1470-2045, 2017, Volume 18, Issue 5, pp. 682 - 694
Journal Article
Therapeutic Advances in Neurological Disorders, ISSN 1756-2856, 02/2019, Volume 12, pp. 1756286419827688 - 1756286419827688
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2014, Volume 111, Issue 1, pp. 409 - 414
Journal Article
Acta neuropathologica, ISSN 0001-6322, 01/2015, Volume 129, Issue 1, pp. 133 - 146
Journal Article
Neuro-oncology, ISSN 1522-8517, 06/2019, Volume 21, Issue 6, pp. 699 - 700
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 11/2017, Volume 377, Issue 20, pp. 1954 - 1963
The addition of bevacizumab to lomustine in patients with recurrent glioblastoma failed to increase overall survival but was associated with a small increase... 
MEDICINE, GENERAL & INTERNAL | METHYLATION | PROGNOSTIC-FACTORS | PLUS IRINOTECAN | SINGLE-AGENT BEVACIZUMAB | RESPONSE ASSESSMENT | CLINICAL-TRIALS | PHASE-2 | QUALITY-OF-LIFE | RADIOTHERAPY | TEMOZOLOMIDE | Bevacizumab - administration & dosage | Bevacizumab - adverse effects | Humans | Lomustine - adverse effects | Middle Aged | Kaplan-Meier Estimate | Male | Antineoplastic Agents, Alkylating - administration & dosage | Brain Neoplasms - drug therapy | Chemoradiotherapy | Glioblastoma - radiotherapy | Disease-Free Survival | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Intention to Treat Analysis | Aged, 80 and over | Adult | Female | Aged | Brain Neoplasms - mortality | Antineoplastic Agents, Alkylating - adverse effects | Brain Neoplasms - radiotherapy | Glioblastoma - drug therapy | Glioblastoma - mortality | Lomustine - administration & dosage | Patient outcomes | Lomustine | Outcome and process assessment (Health Care) | Dosage and administration | Research | Drug therapy | Glioblastoma multiforme | Methods | Medical research | Nuclear magnetic resonance--NMR | Brain cancer | Methylguanine | Glioblastoma | Clinical trials | Oncology | Cognition | Cancer therapies | Survival | Quality of life | Bevacizumab | O6-methylguanine-DNA methyltransferase | Studies | Brain research | DNA methylation | DNA methyltransferase | Methylation | Cancer | Index Medicus | Abridged Index Medicus
Journal Article